Gender Diversity Cultural Responsiveness Education in Speech-Language Pathology Graduate Programs: A Pilot Survey

Purpose: Gender-affirming voice therapy aims to align a person’s voice and communication with their gender identity. Historically, transgender and gender-nonconforming (TGNC) individuals have been marginalized and continue to face significant healthcare disparities. The goal of this research was to examine the self-perceived preparedness of recent speech-language pathology (SLP) graduates for working with TGNC clients. A survey was developed to include both multiple choice and open-ended questions. Topics included graduate-level training on working with TGNC individuals, perceived preparedness to work with this client population, educational resources sought by respondents, and suggested improvements for SLP graduate programs. Thirty recent (since 2016) SLP graduates completed the survey anonymously. Although a majority (83%) of respondents reported that working with TGNC clients was addressed in their graduate education, 66% of respondents felt that instruction time spent on this topic was insufficient or slightly insufficient. Those who had clinical experiences with TGNC clients, or who learned from the perspectives of the TGNC community (e.g., from a guest speaker or video), reported that their graduate education better prepared them to work with TGNC clients. One of the most common recommendations to improve graduate education was to invite TGNC speakers to share their experiences. The majority of respondents identified a need for improvement of gender diversity education in SLP graduate programs. Further research is needed to determine the efficacy of different curricula in increasing the knowledge and skills of SLP graduates specific to TGNC clients to ensure clinical competency and equitable care

The Evolution of Early-type Field Galaxies Selected from a NICMOS Map of the Hubble Deep Field North

The redshift distribution of well-defined samples of distant early-type galaxies offers a means to test the predictions of monolithic and hierarchical galaxy formation scenarios. NICMOS maps of the entire Hubble Deep Field North in the F110W and F160W filters, when combined with the available WFPC2 data, allow us to calculate photometric redshifts and determine the morphological appearance of galaxies at rest-frame optical wavelengths out to z ~ 2.5. Here we report results for two subsamples of early-type galaxies, defined primarily by their morphologies in the F160W band, which were selected from the NICMOS data down to H160_{AB} < 24.0. The observed redshift distributions of our two early-type samples do not match that predicted by a monolithic collapse model, which shows an overabundance at z > 1.5. A hierarchical formation model better matches the redshift distribution of the HDF-N early-types at z > 1.5, but still does not adequately describe the observed early-types. The hierarchical model predicts significantly bluer colors on average than the observed early-type colors, and underpredicts the observed number of early-types at z < 1. [abridged]Comment: Accepted for publication in the Astronomical Journal; 54 pages, 21 figures. Figures 10 and 11 are included separately in JPEG forma

The Large-scale and Small-scale Clustering of Lyman-Break Galaxies at 3.5 < z< 5.5 from the GOODS survey

We report on the angular correlation function of Lyman-break galaxies (LBGs) at z~4 and 5 from deep samples obtained from the Great Observatories Deep Origins Survey (GOODS). Similar to LBGs at z~3, the shape of w(theta) of the GOODS LBGs is well approximated by a power-law with slope beta~0.6 at angular separation theta > 10 arcsec. The clustering strength of z~4, 5 LBGs also depends on the rest-frame UV luminosity, with brighter galaxies more strongly clustered than fainter ones, implying a general correlation between halos' mass and LBGs' star-formation rate. At smaller separations, w(theta) of deep samples significantly exceeds the extrapolation of the large-scale power-law fit, implying enhanced spatial clustering at scales r < 1 Mpc. We also find that bright LBGs statistically have more faint companions on scales theta < 20 arcsec than fainter ones, showing that the enhanced small-scale clustering is very likely due to sub-structure, namely the fact that massive halos can host multiple galaxies. A simple model for the halo occupation distribution and the CDM halo mass function reproduce well the observed w(theta). The scaling relationship of the clustering strength with volume density and with redshift is quantitatively consistent with that of CDM halos. A comparison of the clustering strength of three samples of equal luminosity limit at z ~ 3, 4 and 5 shows that the LBGs at z~5 are hosted in halos about one order of magnitude less massive than those in the lower redshift bins, suggesting that star-formation was more efficient at higher-redshift.Comment: replaced with the version accepted for publication in ApJ. 46 pages, 10 figures; minor changes to text, one subsection adde

