A multidisciplinary approach using LCCA and micro-simulation 10 model for the management of the urban pavements

The maintenance and the rehabilitation of the urban road pavements are not often based on systematic program and scheduling but rather on emergency or on other not identified reasons. Moreover the Life Cycle Cost Analysis (LCCA), the only peculiar procedure for the management pavement, finds its own application for highway and motorway, even if it is possible to search the best investment for the urban interstate and arterials. By the light of the quantity of the involved resources, it seems necessary to define an operative methodology for programming the maintenance and rehabilitation activities for the urban pavement. The paper is oriented towards the development of a multidisciplinary approach to make decision on management of urban pavement using the basic concepts of the LCCA and micro-simulation model to define a scheme of work zone that minimizes the delay on the traffic flow. The best rehabilitation strategy should be characterized by the lowest users\u2019 cost that depends on the time period of the work zone, which is conditioned by both own scheme and the provided treatment, and on \u201csocial cost\u201d as increased travel time for queue generation . Different scenarios for different work zone plans were developed and a micro-simulation model was used to assess increased total travel time of a traffic flow within the maintenance area. In this work an analysis by means of the above mentioned approach was carried out on real scenario in the city of Palermo in order to point out the several frames of the adopted methodology

Chandra Observation of the Persistent Emission from the Dipping Source XB 1916-053

We present the results of a 50 ks long Chandra observation of the dipping source XB 1916-053. During the observation two X-ray bursts occurred and the dips were not present at each orbital period. From the zero-order image we estimate the precise X-ray coordinates of the source with a 90% uncertainty of 0.6''. In this work we focus on the spectral study of discrete absorption features, during the persistent emission, using the High Energy Transmission Grating Spectrometer on board the Chandra satellite. We detect, for the first time in the 1st-order spectra of XB 1916-053, absorption lines associated to Ne X, Mg XII, Si XIV, and S XVI, and confirm the presence of the Fe XXV and Fe XXVI absorption lines with a larger accuracy with respect to the previous XMM EPIC pn observation. Assuming that the line widths are due to a bulk motion or a turbulence associated to the coronal activity, we estimate that the lines are produced in a photoionized absorber distant from the neutron star 4 x 10^{10} cm, near the disk edge.Comment: 20 pages, 10 figures, submitted to ApJ on 2005-09-22, accepted by ApJ on 2006-05-0

Broad-band Spectral Evolution of Scorpius X-1 along its Color-Color Diagram

We analyze a large collection of RXTE archive data from April 1997 to August 2003 of the bright X-ray source Scorpius X-1 in order to study the broadband spectral evolution of the source for different values of the inferred mass accretion rate by studying energy spectra from selected regions in the Z-track of its Color-Color Diagram. A two-component model, consisting of a soft thermal component interpreted as thermal emission from an accretion disk and a thermal Comptonization component, is unable to fit the whole 3--200 keV energy spectrum at low accretion rates. Strong residuals in the highest energy band of the spectrum require the addition of a third component that can be fitted with a power-law component, that could represent a second thermal Comptonization from a much hotter plasma, or a hybrid thermal/non-thermal Comptonization. We discuss the physical implications derived from the results of our analysis, with a particular emphasis on the hardest part of the X-ray emission and its possible origins.Comment: 18 pages. Accepted for publication in Ap

Bipolar disorder and peripartum mood episodes: Epidemiology and clinical correlates

INTRODUCTION: It is known that the peripartum period is a high-risk period of recurrence in bipolar disorder (BD). However, data on correlations between reproductive life events, such as age at menarche and peripartum period, are mixed in BD. OBJECTIVES: The aims of this retrospective study are to investigate the lifetime rate of peripartum mood episodes, the clinical correlates and the relationship between age at menarche and peripartum episode in a sample of women with BD. METHODS: The study focused on comparisons between women with vs. without peripartum mood episodes (n = 292). Socio-demographic and clinical characteristics between women with vs without BD peripartum episode were examined through descriptive statistics.Adjusted logistic regression analysis was run to examine the association between variables. RESULTS: In our sample, 30% had at least one BD peripartum episode. Women with peripartum episode had significantly earlier age at menarche, earlier onset of BD and longer duration of untreated disorder compared to women without peripartum episode. After adjustment, the late menarche (>15 years) was associated with lower probability of BD episodes during the peripartum period compared to normal menarche (12-14 years). CONCLUSIONS: Peripartum mood episodes are common in BD and are correlated with early onset of BD and long duration of untreated disorder. Moreover, age at menarche may be related to the risk of peripartum mood episodes. The results deserve to be deepened in further studies

