721 research outputs found

    Music enrichment for gifted children in the first grade

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    Thesis (Ed.M.)--Boston Universit

    Family health narratives : midlife womenā€™s concepts of vulnerability to illness

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    Perceptions of vulnerability to illness are strongly influenced by the salience given to personal experience of illness in the family. This article proposes that this salience is created through autobiographical narrative, both as individual life story and collectively shaped family history. The paper focuses on responses related to health in the family drawn from semi-structured interviews with women in a qualitative study exploring midlife womenā€™s health. Uncertainty about the future was a major emergent theme. Most respondents were worried about a specified condition such as heart disease or breast cancer. Many women were uncertain about whether illness in the family was inherited. Some felt certain that illness in the family meant that they were more vulnerable to illness or that their relativesā€™ ageing would be mirrored in their own inevitable decline, while a few expressed cautious optimism about the future. In order to elucidate these responses, we focused on narratives in which family membersā€™ appearance was discussed and compared to that of others in the family. The visualisation of both kinship and the effects of illness, led to strong similarities being seen as grounds for worry. This led to some women distancing themselves from the legacies of illness in their families. Women tended to look at the whole family as the context for their perceptions of vulnerability, developing complex patterns of resemblance or difference within their families

    Black Women in the Economy: Facing Glass Ceilings in Academia

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    The shrinking population of Black male doctoral degree holders may hold much of the key to the problems of Black women. Declines in Black male interest in doctoral degrees, has clearly not spelled gains for the recruitment of Black female scholars. New evidence of these patterns is visible in the latest government data on academic achievement of Black women and teaching job success. While Black women are achieving at high rates, they are also systematically by-passed by an expanded recruitment of African and Caribbean males to fill teaching positions in doctoral and research institutions. This new trend has probably reduced Black women\u27s chances more than any other. Second, the new found Black male networks have had major success in assuring members get support and information on academic jobs. Major questions need to be raised about these trends and more attention focused on unearthing and correcting root causes of specific discriminatory treatment of Black women in university faculty hiring and promotion

    Prenatal to Grade 3 Alignment Initiative

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    The purpose of this project is to create stronger connections between elementary schools & providers of early childhood care/education programs; and between schools & parents of young children in 10 grantee communities across Oregon. The evaluation team developed data collection tools and is currently providing data collection and utilization training and technical assistance, and conducting systems evaluation data collection and analysis

    Involving older adults and unpaid carers in the research cycle: reflections on implementing the UK National Standards for Public Involvement into practice

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    PurposeThis paper aims to share how the Centre for Ageing and Dementia Research co-designs research within a national programme of work to improve the lives of older adults and those affected by dementia. Through examples of this work, the authors identify the barriers and enablers to participatory approaches and lessons to inform future involvement activities.Design/methodology/approachThis study reflects on implementing the UK National Standards for Public Involvement into practice. Of international relevance, the observations span the research process from research prioritisation and design to research implementation and knowledge exchange.FindingsThis study demonstrates the importance of using a relational approach, working toward a common purpose and engaging in meaningful dialogue. Only through offering choice and flexibility and actively learning from one another can co-design lead to synergistic relationships that benefit everyone.Research limitations/implicationsKey implications for researchers engaged in patient and public involvement are be receptive to other peopleā€™s views and acknowledge expertise of those with lived experience alongside those with academic expertise. Training, resources and time are required to effectively support involvement and meaningful relationships. A nominated contact person enables trust and mutual understanding to develop. This is an ongoing collective learning experience that should be embedded throughout the entire research process.Originality/valueThis paper demonstrates how the standards are implemented with people who are often excluded from research to influence a national programme of work

    Interference of the T cell and antigen-presenting cell costimulatory pathway using CTLA4-Ig (abatacept) prevents Staphylococcal enterotoxin B pathology

