Discrete fourier transform-based TOA estimation in UWB systems

In this paper, we propose two time of arrival estimators for ultra wideband signals based on the phase difference between the discrete Fourier transforms (DFT) of the transmitted and received signals. The first estimator is based on the slope of the unwrapped phase and the second one on the absolute unwrapped phase. We derive the statistics of the unwrapped phase. We show that slope-based estimation almost achieves asymptotically the baseband Cramer-Rao lower bound (CRLB), while the absolute-phase-based estimator achieves asymptotically the passband CRLB. We compare the proposed estimators to the time-domain maximum likelihood estimator (MLE). We show that the MLE achieves the CRLB faster than the DFT-based estimator, while the DFT-based estimator outperforms the MLE for low signal to noise ratios. We describe also how to use the proposed estimators in multipath UWB channels

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Non-Gaussianities due to Relativistic Corrections to the Observed Galaxy Bispectrum

High-precision constraints on primordial non-Gaussianity (PNG) will significantly improve our understanding of the physics of the early universe. Among all the subtleties in using large scale structure observables to constrain PNG, accounting for relativistic corrections to the clustering statistics is particularly important for the upcoming galaxy surveys covering progressively larger fraction of the sky. We focus on relativistic projection effects due to the fact that we observe the galaxies through the light that reaches the telescope on perturbed geodesics. These projection effects can give rise to an effective $f_{\rm NL}$ that can be misinterpreted as the primordial non-Gaussianity signal and hence is a systematic to be carefully computed and accounted for in modelling of the bispectrum. We develop the technique to properly account for relativistic effects in terms of purely observable quantities, namely angles and redshifts. We give some examples by applying this approach to a subset of the contributions to the tree-level bispectrum of the observed galaxy number counts calculated within perturbation theory and estimate the corresponding non-Gaussianity parameter, $f_{\rm NL}$, for the local, equilateral and orthogonal shapes. For the local shape, we also compute the local non-Gaussianity resulting from terms obtained using the consistency relation for observed number counts. Our goal here is not to give a precise estimate of $f_{\rm NL}$ for each shape but rather we aim to provide a scheme to compute the non-Gaussian contamination due to relativistic projection effects. For the terms considered in this work, we obtain contamination of $f_{\rm NL}^{\rm loc} \sim {\mathcal O}(1)$.Comment: 31 pages, 6 figures, Typos corrected to match the published version in JCA

Spontaneous Peierls dimerization and emergent bond order in one-dimensional dipolar gases

We investigate the effect of dipolar interactions in one-dimensional systems in connection with the possibility of observing exotic many-body effects with trapped atomic and molecular dipolar gases. By combining analytical and numerical methods, we show how the competition between short- and long-range interactions gives rise to frustrating effects which lead to the stabilization of spontaneously dimerized phases characterized by a bond ordering. This genuine quantum order is sharply distinguished from Mott and spin-density-wave phases, and can be unambiguously probed by measuring nonlocal order parameters via in situ imaging techniques

Analysis of meiotic segregation by triple-color fish on both total and motile sperm fractions in a t(1p;18) river buffalo bull

Chromosomal aberrations are relatively frequent pathologies in both humans and animals. Among them, translocations present a specific meiotic segregation pattern able to give a higher percentage of unbalanced gametes that can induce fertility problems. In this study, the meiotic segregation patterns of 1p, 1q and 18 Bubalus bubalis chromosomes were analyzed in both total sperm fraction and motile sperm fraction of a t(1p;18) carrier and a control bulls by triple-color FISH analysis with a pool of specific BAC probes. The frequencies of each total sperm fraction products in the carrier resulting from alternate, adjacent I, adjacent II and 3:1 segregation were 39%, 20%, 1% and 38%, respectively. On the other hand, the frequencies of each motile sperm fraction products in the carrier resulting from alternate, adjacent I, adjacent II and 3:1 segregation were 93%, 5%, 0% and 2%, respectively. The frequencies of normal sperms in the carrier were 27% and 69% in total sperm fraction and motile sperm fraction, respectively. The frequencies detected in motile sperm fraction were also validated by comparison with bull's progeny. To our knowledge, this is the first report on the meiotic segregation patterns in motile sperm fractions of B. bubalis bull carrying a chromosomal translocation. These data suggest that translocation has a very limited effect on aneuploidy in the gametes, and therefore, on the reproductive abilities of the bull

Characterization of chenopodin isoforms from quinoa seeds and assessment of their potential anti-inflammatory activity in Caco-2 cells

Several food-derived molecules, including proteins and peptides, can show bioactivities toward the promotion of well-being and disease prevention in humans. There is still a lack of information about the potential effects on immune and inflammatory responses in mammalian cells following the ingestion of seed storage proteins. This study, for the first time, describes the potential immunomodulation capacity of chenopodin, the major protein component of quinoa seeds. After characterizing the molecular features of the purified protein, we were able to separate two different forms of chenopodin, indicated as LcC (Low charge Chenopodin, 30% of total chenopodin) and HcC (High charge Chenopodin, 70% of total chenopodin). The biological effects of LcC and HcC were investigated by measuring NF-\u3baB activation and IL-8 expression studies in undifferentiated Caco-2 cells. Inflammation was elicited using IL-1\u3b2. The results indicate that LcC and HcC show potential anti-inflammatory activities in an intestinal cell model, and that the proteins can act differently, depending on their structural features. Furthermore, the molecular mechanisms of action and the structural/functional relationships of the protein at the basis of the observed bioactivity were investigated using in silico analyses and structural predictions

