Inferring the high velocity of landslides in Valles Marineris on Mars from morphological analysis

The flow characteristics and velocities of three landslides in Valles Marineris on Mars are investigated using detailed morphological analyses of high-resolution images and dynamical calculations based on the run-up and curvature of the landslide deposits. The morphologies of the landslides are described, especially concerning those characteristics that can provide information on the dynamics and velocity. The long runout and estimated high velocities, often exceeding 100 m/s, confirm a low basal friction experienced by these landslides. Because subaqueous landslides on Earth exhibit reduced friction, we explore the scenario of sub-lacustrine failures, but find little support to this hypothesis. The environmental conditions that better explain the low friction and the presence of longitudinal furrows suggest an aerial environment with a basal soft and naturally lubricating medium on which friction diminished gradually; in this perspective, ice is the most promising candidate

Black Cohosh Hepatic Safety: Follow-Up of 107 Patients Consuming a Special Cimicifuga racemosa rhizome Herbal Extract and Review of Literature

European Medicines Agency (EMEA) and the Committee on Herbal Medicinal Products (HMPC) on July 2006 have released an alert to get European sanitary authorities aware of 42 cases of suspected hepatotoxic reactions in patients consuming Cimicifuga racemosa rhizome. In the public statement EMEA itself considered reliable as hepatotoxic reactions only four cases, on the base of RUCAM score: two were considered possible and two probable. Lacking in almost all of them a precise description of cases, especially a botanical-chemical analysis of the suspected substance, we think there is no real proof of supposed C. racemosa rhizome hepatotoxicity. In our department we administer from about 10 years C. racemosa as special herbal dry extract as single substance or mixed with other medicinal plants at the dose of 500–1000 mg daily, for treatment of menopause related disorders without any reported adverse effect. After EMEA's official signal we have contacted all our patients using a C. racemosa rhizome herbal extract continuously from more than 12 months to verify possible hepatotoxic effects. We followed-up 107 women, and asked them by telephone (33/107) and/or after anamnesis and clinical examination (74/107) to undergo a blood sample examination. In all the patients there was no sign of hepatic disease, or worsening of already altered but stable parameters. We think on the base of these data and current literature C. racemosa rhizome extract should not be considered a potential hepatotoxic substance

Vanillin production using metabolically engineered Escherichia coli under non-growing conditions

BACKGROUND: Vanillin is one of the most important aromatic flavour compounds used in the food and cosmetic industries. Natural vanillin is extracted from vanilla beans and is relatively expensive. Moreover, the consumer demand for natural vanillin highly exceeds the amount of vanillin extracted by plant sources. This has led to the investigation of other routes to obtain this flavour such as the biotechnological production from ferulic acid. Studies concerning the use of engineered recombinant Escherichia coli cells as biocatalysts for vanillin production are described in the literature, but yield optimization and biotransformation conditions have not been investigated in details. RESULTS: Effect of plasmid copy number in metabolic engineering of E. coli for the synthesis of vanillin has been evaluated by the use of genes encoding feruloyl-CoA synthetase and feruloyl hydratase/aldolase from Pseudomonas fluorescens BF13. The higher vanillin production yield was obtained using resting cells of E. coli strain JM109 harbouring a low-copy number vector and a promoter exhibiting a low activity to drive the expression of the catabolic genes. Optimization of the bioconversion of ferulic acid to vanillin was accomplished by a response surface methodology. The experimental conditions that allowed us to obtain high values for response functions were 3.3 mM ferulic acid and 4.5 g/L of biomass, with a yield of 70.6% and specific productivity of 5.9 μmoles/g × min after 3 hours of incubation. The final concentration of vanillin in the medium was increased up to 3.5 mM after a 6-hour incubation by sequential spiking of 1.1 mM ferulic acid. The resting cells could be reused up to four times maintaining the production yield levels over 50%, thus increasing three times the vanillin obtained per gram of biomass. CONCLUSION: Ferulic acid can be efficiently converted to vanillin, without accumulation of undesirable vanillin reduction/oxidation products, using E. coli JM109 cells expressing genes from the ferulic acid-degrader Pseudomonas fluorescens BF13. Optimization of culture conditions and bioconversion parameters, together with the reuse of the biomass, leaded to a final production of 2.52 g of vanillin per liter of culture, which is the highest found in the literature for recombinant strains and the highest achieved so far applying such strains under resting cells conditions

A quantum particle in a box with moving walls

We analyze the non-relativistic problem of a quantum particle that bounces back and forth between two moving walls. We recast this problem into the equivalent one of a quantum particle in a fixed box whose dynamics is governed by an appropriate time-dependent Schroedinger operator.Comment: 12 pages, 0 figure

