Veldhandleiding voor het beschrijven van bodems bij archeologisch onderzoek in Vlaanderen

Er is in Vlaanderen al enige tijd vraag naar een handleiding bodemkunde die toegespitst is op de context van archeologisch onderzoek. De Code van Goede Praktijk voor de uitvoering van en rapportering over archeologisch vooronderzoek en archeologische opgravingen en het gebruik van metaaldetectoren (versie 4.0) (hierna CGP) legt heel precies vast wat de aardkundige of de assistent-aardkundige minimaal moet beschrijven bij aardkundig onderzoek (zowel voor boringen als bij profielen) in de context van archeologisch onderzoek in Vlaanderen, maar zegt niet precies hoe dit te doen. Deze Veldhandleiding voor het beschrijven van bodems bij archeologisch onderzoek in Vlaanderen komt tegemoet aan de vraag naar ondersteuning bij het kwaliteitsvol uitvoeren van handelingen die de CGP vereist

Carnivore Translocations and Conservation: Insights from Population Models and Field Data for Fishers (Martes pennanti)

Translocations are frequently used to restore extirpated carnivore populations. Understanding the factors that influence translocation success is important because carnivore translocations can be time consuming, expensive, and controversial. Using population viability software, we modeled reintroductions of the fisher, a candidate for endangered or threatened status in the Pacific states of the US. Our model predicts that the most important factor influencing successful re-establishment of a fisher population is the number of adult females reintroduced (provided some males are also released). Data from 38 translocations of fishers in North America, including 30 reintroductions, 5 augmentations and 3 introductions, show that the number of females released was, indeed, a good predictor of success but that the number of males released, geographic region and proximity of the source population to the release site were also important predictors. The contradiction between model and data regarding males may relate to the assumption in the model that all males are equally good breeders. We hypothesize that many males may need to be released to insure a sufficient number of good breeders are included, probably large males. Seventy-seven percent of reintroductions with known outcomes (success or failure) succeeded; all 5 augmentations succeeded; but none of the 3 introductions succeeded. Reintroductions were instrumental in reestablishing fisher populations within their historical range and expanding the range from its most-contracted state (43% of the historical range) to its current state (68% of the historical range). To increase the likelihood of translocation success, we recommend that managers: 1) release as many fishers as possible, 2) release more females than males (55–60% females) when possible, 3) release as many adults as possible, especially large males, 4) release fishers from a nearby source population, 5) conduct a formal feasibility assessment, and 6) develop a comprehensive implementation plan that includes an active monitoring program

Natalizumab treatment shows low cumulative probabilities of confirmed disability worsening to EDSS milestones in the long-term setting.

