LFM based Wideband DOA Estimation using Deep Neural Network at Low SNR

This work focuses on deep learning-based wideband direction-of-arrival (DoA) estimation for a wideband in particular LFM in case of extreme noise. We propose a convolutional neural network (CNN) that utilizes the correlation matrix to estimate and trained using multi-channel data in low SNR conditions. By using a systematic approach and treating the problem as a way to identify multiple possible DoAs, the CNN is trained to predict DoAs under different SNR conditions. This allows the CNN to accurately estimate the directions from which signals are coming, regardless of the level of noise in the environment. The architecture proposed exhibits robustness to noise, works effectively with a small number of snapshots, and achieves high resolution in angle estimation. Experimental findings demonstrate notable enhancements in performance under low SNR conditions when compared to existing methods, without the need for parameter tuning for correlated and uncorrelated sources. The enhanced robustness of our solution has broad applications in various fields, including wireless array sensors, acoustic microphones, and sonars

QSAR studies on aminopyrazoles for the prediction of inhibition of CDK2/Cyclin A as antitumor agents

Cylin dependent kinases (CDKs) have emerged as novel mechanistic target due to their direct involvement in underlying genetic changes during the cancerous state. In order to identify the essential physiochemical parameters for CDK2 inhibitory activity in some 3-aminopyrazole derivatives, Quantitative Structure-Activity Relationship (QSAR) studies have been carried out on a series of total 35 compounds (taking 24 and 11 molecules in trainings set and test set respectively) using the multiple linear regression MLR) method. Among the generated models, the best QSAR model with good correlation coefficient (r2 = 0.643) along high statistical significance (> 99.9 %) well explained variance in activity for both training and test set molecules (Pred. r2 = 0.632). The two dimensional QSAR studies revealed that the activity is positively controlled by the indicator parameter (I), electronic parameter (field effect, F) and hydrophobic fragmentation constant (Fr) of substituents. Apart from that one of the interesting finding is that this model well discriminates between the Molar refractivity (MR) and hydrophobic fragmentation constant (Fr) in prediction of inhibitory activities based on the regression coefficient and associated error. Further the calculation of important descriptors like log P, hydrogen bond donor and acceptors etc. indicates the potential of these molecules in clinical trial as an anticancer drug.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Expression of antixenosis and antibiosis components of resistance to spotted stem borer Chilo partellus in sorghum under greenhouse conditions

We studied antixenosis and antibiosis mechanisms of resistance to C. partellus at the seedling stage in a diverse array of stem borer resistant genotypes, and landraces/improved varieties susceptible to stem borer under greenhouse conditions

Antibiosis mechanism of resistance to spotted stem borer, Chilo partellus in sorghum, Sorghum bioclor

Spotted stem borer, Chilo partellus (Swinhoe), is the most important pest of sorghum in Asia and South and Eastern Africa, and host plant resistance is an important component for controlling this pest under subsistence farming conditions. Therefore, we studied the antibiosis mechanism of resistance in a diverse array of 20 sorghum genotypes at the seedling stage by incorporating the freeze-dried leaf powder into artificial diet. Freeze-dried sorghum leaf powder at 12.5 g per 250 ml of the standard artificial diet or replacement of chickpea flour in the artificial diet by 50% with sorghum leaf powder can be used to quantify the extent of antibiosis mechanism of resistance to C. partellus in sorghum. There was a significant variation in larval survival, larval and pupal weights, larval and pupal periods, and percentage pupation and adult emergence in diets impregnated with freeze-dried leaf powder of different sorghum genotypes. Sorghum genotypes such as IS 1044, IS 2123, IS 1054, IS 18573, and ICSV 714 showed antibiosis to C. partellus in terms of reduced survival and development. Principal component analysis indicated that there is considerable diversity in sorghum genotypes for antibiosis to C. partellus. Genotypes placed in different groups can be used in resistance breeding programs to diversify the basis of resistance to this pest

Syntheses of biliverdins (Bilin-1,19-diones) from a, c-biladienes and b-bilenes

Treatment of readily accessible 1,19-bis(t-butoxycarbonyl)-a, c-biladienes or b-bilenes with bromine in trifluoroacetic acid affords excellent yields of biliverdins (bilin-1,19-diones). © The Royal Society of Chemistry, 1982

Bile pigment studies-VI. Syntheses of model systems

The synthesis of various mammalian and algal bile pigment models from monopyrroles and by ring cleavage of intact metalloporphyrins and metallochlorins is discussed. A previously reported synthesis of etiobiliverdin IVγ (6) from the self-condensation of a 5-bromo-5\u27-bromomethyldipyrrylmethene hydrobromide (5) is modified to afford a new, efficient and general route to biliverdins through 1,19-di-t-butoxycarbonyl-a, c-biladienes or -b-bilenes. Owing to symmetry limitations inherent in the a,c-biladiene route, that through b-bilenes is shown to be more generally effective for the synthesis of biliverdins. The key step in the transformation of the biladiene or bilene into biliverdin involves treatment with bromine in trifluoroacetic acid, and this affords biliverdin in high yield. The route is proposed to proceed through a 1,19-dibromo-a,b,c-bilitriene and then a 1,19-di-(trifluoroacetoxy)-a,b,c-bilitriene, though these intermediates are not isolated. © 1983

Synthesis of Oxadiazolo-, Pyrimido-, Imidazolo-, and Benzimidazolo-Containing Derivatives of 1,4-Benzodiazepin-5-(4′-methylpiperazinyl)-carboxamide Through Phenylamino Spacer

<div><p></p><p>Versatility of amidine and imidate derivatives of 5-carboxamido-1,4-benzodiazepin-5-(4′-methylpiperazinyl)-carboxamide (<b>8</b> and <b>9</b>) was explored to provide easy access to its 2-(oxadiazolo, pyrimido, imidazolo, and benzimidazolo)-substituted analogs <b>10</b>, <b>11</b>, <b>13</b>, and <b>14</b>, respectively, through the phenylamino spacer.</p> </div