6,118 research outputs found
Application of quasi-Monte Carlo methods to PDEs with random coefficients -- an overview and tutorial
This article provides a high-level overview of some recent works on the
application of quasi-Monte Carlo (QMC) methods to PDEs with random
coefficients. It is based on an in-depth survey of a similar title by the same
authors, with an accompanying software package which is also briefly discussed
here. Embedded in this article is a step-by-step tutorial of the required
analysis for the setting known as the uniform case with first order QMC rules.
The aim of this article is to provide an easy entry point for QMC experts
wanting to start research in this direction and for PDE analysts and
practitioners wanting to tap into contemporary QMC theory and methods.Comment: arXiv admin note: text overlap with arXiv:1606.0661
A systematic review of associations between environmental exposures and development of asthma in children aged up to 9 years
Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.Peer reviewedPublisher PD
Fragmentation pathways of nanofractal structures on surface
We present a detailed systematical theoretical analysis of the post-growth
processes occurring in nanofractals grown on surface. For this study we
developed a method which accounts for the internal dynamics of particles in a
fractal. We demonstrate that particle diffusion and detachment controls the
shape of the emerging stable islands on surface. We consider different
scenarios of fractal post-growth relaxation and analyze the time evolution of
the island's morphology. The results of our calculations are compared with
available experimental observations, and experiments in which the post-growth
relaxation of deposited nanostructures can be probed are suggested.Comment: 34 pages, 11 figure
Leptogenesis with Dirac Neutrinos
We describe a "neutrinogenesis" mechanism whereby, in the presence of
right-handed neutrinos with sufficiently small pure Dirac masses,
(B+L)-violating sphaleron processes create the baryon asymmetry of the
Universe, even when B=L=0 initially. It is shown that the resulting neutrino
mass constraints are easily fulfilled by the neutrino masses suggested by
current experiments. We present a simple toy model which uses this mechanism to
produce the observed baryon asymmetry of the Universe. (PostScript Errors
corrected in latest Version).Comment: 4 pages, Latex (using amsmath,feynmp,graphicx), 4 figure
Non-canonical functions of the RB protein in cancer
The canonical model of RB-mediated tumour suppression developed over the past 30 years is based on the regulation of E2F transcription factors to restrict cell cycle progression. Several additional functions have been proposed for RB, on the basis of which a non-canonical RB pathway can be described. Mechanistically, the non-canonical RB pathway promotes histone modification and regulates chromosome structure in a manner distinct from cell cycle regulation. These functions have implications for chemotherapy response and resistance to targeted anticancer agents. This Opinion offers a framework to guide future studies of RB in basic and clinical research
Hot new directions for quasi-Monte Carlo research in step with applications
This article provides an overview of some interfaces between the theory of
quasi-Monte Carlo (QMC) methods and applications. We summarize three QMC
theoretical settings: first order QMC methods in the unit cube and in
, and higher order QMC methods in the unit cube. One important
feature is that their error bounds can be independent of the dimension
under appropriate conditions on the function spaces. Another important feature
is that good parameters for these QMC methods can be obtained by fast efficient
algorithms even when is large. We outline three different applications and
explain how they can tap into the different QMC theory. We also discuss three
cost saving strategies that can be combined with QMC in these applications.
Many of these recent QMC theory and methods are developed not in isolation, but
in close connection with applications
Selective Radionuclide Localisation in Primary Liver Tumours
The therapeutic potential of 131I-Lipiodol was investigated in 8 patients with cholangiocarcinoma (CCA)
and 15 patients with hepatocellullar carcinoma (HCC). Patients received one or two doses of
131I-Lipiodol via hepatic arterial injection. The mean total administered activity was 668 (SD 325) MBq
in CCA and 953 (SD 477) MBq in HCC. One patient with CCA retained 131I-Lipiodol. The cumulative
radiation dose was 9.6 Gy to tumour, 6.4 Gy to liver and 1.5 Gy to lung. The patient remained
asymptomatic with no evidence of tumour 30 months from the start of treatment, whereas the remaining
7 patients exhibited tumour progression. The mean survival in CCA was 11.6 (SD 14.5) months. All 15
patients with HCC retained 131I with tumour: liver ratios of up to 30:1. The mean cumulative radiation
dose was 34.7 (SD 32.4) Gy to tumour, 3.3 (SD 1.5) Gy to liver and 4.4 (SD 2.3) Gy to lung. The mean
dose per administered activity was 3.8 (SD 4.1) cGy/MBq. Partial response (reduction in tumour size >
50%) was observed in 6 patients (40%). The mean survival was 7.1 (SD 6.0) months
Lipopeptides as dimerization inhibitors of HIV-1 protease
In AIDS therapy, attempts have been made to inhibit the virus-encoded enzymes, e.g, HIV-1 protease, using active site-directed inhibitors. This approach is questionable, however, due to virus mutations and the high toxicity of the drugs, An alternative method to inhibit the dimeric HIV protease is the targeting of the interface region of the protease subunits in order to prevent subunit dimerization and enzyme activity, This approach should be less prone to inactivation by mutation, A list of improved 'dimerization inhibitors' of HIV-1 protease is presented. The main structural features are a short `interface' peptide segment, including non-natural amino acids, and an aliphatic N-terminal blocking group. The high inhibitory power of some of the lipopeptides {[}e.g, palmitoyl-Tyr-Glu-Leu-OH, palmitoyl-Tyr-Glu-(L-thyronine)-OH, palmitoyl-Tyr-Glu-(L-biphenyl-alanine)-OH] with low nanomolar K-i values in the enzyme test suggests that mimetics with good bio-availability can be derived for AIDS therapy
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