6,630 research outputs found
Cumulants and convolutions via Abel polynomials
We provide an unifying polynomial expression giving moments in terms of
cumulants, and viceversa, holding in the classical, boolean and free setting.
This is done by using a symbolic treatment of Abel polynomials. As a
by-product, we show that in the free cumulant theory the volume polynomial of
Pitman and Stanley plays the role of the complete Bell exponential polynomial
in the classical theory. Moreover via generalized Abel polynomials we construct
a new class of cumulants, including the classical, boolean and free ones, and
the convolutions linearized by them. Finally, via an umbral Fourier transform,
we state a explicit connection between boolean and free convolution
Natural statistics for spectral samples
Spectral sampling is associated with the group of unitary transformations
acting on matrices in much the same way that simple random sampling is
associated with the symmetric group acting on vectors. This parallel extends to
symmetric functions, k-statistics and polykays. We construct spectral
k-statistics as unbiased estimators of cumulants of trace powers of a suitable
random matrix. Moreover we define normalized spectral polykays in such a way
that when the sampling is from an infinite population they return products of
free cumulants.Comment: Published in at http://dx.doi.org/10.1214/13-AOS1107 the Annals of
Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical
Statistics (http://www.imstat.org
Ku & C Band solid state switch matrix for satellite payloads using LTCC multilayer substrate
This paper describes the design and development of Ku and C band solid state switch matrix for multimedia satellite payloads. The design, through the use of advanced packaging techniques, allows significant savings on mass and volume with respect to traditional electromechanical switches while guaranteeing a comparable reliability
Vestibulo-Ocular Reflex Modification after Virtual Environment Exposure
Immersion in an illusory world is possible by means of virtual reality (VR), where environmental perception is modi
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c1c ed by artificial sensorial stimulation. The application of VR for the assessment and rehabilitation of pathologies affecting the vestibular system, in terms of both diagnosis and care, could represent an interesting new line of research. Our perception of reality is in fact based on static and dynamic spatial information perceived by our senses. During head movements in a virtual environment the images on the display and the labyrinthine information relative to the head angular accelerations differ and therefore a visuo-vestibular conflict is present. It is known that mismatches between visual and labyrinthine information may modify the vestibulo-oculomotor reflex (VOR) gain. We studied the post-immersion modifications in 20 healthy subjects (mean age 25 years) exposed to a virtual environment for 20 min by wearing a head-mounted display. VOR gain and phase were measured by means of harmonic sinusoidal stimulation in the dark before, at the end of and 30 min after VR exposure. A VOR gain reduction was observed in all subjects at the end of VR exposure which disappeared after 30 min. Our data show that exposure to a virtual environment can induce a temporary modi
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c1c cation of the VOR gain. This
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c1c nding can be employed to enable an artificial, instrumental modification of the VOR gain and therefore opens up new perspectives in the assessment and rehabilitation of vestibular diseases
Investigating feedforward neural regulation of circulation from analysis of spontaneous arterial pressure and heart rate fluctuations in conscious rats.
Investigating feedforward neural regulation
of circulation from analysis of spontaneous arterial pressure and
heart rate fluctuations in conscious rats. Am J Physiol Heart Circ
Physiol 296: H202–H210, 2009. First published November 14, 2008;
doi:10.1152/ajpheart.00358.2008.—It has been suggested in anesthetized
animals that the occurrence of sequences of consecutive beats
characterized by systolic arterial pressure (SAP) and RR or pulse
interval (PI) changing in the opposite direction (SAP /RR and
SAP /RR , nonbaroreflex sequences) might represent the expression
of neural cardiovascular regulatory mechanisms operating with feedforward
characteristics. The aim of the present study was to study
nonbaroreflex sequences in a more physiological experimental model,
i.e., in conscious freely moving rats. We studied conscious rats before
and after 1) complete autonomic blockade (n 12), 2) sympathetic
blockade (n 10), 3) (n 7)- and (n 8)-adrenergic blockade,
and 4) parasympathetic blockade (n 10). Nonbaroreflex sequences
were defined as three or more beats in which SAP and PI of the
following beat changed in the opposite direction. Complete autonomic
blockade reduced the number of nonbaroreflex sequences (95.6 9.0
vs. 45.2 4.1, P 0.001), as did sympathetic blockade (80.9 12.6
vs. 30.9 6.1, P 0.001). The selective -receptor blockade did not
induce significant changes (80.9 12.5 in baseline vs. 79.0 14.7
after prazosin), whereas -receptor blockade significantly reduced
nonbaroreflex sequence occurrence (80.9 12.5 in baseline vs.