Morphologies and Spectral Energy Distributions of Extremely Red Galaxies in the GOODS-South Field

Using U'- through Ks-band imaging data in the GOODS-South field, we construct a large, complete sample of 275 ``extremely red objects'' (EROs; K_s<22.0, R-K_s>3.35; AB), all with deep HST/ACS imaging in B_435, V_606, i_775, and z_850, and well-calibrated photometric redshifts. Quantitative concentration and asymmetry measurements fail to separate EROs into distinct morphological classes. We therefore visually classify the morphologies of all EROs into four broad types: ``Early'' (elliptical-like), ``Late'' (disk galaxies), ``Irregular'' and ``Other'' (chain galaxies and low surface brightness galaxies), and calculate their relative fractions and comoving space densities. For a broad range of limiting magnitudes and color thresholds, the relative number of early-type EROs is approximately constant at 33-44%, and the comoving space densities of Early- and Late-type EROs are comparable. Mean rest-frame spectral energy distributions (SEDs) at wavelengths between 0.1 and 1.2 um are constructed for all EROs. The SEDs are extremely similar in their range of shapes, independent of morphological type. The implication is that any differences between the broad-band SEDs of Early-type EROs and the other types are relatively subtle, and there is no robust way of photometrically distinguishing between different morphological types with usual optical/near-infrared photometry.Comment: Submitted to the ApJL. A version with full-resolution figures, all GOODS data and all GOODS collaboration papers may be found at http://www.stsci.edu/science/goods

FGF4 retrogene on CFA12 is responsible for chondrodystrophy and intervertebral disc disease in dogs.

Chondrodystrophy in dogs is defined by dysplastic, shortened long bones and premature degeneration and calcification of intervertebral discs. Independent genome-wide association analyses for skeletal dysplasia (short limbs) within a single breed (PBonferroni = 0.01) and intervertebral disc disease (IVDD) across breeds (PBonferroni = 4.0 × 10-10) both identified a significant association to the same region on CFA12. Whole genome sequencing identified a highly expressed FGF4 retrogene within this shared region. The FGF4 retrogene segregated with limb length and had an odds ratio of 51.23 (95% CI = 46.69, 56.20) for IVDD. Long bone length in dogs is a unique example of multiple disease-causing retrocopies of the same parental gene in a mammalian species. FGF signaling abnormalities have been associated with skeletal dysplasia in humans, and our findings present opportunities for both selective elimination of a medically and financially devastating disease in dogs and further understanding of the ever-growing complexity of retrogene biology

Cell-based therapy in prophylaxis and treatment of chronic graft-versus-host disease

Copyright © 2022 Doglio, Crossland, Alho, Penack, Dickinson, Stary, Lacerda, Eissner and Inngjerdingen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Hematopoietic allogeneic stem cell transplantation (allo-SCT) is a curative option for patients with hematological malignancies. However, due to disparities in major and minor histocompatibility antigens between donor and recipient, severe inflammatory complications can occur, among which chronic graft-versus-host disease (cGVHD) can be life-threatening. A classical therapeutic approach to the prevention and treatment of cGVHD has been broad immunosuppression, but more recently adjuvant immunotherapies have been tested. This review summarizes and discusses immunomodulatory approaches with T cells, including chimeric antigen receptor (CAR) and regulatory T cells, with natural killer (NK) cells and innate lymphoid cells (ILCs), and finally with mesenchymal stromal cells (MSC) and extracellular vesicles thereof. Clinical studies and pre-clinical research results are presented likewise.This work was supported by COST (European Cooperation in Science and Technology). www.cost.eu - COST Action 17138 EUROGRAFT.info:eu-repo/semantics/publishedVersio