Dust formation in the winds of AGBs: the contribution at low metallicities

We present new models for the evolution of stars with mass in the range 1Msun < M < 7.5Msun, followed from the pre-main-sequence through the asymptotic giant branch phase. The metallicity adopted is $Z=3*10^{-4} (which, with an alpha-enhancement of +0.4, corresponds to [Fe/H]=-2). Dust formation is described by following the growth of dust grains of various types as the wind expands from the stellar surface. Models with mass M>3Msun experience Hot Bottom Burning, thus maintaining the surface C/O below unity. Unlike higher Z models, the scarcity of silicon available in the envelope prevents the formation of silicates in meaningful quantities, sufficient to trigger the acceleration of the wind via radiation pressure on the dust grains formed. No silicate formation occurs below a threshold metallicity of Z=10^{-3}. Low--mass stars, with M< 2.5Msun become carbon stars, forming solid carbon dust in their surroundings. The total dust mass formed depends on the uncertain extent of the inwards penetration of the convective envelope during the Third Dredge--Up episodes following the Thermal Pulses. Carbon grains have sizes 0.08 micron < a_C < 0.12 micron and the total amount of dust formed (increasing with the mass of the star) is M_C=(2-6)*10^{-4}Msun. Our results imply that AGB stars with Z=3*10^{-4} can only contribute to carbon dust enrichment of the interstellar medium on relatively long timescales, > 300 Myr, comparable to the evolutionary time of a 3Msun star. At lower metallicities the scarcity of silicon available and the presence of Hot Bottom Burning even in M< 2Msun, prevents the formation of silicate and carbon grains. We extrapolate our conclusion to more metal--poor environments, and deduce that at Z < 10^{-4} dust enrichment is mostly due to metal condensation in supernova ejecta.Comment: 13 pages, 8 figures, accepted for publication on MNRA

Cytoreduction and HIPEC in the treatment of "unconventional" secondary peritoneal carcinomatosis

BACKGROUND: Peritoneal metastasis (PM) is considered a terminal and incurable disease. In the last 30 years, cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) radically changed the therapeutic approach for these patients and is regarded as the standard of care for pseudomyxoma peritonei from appendiceal cancer and peritoneal mesotheliomas. Improved survival has also been reported in treating PM from ovarian, gastric, and colorectal cancers. However, PM often seriously complicates the clinical course of patients with other primary digestive and non-digestive cancers. There is increasing literature evidence that helped to identify not only the primary tumors for which CRS and HIPEC showed a survival advantage but also the patients who may benefit form this treatment modality for the potential lethal complications. Our goal is to report our experience with cytoreduction and HIPEC in patients with PM from rare or unusual primary tumors, discussing possible "unconventional" indications, outcome, and the peculiar issues related to each tumor. METHODS: From a series of 253 consecutive patients with a diagnosis of peritoneal carcinomatosis and treated by CRS and HIPEC, we selected only those with secondary peritoneal carcinomatosis from rare or unusual primary tumors, excluding pseudomyxoma peritonei, peritoneal mesotheliomas, ovarian, gastric, and colorectal cancers. Complications and adverse effects were graded from 0 to 5 according to the WHO Common Toxicity Criteria for Adverse Events (CTCAE). Survival was expressed as mean and median. RESULTS: We admitted and treated by CRS and HIPEC 28 patients with secondary peritoneal carcinomatosis from rare or unusual primary tumors. Morbidity and mortality rates were in line with those reported for similar procedures. Median survival for the study group was 56 months, and 5-year overall survival reached 40.3 %, with a difference between patients with no (CC0) and minimal (CC1) residual disease (52.3 vs. 25.7), not reaching statistical significance. Ten patients are alive disease-free, and eight are alive with disease. CONCLUSIONS: Cytoreduction and HIPEC should not be excluded "a priori" for the treatment of peritoneal metastases from unconventional primary tumors. This combined therapeutic approach, performed in an experienced center, is safe and can provide a survival benefit over conventional palliative treatments

on the rapid discharge of subsea accumulators remarks on the normed design method and proposal of improvement

n/

Soft Tissue Contour Impression with Analogic or Digital Work Flow: A Case Report

Transferring precise information to the dental laboratory is one of the key factors to achieving clinical success. The aim of the present study was to describe classical and digital work-flows used to rehabilitate an implant with a convergent collar in the aesthetic zone following the BOPT (biologically oriented preparation technique) approach and to report the three years follow-up outcomes of two patients rehabilitated following such procedures