498 research outputs found
A SYSTEMS APPROACH TO THE PROBLEM OF FALLS IN OLD AGE
The problem of falls in old age is enormously costly and disruptive for the older individual, others, and society, and its severity is likely to intensify as our population ages. This dissertation takes a systems-oriented approach toward the falls problem and is presented in two parts. The first part critically develops a new approach to the problem of falls. The second part describes an empirical study that applies this new approach in a pragmatic manner.
Conventional fall prevention strategies employ a reductionist approach to the problem of falls. This approach is questioned because it corresponds poorly to the holistic nature of postural control. A systems-oriented conceptual framework explains postural instability in old age as the gradual decline of a postural control systemâs ability to adapt.
Realizing that falls arise from a complex system of interacting components of various levels and domains makes it imperative to investigate interventions aimed toward systemically fostering robust postural control. A dynamic systems theoretical framework is outlined that views postural control to be the result of synergies which function to control myriad inherent degrees of freedom. Complexity-based measures of postural sway are suggested as indicators of postural control system robustness.
This new approach to the problem of falls is applied in an empirical study in which Tai Chi serves as a systems-oriented intervention. Using a dynamic systems perspective, motor imagery, along with other Tai Chi principles, are hypothesized to provide interacting physical and cognitive constraints on motor behavior that form synergies which enable robust postural stability into old age.
This hypothesis was tested in a quasi-experiment comparing effects of Tai Chi motor imagery in Tai Chi experts and non-experts. The expected significant effects on postural sway complexity were not found, but significant main effects and interactions on sway variability and ease of imagery were discovered with respect to expertise and imagery type. Findings, results, innovations, implications and future directions are presented, and discussed as they pertain to four specific aims, and to ameliorating the problem of falls in old age
Case Report Anti-Yo Mediated Paraneoplastic Cerebellar Degeneration Associated with Pseudobulbar Affect in a Patient with Breast Cancer
Paraneoplastic cerebellar degeneration (PCD) is a rare anti-Yo mediated paraneoplastic syndromes rarely that is infrequently associated with breast cancer. We present a case of a 52-year-old female presenting with diplopia, gait instability, dysarthria, dysphagia, nystagmus, and, most notably, new onset paroxysmal episodes of uncontrollable crying concerning for pseudobulbar affect (PBA). Serologic testing showed anti-Yo antibodies. The patient was found to have stage IIIA breast cancer as the inciting cause of the paraneoplastic syndrome. The patient was treated with neoadjuvant chemotherapy, modified radical mastectomy, adjuvant Herceptin, and pertuzumab. She was given IVIG for paraneoplastic syndrome, antidepressants, and dextromethorphan-quinidine (Nuedexta), the first FDA-approved therapy for PBA. With multimodality therapy, she demonstrated significant improvement in neurologic and mood symptoms associated with PCD and PBA
The Hydrogen Epoch of Reionization Array Dish II: Characterization of Spectral Structure with Electromagnetic Simulations and its science Implications
We use time-domain electromagnetic simulations to determine the spectral
characteristics of the Hydrogen Epoch of Reionization Arrays (HERA) antenna.
These simulations are part of a multi-faceted campaign to determine the
effectiveness of the dish's design for obtaining a detection of redshifted 21
cm emission from the epoch of reionization. Our simulations show the existence
of reflections between HERA's suspended feed and its parabolic dish reflector
that fall below -40 dB at 150 ns and, for reasonable impedance matches, have a
negligible impact on HERA's ability to constrain EoR parameters. It follows
that despite the reflections they introduce, dishes are effective for
increasing the sensitivity of EoR experiments at relatively low cost. We find
that electromagnetic resonances in the HERA feed's cylindrical skirt, which is
intended to reduce cross coupling and beam ellipticity, introduces significant
power at large delays ( dB at 200 ns) which can lead to some loss of
measurable Fourier modes and a modest reduction in sensitivity. Even in the
presence of this structure, we find that the spectral response of the antenna
is sufficiently smooth for delay filtering to contain foreground emission at
line-of-sight wave numbers below Mpc, in
the region where the current PAPER experiment operates. Incorporating these
results into a Fisher Matrix analysis, we find that the spectral structure
observed in our simulations has only a small effect on the tight constraints
HERA can achieve on parameters associated with the astrophysics of
reionization.Comment: Accepted to ApJ, 18 pages, 17 Figures. Replacement matches accepted
manuscrip
The Hydrogen Epoch of Reionization Array Dish I: Beam Pattern Measurements and Science Implications
The Hydrogen Epoch of Reionization Array (HERA) is a radio interferometer
aiming to detect the power spectrum of 21 cm fluctuations from neutral hydrogen
from the Epoch of Reionization (EOR). Drawing on lessons from the Murchison
Widefield Array (MWA) and the Precision Array for Probing the Epoch of
Reionization (PAPER), HERA is a hexagonal array of large (14 m diameter) dishes
with suspended dipole feeds. Not only does the dish determine overall
sensitivity, it affects the observed frequency structure of foregrounds in the
interferometer. This is the first of a series of four papers characterizing the
frequency and angular response of the dish with simulations and measurements.