The Grizzly, October 8, 2015

Regional Threat Prompts Increased Safety Measures • Students Help Teach English to Cleaning Staff • U-Imagine Resources Help Entrepreneurs get Started • Not Your Ordinary Librarian: Interview with Ursinus\u27 New Instructional Technology Librarian • Fighting for Ophelia Hosts Biannual Kindness Week • UC Students Use Spanish Outside the Classroom • Hungry for a Good Discussion • An Honor and Opportunity • Opinions: Another Home: Studying Abroad; New Film Black Mass Rates 6 / 10 • Volleyball Eyes Turnaround in Second Half of Season • Making Strides • Football Looks to Bounce Back Strong After Bye Weekhttps://digitalcommons.ursinus.edu/grizzlynews/1673/thumbnail.jp

The Grizzly, December 10, 2015

Museum Studies Minor Coming in Spring 2016 • Students Demand Diversity • BEAR Pitch Competition Crowns Winners • International Perspective: Differences in Cultural Cleaning Routines • Flapjacks for Finals • Artists\u27 Tribute to Chadwick • Bringing Safety to the Students • Opinions: Protests Prompt Hate on Yik Yak; Why Syrian Refugees Don\u27t Pose a Threat • Outrunning the Competition • Men\u27s Basketball Set to Take on Division I Pennhttps://digitalcommons.ursinus.edu/grizzlynews/1679/thumbnail.jp

The Grizzly, October 1, 2015

Safety First: New Campus Safety Officer Looks to Connect with Students • Artist Transforms Ursinus Faces into Famous Painting • Design Philly Festival Kicks Off with Pop-up Exhibition • Politics Professor Looks to Expand Research on Africa • U-Imagine Center Promotes Entrepreneurship • UC Students Get Down to the Heart of the Matter • Putting Passion into Practice • Opinions: Is Fun Home Appropriate for CIE?; The Cleaning Staff Should Not be Ignored • In the Swing of Things • Men\u27s and Women\u27s Rugby Teams Prepare for Seasonhttps://digitalcommons.ursinus.edu/grizzlynews/1672/thumbnail.jp

Glucocorticoid Regulation of SLIT/ROBO Tumour Suppressor Genes in the Ovarian Surface Epithelium and Ovarian Cancer Cells

The three SLIT ligands and their four ROBO receptors have fundamental roles in mammalian development by promoting apoptosis and repulsing aberrant cell migration. SLITs and ROBOs have emerged as candidate tumour suppressor genes whose expression is inhibited in a variety of epithelial tumours. We demonstrated that their expression could be negatively regulated by cortisol in normal ovarian luteal cells. We hypothesised that after ovulation the locally produced cortisol would inhibit SLIT/ROBO expression in the ovarian surface epithelium (OSE) to facilitate its repair and that this regulatory pathway was still present, and could be manipulated, in ovarian epithelial cancer cells. Here we examined the expression and regulation of the SLIT/ROBO pathway in OSE, ovarian cancer epithelial cells and ovarian tumour cell lines. Basal SLIT2, SLIT3, ROBO1, ROBO2 and ROBO4 expression was lower in primary cultures of ovarian cancer epithelial cells when compared to normal OSE (P<0.05) and in poorly differentiated SKOV-3 cells compared to the more differentiated PEO-14 cells (P<0.05). Cortisol reduced the expression of certain SLITs and ROBOs in normal OSE and PEO-14 cells (P<0.05). Furthermore blocking SLIT/ROBO activity reduced apoptosis in both PEO-14 and SKOV-3 tumour cells (P<0.05). Interestingly SLIT/ROBO expression could be increased by reducing the expression of the glucocorticoid receptor using siRNA (P<0.05). Overall our findings indicate that in the post-ovulatory phase one role of cortisol may be to temporarily inhibit SLIT/ROBO expression to facilitate regeneration of the OSE. Therefore this pathway may be a target to develop strategies to manipulate the SLIT/ROBO system in ovarian cancer