Rediseño de la modalidad de enseñanza en la Cátedra de Diagnóstico y Terapéutica por Imágenes

La Facultad de Ciencias Médicas (FCM) de la Universidad Nacional de La Plata (UNLP) tiene como misión la formación académica, humanística, científica y técnica de los profesionales de las Ciencias de la Salud. La materia Diagnóstico y Terapéutica por Imágenes se dicta de manera bimestral en 4° y 5° año, y desde el año 2019 registra un aumento drástico en el número de estudiantes. El problema aquí radica en que la enseñanza es implementada con el mismo número de docentes y Nodocentes, así como con las mismas herramientas y los mismos recursos edilicios. La materia de Diagnóstico y Terapéutica por imágenes presenta la particularidad de poder prescindir de pacientes presenciales físicamente debido a la digitalización de la especialidad en donde los estudios y sus resultados se presentan en formato imagen digital y accesibles desde diferentes plataformas, a diferencia de otras materias de la misma casa de estudio en donde la inspección de un paciente resultaría difícilmente reemplazable. Entonces la pregunta-problema de intervención es: ¿cómo se puede rediseñar la modalidad de enseñanza de manera bimodal para mantener la calidad educativa, ampliando las opciones para aprender esta materia? En el marco del Trabajo Final Integrador de la Carrera de Especialización en Docencia Universitaria, propongo una innovación pedagógica en la Cátedra de Diagnóstico y Terapéutica por imágenes de la FCM de la UNLP que aproveche las TIC para enseñar y aprender en la Universidad, optimizando el tiempo y los espacios para la enseñanza, y que permita afrontar el problema de la masividad. Ante los hechos descritos hasta el momento, se plantea una alternativa pedagógica para la enseñanza de grupos numerosos. Se considera fundamental multiplicar el espacio que ofrece nuestra Facultad, ampliando el territorio institucional, en donde el encuentro docente-estudiante y estudiante-estudiante se genere en dos esferas: presencial y virtual.  Facultad de Ciencias Médica

Psicología Educativa: Diversos enfoques sobre lectoescritura y comprensión lectora en publicaciones actuales

The aim was identify approaches on literacy and reading comprehension analyzing differences and explicit similarities in publications in this epistemic area. There were selected 12 recent papers belonging to the Spanish journal “Psicología Educativa”, the most impacting in the area in Spanish context. The results showed predominance of studies on indicators of reading comprehension and quantitative studies with questionnaires applied to primary and secondary school children. The corpus analyzed had predilection for structured and orthodox research studies, with quantitative data analysis and the use of standardized instruments dismissing the idea of comprehension as a situated construction.El objetivo fue identificar abordajes sobre lectura y comprensión lectora analizando diferencias y similitudes explícitas en publicaciones en el área temática. Se seleccionaron doce artículos recientes de la revista española “Psicología Educativa” debido a su impacto en el área de estudio en habla hispana. Los resultados mostraron predominancia de estudios sobre indicadores de comprensión lectora cuantitativos con cuestionarios y aplicados en niños de escuela primaria y secundaria. En el corpus analizado hubo predilección por investigaciones estructuradas y ortodoxas, con análisis de datos cuantitativos y utilización de instrumentos estandarizados mostrándose escasamente la comprensión lectora como construcción situada

The Simplest Explanation is Usually the Correct One (A Medical Case in Which the "Ockham's Razor" was Fulfilled)

A 77-year-old female patient was admitted at the Internal Medicine Unit for symptoms of fever lasting for about a week despite of an antibiotic treatment with levofloxacin (maximum body temperature of about 38 °C

Spontaneous polarisation of the neutral interface for valence asymmetric coulombic systems

In this paper, we discuss the phenomenon of a spontaneous polarisation of a neutral hard planar interface for valence asymmetric coulombic systems. Within a field theoretical description, we account for the existence of non trivial charge density and electric potential profiles. The analysis of the phenomenon shows that the effect is related to combinatorics in relation with the existence of the two independent species cations and anions. This simple and basic feature is related to the quantum mechanical properties of the system. The theoretical results are compared with numerical simulations data and are shown to be in very good agreement, which a fortiori justifies our physical interpretation.Comment: 12 pages, 11 figure

