Wo steht mein Schreibtisch in der virtuellen Bibliothek?

Die Krise, in der die Bibliothekare ihren Beruf augenscheinlich permanent sehen, hat Ihre Ursache in einer Diskrepanz zwischen dem Muster spezialisierter Tätigkeiten (Bibliothekarberuf) und dem gesellschaftlichen Funktionsausschnitt, auf den sich der Beruf bezieht (gesellschaftliche Rolle der Bibliotheken). Zukünftig wird es darauf ankommen, ein bibliothekarisches Berufsbild institutionsunabhängig zu formulieren. Es werden Trends umrissen, die auf das Bibliothekswesen und verwandte Bereiche einwirken oder innerhalb des Bibliothekswesens oder verwandter Bereiche entstehen: rechtliche, technische, politische, wirtschaftliche Rahmenbedingungen, die Annäherung des wissenschaftlichen und öffentlichen Bibliothekswesens, des Dokumentations- und Archivbereichs, Ausbildung, Studium und Berufsinhalte, interne und externe Organisation, Finanzierung, bibliothekarische Dienstleistungen, Ziele und Leitbilder. Bibliothekare werden sich auf vielfältige Aufgaben der Informations- und Medienbeschaffung, -selektion, -aufbereitung, -erschließung, -vermittlung, -archivierung in allen möglichen Branchen und Bereichen, aber weniger in Bibliotheken einzustellen haben

Global Retinoblastoma Presentation and Analysis by National Income Level.

Importance: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale. Objectives: To report the retinoblastoma stage at diagnosis in patients across the world during a single year, to investigate associations between clinical variables and national income level, and to investigate risk factors for advanced disease at diagnosis. Design, Setting, and Participants: A total of 278 retinoblastoma treatment centers were recruited from June 2017 through December 2018 to participate in a cross-sectional analysis of treatment-naive patients with retinoblastoma who were diagnosed in 2017. Main Outcomes and Measures: Age at presentation, proportion of familial history of retinoblastoma, and tumor stage and metastasis. Results: The cohort included 4351 new patients from 153 countries; the median age at diagnosis was 30.5 (interquartile range, 18.3-45.9) months, and 1976 patients (45.4%) were female. Most patients (n = 3685 [84.7%]) were from low- and middle-income countries (LMICs). Globally, the most common indication for referral was leukocoria (n = 2638 [62.8%]), followed by strabismus (n = 429 [10.2%]) and proptosis (n = 309 [7.4%]). Patients from high-income countries (HICs) were diagnosed at a median age of 14.1 months, with 656 of 666 (98.5%) patients having intraocular retinoblastoma and 2 (0.3%) having metastasis. Patients from low-income countries were diagnosed at a median age of 30.5 months, with 256 of 521 (49.1%) having extraocular retinoblastoma and 94 of 498 (18.9%) having metastasis. Lower national income level was associated with older presentation age, higher proportion of locally advanced disease and distant metastasis, and smaller proportion of familial history of retinoblastoma. Advanced disease at diagnosis was more common in LMICs even after adjusting for age (odds ratio for low-income countries vs upper-middle-income countries and HICs, 17.92 [95% CI, 12.94-24.80], and for lower-middle-income countries vs upper-middle-income countries and HICs, 5.74 [95% CI, 4.30-7.68]). Conclusions and Relevance: This study is estimated to have included more than half of all new retinoblastoma cases worldwide in 2017. Children from LMICs, where the main global retinoblastoma burden lies, presented at an older age with more advanced disease and demonstrated a smaller proportion of familial history of retinoblastoma, likely because many do not reach a childbearing age. Given that retinoblastoma is curable, these data are concerning and mandate intervention at national and international levels. Further studies are needed to investigate factors, other than age at presentation, that may be associated with advanced disease in LMICs

The global retinoblastoma outcome study : a prospective, cluster-based analysis of 4064 patients from 149 countries

DATA SHARING : The study data will become available online once all analyses are complete.BACKGROUND : Retinoblastoma is the most common intraocular cancer worldwide. There is some evidence to suggest that major differences exist in treatment outcomes for children with retinoblastoma from different regions, but these differences have not been assessed on a global scale. We aimed to report 3-year outcomes for children with retinoblastoma globally and to investigate factors associated with survival. METHODS : We did a prospective cluster-based analysis of treatment-naive patients with retinoblastoma who were diagnosed between Jan 1, 2017, and Dec 31, 2017, then treated and followed up for 3 years. Patients were recruited from 260 specialised treatment centres worldwide. Data were obtained from participating centres on primary and additional treatments, duration of follow-up, metastasis, eye globe salvage, and survival outcome. We analysed time to death and time to enucleation with Cox regression models. FINDINGS : The cohort included 4064 children from 149 countries. The median age at diagnosis was 23·2 months (IQR 11·0–36·5). Extraocular tumour spread (cT4 of the cTNMH classification) at diagnosis was reported in five (0·8%) of 636 children from high-income countries, 55 (5·4%) of 1027 children from upper-middle-income countries, 342 (19·7%) of 1738 children from lower-middle-income countries, and 196 (42·9%) of 457 children from low-income countries. Enucleation surgery was available for all children and intravenous chemotherapy was available for 4014 (98·8%) of 4064 children. The 3-year survival rate was 99·5% (95% CI 98·8–100·0) for children from high-income countries, 91·2% (89·5–93·0) for children from upper-middle-income countries, 80·3% (78·3–82·3) for children from lower-middle-income countries, and 57·3% (52·1-63·0) for children from low-income countries. On analysis, independent factors for worse survival were residence in low-income countries compared to high-income countries (hazard ratio 16·67; 95% CI 4·76–50·00), cT4 advanced tumour compared to cT1 (8·98; 4·44–18·18), and older age at diagnosis in children up to 3 years (1·38 per year; 1·23–1·56). For children aged 3–7 years, the mortality risk decreased slightly (p=0·0104 for the change in slope). INTERPRETATION : This study, estimated to include approximately half of all new retinoblastoma cases worldwide in 2017, shows profound inequity in survival of children depending on the national income level of their country of residence. In high-income countries, death from retinoblastoma is rare, whereas in low-income countries estimated 3-year survival is just over 50%. Although essential treatments are available in nearly all countries, early diagnosis and treatment in low-income countries are key to improving survival outcomes.The Queen Elizabeth Diamond Jubilee Trust and the Wellcome Trust.https://www.thelancet.com/journals/langlo/homeam2023Paediatrics and Child Healt