48.9 15.3 after propranolol). Parasympathetic blockade produced a
significant increase of nonbaroreflex sequences (95.1 6.9 vs.
136.0 12.4, P 0.01). These results demonstrate the physiological
role of the nonbaroreflex sequences as an expression of a feedforward
type of short-term cardiovascular regulation able to interact dynamically
with the feedback mechanisms of baroreflex origin in the neural
control of the sinus node
Atrial natriuretic peptide effects on intracellular pH changes and ROS production in HEPG2 cells: Role of p38 MAPK and phospholipase D
Aims: The present study was performed to evaluate Atrial Natriuretic Peptide ( ANP) effects on intracellular pH, phospholipase D and ROS production and the possible relationship among them in HepG2 cells. Cancer extracellular microenvironment is more acidic than normal tissues and the activation of NHE- 1, the only system able to regulate pHi homeostasis in this condition, can represent an important event in cell proliferation and malignant transformation. Methods: The ANP effects on pHi were evaluated by fluorescence spectrometry. The effects on p38 MAPK and ROS production were evaluated by immunoblots and analysis of DCF- DA fluorescence, respectively. RT- PCR analysis and Western blotting were used to determine the ANP effect on mRNA NHE- 1 expression and protein levels. PLD- catalyzed conversion of phosphatidylcholine to phosphatydilethanol ( PetOH), in the presence of ethanol, was monitored by thin layer chromatography. Results: A significant pHi decrease was observed in ANP- treated HepG2 cells and this effect was paralleled by the enhancement of PLD activity and ROS production. The ANP effect on pHi was coupled to an increased p38 MAPK phosphorylation and a down- regulation of mRNA NHE- 1 expression and protein levels. Moreover, the relationship between PLD and ROS production was demonstrated by calphostin- c, a potent inhibitor of PLD. At the same time, all assessed ANP- effects were mediated by NPR- C receptors. Conclusion: Our results indicate that ANP recruits a signal pathway associated with p38 MAPK, NHE- 1 and PLD responsible for ROS production, suggesting a possible role for ANP as novel modulator of ROS generation in HepG2 cells. Copyright (C) 2005 S. Karger AG, Basel
Carbon nanomaterials-based electrically conductive scaffolds to repair the ischaemic heart tissue
Ischaemic heart diseases are the leading causes of morbidity around the world and pose serious socio-economic burdens. Ischaemic events, such as myocardial infarction, lead to severe tissue damage and result in the formation of scar tissue. This scar tissue, being electrically inert, does not conduct electrical currents and thus generates lethal arrhythmias. The ventricle dilates with time due to asynchronous beating due to the scar, and it eventually leads to total heart failure. The current pharmacological approaches only cure heart failure symptoms without inducing tissue regeneration. Therefore, heart transplant remains the gold standard to date, but the limited organ donors and the possibility of immune rejection make this approach elusive. Cardiac tissue engineering has the potential to address this issue by engineering artificial heart tissues using 3D scaffolds cultured with cardiac stem cells. Compared with the traditional non-conductive scaffold, electroconductive scaffolds can transfer feeble electric currents among the cultured cells by acting as a "wire". This improves intercellular communication and synchronisation that otherwise is not possible using non-conductive scaffolds. This article reviews the recent advances in carbon nanomaterials-based electroconductive scaffolds, their in vitro/in vivo efficacy, and their potential to repair ischaemic heart tissue
Recovery of viral RNA and infectious foot-and-mouth disease virus from positive lateral-flow devices