Human primary endothelial cells are impaired in nucleotide excision repair and sensitive to benzo[a]pyrene compared with smooth muscle cells and pericytes

The endothelium represents the inner cell layer of blood vessels and is supported by smooth muscle cells and pericytes, which form the vessel structure. The endothelium is involved in the pathogenesis of many diseases, including the development of atherosclerosis. Due to direct blood contact, the blood vessel endothelium is inevitably exposed to genotoxic substances that are systemically taken up by the body, including benzo[a]pyrene, which is a major genotoxic component in cigarette smoke and a common environmental mutagen and human carcinogen. Here, we evaluated the impact of benzo[a]pyrene diol epoxide (BPDE), which is the reactive metabolite of benzo[a]pyrene, on the three innermost vessel cell types. Primary human endothelial cells (HUVEC), primary human smooth muscle cells (HUASMC) and primary human pericytes (HPC) were treated with BPDE, and analyses of cytotoxicity, cellular senescence and genotoxic effects were then performed. The results showed that HUVEC were more sensitive to the cytotoxic activity of BPDE than HUASMC and HPC. We further show that HUVEC display a detraction in the repair of BPDE-induced adducts, as determined through the comet assay and the quantification of BPDE adducts in post-labelling experiments. A screening for DNA repair factors revealed that the nucleotide excision repair (NER) proteins ERCC1, XPF and ligase I were expressed at lower levels in HUVEC compared with HUASMC and HPC, which corresponds with the impaired NER-mediated removal of BPDE adducts from DNA. Taken together, the data revealed that HUVEC exhibit an unexpected DNA repair-impaired phenotype, which has implications on the response of the endothelium to genotoxicants that induce bulky DNA lesions, including the development of vascular diseases resulting from smoking and environmental pollution

Concentrating Solar Power: The State of the Art, Research Gaps and Future Perspectives

In recent decades, the fight against climate change and the commitment to reduce greenhouse gases have shed a light on the production of energy from renewable sources, in particular those derived from solar energy. This has required the involvement of all stakeholders (producers, but also energy operators, authorities, distributors, and final consumers) which has led to the outline of a new scenario characterized by more efficient technologies, dedicated strategies and business models, and the research of alternatives solutions. Within solar technology, great attention has been given in recent years to concentrating solar power (CSP) technologies, both from research studies and technological development sides. This paper provides a theoretical framework based on a CSP literature review to define the state of the art and to identify research gaps and future research steps related to this technology. The work is based on an innovative bibliometric study to explore technical fields related to CSP, providing both a comprehensive framework with reference to the state of the art of the technology investigated, and a detailed analysis on CSP commercial applications, making the review a very useful tool for stakeholders and decision makers The results of the analysis: (1) help to clarify the technological advances of CSP, the strengths and weaknesses of the current technologies used (parabolic and tower systems are the most widespread), and indications of the prospects for dish systems; (2) identify an alternative to the economic problem that represents an obstacle to the diffusion of CSP, for example, by identifying the ability to couple it with thermal storage as a valid method to increase the flexibility of the system and reduce costs; (3) suggested hybrids, both with renewable and non-renewable technologies, identifying strengths and weaknesses for all the proposed proposals; (4) show that it is possible to identify new ongoing research such as that related to hydrogen production. This paper represents the first part of a larger research study developed within the SOLARGRID Project, which promotes and supports the development of innovative solutions for systems and components for CSP and concentrated photovoltaics (CPV) technologies, with the aim to enhance their energetic performances and economic competitiveness in applications for the distributed generation of both electric and thermal energy frameworks. The main findings of our study highlight that, though there is an increasing number of papers on the topic of CSP, several issues remain neglected

Vulvar lipoma: rare case, rare location

Background. Vulvar lipomas are very rare pathologies: indeed, only few cases are reported in the literature. Case presentation. We reported clinical, diagnostic and therapeutical choices of a 44-year aged patient with a rare abnormally sized vulvar lipoma. A Diamond-shaped skin incision was performed and the neoformation was removed without capsule lesions. A vaginal plastic skin-reducing was performed to reduce redundant tissue. The deep planes of the lesion have been reconstructed to avoid leakage. Conclusions. This kind of lipomas can be potentially diagnosed through clinical examination because of their specific characteristics. However, imaging is advisable to differentiate benign neoplasm from malignant one. Different approaches can be achieved for lipomas based on the size of lump, patient’s feelings and necessities and the operation goals; however, the complete surgical excision with the removal of capsules to prevent recurrence remains the treatment of choice for vulvar lipomas. Different surgical approaches aim to achieve better esthetical results, less scarring, and less colour discordance of the connected tissues post-surgery. Surgery is the gold standard for treatment of vulvar lesions. Currently, there is no evidence of long-term follow-up in the literature. We recommend an adequate counselling with the patient to understand their needs and encouraging them to seek medical advice and to tailor the treatment of such lesions