Electroweak Measurements

The measurements of electroweak sector of the Standard Model are presented, including most recent results from LEP, Tevatron and HERA colliders. The robustness of the Standard Model is illustrated with the precision measurements, the electroweak fits and the comparisons to the results obtained from low energy experiments. The status of the measurements of the $W$ boson properties and rare production processes involving weak bosons at colliders is examined, together with the measurements of the electroweak parameters in $ep$ collisions.Comment: 12 pages, Proceedings of "Lepton-Photon 2005", Upsalla, Swede

Pheochromocytoma – clinical manifestations, diagnosis and current perioperative management

Pheochromocytoma is a neuroendocrine tumor characterized by the excessive production of catecholamines (epinephrine, norepinephrine, and dopamine). The diagnosis is suspected due to hypertensive paroxysms, associated with vegetative phenomena, due to the catecholaminergic hypersecretion. Diagnosis involves biochemical tests that reveal elevated levels of catecholamine metabolites (metanephrine and normetanephrine). Functional imaging, such as 123I-metaiodobenzylguanidine scintigraphy (123I-MIBG), has increased specificity in identifying the catecholamine-producing tumor and its metastases. The gold-standard treatment for patients with pheochromocytoma is represented by the surgical removal of the tumor. Before surgical resection, it is important to optimize blood pressure and intravascular volume in order to avoid negative hemodynamic events

Pelvic floor disorders in gynecological malignancies. An overlooked problem?

Cervical, endometrial, ovarian, vulvar, and vaginal cancers affect women of a broad age spectrum. Many of these women are still sexually active when their cancer is diagnosed. Treatment options for gynecological malignancies, such as gynecological surgery, radiation, and chemotherapy, are proven risk factors for pelvic floor dysfunction. The prevalence of urinary incontinence, fecal incontinence, and sexual dysfunction before cancer treatment is still unclear. Hypotheses have been raised in the literature that these manifestations could represent early symptoms of pelvic cancers, but most remain overlooked even in cancer surviving patients. The primary focus of therapy is always cancer eradication, but as oncological and surgical treatment options become more successful, the number of cancer survivors increases. The quality of life of patients with gynecological cancers often remains an underrated subject. Pelvic floor disorders are not consistently reported by patients and are frequently overlooked by many clinicians. In this brief review we discuss the importance of pelvic floor dysfunction in patients with gynecological malignant tumors

The importance of early arthritis in patients with rheumatoid arthritis

Rheumatoid arthritis (RA) is a systemic inflammatory disorder that manifests predominantly in the synovial joint, where it causes a chronic inflammatory process, leading to early osteoarticular destructions. These destructions are progressive and irreversible, generating a significant functional deficiency. During the last years, the diagnostic approach of RA has focused on early arthritis. Early arthritis can develop into established RA or another established arthropathy, like systemic lupus erythematosus or psoriatic arthritis. It can have a spontaneous resolution or may remain undifferentiated for indefinite periods of time. The management of early arthritis has changed considerably in the past few years, under the influence of new concepts of diagnosis and new effective therapies. The treatment goal of early arthritis should now be the clinical remission and prevention of joint destruction. Methotrexate is the first line of therapy, used to treat early arthralgia and to reverse or limit impending exacerbation to RA. Biological treatment is used as a second line therapy in patients with severe disease who do not respond or have a contraindication to disease-modifying antirheumatic drugs (DMARDs). Patients with early arthritis should usually be identified and directed to rheumatologists to confirm the presence of arthritis, and to establish the correct diagnosis plus to initiate the proper treatment strategies

Current pharmacological treatment of painful diabetic neuropathy: A narrative review

