Risk management on application of minimum-cost feed ration for nitrogen and phosphorus reduction on dairy farm

The traditional mathematical programming model with the objective function of feed ration cost minimization is used to accommodate risk management responses to price variability associated with feeding a particular feed ration over time. The model incorporated biophysical simulation data using Cornell Net Carbohydrate and Protein System (CNCPS) software in addressing nutrient requirements and excretions. In addition, it used historic feedstuff prices in a mean-variance (E-V) framework analysis. The optimized seasonal feeding indicated to have a lower mean ration cost and lowest nutrient loading followed by optimized uniform feeding program. The feed cost optimization proved to be a better strategy in minimizing ration cost and reducing excretions both manure and nutrients. The results in this study can be used as guidelines for making nutrient. The information in this study can be used by a producer facing feed price risk to select optimal ration while reducing environmental pollution.Risk and Uncertainty,

An Integrated Precision Production and Environmental Management Analysis of a Kentucky Dairy Farm

This study compares and contrasts the profitability of different dairy management practices through precision livestock farming. Feed analysis and crop yields were simulated. The proposed alternative feeding program demonstrated less manure and nutrient excretions. When mathematical programming model was employed, uniform rate application manifested the highest selected economic values.Management practices, environmental, Environmental Economics and Policy,

Assessment of end-of-life design in solid-state lighting

Consumers in the US market and across the globe are beginning to widely adopt light emitting diode (LED) lighting products while the technology continues to undergo significant changes. While LED products are evolving to consume less energy, they are also more complex than traditional lighting products with a higher number of parts and a larger number of electronic components. Enthusiasm around the efficiency and long expected life span of LED lighting products is valid, but research to optimize product characteristics and design is needed. This study seeks to address that gap by characterizing LED lighting products’ suitability for end of life (EOL) recycling and disposal. The authors disassembled and assessed 17 different lighting products to understand how designs differ between brands and manufacture year. Products were evaluated based on six parameters to quantify the design. The analysis indicates that while the efficiency of LED products has improved dramatically in the recent past, product designers and manufacturers could incorporate design strategies to improve environmental performance of lighting products at end-of-life

Characteristics of Mid-Frequency Sensorineural Hearing Loss Progression.

OBJECTIVES:To characterize the progression of mid-frequency sensorineural hearing loss (MFSNHL) over time. METHODS:A retrospective chart review spanning 2012 to 2017 was performed at a tertiary care audiology and neurotology center. Our cohort included 37 patients met the criteria for MFSNHL also known as "cookie bite hearing loss." It was defined as having a 1, 2, and 4 kHz average pure tone audiometry greater than 10 dB in intensity compared with the average threshold at 500 Hz and 8 kHz. RESULTS:Average age at initial presentation was 11.8 years (range, 8 mo to 70 yr). Across all individuals, the average mid-frequency threshold was 47 dB, compared with 27 dB at 500 Hz and 8 kHz. Twenty-three patients (62%) had multiple audiograms with 4-year median follow up time. Average values across all frequencies (0.5, 1, 2, 4, 8 kHz) in the initial audiogram was 37 dB, compared with an average of 39 dB demonstrated on final audiogram. Of those with serial audiograms, only five patients demonstrated threshold changes of 10 dB or more. Of these five patients, only one was found to have clinical worsening of MFSNHL. CONCLUSIONS:MFSNHL is an uncommon audiometric finding with unspecified long-term outcomes. We demonstrated that most patients (96%) with MFSNHL do not experience clinical worsening of their hearing threshold over almost 4 years of follow up. Future prospective studies aimed at collecting longer-term data are warranted to further elucidate the long-term trajectory of MFSNHL patients

Medical Malpractice of Vestibular Schwannoma: A 40-Year Review of the United States Legal Databases.

OBJECTIVES:To analyze medical malpractice lawsuit trends pertaining to cases of vestibular schwannomas (VS). METHODS:Two major computerized legal databases (LexisNexis and WestLaw) were queried and reviewed for evaluation of all the US state and federal court records from civil trials alleging malpractice between 1976 and 2016. RESULTS:A total of 32 VS cases were identified. Allegations were divided into four categories: misdiagnosis/delayed diagnosis (47%), postoperative complications (44%), failure of informed consent or information sharing (16%), and other (3%). Postoperative complications included facial nerve paralysis, myocardial infarction, meningitis, and intracranial hemorrhage. Judgment amounts ranged from $300,000 to$2,000,000. The specialist type was specified for 24 of the 32 cases (75%): neurosurgeons (n = 9; 37%), neurotologists (n = 6; 25%), general otolaryngologists (n = 5; 21%), primary care physicians (n = 4; 17%), neurologists (n = 3; 12%), radiologists (n = 3; 12%), anesthesiologists (n = 2; 8%), radiation oncologists (n = 1; 4%), and general surgeon (n = 1; 4%). Of these 24 cases, (n = 9; 37%) two or more physicians were named as defendants in the lawsuit. CONCLUSIONS:Enhanced physician-patient communication, ensuring proper and adequate patient consent procedures, and proper documentation are good practices that may decrease the likelihood of lawsuits

Grounding Technologies: The creative use of mundane and emerging technologies for place-based, just climate action

Putting people and place at the heart of our work, Grounding Technologies explores how everyday, emergent and mundane technologies can support community-centred climate action.Such ambitions were achieved through a programme of public calls that brought together activists, artists, designers, researchers, programmers, creative makers, hackers, social enterprises, commercial businesses and creative producers in the West of England region. Across 10 months, over 100 people engaged in the programme, with 6 groups each receiving £15K to develop pilot projects.In establishing a new network in the West of England that focuses on the role of creative practice and climate action, we’ve discovered a hunger across the region for working with emerging and commonplace technologies for bottom-up, social and environmentally engaged work. The region’s deep history in environmental work, engineering expertise and technological know-how also highlights the value of bridging communities of practice. Our findings show that there is a wealth of potential in supporting interdisciplinary, cross-sector and intergenerational knowledge transfer.Findings from our cohort have shown that inviting creative approaches to a just transition can be done in a responsible, careful manner that moves away from business-as-usual, but that still allows us all to thrive. To deepen the impact of this work, we propose a re-focus on three key areas to address regional disparities of opportunity and identity: place-based, longer-term support and more flexible funding mechanisms are necessary for building meaningful collaborations across sectors and scales to energise a just transition

Production of Extrachromosomal MicroDNAs Is Linked to Mismatch Repair Pathways and Transcriptional Activity

SummaryMicroDNAs are <400-base extrachromosomal circles found in mammalian cells. Tens of thousands of microDNAs have been found in all tissue types, including sperm. MicroDNAs arise preferentially from areas with high gene density, GC content, and exon density from promoters with activating chromatin modifications and in sperm from the 5′-UTR of full-length LINE-1 elements, but are depleted from lamin-associated heterochromatin. Analysis of microDNAs from a set of human cancer cell lines revealed lineage-specific patterns of microDNA origins. A survey of microDNAs from chicken cells defective in various DNA repair proteins reveals that homologous recombination and non-homologous end joining repair pathways are not required for microDNA production. Deletion of the MSH3 DNA mismatch repair protein results in a significant decrease in microDNA abundance, specifically from non-CpG genomic regions. Thus, microDNAs arise as part of normal cellular physiology—either from DNA breaks associated with RNA metabolism or from replication slippage followed by mismatch repair