Design, synthesis and anticonvulsant activity of some new 5,7-dibromoisatin semicarbazone derivatives

A series of 5,7-dibromoisatin semicarbazones have been synthesized in good yield, involving aryl urea and aryl semicarbazide formation. The structures of the synthesized compounds were confirmed on the basis of their spectral data. All the compounds were evaluated for anticonvulsant and CNS depressant activities. Anticonvulsant activity was determined after intraperitoneal (i.p.) administration to mice by maximal electroshock (MES) induced seizure method and minimal motor impairment was determined by rotarod test. A computational study was carried out for prediction of pharmacokinetic properties and making them potentially promising agents for the treatment of epilepsy. Compounds (Z)-1-(5,7-dibromo-2-oxoindolin-3-ylidene)-4-(4-chlorophenyl)semicarbazide (DH-05), (Z)-1-(5,7-dibromo-2-oxoindolin-3-ylidene)-4-(3-chloro-4-fluorophenyl)semicarbazide (DH-11) and (Z)-1-(5,7-dibromo-1-methyl-2-oxoindolin-3-ylidene)-4-(3-chloro-4-fluorophenyl)semicarbazide (DH-12) exhibited prominent anticonvulsant effect in the series with little or no neurotoxicity and little CNS depressant effect as compared to standard drug

A randomized, double-blind, parallel, placebo-controlled study to evaluate efficacy and safety of a synergistic multi-herbal extract blend KaraHeart™ in supporting healthy cholesterol levels

Background: Hyperlipidemia is a condition involving abnormally high levels of lipids in the blood. Hyperlipidemia is a major risk factor for cardiovascular diseases and refers to either high levels of triglycerides (TGL) or cholesterol. Herbal supplements have been used in the management of cholesterol levels in Ayurveda, a complete medical system originating in India. KaraHeart™ is a multi-herbal extract synergistic blend that may help in the management of healthy cholesterol levels. The current study tested the efficacy, tolerability, and safety of KaraHeart™ versus a placebo in the management of cholesterol levels of patients with mild hyperlipidemia.Methods: This was a randomized, double-blind, parallel, and placebo-controlled study. A total of 100 patients were divided into two groups. One group was given KaraHeart™ and the other group was given a placebo for 120 days. Treatment results were assessed by checking the lipid profile parameters such as total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), and TGL.Results: The study found that the herbal supplement KaraHeart™ significantly reduced levels of LDL, VLDL, TGL, and total cholesterol, while increasing the levels of HDL in the blood. Additionally, the study concluded that KaraHeart™ was safe to use.Conclusions: KaraHeart™ was shown to be safe and effective in the management of cholesterol levels

Assessment of safety and efficacy of Karallief® Easy ClimbTM, an herbal extract blend for supporting joint health: a double-blind, placebo-controlled, randomized clinical trial

Background: Osteoarthritis is common among the aging population worldwide. The current techniques to manage osteoarthritis focus on relieving pain and slowing the progression of the disease. Herbal or natural supplements have shown promise in achieving both these treatment goals. Two new proprietary herbal extract blends, Karallief® Easy ClimbTM (KEC) and herbal extracts with glucosamine (HEG), are combinations of several natural products shown to be effective in the treatment of knee osteoarthritis. The current study tested the efficacy and safety of KEC and HEG versus a placebo control.Methods: This is a randomized, double-blind and placebo-controlled study. A total of 120 patients were divided into 3 groups and were given KEC, HEG and Placebo in the ratio 1:1:1. Treatment results were assessed using the 30 second chair stand test, WOMAC test, knee flexion test and joint space measurement using X-rays of the knee joint.Results: The study found that the herbal supplements HEG and KEC significantly reduced osteoarthritis-related knee pain and increased joint mobility and were safe to use during 120 days of treatment. Both supplements resulted in an improvement in the 30 second chair stand test results, WOMAC pain scores, knee flexion, and joint space width as measured by X-ray, as compared to the placebo.Conclusions: Natural supplements such as HEG and KEC improve knee osteoarthritis symptoms and can be a safe and effective treatment option for patients with osteoarthritis