Timing of the Accreting Millisecond Pulsar XTE J1814-338

We present a precise timing analysis of the accreting millisecond pulsar XTE J1814-338 during its 2003 outburst, observed by RXTE. A full orbital solution is given for the first time; Doppler effects induced by the motion of the source in the binary system were corrected, leading to a refined estimate of the orbital period, P_orb=15388.7229(2)s, and of the projected semimajor axis, a sini/c= 390.633(9) lt-ms. We could then investigate the spin behaviour of the accreting compact object during the outburst. We report here a refined value of the spin frequency (nu=314.35610879(1) Hz) and the first estimate of the spin frequency derivative of this source while accreting (nu^dot=(-6.7 +/- 0.7) 10^(-14) Hz/s). This spin down behaviour arises when both the fundamental frequency and the second harmonic are taken into consideration. We discuss this in the context of the interaction between the disc and the quickly rotating magnetosphere, at accretion rates sufficiently low to allow a threading of the accretion disc in regions where the Keplerian velocity is slower than the magnetosphere velocity. We also present indications of a jitter of the pulse phases around the mean trend, which we argue results from movements of the accreting hotspots in response to variations of the accretion rate.Comment: 7 pages, 4 figures, Accepted for publication by MNRA

Evidence for a resonant cyclotron line in IGR J16493-4348 from the Swift-BAT hard X-ray survey

Resonant absorption cyclotron features are a key diagnostic tool to directly measure the strength of the magnetic field of accreting neutron stars. However, typical values for cyclotron features lie in the high-energy part of the spectrum between 20 keV and 50 keV, where detection is often damped by the low statistics from single pointed observations. We show that long-term monitoring campaign performed with Swift-BAT of persistently, but faint, accreting high-mass X-ray binaries is able to reveal in their spectra the presence of cyclotron features. We extracted the average Swift-BAT 15-150 keV spectrum from the 54 months long Swift-BAT survey of the high-mass X-ray source IGR J16493-4348. To constrain the broadband spectrum we used soft X-ray spectra from Swift-XRT and Suzaku pointed observations. We model the spectra using a set of phenomenological models usually adopted to describe the energy spectrum of accreting high-mass X-ray binaries; irrespective of the models we used, we found significant improvements in the spectral fits adding to the models a broad (10 keV width) absorption feature, with best-fitting energy estimate between 30 and 33 keV, that we interpret as evidence for a resonant cyclotron absorption feature. We also discuss instrumental issues related to the use of Swift-BAT for this kind of studies and the statistical method to weight the confidence level of this detection. Correcting for the gravitational redshift of a 1.4 M_{\sun} neutron star, the inferred surface magnetic field is Bsurf 3.7 x 10^{12} Gauss. The spectral parameters of IGR J16493-4348 fit well with empirical correlations observed when the whole sample of high-mass binaries with detected cyclotron features is considered.Comment: Published in Astronomy & Astrophysics, 2011, 532, A7

Resolving the Fe xxv Triplet with Chandra in Cen X-3

We present the results of a 45 ks Chandra observation of the high-mass X-ray binary Cen X--3 at orbital phases between 0.13 and 0.40 (in the eclipse post-egress phases). Here we concentrate on the study of discrete features in the energy spectrum at energies between 6 and 7 keV, i.e. on the iron K$_\alpha$ line region, using the High Energy Transmission Grating Spectrometer on board the Chandra satellite. We clearly see a K$_\alpha$ neutral iron line at $\sim 6.40$ keV and were able to distinguish the three lines of the \ion{Fe}{25} triplet at 6.61 keV, 6.67 keV, and 6.72 keV, with an equivalent width of 6 eV, 9 eV, and 5 eV, respectively. The equivalent width of the K$_\alpha$ neutral iron line is 13 eV, an order of magnitude lower than previous measures. We discuss the possibility that the small equivalent width is due to a decrease of the solid angle subtended by the reflector.Comment: 11 pages, 2 figures, To appear in the Astrophysical Journal Letter

