LLV - Lunar Logistic Vehicle Final report

Evaluation of systems design training institute for engineering facult

PathwayAccess: CellDesigner plugins for pathway databases

Summary: CellDesigner provides a user-friendly interface for graphical biochemical pathway description. Many pathway databases are not directly exportable to CellDesigner models. PathwayAccess is an extensible suite of CellDesigner plugins, which connect CellDesigner directly to pathway databases using respective Java application programming interfaces. The process is streamlined for creating new PathwayAccess plugins for specific pathway databases. Three PathwayAccess plugins, MetNetAccess, BioCycAccess and ReactomeAccess, directly connect CellDesigner to the pathway databases MetNetDB, BioCyc and Reactome. PathwayAccess plugins enable CellDesigner users to expose pathway data to analytical CellDesigner functions, curate their pathway databases and visually integrate pathway data from different databases using standard Systems Biology Markup Language and Systems Biology Graphical Notation

Enabling Multidisciplinary Perspective in Student Design Project: Fast Fashion and Sustainable Manufacturing Systems

Fast fashion retailers are growing faster than any other type of retailer due to their ability to offer trendy low-cost clothing mimicking latest runway trends with turnaround times as low as two weeks. Fueled by short production and distribution lead times, fast fashion retailers combine rapid prototyping, small batches of fashionable product designs, and efficient transportations and delivery. Among others, the methods applied in fast-fashion industry include mass customization and personalization, and lean manufacturing. Current trends in manufacturing lean towards the application of digital and rapid manufacturing methods and increased use of product lifecycle management, knowledge management systems and computer integrated manufacturing. Furthermore, modern fashion systems span geographical regions, wherein design and manufacturing is not necessarily done at the same location and it requires coordination of many pairs of hands and machines, followed by multiple processes and treatments to meet the demands of ever decreasing time-to-market. Hence, there are connections that can be used as a benefit for multidisciplinary student projects which would include fashion merchandising students and engineering students. Therefore, the purpose of this paper is to present a model of a project which would include a team of students with diverse backgrounds and experiences in fashion, engineering, and industrial technology in order to examine various manufacturing system concepts that can be used to enhance the sustainability of fast-fashion systems. These activities would be embedded in their current courses and they would expose engineering students to a fashion manufacturing industry and fashion students to engineering concepts of product lifecycle management and computer aided manufacturing. Special emphasis would be given to female engineering students who are not necessarily exposed to this kind of industry in their major

Attempting to Acutely Manipulate Ground Contact Time Imbalances Impairs Running Economy

Running economy (RE) is a key performance determinant. Biomechanical markers have been linked to RE, including ground contact time (GCT), cadence, and vertical oscillation (VO). Recently, we showed a strong relationship between GCT imbalances and RE. Because these markers can be tracked real-time with consumer-wearable devices, runners now have access to instant feedback concerning their mechanics. PURPOSE: Determine if attempting to correct GCT imbalances real-time alters mechanics and RE. METHODS: 7 recreational runners (38 ± 15 years, 24.7 ± 2.8 kg/m2, 5 male) completed 2, 10-minute running trials (9.65 km/hr) on separate days. For both trials, subjects ran with a heart rate (HR) monitor/watch that measured GCT, GCT imbalances, cadence, and VO. For the control (CT) trial, subjects were not permitted to receive feedback from the watch. During the feedback (FB) trial, the watch was set to display GCT imbalances, and subjects were prompted every 20-30 seconds to monitor/attempt to correct any imbalances. Both trials were preceded by a dynamic warmup and 5-minute jog. For the FB trial warmup, subjects were acclimated to the watch and allowed to experiment with manipulating their GCT imbalances. VO2 was monitored continuously throughout each 10-minute trial, and average values from 6 to 9 minutes were determined for each trial. Average values for all running biomechanical variables were calculated from 0.5 minutes to 9.5 minutes. Comparisons between trials were made with a dependent sample t-test. RESULTS: The FB trial elicited a significantly higher (p = .011) working VO2 (35.5 ± 1.6 ml/kg/min) compared to the CT trial (33.4 ± 1.8 ml/kg/min). There were no other significant differences between trials for the other measured variables. Average values for each variable by trial were as follows: RER (CT: .91 ± .04; FB: .92 ± .05), HR (CT: 159 ± 26 bpm; FB: 163 ± 24 bpm), GCT % difference (CT: 1.69 ± .67%; FB: 1.70 ± 1.70%), GCT absolute difference (CT: 9 ± 3 ms; FB: 8 ± 7 ms), GCT (CT: 272 ± 26 ms; FB: 268 ± 31 ms), Cadence (CT: 165 ± 9 steps/min; FB: 167 ± 9 steps/min); VO (CT: 9.3 ± 2.0 cm; FB: 9.2 ± 1.9 cm), VO ratio (CT: 9.5 ± 1.6 cm/m; FB: 9.5 ± 1.6 cm/m). CONCLUSIONS: Acutely attempting to correct GCT imbalances did not result in improved mechanics and actually impaired RE. Altering mechanics based on real-time feedback from consumer-wearable devices may impair performance in the short term. Given that GCT imbalances have been linked to impaired RE, future research should determine how to better correct these imbalances rather than attempting to acutely manipulate them

