Sequential fixed-width confidence bands for kernel regression estimation

We consider a random design model based on independent and identically distributed (iid) pairs of observations (Xi, Yi), where the regression function m(x) is given by m(x) = E(Yi|Xi = x) with one independent variable. In a nonparametric setting the aim is to produce a reasonable approximation to the unknown function m(x) when we have no precise information about the form of the true density, f(x) of X. We describe an estimation procedure of non-parametric regression model at a given point by some appropriately constructed fixed-width (2d) confidence interval with the confidence coefficient of at least 1&minus;. Here, d(&gt; 0) and 2 (0, 1) are two preassigned values. Fixed-width confidence intervals are developed using both Nadaraya-Watson and local linear kernel estimators of nonparametric regression with data-driven bandwidths. The sample size was optimized using the purely and two-stage sequential procedure together with asymptotic properties of the Nadaraya-Watson and local linear estimators. A large scale simulation study was performed to compare their coverage accuracy. The numerical results indicate that the confidence bands based on the local linear estimator have the best performance than those constructed by using Nadaraya-Watson estimator. However both estimators are shown to have asymptotically correct coverage properties.<br /

Kaolin shear thickening fluid reinforced UHMWPE composites for protective clothing

This study reports the designing and reinforcing of impact resistant textile composites using kaolin based shear thickening colloidal dispersions as the filler material. The reinforced fabric is targeted for the chest protection of cricketers. A shear thickening fluid (STF) has been prepared using kaolin and glycerol, at kaolin volume fractions of 34% and 38%. A combination of mixing techniques including mechanical blending and ultra-sonication are used to prepare the colloidal dispersions. Ultra high molecular weight polyethylene (UHMWPE) woven fabric structures are reinforced with the STF. The fabric coated with STF are then measured for their flexibility, and impact resistance using Shirley stiffness tester and a series of modified drop tower tests respectively. Kaolin STF at 38% volume fraction shows best results in impregnated fabric samples. STF reinforced fabrics provide better impact resistance with improved moisture absorption and flexibility in comparison to the conventional chest guard material

Triboelectric Nanogenerators: Providing a Fundamental Framework

A new model which comprehensively explains the working principles of contact-mode Triboelectric Nanogenerators (TENGs) based on Maxwell’s equations is presented. Unlike previous models which are restricted to known simple geometries and derived using the parallel plate capacitor model, this model is generic and can be modified to a wide range of geometries and surface topographies. We introduce the concept of a distance-dependent electric field, a factor not taken in to account in previous models, to calculate the current, voltage, charge, and power output under different experimental conditions. The versatality of the model is demonstrated for non-planar geometry consisting of a covex-conave surface. The theoretical results show excellent agreement with experimental TENGs. Our model provides a complete understanding of the working principles of TENGs, and accurately predicts the output trends, which enables the design of more efficient TENG structures

Cardiogenic shock in a patient with hypothyroid myopathy responsive only to thyroxin replacement: a case report

The effect of hypothyroidism on the cardiovascular system has been well documented. Cardiac dysfunction due to hypothyroidism manifests as both systolic and diastolic dysfunction of the heart leading to cardiac arrhythmia and congestive heart failure. Its presentation in the form of refractory hypotension is rare. We describe a 52 year old man on whom Hypothyroid Cardiomyopathy manifested as cardiogenic shock responsive only to thyroxin replacement

Utilization of a deoxynucleoside diphosphate substrate by HIV reverse transcriptase