Diabetes mellitus as a risk factor for ischemic stroke: a case control study

Background: In developed countries, stroke is the third most common cause of mortality, following cancer and coronary heart disease. The increase risk is often seen in individuals with diabetes and is associated with poorer clinical outcomes (including higher mortality). That’s why assessment of risk factors for stroke are important.Methods: This age and sex matched hospital based case control study assessed the risk factors of ischemic stroke in tertiary care hospital for a period of one year. Sample size was calculated for matched case control (1:1 ratio) by n-master software and came out to be 189 pairs. All patients under WHO case definition were enrolled as cases for study purpose, controls were selected from the same hospital with disease other than stroke. Analysis was conducted through calculation of odd ratio (OR) and confidence internal (CI) by using SPSS 22.0 program. Odds ratio (OR) of risk factor was calculated using bivariate analysis.Results: Results revealed that male: female ratio among the case and control was 2.1:1, mean age of case and control were 58.86±13.03 and 58.21±12.67. Out of 189 Case, 59 (31.2%) were suffering from diabetes, while only 39 (20.6%) controls were having diabetes mellitus. P value was 0.02, which is significant.Conclusions: In the present hospital based case control study, it was found that diabetes mellitus was a significant risk factor among the ischemic stroke patients.</jats:p

A randomized, double-blind, parallel, placebo-controlled study to evaluate efficacy and safety of a synergistic multi-herbal extract blend KaraHeart™ in supporting healthy cholesterol levels

Background: Hyperlipidemia is a condition involving abnormally high levels of lipids in the blood. Hyperlipidemia is a major risk factor for cardiovascular diseases and refers to either high levels of triglycerides (TGL) or cholesterol. Herbal supplements have been used in the management of cholesterol levels in Ayurveda, a complete medical system originating in India. KaraHeart™ is a multi-herbal extract synergistic blend that may help in the management of healthy cholesterol levels. The current study tested the efficacy, tolerability, and safety of KaraHeart™ versus a placebo in the management of cholesterol levels of patients with mild hyperlipidemia.Methods: This was a randomized, double-blind, parallel, and placebo-controlled study. A total of 100 patients were divided into two groups. One group was given KaraHeart™ and the other group was given a placebo for 120 days. Treatment results were assessed by checking the lipid profile parameters such as total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), and TGL.Results: The study found that the herbal supplement KaraHeart™ significantly reduced levels of LDL, VLDL, TGL, and total cholesterol, while increasing the levels of HDL in the blood. Additionally, the study concluded that KaraHeart™ was safe to use.Conclusions: KaraHeart™ was shown to be safe and effective in the management of cholesterol levels.</jats:p

Table_1_A botanical extract blend of Mangifera indica and Sphaeranthus indicus combined with resistance exercise training improves muscle strength and endurance over exercise alone in young men: a randomized, blinded, placebo-controlled trial.DOCX

Resistance exercise training (RET) is used to improve muscular strength and function. This study tested the hypothesis that RET alongside daily supplementation of a Sphaeranthus indicus and Mangifera indica extract blend (SMI) would augment bench press (BP) and leg extension (LE) strength and repetitions to failure (RTF) compared to RET alone. Ninety-nine men (age 22 ± 3) completed the trial after randomization into one of four groups: (A1) 425 mg SMI plus one RET set; (A2) 850 mg SMI plus one RET set; (P1) placebo plus one RET set; and (P2) placebo plus two RET sets. RET sets were 6–8 BP and LE repetitions at 80% of a progressive one repetition maximum (1-RM), performed 3x/week for 8 weeks. Strength and RTF were evaluated at baseline and days 14, 28, and 56 while serum values of total testosterone (TT), free testosterone (FT), and cortisol (C) values were evaluated at baseline and day 56. RET significantly (p < 0.05) increased 1-RM, RTF, and T measures above baselines regardless of group assignment, but the increases were greater in the supplemented groups. At week 8, A1 bench pressed more than P1 (71.5.5 ± 17.5 kg vs. 62.0 ± 15.3 kg, p = 0.003), while A2 pressed 13.8 ± 3.0 kg more (95% CI 5.7–21.8, p < 0.001) than P1 and 9.9 ± 13.0 kg more (95% CI 1.7–18.2, p = 0.01) than P2. Also at week 8, the mean LE 1-RM of A1 (159.4 ± 22.6 kg) and A2 (162.2 ± 22.9 kg) was greater (p < 0.05) than that of P1 (142.2 ± 25.6 kg) and P2 (146.5 ± 19.7 kg). Supplementation improved RTF, TT, and FT values over those measured in exercise alone (p < 0.05), while C levels in A2 (9.3 ± 3.8 μg/dL) were lower than P2 (11.7 ± 3.8 μg/dL, p < 0.05). Daily supplementation with SMI was well tolerated and may help optimize muscle adaptive responses to RET in men.</p

Assessment of safety and efficacy of Karallief® Easy ClimbTM, an herbal extract blend for supporting joint health: a double-blind, placebo-controlled, randomized clinical trial