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    Abstract Staphylococcal enterotoxin B (SEB) is a bacterial superantigen that binds the receptors in the APC/T cell synapse and causes increased proliferation of T cells and a cytokine storm syndrome in vivo. Exposure to the toxin can be lethal and cause significant pathology in humans. The lack of effective therapies for SEB exposure remains an area of concern, particularly in scenarios of acute mass casualties. We hypothesized that blockade of the T cell costimulatory signal by the CTLA4-Ig synthetic protein (abatacept) could prevent SEB-dependent pathology. In this article, we demonstrate mice treated with a single dose of abatacept 8 h post SEB exposure had reduced pathology compared with control SEB-exposed mice. SEB-exposed mice showed significant reductions in body weight between days 4 and 9, whereas mice exposed to SEB and also treated with abatacept showed no weight loss for the duration of the study, suggesting therapeutic mitigation of SEB-induced morbidity. Histopathology and magnetic resonance imaging demonstrated that SEB mediated lung damage and edema, which were absent after treatment with abatacept. Analysis of plasma and lung tissues from SEB-exposed mice treated with abatacept demonstrated significantly lower levels of IL-6 and IFN-Ī³ (p &amp;lt; 0.0001), which is likely to have resulted in less pathology. In addition, exposure of human and mouse PBMCs to SEB in vitro showed a significant reduction in levels of IL-2 (p &amp;lt; 0.0001) after treatment with abatacept, indicating that T cell proliferation is the main target for intervention. Our findings demonstrate that abatacept is a robust and potentially credible drug to prevent toxic effects from SEB exposure.</jats:p

    A scoping review of how exposure to urban violence impacts youth access to sexual, reproductive and trauma health care in LMICs

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    Violence in the community can impact access to health care. This scoping review examines the impact of urban violence upon youth (aged 15ā€“24) access to sexual and reproductive health and trauma care in Low and Middle Income Countries (LMICs). We searched key electronic health and other databases for primary peer-reviewed studies from 2010 through June 2020. Thirty five of 6712 studies extracted met criteria for inclusion. They were diverse in terms of study objective and design but clear themes emerged. First, youth experience the environment and interpersonal relationships to be violent which impacts their access to health care. Second, sexual assault care is often inadequate, and stigma and abuse are sometimes reported in treatment settings. Third is the low rate of health seeking among youth living in a violent environment. Fourth is the paucity of literature focusing on interventions to address these issues. The scoping review suggests urban violence is a structural and systemic issue that, particularly in low-income areas in LMICs, contributes to framing the conditions for accessing health care. There is a gap in evidence about interventions that will support youth to access good quality health care in complex scenarios where violence is endemic

    Utilization of Genetic Counseling after Directā€toā€Consumer Genetic Testing: Findings from the Impact of Personal Genomics (PGen) Study

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    Directā€toā€consumer personal genomic testing (DTCā€PGT) results lead some individuals to seek genetic counseling (GC), but little is known about these consumers and why they seek GC services. We analyzed survey data preā€ and postā€PGT from 1026 23andMe and Pathway Genomics customers. Participants were mostly white (91%), female (60%), and of high socioeconomic status (80% college educated, 43% household income of ā‰„$100,000). After receiving PGT results, 43 participants (4%) made or planned to schedule an appointment with a genetic counselor; 390 (38%) would have used inā€person GC had it been available. Compared to nonā€seekers, GC seekers were younger (mean age of 38 vs 46 years), more frequently had children <18 (26% vs 16%), and were more likely to report previous GC (37% vs 7%) and genetic testing (30% vs 15%). In logistic regression analysis, seeking GC was associated with previous GC use (OR = 6.5, CI = 3.1ā€“13.8), feeling motivated to pursue DTCā€PGT for health reasons (OR = 4.3, CI = 1.8ā€“10.1), fair or poor selfā€reported health (OR = 3.1, CI = 1.1ā€“8.3), and selfā€reported uncertainty about the results (OR = 1.8, CI = 1.1ā€“2.7). These findings can help GC providers anticipate who might seek GC services and plan for clinical discussions of DTCā€PGT results.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146977/1/jgc41270.pd
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