Background and Objectives: Distal symmetrical polyneuropathy (DSPN) is one of the most common chronic complications of diabetes mellitus. Although it is usually characterized by progressive sensory loss, some patients may develop chronic pain. Assessment of DSPN is not difficult, but the biggest challenge is making the correct diagnosis and choosing the right treatment. The treatment of DSPN has three primary objectives: glycemic control, pathogenic mechanisms, and pain management. The aim of this brief narrative review is to summarize the current pharmacological treatment of painful DSPN. It also summarizes knowledge on pathogenesis-oriented therapy, which is generally overlooked in many publications and guidelines. Materials and Methods: The present review reports the relevant information available on DSPN treatment. The search was performed on PubMed, Cochrane, Semantic Scholar, Medline, Scopus, and Cochrane Library databases, including among others the terms “distal symmetrical polyneuropathy”, “neuropathic pain treatment”, “diabetic neuropathy”, “diabetes complications”, ”glycaemic control”, “antidepressants”, “opioids”, and “anticonvulsants”. Results: First-line drugs include antidepressants (selective serotonin reuptake inhibitors and tricyclic antidepressants) and pregabalin. Second- and third-line drugs include opioids and topical analgesics. While potentially effective in the treatment of neuropathic pain, opioids are not considered to be the first choice because of adverse reactions and addiction concerns. Conclusions: DSPN is a common complication in patients with diabetes, and severely affects the quality of life of these patients. Although multiple therapies are available, the guidelines and recommendations regarding the treatment of diabetic neuropathy have failed to offer a unitary consensus, which often hinders the therapeutic options in clinical practice

The Cis-regulatory Logic of the Mammalian Photoreceptor Transcriptional Network

The photoreceptor cells of the retina are subject to a greater number of genetic diseases than any other cell type in the human body. The majority of more than 120 cloned human blindness genes are highly expressed in photoreceptors. In order to establish an integrative framework in which to understand these diseases, we have undertaken an experimental and computational analysis of the network controlled by the mammalian photoreceptor transcription factors, Crx, Nrl, and Nr2e3. Using microarray and in situ hybridization datasets we have produced a model of this network which contains over 600 genes, including numerous retinal disease loci as well as previously uncharacterized photoreceptor transcription factors. To elucidate the connectivity of this network, we devised a computational algorithm to identify the photoreceptor-specific cis-regulatory elements (CREs) mediating the interactions between these transcription factors and their target genes. In vivo validation of our computational predictions resulted in the discovery of 19 novel photoreceptor-specific CREs near retinal disease genes. Examination of these CREs permitted the definition of a simple cis-regulatory grammar rule associated with high-level expression. To test the generality of this rule, we used an expanded form of it as a selection filter to evolve photoreceptor CREs from random DNA sequences in silico. When fused to fluorescent reporters, these evolved CREs drove strong, photoreceptor-specific expression in vivo. This study represents the first systematic identification and in vivo validation of CREs in a mammalian neuronal cell type and lays the groundwork for a systems biology of photoreceptor transcriptional regulation

Riscul limfedemului după tratamentul cancerului mamar

Spital Universitar Clinic de Urgențe “Sf. Spiridon”, Iași, Al XI-lea Congres al Asociației Chirurgilor „Nicolae Anestiadi” din Republica Moldova și cea de-a XXXIII-a Reuniune a Chirurgilor din Moldova „Iacomi-Răzeșu” 27-30 septembrie 2011Introducere: Importanța problemei este legată de incidența crescută (între 3 și 87%), consecințele limfedemului fiind asupra integrării profesionale, riscului de erizipel, calității vieții și relației cu membrii familiei. Scopul lucrării: De a sublinia importanța profilaxiei precoce, luând în calcul factori ce țin de boală, chirurg și pacientă. Material și metodă: S-au luat în studiu 1104 paciente tratate pentru neoplasm mamar între 2000 și 2010. La 228 cazuri s-a efectuat intervenție conservatoare (cadranectomie și evidare limfo-gangionara), la 876-operația Madden. S-au evaluat factorii favorizanți ai limfedemului preexistenti terapiei pentru neoplasmul de sân, factorii favorizanți în postoperator și terapia asociată. Rezultate: Cu o dispensarizare la fiecare 3 luni în primul an și la 6 luni ulterior, s-au decelat 42 observații cu limfedem al membrului superior mediu și sever, precoce (până la 21 zile postoperator) - 8 observații, între 21 zile și 12 luni - 4 observații și după 12 luni - 30 observații. Limfedemul sever a apărut în 13 cazuri la paciente de peste 60 ani, ținând cont de factorii favorizanți, 8 paciente au beneficiat de măsuri terapeutice (administrarea de flavonoide micronizate, heparina fractionata, masaj, banda elastică, gimnastica membrului superior, scădere ponderală) cu rezultate bune, iar la 5 paciente nu s-au obținut beneficii evidente. Pacientele cu limfedem moderat (29cazuri) au avut o evoluție favorabilă în urma aplicării acelorași măsuri terapeutice în 25 cazuri, 4 paciente rămânând cu limfedem moderat permanent. Concluzii: Limfedemul mederat și sever au apărut (pe cazuistica analizata) numai după operația Madden. Femeia vârstnică ar fi mai predispusă la limfedem. Ablația minuțioasă a grăsimii din jurul venei axilare ar predispune la limfedem prin interceptarea celor 2 colectoare principale axilare. Greutatea corporală mare, efortul fizic important postoperator constituie factori favorizanti ai limfedemului. Există măsuri terapeutice adjuvante pentru limfedem, cu rezultate favorabile