Background: Deoxynucleoside triphosphates (dNTPs) are the normal substrates for DNA sysnthesis is catalyzed by polymerases such as HIV-1 reverse transcriptase (RT). However, substantial amounts of deoxynucleoside diphosphates (dNDPs) are also present in the cell. Use of dNDPs in HIV-1 DNA sysnthesis could have significant implications for the efficacy of nucleoside RT inhibitors such as AZT which are first line therapeutics fro treatment of HIV infection. Our earlier work on HIV-1 reverse transcriptase (RT) suggested that the interaction between the γ phosphate of the incoming dNTP and RT residue K65 in the active site is not essential for dNTP insertion, implying that this polymerase may be able to insert dNPs in addition to dNTPs. Methodology/Principal Findings: We examined the ability of recombinant wild type (wt) and mutant RTs with substitutions at residue K65 to utilize a dNDP substrate in primer extension reactions. We found that wild type HIV-1 RT indeed catalyzes incorporation of dNDP substrates whereas RT with mutations of residue K645 were unable to catalyze this reaction. Wild type HIV-1 RT also catalyzed the reverse reaction, inorganic phosphate-dependent phosphorolysis. Nucleotide-mediated phosphorolytic removal of chain-terminating 3′-terminal nucleoside inhibitors such as AZT forms the basis of HIV-1 resistance to such drugs, and this removal is enhanced by thymidine analog mutations (TAMs). We found that both wt and TAM-containing RTs were able to catalyze Pi-mediated phosphorolysis of 3′-terminal AZT at physiological levels of Pi with an efficacy similar to that for ATP-dependent AZT-excision. Conclusion: We have identified two new catalytic function of HIV-1 RT, the use of dNDPs as substrates for DNA synthesis, and the use of Pi as substrate for phosphorolytic removal of primer 3′-terminal nucleotides. The ability to insert dNDPs has been documented for only one other DNA polymerase The RB69 DNA polymerase and the reverse reaction employing inorganic phosphate has not been documented for any DNA polymerase. Importantly, our results show that Pi-mediated phosphorolysis can contribute to AZT resistance and indicates that factors that influence HIV resistance to AZT are more complex than previously appreciated. © 2008 Garforth et al

Land use-based participatory assessment of ecosystem services for ecological restoration in village tank cascade systems of Sri Lanka

Village Tank Cascade System (VTCS) landscapes in the dry zone of Sri Lanka provide multiple ecosystem services (ESs) and benefits to local communities, sustaining the productivity of their land use systems (LUSs). However, there is a lack of adequate scientific research on the ESs of LUSs, despite the recent land use changes that have greatly impacted the provisioning of ESs. Collection of baseline ESs data is a pre-requisite for decision making on ESs-based ecological restoration and management of the VTCS. Thus, this study aimed at assessing ESs of the Mahakanumulla VTCS (MVTCS) located in the Anuradhapura district of Sri Lanka by using a participatory approach involving the integration of local knowledge, expert judgements and LUSs attribute data to assess the ESs. The methodology was designed to integrate the biodiversity and land degradation status of LUSs in a way that is directly linked with the supply of ESs. The study identified twenty-four ESs of the MVTCS based on community perceptions. The identified ESs were assessed as a function of LUSs to develop an ecosystem service supply (ESS) and demand (ESD) matrix model. The results reveal that the current overall ESD for regulating and supporting ESs is higher than the ESS capacity of MVTCS. The assessment also revealed that land degradation and biodiversity deterioration reduce the capacity to provide ESs. Downstream LUSs of the meso-catchment were found to be more vulnerable to degradation and insufficient to provide ESs. Further, the study established that ESs in the MVTCS are generated through direct species-based and biophysical-based providers. In addition, it emerged that social and cultural engagements also played an important role in association with both providers to generate certain types of ESs. Therefore, it can be concluded that VTCS ecological restoration depends on the extent to which integrated effort addresses the levels of ecological complexity, as well as the social engagement of communities and stakeholders. The results of this study provide a scientific basis that can inform future land use decision making and practices that are applicable to successful ESs-based ecological restoration and management of the VTCSs in the dry zone of Sri Lanka

Estimating process capability index Cpm using a bootstrap sequential sampling procedure

Construction of a confidence interval for process capability index CPM is often based on a normal approximation with fixed sample size. In this article, we describe a different approach in constructing a fixed-width confidence interval for process capability index CPM with a preassigned accuracy by using a combination of bootstrap and sequential sampling schemes. The optimal sample size required to achieve a preassigned confidence level is obtained using both two-stage and modified two-stage sequential procedures. The procedure developed is also validated using an extensive simulation study.<br /

A new direct detection electron scattering experiment to search for the X17 particle

