Contribution of pulsars to cosmic-ray positrons in light of recent observation of inverse-Compton halos

The hypothesis that pulsar wind nebulae (PWNe) can significantly contribute to the excess of the positron ($e^+$) cosmic-ray flux has been consolidated after the observation of a $\gamma$-ray emission at TeV energies of a few degree size around Geminga and Monogem PWNe, and at GeV energies for Geminga at a much larger extension. The $\gamma$-ray halos around these PWNe are interpreted as due to electrons ($e^-$) and $e^+$ accelerated and escaped by their PWNe, and inverse Compton scattering low-energy photons of the interstellar radiation fields. The extension of these halos suggests that the diffusion around these PWNe is suppressed by two orders of magnitude with respect to the average in the Galaxy. We implement a two-zone diffusion model for the propagation of $e^+$ accelerated by the Galactic population of PWNe. We consider pulsars from the ATNF catalog and build up simulations of the PWN Galactic population. In both scenarios, we find that within a two-zone diffusion model, the total contribution from PWNe and secondary $e^+$ is at the level of AMS-02 data, for an efficiency of conversion of the pulsar spin down energy in $e^\pm$ of $\eta\sim0.1$. For the simulated PWNe, a $1\sigma$ uncertainty band is determined, which is of at least one order of magnitude from 10 GeV up to few TeV. The hint for a decreasing $e^+$ flux at TeV energies is found, even if it is strongly connected to the chosen value of the radius of the low diffusion bubble around each source.Comment: 10 pages, 7 figures. Figures 2, 3 and 5 updated. Results unchange

Reactive oxygen species inhibit the succinate oxidation-supported generation of membrane potential in wheat mitochondria

In order to gain a first insight into the effects of reactive oxygen species (ROS) on plant mitochondria, we studied the effect of the ROS producing system consisting of xanthine plus xanthine oxidase on the rate of membrane potential (ΔΨ) generation due to either succinate or NADH addition to durum wheat mitochondria as monitored by safranin fluorescence. We show that the early ROS production inhibits the succinate-dependent, but not the NADH-dependent, ΔΨ generation and oxygen uptake. This inhibition appears to depend on the impairment of mitochondrial permeability to succinate. It does not involve mitochondrial thiol groups sensitive to either mersalyl or N-ethylmaleimide and might involve both protein residues and/or membrane lipids, as suggested by the mixed nature. We propose that, during oxidative stress, early generation of ROS can affect plant mitochondria by impairing metabolite transport, thus preventing further substrate oxidation, ΔΨ generation and consequent large-scale ROS production. © 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved

Investigation on the topological optimization of cooling channels for extrusion dies

During the extrusion process, high temperatures are generated, due to friction and deformation works, potentially leading to profile and die defects. Among the suggested solutions aimed at controlling the thermal field of the process, the most accredited one involves the manufacturing of cooling channels at the mating face between the die and a third plate. Despite the proven efficiency of well-designed channels, the main drawback lies in the managing of the many variables involved that strongly affect the cooling efficiency and balancing. In this frame, aim of the work is to investigate the applicability of the topological optimization tool, proposed by COMSOL Multiphysics software, for the design of cooling channels in extrusion dies. To validate the tool, an industrial case study has been selected and results compared between not optimized and optimized cooling solutions

Experimental analysis and modeling of the recrystallization behaviour of a AA6060 extruded profile

The microstructure of Al-Mg-Si alloys is gaining nowadays an increasing industrial interest because it influences the strength, crash, corrosion and esthetic properties of the extruded profiles. In order to investigate and predict the recrystallization behaviour in the extrusion of 6XXX aluminum alloys, experimental and numerical activities are still needed. In this work, the extrusion of an industrial-scale AA6060 aluminum alloy hollow profile was carried out. An innovative recrystallization model was developed and optimized by comparing the microstructural data experimentally acquired with the outputs of the simulation performed using the Finite Element commercial code Qform Extrusion. A good correlation between numerical prediction and experimental data was found, thus proving the reliability of the proposed AA6060 recrystallization model

Mixed trichuroid infestation in a dog from Italy

Background: Capillaria aerophila, Capillaria boehmi and Trichuris vulpis are trichuroid nematodes affecting wild and companion animals all over the World. The canine intestinal whipworm, T. vulpis, is the most common and wellknown in veterinary practice, whereas the respiratory C. aerophila and C. boehmi have been rarely reported in pets as a likely consequence of overlapping morphometric and morphological features of the eggs, which impair a correct etiological diagnosis. Findings: In December 2011, a mixed infestation by T. vulpis, C. aerophila and C. boehmi was diagnosed in an asymptomatic dog living in central Italy. Morphometric and morphological findings and pictures of the eggs found at the copromicroscopic analysis are herein reported. Conclusions: The present work demonstrates that when trichuroid eggs are found in a faecal sample from a dog, a careful morphological and morphometric analysis of individual parasite elements is mandatory. Key diagnostic features (i.e., size, wall surface pattern and aspects of plugs) should be carefully examined when eggs with overlapping shape and appearance are detected. In conclusion, given the importance in clinical practice of canine trichuroids and the zoonotic potential of C. aerophila, these nematodes should be included into the differential diagnosis of intestinal and respiratory parasitoses of dogs by a thorough microscopic analysis of all trichuroid ova present in microscopic fields

Advancements in extrusion and drawing: a review of the contributes by the ESAFORM community

The present review paper would celebrate the 25 years anniversary of the ESAFORM association by summarizing the studies performed by the delegates of the ESAFORM conference series within mini-symposium “Extrusion and Drawing” and of the papers published in the International Journal of Material Forming in the same fields. The 160 analyzed papers have been divided in four main categories corresponding to the paper main chapters (Hot Metal Extrusion, Cold Metal Extrusion, Polymer Extrusion and Drawing) then further divided in sub-chapters in order to group them in more specific research subjects. The aim of this review paper is then to provide to the reader a complete overview of the investigated topics and of the research trends over the years within the ESAFORM associate researchers