Future Developments Trends in Mechanical-demining Technology

The authors argue that there is a need to turn toward cheaper and more effective mechanical demining. The future of demining technology is very important for countries with landmine-clearance needs

Panchromatic and Spectral Characterization of Cu Contaminated Semi-Insulating GaAs

Panchromatic (integral) and spectrally resolved cathodoluminescence characterization was used to investigate the near surface gettering properties of Cu in liquid-encapsulated, Czochralski-grown, undoped semi-insulating (SI) GaAs. Samples from two sources were investigated to determine if gettering treatments applied to GaAs result in improvements in uniformity similar to those observed in gettered Si. Before Cu contamination, typical cellular structure is observed for all samples. Experimentally, it is found that the panchromatic CL images change significantly after Cu doping and subsequent gettering processing for all samples. A contrast reversal is generally observed after Cu contamination. After gettering, the image of the samples from one source remained reversed whereas the image of samples from the other source showed a second contrast reversal. Typically, both samples exhibit bright regions after gettering which closely correspond to the dislocation structure. More detailed spectrally resolved CL indicates that Cu luminescence correlates well in most cases with the band edge emission. In only a few cases were discernible differences noted. It is concluded that Cu is observed in locations from which nonradiative recombination centers have been effectively removed

Differential proteomic analysis of abnormal intramyoplasmic aggregates in desminopathy

Desminopathy is a subtype of myofibrillar myopathy caused by desmin mutations and characterized by protein aggregates accumulating in muscle fibers. The aim of this study was to assess the protein composition of these aggregates. Aggregates and intact myofiber sections were obtained from skeletal muscle biopsies of five desminopathy patients by laser microdissection and analyzed by a label-free spectral count-based proteomic approach. We identified 397 proteins with 22 showing significantly higher spectral indices in aggregates (ratio >1.8, p <0.05). Fifteen of these proteins not previously reported as specific aggregate components provide new insights regarding pathomechanisms of desminopathy. Results of proteomic analysis were supported by immunolocalization studies and parallel reaction monitoring. Three mutant desmin variants were detected directly on the protein level as components of the aggregates, suggesting their direct involvement in aggregate-formation and demonstrating for the first time that proteomic analysis can be used for direct identification of a disease-causing mutation in myofibrillar myopathy. Comparison of the proteomic results in desminopathy with our previous analysis of aggregate composition in filaminopathy, another myofibrillar myopathy subtype, allows to determine subtype-specific proteomic profile that facilitates identification of the specific disorder. Biological significance Our proteomic analysis provides essential new insights in the composition of pathological protein aggregates in skeletal muscle fibers of desminopathy patients. The results contribute to a better understanding of pathomechanisms in myofibrillar myopathies and provide the basis for hypothesis-driven studies. The detection of specific proteomic profiles in different myofibrillar myopathy subtypes indicates that proteomic analysis may become a useful tool in differential diagnosis of protein aggregate myopathies. This article is part of a Special Issue entitled: From Genome to Proteome: Open Innovations. (C) 2013 Elsevier B.V. All rights reserved

Semiconductor Material Device Characterization

xxiv, 760 hlm, Ilust, 21 c

Impedance and Other Properties of Gold Doped Silicon P-N Junctions

155 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1968.U of I OnlyRestricted to the U of I community idenfinitely during batch ingest of legacy ETD