Electric-Field Tuning of Spin-Dependent Exciton-Exciton Interactions in Coupled Quantum Wells

We have shown experimentally that an electric field decreases the energy separation between the two components of a dense spin-polarized exciton gas in a coupled double quantum well, from a maximum splitting of $\sim 4$ meV to zero, at a field of $\sim$35 kV/cm. This decrease, due to the field-induced deformation of the exciton wavefunction, is explained by an existing calculation of the change in the spin-dependent exciton-exciton interaction with the electron-hole separation. However, a new theory that considers the modification of screening with that separation is needed to account for the observed dependence on excitation power of the individual energies of the two exciton components.Comment: 5 pages, 4 eps figures, RevTeX, Physical Review Letters (in press

Increased Atmospheric Ammonia over the World's Major Agricultural Areas Detected from Space

This study provides evidence of substantial increases in atmospheric ammonia (NH3) concentrations (14-year) over several of the worlds major agricultural regions, using recently available retrievals from the Atmospheric Infrared Sounder (AIRS) aboard NASA's Aqua satellite. The main sources of atmospheric NH3 are farming and animal husbandry involving reactive nitrogen ultimately derived from fertilizer use; rates of emission are also sensitive to climate change. Significant increasing trends are seen over the U.S. (2.61%per yr), the European Union (EU) (1.83%per yr), and China (2.27%per yr). Over the EU, the trend results from decreased scavenging by acid aerosols. Over the U.S., the increase results from a combination of decreased chemical loss and increased soil temperatures. Over China, decreased chemical loss, increasing temperatures, and increased fertilizer use all play a role. Over South Asia, increased NH3 emissions are masked by increased SO2 and NOX emissions, leading to increased aerosol loading and adverse health effects

The new vertebrate CYP1C family : cloning of new subfamily members and phylogenetic analysis

Author Posting. © The Authors, 2005. This is the author's version of the work. It is posted here by permission of Elsevier B. V. for personal use, not for redistribution. The definitive version was published in Biochemical and Biophysical Research Communications 331 (2005): 1016-1024, doi:10.1016/j.bbrc.2005.03.231.Two novel CYP1 genes from teleost fish constituting a new subfamily have been cloned. These paralogous sequences are designated CYP1C1 and CYP1C2. Both genes were initially obtained from untreated scup Stenotomus chrysops tissues by RT-PCR and RACE. Scup CYP1C1 and CYP1C2 code for 524 and 525 amino acids, respectively, and share 80-81% identity at the nucleotide and amino acid levels. Orthologues of CYP1C1 and CYP1C2 were identified in genome databases for other fish species, and both CYP1B1 and CYP1C1 were cloned from zebrafish (Danio rerio). Phylogenetic analysis shows that CYP1Cs and CYP1Bs constitute a sister clade to the CYP1As. Analysis of sequence domains likely to have functional significance suggests the two CYP1Cs in scup may have catalytic functions and/or substrate specificity that differ from each other and from those of mammalian CYP1Bs or CYP1As. RT-PCR results indicate that CYP1C1 and CYP1C2 are variously expressed in several scup organs.This work was supported by EPA grant R 827102-01-0 and NIH grants 5 P42-ES07381 and ES04696. JVG is supported by a Ruth L. Kirschstein NRSA Fellowship (F32 ES012794)