A new electron scattering experiment (E12-21-003) to verify and understand the nature of hidden sector particles, with particular emphasis on the so-called X17 particle, has been approved at Jefferson Lab. The search for these particles is motivated by new hidden sector models introduced to account for a variety of experimental and observational puzzles: excess in $e^+e^-$ pairs observed in multiple nuclear transitions, the 4.2$\sigma$ disagreement between experiments and the standard model prediction for the muon anomalous magnetic moment, and the small-scale structure puzzle in cosmological simulations. The aforementioned X17 particle has been hypothesized to account for the excess in $e^+e^-$ pairs observed from the $^8$Be M1, $^4$He M0, and, most recently, $^{12}$C E1 nuclear transitions to their ground states observed by the ATOMKI group. This experiment will use a high resolution electromagnetic calorimeter to search for or set new limits on the production rate of the X17 and other hidden sector particles in the $3 - 60$ MeV mass range via their $e^+e^-$ decay (or $\gamma\gamma$ decay with limited tracking). In these models, the $1 - 100$ MeV mass range is particularly well-motivated and the lower part of this range still remains unexplored. Our proposed direct detection experiment will use a magnetic-spectrometer-free setup (the PRad apparatus) to detect all three final state particles in the visible decay of a hidden sector particle for an effective control of the background and will cover the proposed mass range in a single setting. The use of the well-demonstrated PRad setup allows for an essentially ready-to-run and uniquely cost-effective search for hidden sector particles in the $3 - 60$ MeV mass range with a sensitivity of 8.9$\times$10$^{-8}$ - 5.8$\times$10$^{-9}$ to $\epsilon^2$, the square of the kinetic mixing interaction constant between hidden and visible sectors.Comment: 6 pages, 7 figures. arXiv admin note: substantial text overlap with arXiv:2108.1327

The use of common bean (Phaseolus vulgaris ) traditional varieties and their mixtures with commercial varieties to manage bean fly (Ophiomyia spp .) infestations in Uganda

The bean fly (Ophiomyia spp.) is considered the most economically damaging field insect pest of common beans in Uganda. Despite the use of existing pest management approaches, reported damage has remained high. Forty-eight traditional and improved common bean varieties currently grown in farmers’ fields were evaluated for resistance against bean fly. Data on bean fly incidence, severity and root damage from bean stem maggot were collected. Generalized linear mixed model (GLMM) revealed significant resistance to bean fly in the Ugandan traditional varieties. A popular resistant traditional variety and a popular susceptible commercial variety were selected from the 48 varieties and evaluated in pure and mixed stands. The incidence of bean fly infestation on both varieties in mixtures with different arrangements (systematic random versus rows), and different proportions within each of the two arrangements, was measured and analysed using GLMMs. The proportion of resistant varieties in a mixture and the arrangement type significantly decreased bean fly damage compared to pure stands, with the highest decrease in damage registered in the systematic random mixture with at least 50 % of resistant variety. The highest reduction in root damage, obvious 21 days after planting, was found in systematic random mixtures with at least 50 % of the resistant variety. Small holder farmers in East Africa and elsewhere in the world have local preferences for growing bean varieties in genetic mixtures. These mixtures can be enhanced by the use of resistant varieties in the mixtures to reduce bean fly damage on susceptible popular varieties

Cross-over data supporting long-term antibiotic treatment in patients with painful lower urinary tract symptoms, pyuria and negative urinalysis

PURPOSE: To measure the effects of an unplanned, sudden cessation of treatment in an unselected group of patients with chronic painful LUTS managed with protracted antimicrobial treatment and to report these observational data collected from a cross-over process. MATERIALS AND METHODS: The imposition of a guideline resulted in the immediate cessation of antibiotic treatment in a cohort of patients with chronic painful LUTS and microscopic pyuria. Patients were assessed before treatment withdrawal, whilst off treatment, and following reinstatement. Outcome measures included a validated symptom score, microscopic enumeration of urinary white cells and uroepithelial cells, and routine urine culture. RESULTS: These patients had reported treatment-resistant, painful LUTS for a mean of 6.5 years before treatment at this centre. Treatment was stopped in 221 patients (female = 210; male = 11; mean age = 56 years; SD = 17.81). Sixty-six per cent of women were post-menopausal. After unplanned treatment cessation, 199 patients (90%; female = 188; male = 9) reported deterioration. Eleven patients required hospital care in association with disease recurrence, including acute urinary tract infection (UTI) and urosepsis. Symptom scores increased after cessation and recovered on reinitiating treatment (F = 33; df = 2; p < 0.001). Urinary leucocyte (F = 3.7; df = 2; p = 0.026) and urothelial cells counts mirrored symptomatic changes (F = 6.0; df = 2; p = 0.003). Routine urine culture results did not reflect changes in disease status. CONCLUSION: These data support the hypothesis that treating painful LUTS associated with pyuria with long-term antimicrobial courses, despite negative urine culture, is effective. The microscopy of fresh unspun, unstained urine to count white cells and epithelial cells offers a valid method of monitoring disease. An unplanned cessation of antibiotic therapy produced a resurgence of symptoms and lower urinary tract inflammation in patients with chronic LUTS, supporting an infective aetiology below the level of routine detection