Background: Osteoarthritis is common among the aging population worldwide. The current techniques to manage osteoarthritis focus on relieving pain and slowing the progression of the disease. Herbal or natural supplements have shown promise in achieving both these treatment goals. Two new proprietary herbal extract blends, Karallief® Easy ClimbTM (KEC) and herbal extracts with glucosamine (HEG), are combinations of several natural products shown to be effective in the treatment of knee osteoarthritis. The current study tested the efficacy and safety of KEC and HEG versus a placebo control.Methods: This is a randomized, double-blind and placebo-controlled study. A total of 120 patients were divided into 3 groups and were given KEC, HEG and Placebo in the ratio 1:1:1. Treatment results were assessed using the 30 second chair stand test, WOMAC test, knee flexion test and joint space measurement using X-rays of the knee joint.Results: The study found that the herbal supplements HEG and KEC significantly reduced osteoarthritis-related knee pain and increased joint mobility and were safe to use during 120 days of treatment. Both supplements resulted in an improvement in the 30 second chair stand test results, WOMAC pain scores, knee flexion, and joint space width as measured by X-ray, as compared to the placebo.Conclusions: Natural supplements such as HEG and KEC improve knee osteoarthritis symptoms and can be a safe and effective treatment option for patients with osteoarthritis.</jats:p

RSM-Based Optimization of the Parameters Affecting TiO2-Mediated UV Photocatalysis of Vehicular Emissions in Enclosed Parking Garages

In the preceding times, the number of enclosed parking garages has increased significantly in developing nations. The toxic emissions from vehicular exhausts are expected to drastically compromise the environmental conditions of the parking garages. Subsequently, exposure of humans to these accumulated pollutants is also expected to degrade their health. Therefore, in the present investigation, efforts were made to estimate the applicability of TiO2-mediated UV photocatalysis in degrading the concentration of vehicular emissions, viz., NOx and SO2, in the enclosed parking garages (EPGs). In this regard, an artificial EPGs’ environment was created and experiments were designed using the Box-Behnken design in combination with response surface methodology. The process parameters chosen for maximizing the degradation of the pollutants were a concentration of TiO2 emulsion (20 to 120 ml/m2), UV irradiance (1 to 5 mW/cm2), and relative humidity (10 to 50%). Optimization of the laboratory experiments revealed that at optimal conditions of the process parameters, i.e., a concentration of TiO2emulsion=77.50 ml/m2, intensity of UV irradiance=3 mW/cm2, and relative humidity=43.2%, maximum degradation of the NOx and SO2, i.e., 61.24% and 55.05%, respectively, was achieved. Further, it was revealed that relative humidity may prove to be the limiting factor while using the TiO2-mediated UV photocatalysis in humid areas. Findings of this study may prove beneficial in urban planning as it may assist scientific auditory and local authorities in identifying the applicability of TiO2-based photocatalysis in mitigating the impacts of vehicular emissions

RSM-Based Optimization of the Parameters Affecting TiO2-Mediated UV Photocatalysis of Vehicular Emissions in Enclosed Parking Garages

In the preceding times, the number of enclosed parking garages has increased significantly in developing nations. The toxic emissions from vehicular exhausts are expected to drastically compromise the environmental conditions of the parking garages. Subsequently, exposure of humans to these accumulated pollutants is also expected to degrade their health. Therefore, in the present investigation, efforts were made to estimate the applicability of TiO2-mediated UV photocatalysis in degrading the concentration of vehicular emissions, viz., NOx and SO2, in the enclosed parking garages (EPGs). In this regard, an artificial EPGs’ environment was created and experiments were designed using the Box-Behnken design in combination with response surface methodology. The process parameters chosen for maximizing the degradation of the pollutants were a concentration of TiO2 emulsion (20 to 120 ml/m2), UV irradiance (1 to 5 mW/cm2), and relative humidity (10 to 50%). Optimization of the laboratory experiments revealed that at optimal conditions of the process parameters, i.e., a concentration of TiO2 emulsion = 77.50   ml / m 2 , intensity of UV irradiance = 3   mW / c m 2 , and relative humidity = 43.2 % , maximum degradation of the NOx and SO2, i.e., 61.24% and 55.05%, respectively, was achieved. Further, it was revealed that relative humidity may prove to be the limiting factor while using the TiO2-mediated UV photocatalysis in humid areas. Findings of this study may prove beneficial in urban planning as it may assist scientific auditory and local authorities in identifying the applicability of TiO2-based photocatalysis in mitigating the impacts of vehicular emissions.</jats:p