The Interaction Between Redox and Hypoxic Signalling Pathways in the Dynamic Oxygen Environment of Cancer Cells

Oxygen is essential for the survival of all living beings. A balanced oxygen environment is required since both lower and higher than the required oxygen levels can be detrimental to the cells (Figure 1). The oxygen state of a tissue results fr om the relative contributions of oxygen consumption and delivery. Different organs in the body exist under different oxygen environments, depending on the location and function of the cells in an organ. Most healthy organs reside in 3-6% oxygen [1] while conditions lower than 3% oxygen are described as hypoxia. Cells also survive in hypoxic environments during normal development [2]. However, hypoxia is mostly detrimental to the cells by disrupting the oxygen homeostasis

Adénocarcinome de la glande lacrymale dans un rétinoblastome bilatéral traité avec radiothérapie externe : à propos d’un cas

This clinical case report describes the clinical findings and diagnosis of lacrimal gland adenocarcinoma that developed 20 years after external beam radiotherapy in the treatment of bilateral retinoblastoma. Visual acuity, slit lamp biomicroscopy, fundus color photography, nuclear magnetic resonance, lateral orbitotomy and histological analysis are described

Comparing the competitiveness between brazilian and european football (SOCCER) (G-5) – interpretations and suggestions

World sport has been seen as a growing industry, generating revenues of roughly US$1 trillion a year. Playing a major role in this industry, football (soccer) is accountable for an annual turnover of approximately US$ 250 billion – Brazil’s share being approximately 1% of that amount. The growing marketing and globalization of football has brought up new topics such as: the risks associated with competitiveness; the need for professional management; creating corporate teams; sports strategies and marketing; accounting; accountability.This paper aims at: i) understanding the risks associated with the competitiveness of football leagues; ii) comparing the competitive balance in the five largest European football markets (Germany, Spain, France, England and Italy) in relation with Brazilian football and; iii) interpreting these results in view of the literature concerning sports administration

Automated Analysis of MUTEX Algorithms with FASE

In this paper we study the liveness of several MUTEX solutions by representing them as processes in PAFAS s, a CCS-like process algebra with a specific operator for modelling non-blocking reading behaviours. Verification is carried out using the tool FASE, exploiting a correspondence between violations of the liveness property and a special kind of cycles (called catastrophic cycles) in some transition system. We also compare our approach with others in the literature. The aim of this paper is twofold: on the one hand, we want to demonstrate the applicability of FASE to some concrete, meaningful examples; on the other hand, we want to study the impact of introducing non-blocking behaviours in modelling concurrent systems.Comment: In Proceedings GandALF 2011, arXiv:1106.081

eBPF: A New Approach to Cloud-Native Observability, Networking and Security for Current (5G) and Future Mobile Networks (6G and Beyond)

Modern mobile communication networks and new service applications are deployed on cloud-native platforms. Kubernetes (K8s) is the de facto distributed operating system for container orchestration, and the extended version of the Berkeley Packet Filter (eBPF)- in the Linux (and MS Windows) kernel- is fundamentally changing the approach to cloud-native networking, security, and observability. In this paper, we introduce what eBPF is, its potential for Telco cloud, and review some of the most promising pricing and billing models applied to this revolutionary operating system (OS) technology. These models include schemes based on a data source usage model or the number of eBPF agents deployed on the network, linked to specific eBPF modules. These modules encompass network observability, runtime security, and power dissipation monitoring. Next, we present our eBPF platform, named Sauron in this work, and demonstrate how eBPF allows us to write custom code and dynamically load eBPF programs into the kernel. These programs enable us to estimate the energy consumption of cloud-native functions, derive performance counters and gauges for transport networks, 5G applications, and non-access stratum protocols. Additionally, we can detect and respond to unauthorized access to cloud-native resources in real-time using eBPF. Our experimental results demonstrate the technical feasibility of eBPF in achieving highly performant monitoring, observability, and security tooling for current mobile networks (5G, 5G Advanced) as well as future networks (6G and beyond)

OCT is not useful for detection of minimal diabetic retinopathy in type 1 diabetes.

Optical coherence tomography (OCT) has been proven useful in measuring retinal thickness (RT) in patients with diabetes, although with discordant results in different studies. We examined RT in patients with type 1 diabetes (T1D) with or without minimal diabetic retinopathy (MDR) to test whether OCT is able to identify early retinal changes and potential correlations with metabolic parameters. RT of 102 patients with T1D (53 females, 49 males, aged 27.03 +/- 7.4 years) and of 42 healthy controls was examined, with analysis of nine different sectors (fovea, four pericentral and four peripheral sectors). According to the results of basal fundus photography, patients were divided into two groups, without MDR (48 cases) and with MDR (54 cases). Patients with proliferative DR or macular edema were excluded. No difference was found between patients with or without MDR and the control group for all OCT parameters investigated. Mean HbA1c of the last 5 years (P < 0.001), microalbuminuria (P = 0.002), total (P = 0.046) and LDL cholesterol (P = 0.007) and triglyceride (P < 0.001) levels were higher in patients with MDR, along with higher prevalence of hypertension (P = 0.013), younger age at diagnosis (P = 0.018) and longer diabetes duration (P < 0.001) with regard to the patients without MDR and controls, although no significant correlation between these parameters and RT was found. Our study suggests that MDR without macular edema in patients with T1D cannot be detected with OCT. Therefore, the conventional diagnostic methods are mandatory to detect early DR

Comparison of sampling bags for the analysis of volatile organic compounds in breath

Nalophan, Tedlar and Cali-5-Bond polymeric bags were compared to determine the most suitable type for breath sampling and storage when volatile organic compounds are to be determined. Analyses were performed by thermal desorption gas chromatography mass spectrometry. For each bag, the release of contaminants and the chemical stability of a gaseous standard mixture containing eighteen organic compounds, as well as the CO2 partial pressure were assessed. The selected compounds were representative of breath constituents and belonged to different chemical classes (i.e. hydrocarbons, ketones, aldehydes, aromatics, sulfurs and esters). In the case of Nalophan, the influence of the surface-to-volume ratio, related to the bag's filling degree, on the chemical stability was also evaluated. Nalophan bags were found to be the most suitable in terms of contaminants released during storage (only 2-methyl-1,3-dioxalane), good sample stability (up to 24 h for both dry and humid samples), and very limited costs (about 1 for a 20 liter bag). The (film) surface-to-(sample) volume ratio was found to be an important factor affecting the stability of selected compounds, and therefore we recommended to fill the bag completely