We focus in this paper on the angular response (i.e., power pattern), which
sets the relative weighting between sky regions of high and low delay, and
thus, apparent source frequency structure. We measure the angular response at
137 MHz using the ORBCOMM beam mapping system of Neben et al. We measure a
collecting area of 93 m^2 in the optimal dish/feed configuration, implying
HERA-320 should detect the EOR power spectrum at z~9 with a signal-to-noise
ratio of 12.7 using a foreground avoidance approach with a single season of
observations, and 74.3 using a foreground subtraction approach. Lastly we study
the impact of these beam measurements on the distribution of foregrounds in
Fourier space.Comment: 13 pages, 9 figures. Replaced to match accepted ApJ versio
A Broadband Study of the Emission from the Composite Supernova Remnant MSH 11-62
MSH 11-62 (G291.1-0.9) is a composite supernova remnant for which radio and
X-ray observations have identified the remnant shell as well as its central
pulsar wind nebula. The observations suggest a relatively young system
expanding into a low density region. Here we present a study of MSH 11-62 using
observations with the Chandra, XMM-Newton, and Fermi observatories, along with
radio observations from the Australia Telescope Compact Array (ATCA). We
identify a compact X-ray source that appears to be the putative pulsar that
powers the nebula, and show that the X-ray spectrum of the nebula bears the
signature of synchrotron losses as particles diffuse into the outer nebula.
Using data from the Fermi LAT, we identify gamma-ray emission originating from
MSH 11-62. With density constraints from the new X-ray measurements of the
remnant, we model the evolution of the composite system in order to constrain
the properties of the underlying pulsar and the origin of the gamma-ray
emission.Comment: 12 Pages, 12 figures. Accepted for publication in the Astrophysical
Journa
Selective scattering between Floquet-Bloch and Volkov states in a topological insulator
The coherent optical manipulation of solids is emerging as a promising way to
engineer novel quantum states of matter. The strong time periodic potential of
intense laser light can be used to generate hybrid photon-electron states.
Interaction of light with Bloch states leads to Floquet-Bloch states which are
essential in realizing new photo-induced quantum phases. Similarly, dressing of
free electron states near the surface of a solid generates Volkov states which
are used to study non-linear optics in atoms and semiconductors. The
interaction of these two dynamic states with each other remains an open
experimental problem. Here we use Time and Angle Resolved Photoemission
Spectroscopy (Tr-ARPES) to selectively study the transition between these two
states on the surface of the topological insulator Bi2Se3. We find that the
coupling between the two strongly depends on the electron momentum, providing a
route to enhance or inhibit it. Moreover, by controlling the light polarization
we can negate Volkov states in order to generate pure Floquet-Bloch states.
This work establishes a systematic path for the coherent manipulation of solids
via light-matter interaction.Comment: 21 pages, 6 figures, final version to appear in Nature Physic
Mapping Cosmic Dawn and Reionization: Challenges and Synergies
Cosmic dawn and the Epoch of Reionization (EoR) are among the least explored
observational eras in cosmology: a time at which the first galaxies and
supermassive black holes formed and reionized the cold, neutral Universe of the
post-recombination era. With current instruments, only a handful of the
brightest galaxies and quasars from that time are detectable as individual
objects, due to their extreme distances. Fortunately, a multitude of
multi-wavelength intensity mapping measurements, ranging from the redshifted 21
cm background in the radio to the unresolved X-ray background, contain a
plethora of synergistic information about this elusive era. The coming decade
will likely see direct detections of inhomogenous reionization with CMB and 21
cm observations, and a slew of other probes covering overlapping areas and
complementary physical processes will provide crucial additional information
and cross-validation. To maximize scientific discovery and return on
investment, coordinated survey planning and joint data analysis should be a
high priority, closely coupled to computational models and theoretical
predictions.Comment: 5 pages, 1 figure, submitted to the Astro2020 Decadal Survey Science
White Paper cal
Professionalization of a nonstate actor
Can nonstate militants professionalize? That is the core question of this piece. Discussions of professionalism have spread to the state military from civilian professions such as education, medicine, and law. This piece examines whether nonstate actors exhibit the same fundamental processes found within these state-based organizations. These fundamentals are the creation of a recognized internal ethos, which acts as a collective standard for those involved. A commitment to expertise and the punishment of those who do not reach these collective expectations reinforce this ethos. To answer this question, this piece examines the development of the Provisional Irish Republican Army (PIRA) during the Troubles. It highlights consistencies and inconsistencies with traditional forces and argues that groups like the PIRA can professionalize and increase their effectiveness in doing so. This widens the field of professionalism studies and provides an additional lens through which to examine nonstate groups
Demonstrating testâretest reliability of electrophysiological measures for healthy adults in a multisite study of biomarkers of antidepressant treatment response
Growing evidence suggests that loudness dependency of auditory evoked potentials (LDAEP) and resting EEG alpha and theta may be biological markers for predicting response to antidepressants. In spite of this promise, little is known about the joint reliability of these markers, and thus their clinical applicability. New standardized procedures were developed to improve the compatibility of data acquired with different EEG platforms, and used to examine testâretest reliability for the three electrophysiological measures selected for a multisite projectâEstablishing Moderators and Biosignatures of Antidepressant Response for Clinical Care (EMBARC). Thirtyânine healthy controls across four clinical research sites were tested in two sessions separated by about 1 week. Resting EEG (eyesâopen and eyesâclosed conditions) was recorded and LDAEP measured using binaural tones (1000 Hz, 40 ms) at five intensities (60â100 dB SPL). Principal components analysis of current source density waveforms reduced volume conduction and provided referenceâfree measures of resting EEG alpha and N1 dipole activity to tones from auditory cortex. Lowâresolution electromagnetic tomography (LORETA) extracted resting theta current density measures corresponding to rostral anterior cingulate (rACC), which has been implicated in treatment response. There were no significant differences in posterior alpha, N1 dipole, or rACC theta across sessions. Testâretest reliability was .84 for alpha, .87 for N1 dipole, and .70 for theta rACC current density. The demonstration of goodâtoâexcellent reliability for these measures provides a template for future EEG/ERP studies from multiple testing sites, and an important step for evaluating them as biomarkers for predicting treatment response.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135271/1/psyp12758_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/135271/2/psyp12758.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/135271/3/psyp12758-sup-0001-suppinfo1.pd
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