2,401 research outputs found
Ultraspinning instability: the missing link
We study linearized perturbations of Myers-Perry black holes in d=7, with two
of the three angular momenta set to be equal, and show that instabilities
always appear before extremality. Analogous results are expected for all higher
odd d. We determine numerically the stationary perturbations that mark the
onset of instability for the modes that preserve the isometries of the
background. The onset is continuously connected between the previously studied
sectors of solutions with a single angular momentum and solutions with all
angular momenta equal. This shows that the near-extremality instabilities are
of the same nature as the ultraspinning instability of d>5 singly-spinning
solutions, for which the angular momentum is unbounded. Our results raise the
question of whether there are any extremal Myers-Perry black holes which are
stable in d>5.Comment: 19 pages. 1 figur
Advances in systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a heterogeneous course and systemic involvement. It is the result of a complex pathogenic pathway that culminates in autoantibody formation. The interaction between environmental triggers and genetic susceptibility is key in this process. Genome-wide association study technology has allowed the recognition of > 80 loci associated with SLE that lead to the formation of key proteins, each contributing a small increase to the risk. Advances in the management of the disease include new validated standardized tools to capture disease activity, damage and quality of life, for clinical and research purposes. The prognosis of SLE has much improved in the last 50 years because of better general management and specific treatment, including better use of immunosuppressive agents and development of a new group of drugs – biological therapies
Ultraspinning instability of anti-de Sitter black holes
Myers-Perry black holes with a single spin in d>5 have been shown to be
unstable if rotating sufficiently rapidly. We extend the numerical analysis
which allowed for that result to the asymptotically AdS case. We determine
numerically the stationary perturbations that mark the onset of the
instabilities for the modes that preserve the rotational symmetries of the
background. The parameter space of solutions is thoroughly analysed, and the
onset of the instabilities is obtained as a function of the cosmological
constant. Each of these perturbations has been conjectured to represent a
bifurcation point to a new phase of stationary AdS black holes, and this is
consistent with our results.Comment: 22 pages, 7 figures. v2: Reference added. Matches published versio
Studying T Cells N-Glycosylation by Imaging Flow Cytometry
Imaging flow cytometry is an emerging imaging technology that combines features of both conventional flow cytometry and fluorescence microscopy allowing quantification of the imaging parameters. The analysis of protein posttranslational modifications by glycosylation using imaging flow cytometry constitutes an important bioimaging tool in the glycobiology field. This technique allows quantification of the glycan fluorescence intensity, co-localization with proteins, and evaluation of the membrane/cytoplasmic expression. In this chapter we provide the guidelines to analyze glycan expression, particularly the ß1,6 GlcNAc branched N-glycans, on the membrane of intestinal T cells from inflammatory bowel disease patients.This work was supported by grants from the Portuguese Foundation for Science and Technology (FCT), project grants (PTDC/DTPPIC/0560/2014; PTDC/BBB-EBI/0786/2012; EXPL/BIMMEC/0149/2012), “financiados no âmbito do Programa Operacional Temático Factores de Competitividade (COMPETE) e comparticipado pelo fundo Comunitário Europeu FEDER,” e do Quadro de Referência Estratégia Nacional QREN. This work was further supported by a Portuguese grant from “Grupo de Estudo da Doença Infl amatória Intestinal” (GEDII). This work had also the fi nantial support of FCT/MEC through National Funds and, when applicable, co-fi nanced by the FEDER via the PT2020 Partnership Agreement under the 4293 Unit I&D. S.S.P. (SFRH/BPD/63094/2009) also acknowledges FCT. A.M.D. PD/BD/105982/2014 also acknowledges FCT and BiotechHealth Doctoral Programme. The Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) integrates the Institute for Research and Innovation in Health (I3S), which is partially supported by the Portuguese Foundation for Science and Technology (FCT). Data was acquired at the Bioimaging Center for Biomaterials and Regenerative Therapies (b.IMAGE, INEB, Porto, Portugal)
A scalar field condensation instability of rotating anti-de Sitter black holes
Near-extreme Reissner-Nordstrom-anti-de Sitter black holes are unstable
against the condensation of an uncharged scalar field with mass close to the
Breitenlohner-Freedman bound. It is shown that a similar instability afflicts
near-extreme large rotating AdS black holes, and near-extreme hyperbolic
Schwarzschild-AdS black holes. The resulting nonlinear hairy black hole
solutions are determined numerically. Some stability results for (possibly
charged) scalar fields in black hole backgrounds are proved. For most of the
extreme black holes we consider, these demonstrate stability if the ``effective
mass" respects the near-horizon BF bound. Small spherical
Reissner-Nordstrom-AdS black holes are an interesting exception to this result.Comment: 34 pages; 13 figure
Stable non-uniform black strings below the critical dimension
The higher-dimensional vacuum Einstein equation admits translationally
non-uniform black string solutions. It has been argued that infinitesimally
non-uniform black strings should be unstable in 13 or fewer dimensions and
otherwise stable. We construct numerically non-uniform black string solutions
in 11, 12, 13, 14 and 15 dimensions. Their stability is investigated using
local Penrose inequalities. Weakly non-uniform solutions behave as expected.
