The Future of Enterprise Security with Regards to Mobile Technology and Applications

The utilisation of work assigned mobile technology by enterprise staff to chat and upload contents to the social media applications for personal use has become a key issue for a significant number of enterprises. This work aims to understand the trends amongst the users of work assigned phones when unknowingly downloading and using applications which could breach the security of the enterprise. In this paper; we assess current trends amongst employees and organisations’ use and trust of hybrid and web based social media applications used on a daily basis to communicate. This information is then evaluated alongside human related cyber security risks presented by such applications to provide instructions and advice on the management of social media application use within organisations in the Healthcare, Education and Energy sectors. The findings may be employed to develop a more robust cyber security strategy which focuses at reducing the user related risks

Management of Treatment and Prevention of Acute OP Pesticide Poisoning by Medical Informatics, Telemedicine and Nanomedicine

Acute organophosphorous pesticide (OP) poisoning kills a lot of people each year. Treatment of acute OP poisoning is of very difficult task and is a time taking event. Present day informatics methods (telemedicine), bioinformatics methods (data mining, molecular modeling, docking, cheminformatics), and nanotechnology (nanomedicine) should be applied in combination or separately to combat the rise of death rate due to OP poisoning. Use of informatics method such as Java enabled camera mobiles will enable us early detection of insecticidal poisoning. Even the patients who are severely intoxicated (suicidal attempts) can be diagnosed early. Telemedicine can take care for early diagnosis and early treatment. Simultaneously efforts must be taken with regard to nanotechnology to find lesser toxic compounds (use less dose of nanoparticle mediated compounds: nano-malathion) as insecticides and find better efficacy of lesser dose of compounds for treatment (nano-atropine) of OP poisoning. Nano-apitropine (atropine oxide) may be a better choice for OP poisoning treatment as the anticholinergic agent; apitropine and hyoscyamine have exhibited higher binding affinity than atropine sulfate. Synthesis of insecticides (malathion) with an antidote (atropine, apitropine) in nanoscale range will prevent the lethal effect of insecticides

Identification of Clinical Immunological Determinants in Asymptomatic VL and Post Kala-azar Dermal Leishmaniasis Patients

Background: Visceral Leishmaniasis (VL) caused by protozoa belonging to the genus Leishmania, usually have anthroponotic mode of transmission and is issue of great public health importance in Indian subcontinent. Asymptomatic cases of VL and PKDL are subject of keen interest to find their role in the transmission of VL in epidemic areas. We evaluated the immunological cytokine determinants expressed in most clinical suspects of asymptomatic VL and PKDL (IL-10, IFN-γ, and TNF-α). Methods: Eighty-four participants were included at RMRIMS, Patna, India in 2016-17 out of which 64 asymptomatic individual positive for rK-39, without sign and symptoms of VL; 15 PKDL patient’s with past history of VL and 5 endemic healthy subjects were recruited from VL endemic areas. DAT and quantitative assessment of plasma cytokines was determined from the blood samples collected in a plain and sodium-EDTA vacutainer respectively from the subjects. Results: The mean level of IL-10 in DATposLOW of asymptomatic VL and PKDL was significantly higher than endemic healthy (P<0.05). The cytokine polarization index (IFN-γ versus IL-10) was significantly low in PKDL cases compared with asymptomatic VL cases in DATposLOW titre (P<0.05). This index was low again but statistically not significant in PKDL than in asymptomatic VL when TNF-α was considered against IL-10. The ratio of IFN-γ: IL-10 and TNF-α: IL-10 was observed decreased both in asymptomatic VL and PKDL cases than in healthy from endemic areas. Conclusion: Collectively we surmise from our data that asymptomatic VL can also play an important role like PKDL in transmission of VL

Elucidation of conserved multi-epitope vaccine against <i>Leishmania donovani</i> using reverse vaccinology

Visceral leishmaniasis (VL) is a tropical disease that causes severe public health problems in humans when untreated. As no licensed vaccine exists against VL, we aimed to formulate a potential MHC-restricted chimeric vaccine construct against this dreadful parasitic disease. Amastin-like protein derived from L. donovani is considered to be stable, immunogenic and non-allergic. A comprehensive established framework was used to explore the set of immunogenic epitopes with estimated population coverage of 96.08% worldwide. The rigorous assessment revealed 6 promiscuous T-epitopes which can plausibly be presented by more than 66 diverse HLA alleles. Further docking and simulation study of peptide receptor complexes identified a strong and stable binding interaction with better structural compactness. The predicted epitopes were combined with appropriate linkers and adjuvant molecules and their translation efficiency was evaluated in pET28+(a), an bacterial expression vector using in-silico cloning. Molecular docking followed by MD simulation study revealed a stable interaction between chimeric vaccine construct with TLRs. Immune simulation of the chimeric vaccine constructs showed an elevated Th1 immune response against both B and T epitopes. With this, the detailed computational analysis suggested that the chimeric vaccine construct can evoke a robust immune response against Leishmania donovani infection. Future studies are required to validate the role of amastin as a promising vaccine target. Communicated by Ramaswamy H. Sarma</p

Improving the efficiency of a FTO/PCBM/Cs2AgBiBr6/NiOx/Au lead-free double perovskite solar cell using numerical simulation through optimizing the absorption layer thickness and work function of electrodes

Lead-free perovskite solar cells are proposed to reduce environmental toxicity. However, the efficiency of these solar cells is significantly lower than that of those based on lead. The maximum Photo Conversion Efficiency(PCE) reported experimentally for lead free solar cells is 6.37%, which is significantly lower than that of lead-based solar cells. Attempts have been made to improve the PCE of lead-free solar cells using numerical simulations in order to build a lead-free solar cell with the highest efficiency attainable. Recently, a lead-free solar cell with the configuration ITO/SnO2/Cs2AgBiBr6/P3HT/Au and a maximum PCE of 11.69% was numerically investigated. In this study, we suggested a lead-free solar cell structure using FTO/PCBM/Cs2AgBiBr6/NiOx/Au configuration and showed that,when operated in the wavelength range 400–700 nm, a PCE of 15.49% with Jsc = 8.17 mA/cm2, Voc = 2.49 V and FF = 76.16% can be attained by optimizing the thickness of the absorption layer and the work function of the electrode. While in the same configuration the PCE can be increased to 21.92% when operated in the wavelength range of 350–750 nm. This investigation's findings can be used to manufacture more efficient and stable lead-free solar cells forfuturenon-hazardous environmental applications