Phytoremediation of Heavy Metal Contaminated Wastes From Small-Scale Gold Mining Using Pityrogramma calomelanos

In this study, viability of employing the waste treatment technique for industrial application was conducted by setting up a phytoremediation protocol for field application where heavy metal (Arsenic and Copper) contaminated adsorbents, i.e. coco peat and nanofiber membrane, used for the treatment of wastewater were also included. An arsenic hyperaccumulator, Pityrogramma calomelanos was used for the treatment of mine wastes-tailings, coco peat and nanofiber membrane. Phytoremediation procedure was established by investigating planting parameters namely ; plot height - (9 cm and 15 cm) and planting distance- (15 cm and 20 cm) for a period of five months. Translocation factor and % uptake of As and Cu by ferns were measured. According to the results, % uptake of As and Cu by P. Calomelanos was 0.16 % and 0.01 % and translocation factor of As and Cu was 6.78 and 0.04, respectively. Plant growth factors (root length, frond height and dry weight) in tailings mixture plant boxes and control soil were also determined. Accordingly, P. calomelanos grew well in tailings mixture without the symptom of phytotoxicity. Therefore, P. calomelanos can be used for the phytoremediation of the said heavy metal contaminated mine wastes. Based on this study, 15 cm plot height and 20 cm plant distance were suitable for field experiment although long term research data is required. The overall protocol for the treatment of mine wastes as field experiment was proposed based on the results

Countdown to 2030 : tracking progress towards universal coverage for reproductive, maternal, newborn, and child health

Building upon the successes of Countdown to 2015, Countdown to 2030 aims to support the monitoring and measurement of women's, children's, and adolescents' health in the 81 countries that account for 95% of maternal and 90% of all child deaths worldwide. To achieve the Sustainable Development Goals by 2030, the rate of decline in prevalence of maternal and child mortality, stillbirths, and stunting among children younger than 5 years of age needs to accelerate considerably compared with progress since 2000. Such accelerations are only possible with a rapid scale-up of effective interventions to all population groups within countries (particularly in countries with the highest mortality and in those affected by conflict), supported by improvements in underlying socioeconomic conditions, including women's empowerment. Three main conclusions emerge from our analysis of intervention coverage, equity, and drivers of reproductive, maternal, newborn, and child health (RMNCH) in the 81 Countdown countries. First, even though strong progress was made in the coverage of many essential RMNCH interventions during the past decade, many countries are still a long way from universal coverage for most essential interventions. Furthermore, a growing body of evidence suggests that available services in many countries are of poor quality, limiting the potential effect on RMNCH outcomes. Second, within-country inequalities in intervention coverage are reducing in most countries (and are now almost non-existent in a few countries), but the pace is too slow. Third, health-sector (eg, weak country health systems) and non-health-sector drivers (eg, conflict settings) are major impediments to delivering high-quality services to all populations. Although more data for RMNCH interventions are available now, major data gaps still preclude the use of evidence to drive decision making and accountability. Countdown to 2030 is investing in improvements in measurement in several areas, such as quality of care and effective coverage, nutrition programmes, adolescent health, early childhood development, and evidence for conflict settings, and is prioritising its regional networks to enhance local analytic capacity and evidence for RMNCH

Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis

Multifactorial mechanisms underlying late-onset Alzheimer's disease (LOAD) are poorly characterized from an integrative perspective. Here spatiotemporal alterations in brain amyloid-β deposition, metabolism, vascular, functional activity at rest, structural properties, cognitive integrity and peripheral proteins levels are characterized in relation to LOAD progression. We analyse over 7,700 brain images and tens of plasma and cerebrospinal fluid biomarkers from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Through a multifactorial data-driven analysis, we obtain dynamic LOAD–abnormality indices for all biomarkers, and a tentative temporal ordering of disease progression. Imaging results suggest that intra-brain vascular dysregulation is an early pathological event during disease development. Cognitive decline is noticeable from initial LOAD stages, suggesting early memory deficit associated with the primary disease factors. High abnormality levels are also observed for specific proteins associated with the vascular system's integrity. Although still subjected to the sensitivity of the algorithms and biomarkers employed, our results might contribute to the development of preventive therapeutic interventions

Phytoremediation of Heavy metal Contaminated Wastes from Small-scale Gold Mining Using

In this study, viability of employing the waste treatment technique for industrial application was conducted by setting up a phytoremediation protocol for field application where heavy metal (Arsenic and Copper) contaminated adsorbents, i.e. coco peat and nanofiber membrane, used for the treatment of wastewater were also included. An arsenic hyperaccumulator, Pityrogramma calomelanos was used for the treatment of mine wastes-tailings, coco peat and nanofiber membrane. Phytoremediation procedure was established by investigating planting parameters namely ; plot height - (9 cm and 15 cm) and planting distance- (15 cm and 20 cm) for a period of five months. Translocation factor and % uptake of As and Cu by ferns were measured. According to the results, % uptake of As and Cu by P. Calomelanos was 0.16 % and 0.01 % and translocation factor of As and Cu was 6.78 and 0.04, respectively. Plant growth factors (root length, frond height and dry weight) in tailings mixture plant boxes and control soil were also determined. Accordingly, P. calomelanos grew well in tailings mixture without the symptom of phytotoxicity. Therefore, P. calomelanos can be used for the phytoremediation of the said heavy metal contaminated mine wastes. Based on this study, 15 cm plot height and 20 cm plant distance were suitable for field experiment although long term research data is required. The overall protocol for the treatment of mine wastes as field experiment was proposed based on the results

The Genotype-Tissue Expression (GTEx) project

Genome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the mechanisms underlying disease susceptibility remain unknown. Most associated variants are not correlated with protein-coding changes, suggesting that polymorphisms in regulatory regions probably contribute to many disease phenotypes. Here we describe the Genotype-Tissue Expression (GTEx) project, which will establish a resource database and associated tissue bank for the scientific community to study the relationship between genetic variation and gene expression in human tissues