However, in 12 and 13 dimensions, strongly non-uniform solutions appear to be
stable and can have greater horizon area than a uniform string of the same
mass. In 14 and 15 dimensions all non-uniform black strings appear to be
stable.Comment: 26 pages, 11 figures. V2: reference added, matches published versio
An instability of higher-dimensional rotating black holes
We present the first example of a linearized gravitational instability of an
asymptotically flat vacuum black hole. We study perturbations of a Myers-Perry
black hole with equal angular momenta in an odd number of dimensions. We find
no evidence of any instability in five or seven dimensions, but in nine
dimensions, for sufficiently rapid rotation, we find perturbations that grow
exponentially in time. The onset of instability is associated with the
appearance of time-independent perturbations which generically break all but
one of the rotational symmetries. This is interpreted as evidence for the
existence of a new 70-parameter family of black hole solutions with only a
single rotational symmetry. We also present results for the Gregory-Laflamme
instability of rotating black strings, demonstrating that rotation makes black
strings more unstable.Comment: 38 pages, 13 figure
d=3 Bosonic Vector Models Coupled to Chern-Simons Gauge Theories
We study three dimensional O(N)_k and U(N)_k Chern-Simons theories coupled to
a scalar field in the fundamental representation, in the large N limit. For
infinite k this is just the singlet sector of the O(N) (U(N)) vector model,
which is conjectured to be dual to Vasiliev's higher spin gravity theory on
AdS_4. For large k and N we obtain a parity-breaking deformation of this
theory, controlled by the 't Hooft coupling lambda = 4 \pi N / k. For infinite
N we argue (and show explicitly at two-loop order) that the theories with
finite lambda are conformally invariant, and also have an exactly marginal
(\phi^2)^3 deformation.
For large but finite N and small 't Hooft coupling lambda, we show that there
is still a line of fixed points parameterized by the 't Hooft coupling lambda.
We show that, at infinite N, the interacting non-parity-invariant theory with
finite lambda has the same spectrum of primary operators as the free theory,
consisting of an infinite tower of conserved higher-spin currents and a scalar
operator with scaling dimension \Delta=1; however, the correlation functions of
these operators do depend on lambda. Our results suggest that there should
exist a family of higher spin gravity theories, parameterized by lambda, and
continuously connected to Vasiliev's theory. For finite N the higher spin
currents are not conserved.Comment: 34 pages, 29 figures. v2: added reference
A scalar field instability of rotating and charged black holes in (4+1)-dimensional Anti-de Sitter space-time
We study the stability of static as well as of rotating and charged black
holes in (4+1)-dimensional Anti-de Sitter space-time which possess spherical
horizon topology. We observe a non-linear instability related to the
condensation of a charged, tachyonic scalar field and construct "hairy" black
hole solutions of the full system of coupled Einstein, Maxwell and scalar field
equations. We observe that the limiting solution for small horizon radius is
either a hairy soliton solution or a singular solution that is not a regular
extremal solution. Within the context of the gauge/gravity duality the
condensation of the scalar field describes a holographic
conductor/superconductor phase transition on the surface of a sphere.Comment: 16 pages including 8 figures, v2: discussion on soliton solutions
extended; v3: matches version accepted for publication in JHE
Thermodynamic instability of doubly spinning black objects
We investigate the thermodynamic stability of neutral black objects with (at
least) two angular momenta. We use the quasilocal formalism to compute the
grand canonical potential and show that the doubly spinning black ring is
thermodynamically unstable. We consider the thermodynamic instabilities of
ultra-spinning black objects and point out a subtle relation between the
microcanonical and grand canonical ensembles. We also find the location of the
black string/membrane phases of doubly spinning black objects.Comment: 25 pages, 7 figures v2: matches the published versio
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