DYNLRB1 is essential for dynein mediated transport and neuronal survival

The cytoplasmic dynein motor complex transports essential signals and organelles from the cell periphery to the perinuclear region, hence is critical for the survival and function of highly polarized cells such as neurons. Dynein Light Chain Roadblock-Type 1 (DYNLRB1) is thought to be an accessory subunit required for specific cargos, but here we show that it is essential for general dynein-mediated transport and sensory neuron survival. Homozygous Dynlrb1 null mice are not viable and die during early embryonic development. Furthermore, heterozygous or adult knockdown animals display reduced neuronal growth, and selective depletion of Dynlrb1 in proprioceptive neurons compromises their survival. Conditional depletion of Dynlrb1 in sensory neurons causes deficits in several signaling pathways, including beta-catenin subcellular localization, and a severe impairment in the axonal transport of both lysosomes and retrograde signaling endosomes. Hence, DYNLRB1 is an essential component of the dynein complex, and given dynein\u27s critical functions in neuronal physiology, DYNLRB1 could have a prominent role in the etiology of human neurodegenerative diseases

Assessing the extent and timing of chemosensory impairments during COVID-19 pandemic

Chemosensory impairments have been established as a specific indicator of COVID-19. They affect most patients and may persist long past the resolution of respiratory symptoms, representing an unprecedented medical challenge. Since the SARS-CoV-2 pandemic started, we now know much more about smell, taste, and chemesthesis loss associated with COVID-19. However, the temporal dynamics and characteristics of recovery are still unknown. Here, capitalizing on data from the Global Consortium for Chemosensory Research (GCCR) crowdsourced survey, we assessed chemosensory abilities after the resolution of respiratory symptoms in participants diagnosed with COVID-19 during the first wave of the pandemic in Italy. This analysis led to the identification of two patterns of chemosensory recovery, partial and substantial, which were found to be associated with differential age, degrees of chemosensory loss, and regional patterns. Uncovering the self-reported phenomenology of recovery from smell, taste, and chemesthetic disorders is the first, yet essential step, to provide healthcare professionals with the tools to take purposeful and targeted action to address chemosensory disorders and their severe discomfort

Assessing the extent and timing of chemosensory impairments during COVID-19 pandemic

Chemosensory impairments have been established as a specific indicator of COVID-19. They affect most patients and may persist long past the resolution of respiratory symptoms, representing an unprecedented medical challenge. Since the SARS-CoV-2 pandemic started, we now know much more about smell, taste, and chemesthesis loss associated with COVID-19. However, the temporal dynamics and characteristics of recovery are still unknown. Here, capitalizing on data from the Global Consortium for Chemosensory Research (GCCR) crowdsourced survey, we assessed chemosensory abilities after the resolution of respiratory symptoms in participants diagnosed with COVID-19 during the first wave of the pandemic in Italy. This analysis led to the identification of two patterns of chemosensory recovery, partial and substantial, which were found to be associated with differential age, degrees of chemosensory loss, and regional patterns. Uncovering the self-reported phenomenology of recovery from smell, taste, and chemesthetic disorders is the first, yet essential step, to provide healthcare professionals with the tools to take purposeful and targeted action to address chemosensory disorders and their severe discomfort

Development of Matrix Metalloproteinase-2 Inhibitors for Cardioprotection

The objective of our present study is to develop novel inhibitors for MMP-2 for acute cardioprotection. In a series of pilot studies, novel substituted carboxylic acid derivatives were synthesized based on imidazole and thiazole scaffolds and then tested in a screeening cascade for MMP inhibition. We found that the MMP-inhibiting effects of imidazole and thiazole carboxylic acid-based compounds are superior in efficacy in comparison to the conventional hydroxamic acid derivatives of the same molecules. Based on these results, a 568-membered focused library of imidazole and thiazole compounds was generated in silico and then the library members were docked to the 3D model of MMP-2 followed by an in vitro medium throughput screening (MTS) based on a fluorescent assay employing MMP-2 catalytic domain. Altogether 45 compounds showed a docking score of >70, from which 30 compounds were successfully synthesized. Based on the MMP-2 inhibitory tests using gelatin zymography, 7 compounds were then selected and tested in neonatal rat cardiac myocytes subjected to simulated I/R injury. Six compounds showed significant cardio-cytoprotecion and the most effective compound (MMPI-1154) significantly decreased infarct size when applied at 1 μM in an ex vivo model for acute myocardial infarction. This is the first demonstration that imidazole and thiazole carboxylic acid-based compounds are more efficacious MMP-2 inhibitor than their hydroxamic acid derivatives. MMPI-1154 is a promising novel cardio-cytoprotective imidazole-carboxylic acid MMP-2 inhibitor lead candidate for the treatment of acute myocardial infarction