Spin up and phase fluctuations in the timing of the accreting millisecond pulsar XTE J1807-294

We performed a timing analysis of the 2003 outburst of the accreting X-ray millisecond pulsar XTE J1807-294 observed by RXTE. Using recently refined orbital parameters we report for the first time a precise estimate of the spin frequency and of the spin frequency derivative. The phase delays of the pulse profile show a strong erratic behavior superposed to what appears as a global spin-up trend. The erratic behavior of the pulse phases is strongly related to rapid variations of the light curve, making it very difficult to fit these phase delays with a simple law. As in previous cases, we have therefore analyzed separately the phase delays of the first harmonic and of the second harmonic of the spin frequency, finding that the phases of the second harmonic are far less affected by the erratic behavior. In the hypothesis that the second harmonic pulse phase delays are a good tracer of the spin frequency evolution we give for the first time a estimation of the spin frequency derivative in this source. The source shows a clear spin-up of $\dot \nu = 2.5(7) \times 10^{-14}$ Hz sec$^{-1}$ (1 $\sigma$ confidence level). The largest source of uncertainty in the value of the spin-up rate is given by the uncertainties on the source position in the sky. We discuss this systematics on the spin frequency and its derivative.Comment: 17 pages, 4 figures, Accepted by Ap

Lymphocyte Subsets and Inflammatory Cytokines of Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma

Almost all multiple myeloma (MM) cases have been demonstrated to be linked to earlier monoclonal gammopathy of undetermined significance (MGUS). Nevertheless, there are no identified characteristics in the diagnosis of MGUS that have been helpful in differentiating subjects whose cancer may progress to a malignant situation. Regarding malignancy, the role of lymphocyte subsets and cytokines at the beginning of neoplastic diseases is now incontestable. In this review, we have concentrated our attention on the equilibrium between the diverse lymphocyte subsets and the cytokine system and summarized the current state of knowledge, providing an overview of the condition of the entire system in MGUS and MM. In an age where the therapy of neoplastic monoclonal gammopathies largely relies on drugs capable of acting on the immune system (immunomodulants, immunological checkpoint inhibitors, CAR-T), detailed knowledge of the the differences existing in benign and neoplastic forms of gammopathy is the main foundation for the adequate and optimal use of new drugs

Optical pulsations from a transitional millisecond pulsar

Weakly magnetic, millisecond spinning neutron stars attain their very fast rotation through a 1E8-1E9 yr long phase during which they undergo disk-accretion of matter from a low mass companion star. They can be detected as accretion-powered millisecond X-ray pulsars if towards the end of this phase their magnetic field is still strong enough to channel the accreting matter towards the magnetic poles. When mass transfer is much reduced or ceases altogether, pulsed emission generated by particle acceleration in the magnetosphere and powered by the rotation of the neutron star is observed, preferentially in the radio and gamma-ray bands. A few transitional millisecond pulsars that swing between an accretion-powered X-ray pulsar regime and a rotationally-powered radio pulsar regime in response to variations of the mass in-flow rate have been recently identified. Here we report the detection of optical pulsations from a transitional pulsar, the first ever from a millisecond spinning neutron star. The pulsations were observed when the pulsar was surrounded by an accretion disk and originated inside the magnetosphere or within a few hundreds of kilometres from it. Energy arguments rule out reprocessing of accretion-powered X-ray emission and argue against a process related to accretion onto the pulsar polar caps; synchrotron emission of electrons in a rotation-powered pulsar magnetosphere seems more likely.Comment: 32 pages, 7 figures. The first two authors contributed equally to this wor