Electronic paddle-wheels in a solid-state electrolyte

Solid-state superionic conductors (SSICs) are promising alternatives to liquid electrolytes in batteries and other energy storage technologies. The rational design of SSICs and ultimately their deployment in battery technologies is hindered by the lack of a thorough understanding of their ion conduction mechanisms. In SSICs containing molecular ions, rotational dynamics couple to translational diffusion to create a 'paddle-wheel' effect that facilitates conduction. The paddle-wheel mechanism explains many important features of molecular SSICs, but an explanation for ion conduction and anharmonic lattice dynamics in SSICs composed of monatomic ions is still needed. We predict that ion conduction in the classic SSIC AgI involves 'electronic paddle-wheels,' rotational motion of lone pairs that couple to and facilitate ion diffusion. The electronic paddle-wheel mechanism creates a universal perspective for understanding ion conductivity in both monatomic and molecular SSICs that will create design principles for engineering solid-state electrolytes from the electronic level up to the macroscale.Comment: 6 pages, 3 figure

Biliary ductal variations and its clinical implications: a cadaveric study

Background: Biliary ductal region being frequently abnormal has been the subject of research since long time for anatomists, surgeons and radiologists as well.Methods: The present study was carried out in the department of Anatomy at PGIMS, Rohtak on 50 specimens of liver taken unblock with associated structures.Results: Accessory hepatic and accessory cystic ducts were observed in 4% cases each.  2% cases exhibited abnormal low fusion of cystic duct with common hepatic duct.Conclusions: These anomalies may add to postoperative complications if ignored. Present study is a step in the direction of creating awareness about these variations among the clinicians

Morphometric analysis of menisci of adult human knee joint in North Indian population

Background: Of the synovial joints in the body knee joint is the largest. Each meniscus is a piece of fibrocartilage with a thickened outside edge and a thin inner edge so that it is wedge-shaped in cross section. The purpose of the present study was to establish database on standard dimensions in knee menisci of adults of north Indian population.Methods: The sample for this study was collected from April, 2012 to June, 2013. For this study, 200 menisci (100 right and left each) of 50 adult humans were taken for analysis. Measurements were done with the help of non-elastic thread and digital vernier calipers. All dissections were performed in a systematic fashion.Results: The width of the lateral meniscus was significantly different form medial meniscus with lateral and medial menisci widest in middle and posterior third respectively. The middle one third of both lateral and middle menisci was the thickest.Conclusions: It is always good to have a set of anatomical morphometric parameters of the menisci like the width and thickness. The measurements of suitable grafts may provide a more acceptable meniscal replacement in the future

Tuberculids: A narrative review

Tuberculids are a group of dermatoses with tuberculoid histology and the absence of tubercle bacilli. They are considered to be hypersensitivity reactions to circulating Mycobacterium tuberculosis (M. tb) or its antigens in individuals with good immunity. The objective of the review is to provide a detailed literature review of all available articles on tuberculids in the past 10 years and provide an update on epidemiology, etiopathogenetic mechanisms, clinical manifestations, and treatment. A search was performed on PubMed using the keywords lichen scrofulosorum, papulonecrotic tuberculid, erythema induratum, and erythema nodosum tuberculosis for all articles, with no restrictions on age, gender, or nationalities. An update on tuberculids, including some new concepts in pathogenesis, atypical presentations, new investigative modalities, and treatments are reviewed

Bullous hemorrhagic dermatosis: A rare cutaneous reaction of heparin

Bullous hemorrhagic dermatosis is a rare cutaneous reaction of heparin, a commonly used anticoagulant. Exact etiopathogenesis remains elusive but immune related mechanisms as well as dose dependent relationship have been proposed. Clinically, it is characterized by asymptomatic, tense hemorrhagic bullae on extremities or abdomen occurring 5-21 days after initiation of therapy. We report bilateral symmetrically grouped lesions, in a previously unreported distribution of this entity in both the forearms in a 50-year-old male admitted with acute coronary syndrome on oral ecosprin, oral clopidogrel and subcutaneous enoxaparin. The condition is self-resolving and discontinuation of drug is not required

Data of drowning related deaths with reference to entomological evidence from Haryana

Most often the newspapers and bulletin come out with voluminous cases of deaths due to drowning. At the same time an ample section of such cases encompass entomological evidences, that can be scrutinized as a very useful parameter in estimating post mortem interval (PMI). This research database is an outcome of a 2 years reflective study, based on an assessment of records related to human deaths due to drowning. The drowned bodies from various districts of Haryana are sent to PGIMS (Post Graduate Institute of Medical Sciences), Rohtak. The study took the data of year 2015â2016 into consideration. All the cases were reviewed and summarized in terms of monthly occurrence of total cases, age differentiation, gender differentiation and month wise occurrence of entomological evidences on the dead bodies through detailed study of post mortem findings. This data will lead to an insight into the magnitude of drowning deaths in Haryana along with the usage of entomological data for determining Post Mortem Submersion Intervals (PMSI). Keywords: Drowning, Entomological evidences, PM

A Grusome trend in Homicidal Crimes, Cut Throat- A case series Medical Science The International Weekly Journal for Medicine The International Weekly Journal for Medicine

Globally, cut throat injuries account for approximately 5 % to 10 % of all traumatic injuries. The distinction between homicidal, suicidal and accidental wounding is a central issue for forensic experts. Cut-throat wounds are “effective ” in homicidal attacks with sharp & heavy sharp weapons. While accidental injuries in this topographic region caused by sharp objects are rarely seen and most often caused by broken glass. Suicidal incised neck wounds are typically multiple, being characterized by a number of hesitation cuts parallel to the wound. In these cases, presence or absence of particular features (e.g., hesitation marks, defensive wounds) can allow distinction between suicide and homicide, especially if further circumstances, i.e. atypical crime scene scenarios or missing suicide notes, need the forensic pathologist to have an incredulous approach regarding the manner of death. The present article describes five cases of homicidal cut throat injuries- history and autopsy findings are discussed. Key Words: sharp weapon injuries, cut-throat, homicide, autopsy. 1

Tuning Brønsted Acidity by up to 12 pKa Units in a Redox-Active Nanopore Lined with Multifunctional Metal Sites

Electrostatic interactions, hydrogen bonding, and solvation effects can alter the free energies of ionizable functional groups in proteins and other enclosed porous architectures, allowing these nanostructures to tune acid-base chemistry as needed to support specific functions. Herein, we expand on this theme to examine how metal sites (M = H2, ZnII, CoII, CoI) affect the pKa of benzoic acid guests bound in discrete porphyrin nanoprisms (M3TriCage), which were chosen as model systems for better understanding how porous metalloporphyrin electrocatalysts might influence H+ transfer processes that are needed to support many important electrochemical reactions (e.g., reductions of H+, O2, or CO2). Lewis acidic CoII and ZnII ions increase the Brønsted acidities of the guests by 4 and 8 pKa units, respectively, while reduction of the CoII sites to anionic CoI sites produces an electrostatic potential that lowers acidity by ca. 4 units (8 units relative to the CoII state). Lacking functional metal sites, H6TriCage increases the acidity of the guests by just 2.5 pKa units despite the 12+ charge of the host and contributions from other factors (hydrogen bonding, pore hydration) that might stabilize the depro-tonated guests. Thus, the metal sites have dominant effects on acid-base chemistry in the M3TriCages, providing a larger pKa range (12.75 to ≥24.5 in CD3CN) for the encapsulated acid than attained via other confinement effects in proteins and artificial porous materials