Expedient approach to novel N-unprotected bicyclic azapyrimidine and pyridine structures.

International audienceA direct route to novel bicyclic N-unprotected azapyrimidine structures including fused five-, six-, and seven-membered rings is described involving radical addition and cyclization of xanthates; this approach could be partially extended to pyridines

Synthesis and study of the first n-aryl acyclic diaminocarbene and its transition-metal complexes

The first acyclic diaminocarbene (ADC) featuring N-aryl groups, as well as two complexes containing this ligand, (ADC)RhCl(1,5-cis,cis-cyclooctadiene) and (ADC)RhCl(CO)(2), were synthesized and characterized. Insight into controlling conformational diversity in acyclic diaminocarbenes with N-aryl groups through judicious N substitution was also explored

Stereocontrol in Synthesis of Homoallylic Amines. Syn Selective Direct Allylation of Hydrazones with Allylboronic Acids

Allylboronic acids directly react with acyl hydrazones, affording homoallylic amine derivatives. The reaction proceeds with very high syn selectivity, which is the opposite of the stereochemistry observed for allylboration of imines. The reaction can be carried out with both aromatic and aliphatic acyl hydrazones. Based on our studies the excellent syn stereochemistry can be explained by chelation control of the acyl hydrazone and the B(OH)(2) moiety.AuthorCount:4;</p