Abstract Background Though the Expanded Disability Status Scale (EDSS) is commonly used to assess disability level in relapsing-remitting multiple sclerosis (RRMS), the criteria defining disability progression are used for patients with a wide range of baseline levels of disability in relatively short-term trials. As a result, not all EDSS changes carry the same weight in terms of future disability, and treatment benefits such as decreased risk of reaching particular disability milestones may not be reliably captured. The objectives of this analysis are to assess the probability of confirmed disability worsening to specific EDSS milestones (i.e., EDSS scores ≥3.0, ≥4.0, or ≥6.0) at 288 weeks in the Tysabri Observational Program (TOP) and to examine the impact of relapses occurring during natalizumab therapy in TOP patients who had received natalizumab for ≥24 months. Methods TOP is an ongoing, open-label, observational, prospective study of patients with RRMS in clinical practice. Enrolled patients were naive to natalizumab at treatment initiation or had received ≤3 doses at the time of enrollment. Intravenous natalizumab (300 mg) infusions were given every 4 weeks, and the EDSS was assessed at baseline and every 24 weeks during treatment. Results Of the 4161 patients enrolled in TOP with follow-up of at least 24 months, 3253 patients with available baseline EDSS scores had continued natalizumab treatment and 908 had discontinued (5.4% due to a reported lack of efficacy and 16.4% for other reasons) at the 24-month time point. Those who discontinued due to lack of efficacy had higher baseline EDSS scores (median 4.5 vs. 3.5), higher on-treatment relapse rates (0.82 vs. 0.23), and higher cumulative probabilities of EDSS worsening (16% vs. 9%) at 24 months than those completing therapy. Among 24-month completers, after approximately 5.5 years of natalizumab treatment, the cumulative probabilities of confirmed EDSS worsening by 1.0 and 2.0 points were 18.5% and 7.9%, respectively (24-week confirmation), and 13.5% and 5.3%, respectively (48-week confirmation). The risks of 24- and 48-week confirmed EDSS worsening were significantly higher in patients with on-treatment relapses than in those without relapses. An analysis of time to specific EDSS milestones showed that the probabilities of 48-week confirmed transition from EDSS scores of 0.0–2.0 to ≥3.0, 2.0–3.0 to ≥4.0, and 4.0–5.0 to ≥6.0 at week 288 in TOP were 11.1%, 11.8%, and 9.5%, respectively, with lower probabilities observed among patients without on-treatment relapses (8.1%, 8.4%, and 5.7%, respectively). Conclusions In TOP patients with a median (range) baseline EDSS score of 3.5 (0.0–9.5) who completed 24 months of natalizumab treatment, the rate of 48-week confirmed disability worsening events was below 15%; after approximately 5.5 years of natalizumab treatment, 86.5% and 94.7% of patients did not have EDSS score increases of ≥1.0 or ≥2.0 points, respectively. The presence of relapses was associated with higher rates of overall disability worsening. These results were confirmed by assessing transition to EDSS milestones. Lower rates of overall 48-week confirmed EDSS worsening and of transitioning from EDSS score 4.0–5.0 to ≥6.0 in the absence of relapses suggest that relapses remain a significant driver of disability worsening and that on-treatment relapses in natalizumab-treated patients are of prognostic importance

Fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin with gemtuzumab ozogamicin improves event-free survival in younger patients with newly diagnosed aml and overall survival in patients with npm1 and flt3 mutations

Purpose To determine the optimal induction chemotherapy regimen for younger adults with newly diagnosed AML without known adverse risk cytogenetics. Patients and Methods One thousand thirty-three patients were randomly assigned to intensified (fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin [FLAG-Ida]) or standard (daunorubicin and Ara-C [DA]) induction chemotherapy, with one or two doses of gemtuzumab ozogamicin (GO). The primary end point was overall survival (OS). Results There was no difference in remission rate after two courses between FLAG-Ida + GO and DA + GO (complete remission [CR] + CR with incomplete hematologic recovery 93% v 91%) or in day 60 mortality (4.3% v 4.6%). There was no difference in OS (66% v 63%; P = .41); however, the risk of relapse was lower with FLAG-Ida + GO (24% v 41%; P < .001) and 3-year event-free survival was higher (57% v 45%; P < .001). In patients with an NPM1 mutation (30%), 3-year OS was significantly higher with FLAG-Ida + GO (82% v 64%; P = .005). NPM1 measurable residual disease (MRD) clearance was also greater, with 88% versus 77% becoming MRD-negative in peripheral blood after cycle 2 (P = .02). Three-year OS was also higher in patients with a FLT3 mutation (64% v 54%; P = .047). Fewer transplants were performed in patients receiving FLAG-Ida + GO (238 v 278; P = .02). There was no difference in outcome according to the number of GO doses, although NPM1 MRD clearance was higher with two doses in the DA arm. Patients with core binding factor AML treated with DA and one dose of GO had a 3-year OS of 96% with no survival benefit from FLAG-Ida + GO. Conclusion Overall, FLAG-Ida + GO significantly reduced relapse without improving OS. However, exploratory analyses show that patients with NPM1 and FLT3 mutations had substantial improvements in OS. By contrast, in patients with core binding factor AML, outcomes were excellent with DA + GO with no FLAG-Ida benefit

Gutton (Jean-l'ierre). Reinages, abbayes de jeunesse et confréries dans les villages de l'ancienne France. Cahiers d'histoire, t. XX, 1975, pp. 443-453