The study of the relationship between life limiting factor and stress level for FGH96

FGH96 is a Chinese made powder metallurgy nickel based superalloy. This reserach aims to investigate the effect of stress on the microstructure of the worst fatigue life at 600°C. The specimens were first polished by abrasive paper and then electropolished to elimate the effect of surface residual stress. The fatigue tests were conducted at 600°C, and the loading ratio was 0.05 at the frequency of 5Hz. Tests were conducted at 900, 1000, 1100, 1200MPa respectively. The fatigue life under the same condition were compared and the fractography of specimens were examined under SEM to further identify the life-limiting factors of the material. The initiation mode transferred from facet initiated to inclusion initiated from lower stress level to higher stress level. Meanwhile, the initiation position transferred from internal to surface with the increase of stress level. This means at higher stress level, fatigue life is mainly limited by inclusion at surface while at lower stress level the limit is controlled by internal facet

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The study of the relationship between life limiting factor and stress level for FGH96

FGH96 is a Chinese made powder metallurgy nickel based superalloy. This reserach aims to investigate the effect of stress on the microstructure of the worst fatigue life at 600°C. The specimens were first polished by abrasive paper and then electropolished to elimate the effect of surface residual stress. The fatigue tests were conducted at 600°C, and the loading ratio was 0.05 at the frequency of 5Hz. Tests were conducted at 900, 1000, 1100, 1200MPa respectively. The fatigue life under the same condition were compared and the fractography of specimens were examined under SEM to further identify the life-limiting factors of the material. The initiation mode transferred from facet initiated to inclusion initiated from lower stress level to higher stress level. Meanwhile, the initiation position transferred from internal to surface with the increase of stress level. This means at higher stress level, fatigue life is mainly limited by inclusion at surface while at lower stress level the limit is controlled by internal facet

Influence of orientation and temperature on the fatigue crack growth of directionally solidification superalloys DZ125

The influence of orientation and temperature on the fatigue crack growth of a directionally solidification superalloys named DZ125 were investigated in this study. The specimens were designed based on ASTM E647 standard and the compliance method was employed to monitor the crack growth. Tests were conducted at room temperature, 760°C and 850°C respectively. The longitudinal and transverse orientation were both studied in this tests. Results show that the orientation dependence is weak at elevated temperature compared with that at room temperature. However, the temperature influences the fatigue crack growth rate significantly and the largest difference can be an order of magnitude on the da/dN-ΔK graph. But the reduction in higher ΔK area of elevated temperature can still be observed. Potential reasons and hypothesis were explained in this paper. In addition, the crack growth mode appears to transfer from type I with the increase of temperature which also reflects the influence of temperature

Influence of orientation and temperature on the fatigue crack growth of directionally solidification superalloys DZ125

The influence of orientation and temperature on the fatigue crack growth of a directionally solidification superalloys named DZ125 were investigated in this study. The specimens were designed based on ASTM E647 standard and the compliance method was employed to monitor the crack growth. Tests were conducted at room temperature, 760°C and 850°C respectively. The longitudinal and transverse orientation were both studied in this tests. Results show that the orientation dependence is weak at elevated temperature compared with that at room temperature. However, the temperature influences the fatigue crack growth rate significantly and the largest difference can be an order of magnitude on the da/dN-ΔK graph. But the reduction in higher ΔK area of elevated temperature can still be observed. Potential reasons and hypothesis were explained in this paper. In addition, the crack growth mode appears to transfer from type I with the increase of temperature which also reflects the influence of temperature

Predictor-Based Neural Dynamic Surface Control of a Nontriangular System With Unknown Disturbances

For a class of nontriangular nonlinear systems in presence of unknown disturbances, we propose a predictor-based neural dynamic surface control (PNDSC) strategy in this paper. This nontriangular system is transformed via the mean value theorem, and a predictor is then constructed. To avoid an algebraic loop problem, partial state vectors are employed as input signals of neural networks (NNs) for approximating unknown dynamics, and compensation items are designed to compensate for approximation errors from NNs. Different from the traditional NDSC, the PNDSC in this paper utilizes prediction errors to update learning parameters for improving NNs' learning behaviors with overlarge adaptive gains. On the basis of improved NNs' approximation behaviors, a predictor-based NNs disturbance observer (PNNDO) is constructed for compensation for external disturbances and approximation errors from NNs. Furthermore, with predictors, a normalization method of weights is developed to reduce the number of online learning parameters. On the basis of the aforementioned result, measurement noises are taken into account in our predictor-based neural control strategy. We employ predictor states, rather than measurement information paralyzed by noises, in design of our control strategy. This reduces high-frequency oscillations in control input. A Lyapunov-based stability analysis shows that all signals are ultimately bounded in the closed-loop system. Finally, the effectiveness of the proposed control strategy is verified by a numerical example and a permanent magnet brushless DC motor system