Low voltage acoustic particle velocity sensor with integrated low noise chopper pre-amplifier

Novel acoustic particle velocity (APV) sensors suitable for low voltage, battery-powered systems are proposed. The sensing structure consists of four silicide polysilicon wires placed over suspended dielectric membranes and arranged in a Wheatstone full-bridge configuration. The device has been fabricated combining a commercial CMOS process with a simple and low cost post-processing technique. An ultra low noise chopper pre-amplifier has been integrated on the same chip. Preliminary noise and acoustic characterization is presented

Klippel-Feil syndrome. When using fiberoptic bronchoscopy guide, a case report

Klippel-Feil syndrome is a rare disease with congenital musculoskeletal condition characterized by faulty segmentation of cervical vertebrae and consists of cervical vertebra fusions with limitation of head movements, short neck and low posterior hairline. In several cases the syndrome is associated with cardiovascular malformations. Patients affected by Klippel-Feil syndrome could be an anesthetic challenge, not only during cardiac surgery. We are presenting a case of Klippel-Feil Syndrome in an adult patient, who was operated on for a pulmonary valve insufficiency in a previously corrected Tetralogy of Fallot Syndrome. We are going to discuss the features of this rare syndrome

Precision medicine in lymphoma by innovative instrumental platforms

Since the last years, many efforts have been addressed to the growing field of precision medicine in order to offer individual treatments to every patient on the basis of his/her genetic background. Formerly adopted to achieve new disease classifications as it is still done, innovative platforms, such as microarrays, genome-wide association studies (GWAS) and next generation sequencing (NGS), have made the progress in pharmacogenetics faster and cheaper than previously expected. Several studies in lymphoma patients have demonstrated that these platforms can be used to identify biomarkers predictive of drug efficacy and tolerability, discovering new possible druggable proteins. Indeed, GWAS and NGS allow the investigation of the human genome, finding interesting associations with putative or unexpected targets, which in turns may represent new therapeutic possibilities. Importantly, some objective difficulties have initially hampered the translation of findings in clinical routines, such as the poor quantity/quality of genetic material or the paucity of targets that could be investigated at the same time. At present, some of these technical issues have been partially solved. Furthermore, these analyses are growing in parallel with the development of bioinformatics and its capabilities to manage and analyze big data. Because of pharmacogenetic markers may become important during drug development, regulatory authorities (i.e., EMA, FDA) are preparing ad hoc guidelines and recommendations to include the evaluation of genetic markers in clinical trials. Concerns and difficulties for the adoption of genetic testing in routine are still present, as well as affordability, reliability and the poor confidence of some patients for these tests. However, genetic testing based on predictive markers may offers many advantages to caregivers and patients and their introduction in clinical routine is justified

Axion-electron decoupling in nucleophobic axion models

The strongest upper bounds on the axion mass come from astrophysical observations like the neutrino burst duration of SN1987A, which depends on the axion couplings to nucleons, or the white-dwarf cooling rates and red-giant evolution, which involve the axion-electron coupling. It has been recently argued that in variants of Dine-Fischler-Srednicki-Zhitnitsky (DFSZ) models with generation-dependent Peccei-Quinn charges an approximate axion-nucleon decoupling can occur, strongly relaxing the SN1987A bound. However, as in standard DFSZ models, the axion remains in general coupled to electrons, unless an ad hoc cancellation is engineered. Here we show that axion-electron decoupling can be implemented without extra tunings in DFSZ-like models with three Higgs doublets. Remarkably, the numerical value of the quark mass ratio m u / m d ∼ 1 / 2 is crucial to open up this possibility

Characterization and modeling of CMOS-compatible acoustical particle velocity sensors for applications requiring low supply voltages

Acoustic particle velocity sensors have been obtained applying simple low resolution micromachining steps to chips fabricated using a standard microelectronic process. Each sensor consists of four silicided polysilicon wires, suspended over cavities etched into the substrate, and connected to form a heatstone bridge. Full compatibility of the micromachining procedure with the original process is demonstrated by integrating a simple pre-amplifier on the same chip as the sensors and showing that both blocks are functional. Proper design of the sensing structures allows them to operate with a single 3.3 V power supply. Sensitivity and noise measurements, performed to estimate the sensor detection limit, are described. Excess noise with a flicker-like behavior, not ascribable to the amplifier, is found when the bridges are biased in working conditions. In addition, the dependence of the sensitivity on the dc bias voltage of the bridges is investigated, comparing the experimental data with the results of a simple analytical model and finite element method simulations

A new HPLC-UV method compared with HPLC-MS for daptomycin levels in human plasma samples

Application of a new HPLC-UV method on 122 plasma samples of patients from various AOUP wards, after analytical method settings, validation and comparison with a reference LC-MS/MS method. All research activities were performed according to the “Daptolin” protocol (approved by the Pisa University Hospital Ethics Committee, prot. num. 55945

Use of a reactive transport model to describe reductive dechlorination (RD) as a remediation design tool: application at a CAH-contaminated site

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