Foot-and-mouth disease Virus (FMDV) is an economically important, highly contagious picornavirus that affects both wild and domesticated cloven hooved animals. In developing countries, the effective laboratory diagnosis of foot-and-mouth disease (FMD) is often hindered by inadequate sample preservation due to difficulties in the transportation and storage of clinical material. These factors can compromise the ability to detect and characterise FMD virus in countries where the disease is endemic. Furthermore, the high cost of sending infectious virus material and the biosecurity risk it presents emphasises the need for a thermo-stable, non-infectious mode of transporting diagnostic samples. This paper investigates the potential of using FMDV lateral-flow devices (LFDs) for dry transportation of clinical samples for subsequent nucleic acid amplification, sequencing and recovery of infectious virus by electroporation. FMDV positive samples (epithelial suspensions and cell culture isolates) representing four FMDV serotypes were applied to antigen LFDs: after which it was possible to recover viral RNA that could be detected using real-time RT-PCR. Using this nucleic acid, it was also possible to recover VP1 sequences and also successfully utilise protocols for amplification of complete FMD virus genomes. It was not possible to recover infectious FMDV directly from the LFDs, however following electroporation into BHK-21 cells and subsequent cell passage, infectious virus could be recovered. Therefore, these results support the use of the antigen LFD for the dry, non-hazardous transportation of samples from FMD endemic countries to international reference laboratories
Extrinsically conductive nanomaterials for cardiac tissue engineering applications
Myocardial infarction (MI) is the consequence of coronary artery thrombosis resulting in ischemia and necrosis of the myocardium. As a result, billions of contractile cardiomyocytes are lost with poor innate regeneration capability. This degenerated tissue is replaced by collagen-rich fibrotic scar tissue as the usual body response to quickly repair the injury. The non-conductive nature of this tissue results in arrhythmias and asynchronous beating leading to total heart failure in the long run due to ventricular remodelling. Traditional pharmacological and assistive device approaches have failed to meet the utmost need for tissue regeneration to repair MI injuries. Engineered heart tissues (EHTs) seem promising alternatives, but their non-conductive nature could not resolve problems such as arrhythmias and asynchronous beating for long term in-vivo applications. The ability of nanotechnology to mimic the nano-bioarchitecture of the extracellular matrix and the potential of cardiac tissue engineering to engineer heart-like tissues makes it a unique combination to develop conductive constructs. Biomaterials blended with conductive nanomaterials could yield conductive constructs (referred to as extrinsically conductive). These cell-laden conductive constructs can alleviate cardiac functions when implanted in-vivo. A succinct review of the most promising applications of nanomaterials in cardiac tissue engineering to repair MI injuries is presented with a focus on extrinsically conductive nanomaterials
Chemotherapy in patients with early breast cancer: clinical overview and management of long-term side effects
Introduction: Neo/adjuvant therapy for early-stage breast cancer has become increasingly common in the last few decades; as a consequence, the number of breast cancer survivors experiencing often debilitating long-term side effects has increased, and thus the need for a comprehensive approach to the variety of symptoms involved. Areas covered and methods: We performed a literature search on the main public scientific databases (PubMed, Embase, Cochrane, and CrossRef) from 2000 to April 2022 to identify prevention and management strategies for the most common long-term side effects, including fatigue, insomnia, peripheral neuropathy, cognitive impairment, estrogen deprivation, cardiotoxicity, and second cancers. Expert opinion: Long-term toxicities may affect a majority of breast cancer survivors, significantly interfering with their quality of life. Although there are guidelines for the management of isolated side effects, such as peripheral neuropathy, we aim to provide a more inclusive clinical-oriented approach, focusing on both prevention and therapeutic strategies
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