Phenology and temperature‐dependent development of Ceutorhynchus assimilis, a potential biological control agent for Lepidium draba

Lepidium draba (Brassicaceae) is a major concern for agriculture and biodiversity in the western United States. As current control methods do not provide long-term, sustainable solutions, research has been conducted to find biological control agents. Ceutorhynchus assimilis is one of the currently investigated candidates. Known as oligophagous in the literature, a specialist clade of this root-galling weevil exists in southern Europe. This raised the question of its ability to survive in colder climates in the target range. We investigated the phenology of C. assimilis in the field in southern France (specialist clade) and Romania (generalist clade) and measured various temperature-dependent parameters in the laboratory. In both ranges, weevils were univoltine. Oviposition in autumn started later in France compared to Romania, while mature larvae exited galls (to pupate in the soil) earlier the following year. On average, 25% and 32% of galls from France and Romania were completely below the soil surface, respectively, and this appeared to depend on soil substrate. Weevils transported from France to Romania were able to develop, but at a much lower rate than Romanian weevils. Mortality of overwintering larvae of both clades increased with decreasing temperature and exposure time. At −5°C, lethal times Lt50 and Lt95 were 15 and 42 days for the specialist clade and 26 and 72 days for the generalist clade. A higher proportion of third instar larvae compared to first and second instar larvae survived. Pupation time at different temperatures did not differ between weevils from France or Romania. A climate match model (comparing winter temperatures) indicated that the specialist clade of C. assimilis from France has the potential to establish in some parts of the target range (e.g. Washington, Oregon, California). However, temperature extremes and winters without snow cover will likely limit its establishment unless rapid adaptive evolution takes place

Study of Higgs boson production and its b-bbar decay in gamma-gamma processes in proton-nucleus collisions at the LHC

We explore for the first time the possibilities to measure an intermediate-mass (mH = 115-140 GeV/c^2) Standard-Model Higgs boson in electromagnetic proton-lead (pPb) interactions at the CERN Large Hadron Collider (LHC) via its b-bbar decay. Using equivalent Weizsaecker-Williams photon fluxes and Higgs effective field theory for the coupling gamma-gamma --> H, we obtain a leading-order cross section of the order of 0.3 pb for exclusive Higgs production in elastic (pPb --> gamma-gamma --> p H Pb) and semielastic (pPb --> gamma-gamma --> Pb H X) processes at sqrt(s) = 8.8 TeV. After applying various kinematics cuts to remove the main backgrounds (gamma-gamma --> b-bbar and misidentified gamma-gamma-->q-qbar events), we find that a Higgs boson with mH = 120 GeV/c^2 could be observed in the b-bbar channel with a 3sigma-significance integrating 300 pb^-1 with an upgraded pA luminosity of 10^31 cm^-2s^-1. We also provide for the first time semielastic Higgs cross sections, along with elastic t-tbar cross sections, for electromagnetic pp, pA and AA collisions at the LHC.Comment: 22 pages, 8 figures. Tiny changes. Version as publishe