Integrating Green-Infrastructures Design in Strategic Spatial Planning with Geodesign

In the last decades green infrastructure planning, design, and management have been widely recognized as a way to contribute to reach higher levels of sustainability of development. However, often green infrastructures are considered in a sectoral way, while their design should be more integrated within comprehensive planning and design. The paper proposes the use of geodesign methods and technology to support the early phases of integrated strategic territorial planning, in order to enrich the relationships between the design of green infrastructure and of the other relevant systems via more comprehensive planning and design, and by applying systems thinking. A case study developed with architecture and engineering students under the umbrella of the International Geodesign Collaboration is used, to demonstrate how with intensive geodesign workshops it is possible to create spatially explicit design scenarios which take into account the relationships between green infrastructure and other territorial systems and dynamics. A set of analyses on the case study results of the two scales is used to demonstrate the assumption. It is also argued that geodesign intensive workshops can, in a very short time, contribute to raising the awareness among the participants of collaborative design to the importance of green infrastructure in strategic territorial planning

Total thyroidectomy associated to chemotherapy in primary squamous cell carcinoma of the thyroid

Primary squamous cell carcinoma of the thyroid (PSCCT) is a rare malignant disease with rapid fatal prognosis. The onset is generally characterized by sudden bilateral latero-cervical lymphadenopathy. The Authors report patient of 58-year-old who referred for evaluation of rapidly aggravating bilateral latero-cervical lymphadenopathy. The US highlighted the presence of a hypoechoic nodular lesion characterized by peri and intra-nodular vascularization. Multilayer CT showed diffused involvement of mediastinal and bilateral latero-cervical lymph nodes, with no evidence of primary pulmonary neoplasia or elsewhere. The patient underwent total thyroidectomy. The peri-isthmic tissue was removed due to the presence of a small roundish formation, that was due to lymph node metastasis at histological examination. Histological diagnosis: PSCCT. The immunohistochemical panel of the thyroid lesion was indispensable for the differential diagnosis between PSCCT, medullary carcinoma, anaplastic carcinoma, and thyroid metastasis of neoplasia with unknown primitiveness. The patient underwent chemotherapeutic treatment with Carboplatin and Paclitaxel with modest improvement of dysphagia symptoms and reduction of 10-15% of the target lesions. The clinical course was characterized by loco-regional progression of the disease with exitus in 10 months after diagnosis. Survival and quality of life after surgical therapy and chemotherapy were like that of patients undergoing only chemotherapy. Due to the extreme rarity of the neoplasia, 60 cases described in Literature, no exclusive guidelines are reported for PSCCT. More extensive case studies are needed to evaluate the effects of total thyroidectomy with intent R0/R1 on improving survival and quality of life of patients with PSCCT

Secondary structure prediction for RNA binding domain in RNP proteins identifies βαβ as the main structural motif

AbstractIn eukaryotic cells transcript processing is strictly dependent upon binding of specific proteins. Nuclear RNA binding proteins share a common domain, which is involved in RNA binding. In order to characterize RNP-RNA interactions we have performed a secondary structure prediction based both on statistical algorithms and comparative analysis of different proteins. A high conservation for secondary structure propensity between different RNPs was observed

Palmitoylethanolamide is a disease-modifying agent in peripheral neuropathy : pain relief and neuroprotection share a PPAR-alpha-mediated mechanism

Peer reviewedPublisher PD

Once dishonest, always dishonest? The impact of perceived pervasiveness of moral evaluations of the self on motivation to restore a moral reputation

PublishedArticleFour studies specify how moral evaluations of the self regulate behavior aimed at restoring a moral reputation. We propose that people care about evaluations of themselves as moral or immoral because these are perceived as more consequential than other types of information. Therefore people are more inclined to restore their image after being negatively evaluated in terms of morality rather than competence. Studies 1 and 2 revealed that moral information was perceived as having a more enduring impact on one’s reputation, and was more strongly related to anticipate intra-group respect and self-views, than competence and sociability information. This perceived pervasiveness of moral (vs. competence) evaluations mediated intentions to justify and explain one’s behavior (Study 3). Study 4 finally showed that being seen as lacking in morality elicited threat and coping responses, which induced subsequent tendencies to repair one’s moral reputation.This work was made possible due to a FIRB 2012 grant from the Italian Ministry of Education and Research (number RBFR128CR6) awarded to SP and a Spinoza award from the Dutch National Science Foundation (NWO) to NE

Once Dishonest, Always Dishonest? The Impact of Perceived Pervasiveness of Moral Evaluations of the Self on Motivation to Restore a Moral Reputation

PublishedFour studies specify how moral evaluations of the self regulate behavior aimed at restoring a moral reputation. We propose that people care about evaluations of themselves as moral or immoral because these are perceived as more consequential than other types of information. Therefore people are more inclined to restore their image after being negatively evaluated in terms of morality rather than competence. Studies 1 and 2 revealed that moral information was perceived as having a more enduring impact on one’s reputation, and was more strongly related to anticipate intra-group respect and self-views, than competence and sociability information. This perceived pervasiveness of moral (vs. competence) evaluations mediated intentions to justify and explain one’s behavior (Study 3). Study 4 finally showed that being seen as lacking in morality elicited threat and coping responses, which induced subsequent tendencies to repair one’s moral reputation.This work was made possible due to a FIRB 2012 grant from the Italian Ministry of Education and Research (number RBFR128CR6) awarded to SP and a Spinoza award from the Dutch National Science Foundation (NWO) to NE

Student-generated pre-exam questions is an effective tool for participatory learning: a case study from Ecology of Waterborne Pathogens course

This multi-year study helps elucidate how the instructional practice of student-generated questions support learning in a blended classroom in STEM subjects. Students designed multiple-choice pre-exam questions aimed at higher levels of learning, according to Bloom's taxonomy. Student-generated questions were edited by the instructor and then discussed by the students in the classroom and in an online forum. We tested the hypothesis that this intervention improves student learning, measured as student achievement on the exam following the intervention, and compared to student achievement on the traditional exam (prior to which a review session focused on instructor-led recitation of the key concepts). Following the intervention in all years, average grade on the post-intervention exam increased by 7.44%. It is important to point out that not all students benefited equally from this activity. Students who were in the 4th quintile (60-80%) based on the results of the first exam demonstrated the highest achievement improving their performance on average by 12.37% percentage points (measured as a score on the second exam). Gains were not observed in the semesters when the intervention was not implemented. In this study we provided students detailed instructions on how to design questions that focus on testing higher levels of learning

Rising rural body-mass index is the main driver of the global obesity epidemic in adults [Letter]

Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities1,2. This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity3,4,5,6. Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017—and more than 80% in some low- and middle-income regions—was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing—and in some countries reversal—of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories