Phyto-pharmacology of Elettaria cardamomum

Spices are known to add taste, flavor, aroma, color to food. These spices also have been the many traditional medicines in India and elsewhere to provide treatment to various diseases. Elettaria cardamomum is one of the spices used in traditional medicines for several diseases. It is used in treating various gastrointestinal, cardiovascular and neuronal disorders. The inhibitory activity of cardamom extract was studied on human platelets has also been reported. This review aims to highlight the ethno botany, pharmacognostic and pharmacological uses of Elettaria cardamomum. This review will also highlight the patenting trends and the new compositions developed using the actives from Elettaria cardamomum

Bio-evaluation studies of phytoconstituents- A review of the patents granted and filed by CSIR

Botanicals have become a very important part of our life and are increasingly used as a primary source of actives in pharmaceuticals, cosmetics, nutraceuticals and personal care products. Extensive studies have been conducted on botanicals to understand their chemical profile and most of them have a history of safe use. Technical advances to isolate the bioactives, determine their molecular structure as well as their mechanism of action has generated considerable data and are available in the form of scientific publications as well as filing of patents. In this review, we aim to present the information pertaining to therapeutic applications of bioactives from different medicinal plants as disclosed in filed and granted patents to one of the largest publicly funded organizations in India namely Council of Scientific and Industrial Research (CSIR). The review also presents an assignee focused analysis and provides insights into the level of patent filing activity in the area of bioactives and the therapeutic applications by CSIR, India. Such information can provide a valuable tool for exploiting a firm’s portfolio of patent holdings to assist decision-makers to identify the most valuable patents; product area or business opportunities among its own patent holdings

Treatment of the common cold with herbs used in Ayurveda and Jamu : monograph review and the science of ginger, liquorice, turmeric and peppermint

BACKGROUND : The common cold is typically managed with decongestants, antihistamines, antitussives and antipyretics. In addition to these established medications, herbal ingredients have been used over centuries to help treat common cold symptoms. The Ayurveda and Jamu systems of medicine, originating from India and Indonesia, respectively, have leveraged herbal therapies to treat many illnesses. METHOD : An expert roundtable discussion comprising specialists in Ayurveda, Jamu, pharmacology and surgery along with a literature review was conducted to evaluate the use of four herbs – ginger, liquorice, turmeric and peppermint – for common cold symptom management in Ayurvedic texts, Jamu publications and monographs from the World Health Organization, Health Canada and various European guidelines. DISCUSSION : Due to a lack of antivirals, common cold management revolves around maintaining personal hygiene and symptom management. Herbal medicines have been an integral part of many cultures worldwide. Despite its growing acceptance, there is a perception that healthcare providers lack interest and may prevent patients from discussing the use of herbal medicines. Limited education and training may also widen the communication gap between patients and healthcare providers, hindering effective management. CONCLUSION : Evaluation of scientific evidence and the standing in international monographs can offer perspectives on the use of herbal medicines for common cold management.Procter & Gamble Health.http://drugsincontext.comhj2023PharmacologySDG-03:Good heatlh and well-bein

Bio-evaluation studies of phytoconstituents- A review of the patents granted and filed by CSIR

434-450Botanicals have become a very important part of our life and are increasingly used as a primary source of actives in pharmaceuticals, cosmetics, nutraceuticals and personal care products. Extensive studies have been conducted on botanicals to understand their chemical profile and most of them have a history of safe use. Technical advances to isolate the bioactives, determine their molecular structure as well as their mechanism of action has generated considerable data and are available in the form of scientific publications as well as filing of patents. In this review, we aim to present the information pertaining to therapeutic applications of bioactives from different medicinal plants as disclosed in filed and granted patents to one of the largest publicly funded organizations in India namely Council of Scientific and Industrial Research (CSIR). The review also presents an assignee focused analysis and provides insights into the level of patent filing activity in the area of bioactives and the therapeutic applications by CSIR, India. Such information can provide a valuable tool for exploiting a firm’s portfolio of patent holdings to assist decision-makers to identify the most valuable patents; product area or business opportunities among its own patent holdings

Pharmacological and cosmeceutical applications of Bixa Orellana L.: A review of the scientific and patent literature

281-289Medicinal plants or herbs belonging to different traditional medicinal systems have been used as therapeutic agents for curing a number of diseases and infections. Hence, the application of such traditionally known medicinal plants and its phytoconstituents have increased considerably even in modern medicines. Bixa orellana L. — an Indian medicinal plant which belongs to the family Bixaceae is an Ayurvedic herb used since ancient times. This review aims to highlight the ethnopharmacology, pharmacological and cosmeceutical uses of B. orellana not only from scientific literature but also from patent documents. The prior art review of the phytoconstituents shows that B. orellana contains a wide variety of biologically active compounds such as bixin, norbixin, β-carotene, lutein, tocotrienol, tocopherols, sesquiterpenes, monoterpenes, etc. Pharmacological review revealed that this plant is useful as anti-inflammatory, anti-asthma, anti-bacterial, anti-diabetic, anti-convulsant, hepatoprotective, antifungal, anticancer agent. This review also highlights the year wise patent filing trends and the major assignees active in filing patents in this area. Such a review will provide useful insights for further biological or clinical investigations of the bioactive or active fractions from the plant

Design, synthesis and biological evaluation of benzoxazolinone-containing 1,3,4-thiadiazoles as TNF-α inhibitors

A library of nineteen benzoxazolinone-based 1,3,4-thiadiazoles has been synthesized and screened for their anti-inflammatory activity. The compound 1f exhibited a potent anti-inflammatory activity with an inhibition of 65.83% and 32.50% after 3 h and 5 h respectively. It also exhibited a significant in vitro (p < 0.01), TNF- α inhibitory activity with 51.44 % inhibition. The compound 1f showed hydrogen bonding with GLN 61 and interactions with TYR 119, TYR 151 and GLY 121. The histopathology report showed that none of the compounds caused gastric ulceration. The results from the in vivo &amp; in vitro antiinflammatory activity along with In Silico studies exhibit that benzoxazolinone-based 1,3,4-thiadiazoles may be used in the future development of anti-inflammatory drugs

Pharmacological and cosmeceutical applications of Bixa Orellana L.: A review of the scientific and patent literature

Medicinal plants or herbs belonging to different traditional medicinal systems have been used as therapeutic agents for curing a number of diseases and infections. Hence, the application of such traditionally known medicinal plants and its phytoconstituents have increased considerably even in modern medicines. Bixa orellana L. — an Indian medicinal plant which belongs to the family Bixaceae is an Ayurvedic herb used since ancient times. This review aims to highlight the ethnopharmacology, pharmacological and cosmeceutical uses of B. orellana not only from scientific literature but also from patent documents. The prior art review of the phytoconstituents shows that B. orellana contains a wide variety of biologically active compounds such as bixin, norbixin, β-carotene, lutein, tocotrienol, tocopherols, sesquiterpenes, monoterpenes, etc. Pharmacological review revealed that this plant is useful as anti-inflammatory, anti-asthma, anti-bacterial, anti-diabetic, anti-convulsant, hepatoprotective, antifungal, anticancer agent. This review also highlights the year wise patent filing trends and the major assignees active in filing patents in this area. Such a review will provide useful insights for further biological or clinical investigations of the bioactive or active fractions from the plant

Design, Development and Validation of a Portable Gas Sensor Module: A Facile Approach for Monitoring Greenhouse Gases

We report the unique design and prototype of a portable gas sensor module for monitoring greenhouse gases. The commercially available gas sensors (MQ-02, MQ-135, and TGS2602) were adopted in designing the module using Arduino Uno. Different locations in the city of Solapur, India (17.6599&deg; N, 75.9064&deg; E), were scanned for the usability of the developed prototype of the mobile gas sensor module. The choice of gas sensors in combination with Arduino Uno led to an excellent prototype for measuring the concentration of greenhouse gases, and therefore the wrong alarm for toxic gases. The prototype model and corresponding greenhouse gas concentrations (ppm) are described using an interplay of sensor design, software program, and greenhouse gases sites