The Impact of the Spectral Response of an Achromatic Half-Wave Plate on the Measurement of the Cosmic Microwave Background Polarization

We study the impact of the spectral dependence of the linear polarization rotation induced by an achromatic half-wave plate on measurements of cosmic microwave background polarization in the presence of astrophysical foregrounds. We focus on the systematic effects induced on the measurement of inflationary gravitational waves by uncertainties in the polarization and spectral index of Galactic dust. We find that for the experimental configuration and noise levels of the balloon-borne EBEX experiment, which has three frequency bands centered at 150, 250, and 410 GHz, a crude dust subtraction process mitigates systematic effects to below detectable levels for 10% polarized dust and tensor to scalar ratio of as low as r = 0.01. We also study the impact of uncertainties in the spectral response of the instrument. With a top-hat model of the spectral response for each band, characterized by band-center and band-width, and with the same crude dust subtraction process, we find that these parameters need to be determined to within 1 and 0.8 GHz at 150 GHz; 9 and 2.0 GHz at 250 GHz; and 20 and 14 GHz at 410 GHz, respectively. The approach presented in this paper is applicable to other optical elements that exhibit polarization rotation as a function of frequency.Comment: 6 pages, 7 figures, accepted for publication by Astrophysical Journa

A cryogenic rotation stage with a large clear aperture for the half-wave plates in the Spider instrument

We describe the cryogenic half-wave plate rotation mechanisms built for and used in Spider, a polarization-sensitive balloon-borne telescope array that observed the Cosmic Microwave Background at 95 GHz and 150 GHz during a stratospheric balloon flight from Antarctica in January 2015. The mechanisms operate at liquid helium temperature in flight. A three-point contact design keeps the mechanical bearings relatively small but allows for a large (305 mm) diameter clear aperture. A worm gear driven by a cryogenic stepper motor allows for precise positioning and prevents undesired rotation when the motors are depowered. A custom-built optical encoder system monitors the bearing angle to an absolute accuracy of +/- 0.1 degrees. The system performed well in Spider during its successful 16 day flight.Comment: 11 pages, 7 figures, Published in Review of Scientific Instruments. v2 includes reviewer changes and longer literature revie

The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to

The emergence and spread of Plasmodium falciparum resistance to first-line antimalarials creates an imperative to identify and develop potent preclinical candidates with distinct modes of action. Here, we report the identification of MMV688533, an acylguanidine that was developed following a whole-cell screen with compounds known to hit high-value targets in human cells. MMV688533 displays fast parasite clearance in vitro and is not cross-resistant with known antimalarials. In a P. falciparum NSG mouse model, MMV688533 displays a long-lasting pharmacokinetic profile and excellent safety. Selection studies reveal a low propensity for resistance, with modest loss of potency mediated by point mutations in PfACG1 and PfEHD. These proteins are implicated in intracellular trafficking, lipid utilization, and endocytosis, suggesting interference with these pathways as a potential mode of action. This preclinical candidate may offer the potential for a single low-dose cure for malaria

The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to

The emergence and spread of Plasmodium falciparum resistance to first-line antimalarials creates an imperative to identify and develop potent preclinical candidates with distinct modes of action. Here, we report the identification of MMV688533, an acylguanidine that was developed following a whole-cell screen with compounds known to hit high-value targets in human cells. MMV688533 displays fast parasite clearance in vitro and is not cross-resistant with known antimalarials. In a P. falciparum NSG mouse model, MMV688533 displays a long-lasting pharmacokinetic profile and excellent safety. Selection studies reveal a low propensity for resistance, with modest loss of potency mediated by point mutations in PfACG1 and PfEHD. These proteins are implicated in intracellular trafficking, lipid utilization, and endocytosis, suggesting interference with these pathways as a potential mode of action. This preclinical candidate may offer the potential for a single low-dose cure for malaria

Simple scoring system to predict in-hospital mortality after surgery for infective endocarditis

BACKGROUND: Aspecific scoring systems are used to predict the risk of death postsurgery in patients with infective endocarditis (IE). The purpose of the present study was both to analyze the risk factors for in-hospital death, which complicates surgery for IE, and to create a mortality risk score based on the results of this analysis. METHODS AND RESULTS: Outcomes of 361 consecutive patients (mean age, 59.1\ub115.4 years) who had undergone surgery for IE in 8 European centers of cardiac surgery were recorded prospectively, and a risk factor analysis (multivariable logistic regression) for in-hospital death was performed. The discriminatory power of a new predictive scoring system was assessed with the receiver operating characteristic curve analysis. Score validation procedures were carried out. Fifty-six (15.5%) patients died postsurgery. BMI >27 kg/m2 (odds ratio [OR], 1.79; P=0.049), estimated glomerular filtration rate 55 mm Hg (OR, 1.78; P=0.032), and critical state (OR, 2.37; P=0.017) were independent predictors of in-hospital death. A scoring system was devised to predict in-hospital death postsurgery for IE (area under the receiver operating characteristic curve, 0.780; 95% CI, 0.734-0.822). The score performed better than 5 of 6 scoring systems for in-hospital death after cardiac surgery that were considered. CONCLUSIONS: A simple scoring system based on risk factors for in-hospital death was specifically created to predict mortality risk postsurgery in patients with IE

La qualité à l'hôpital : entre incantations managériales et traductions professionnelles

International audienceDire la qualité, faire la qualité. Quel est le pouvoir incantatoire de certains concepts en management? Dans quelle mesure le discours managérial rencontre-t-il les pratiques professionnelles? Et si les démarches de formalisation en œuvre à l'hôpital étaient génératrices de changements inattendus, parcellaires, partiellement contradictoires? Cet article tente de faire le point sur les greffes locales des discours des managers ou représentants de l'État en montrant en quoi les détournements de sens des discours sur " la " qualité régénère les pratiques en place

Polyphenolic composition of a natural pasture. Variation in function of the period of harvesting

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Impact of Simulated Gastrointestinal Conditions on Antiglycoxidant and α-Glucosidase Inhibition Capacities of Cyanidin-3-O-Glucoside

International audienceCyanidin-3-O-glucoside (C3G) is a widespread anthocyanin derivative, which has been reported in vitro to exert potent antioxidant, antiglycation and α-glucosidase inhibition effects. Nevertheless, the physiological relevance of such properties remains uncertain considering its significant instability in gastrointestinal conditions. A simulated digestion procedure was thus instigated to assess the influence of gastric and intestinal media on its chemical integrity and biological activities. HPLC analyses of digested C3G samples confirmed the striking impact of intestinal conditions, as attested by a decomposition ratio of 70%. In contrast, with recovery rates of around 90%, antiglycation, as well as DPPH and ABTS scavenging assays, uniformly revealed a noteworthy persistence of its antiglycoxidant capacities. Remarkably, a prominent increase of its α-glucosidase inhibition activity was even observed after the intestinal phase, suggesting that classical in vitro evaluations might underestimate C3G antidiabetic potential. Consequently, the present data provide novel and specific insights on C3G’s digestive fate, suggesting that the gastrointestinal tract does not profoundly affect its positive action on oxidative and carbonyl stresses. More specifically, it also tends to support its regulating effects on postprandial hyperglycemia and its potential usefulness for diabetes management

Screening and Characterization of Antiglycoxidant Anthocyanins from Vaccinium myrtillus Fruit Using DPPH and Methylglyoxal Pre-Column HPLC Assays

International audienceVaccinium myrtillusfruit (bilberry) is well known for its high richness in anthocyanins,which may be responsible for its preventive effects on several oxidative and carbonyl stress-relatedpathologies. However, limited data are available regarding the antioxidant and antiglycativecontributions of its constituents. Spectrometric analyses were performed to evaluate anthocyanincontent, radical scavenging and antiglycative properties of an anthocyanin-rich extract from bilberries.Additionally, original DPPH and methylglyoxal pre-column HPLC methods were instigated to allowstraightforward identification of the main contributors to radical and carbonyl trapping effects.Finally, representative pure anthocyanins were evaluated using classical DPPH and antiglycationassays. Delphinidin, petunidin and cyanidin glycosides were identified as the most effective radicalscavenging constituents in both HPLC and spectrometric DPPH evaluations. Potent antiglycativeactivities were also assessed for cyanidin, delphinidin and petunidin glucosides as attested by theirrespective IC50values of 114.2±7.8, 130.5±2.8, and 132.4±3.7μM. Interestingly, methylglyoxalspiking evaluation demonstrated that all bilberry anthocyanins exerted noticeable and comparableα-dicarbonyl trapping effects. Anthocyanins can be regarded as potent antiglycoxidant agents thatmight account for some health benefits of bilberries consumption. Besides, significant differences intheir contributions were successfully highlighted by the employed pre-column HPLC assays