Devos Roger. Gutton (Jean-l'ierre). Reinages, abbayes de jeunesse et confréries dans les villages de l'ancienne France. Cahiers d'histoire, t. XX, 1975, pp. 443-453. In: Le Monde alpin et rhodanien. Revue régionale d'ethnologie, n°1-2/1976. p. 219

Pénitents des Alpes-Maritimes, 1981

Devos Roger. Pénitents des Alpes-Maritimes, 1981. In: Le Monde alpin et rhodanien. Revue régionale d'ethnologie, n°1-2/1983. pp. 138-139

Ribotton-Clos (MnieC.). La sorcellerie en Savoie. L'Histoire en Savoie. No 38. septembre 1975

Devos Roger. Ribotton-Clos (MnieC.). La sorcellerie en Savoie. L'Histoire en Savoie. No 38. septembre 1975. In: Le Monde alpin et rhodanien. Revue régionale d'ethnologie, n°1-2/1976. p. 220

Industrie et artisanat en Savoie du Nord, d'après les rapports et les notes de Joseph Despine (1830-1840)

Industry and craftsmanship in North Savoy, after Joseph Despine's reports and notes (1830-1840). Charles-Marie-Joseph Despine (1792-1859), a general surveyor of the mines of the kingdom of Piedmont-Sardinia, has left a huge documentation on industry and craftsmanship in Savoy in the first half of the 19th century. The framework of this article is limited to North Savoy, i.e. the provinces of Carouge, Genevois, Chablais and Faucigny, leaving aside mining and textile industries which could by themselves provide a subject-matter for specific works. This choice has enabled the author to give a detailed view of a very active rural craftsmanship, especially in the field of woodwork and edge-tool industry. Despine's reports and notes give an insight of a pre-industrial microcosmus more important and varied than one might be tempted to believe on reading usual statements on the economic stagnation of the Buon Governo period. And yet, in a country deprived of the main assets of the first Industrial Révolution, concerns liveCharles-Marie-Joseph Despine (1792-1859), inspecteur général des mines du royaume de Piémont-Sardaigne, a laissé une abondante documentation sur l'activité industrielle et artisanale de la Savoie dans la première moitié du XIXe siècle. Dans le cadre de cet article, on s'est limité à la Savoie du Nord, soit aux provinces de Carouge, du Genevois, du Chablais et du Fauciny en laissant de côté les industries extractives et textiles qui pourraient, à elles seules, faire l'objet de travaux spécifiques. Ce choix a permis de donner une vue détaillée d'un artisanat rural très actif, surtout dans le domaine du bois et de la taillanderie. Les rapports et les notes de Despine laissent entrevoir un microcosme pré-industriel plus important et plus varié qu'on pourrait le croire, à la lecture des habituelles affirmations sur la stagnation économique de la période du Buon Governo. Cependant, dans un pays dépourvu des principaux atouts de la première révolution indus trielle, les entreprises vivent à l'ombre d'un protectionnisme frileux qui devra céder le pas devant l'offensive libre-échangiste. under the shadow of a wary protectionism which was to yield in front of the free-trade offensive.Devos Roger. Industrie et artisanat en Savoie du Nord, d'après les rapports et les notes de Joseph Despine (1830-1840). In: Le Monde alpin et rhodanien. Revue régionale d'ethnologie, n°3-4/1987. Industrie, techniques et patrimoine, sous la direction de Jean Guibal et Jacques Vallerant. pp. 11-40

Mariotte (Jean-Yves) et Gabion (Robert). — Guide des Archives de la Haute-Savoie, 1976

Devos Roger. Mariotte (Jean-Yves) et Gabion (Robert). — Guide des Archives de la Haute-Savoie, 1976. In: Le Monde alpin et rhodanien. Revue régionale d'ethnologie, n°1-2/1978. p. 277

Vovelle (Michel). — Piété baroque et déchristianisation en Provence au XVIIIe siècle. Les attitudes devant la mort d'après les clauses des testaments. Coll. Civilisations et mentalités, Paris, Pion, 1973

Devos Roger. Vovelle (Michel). — Piété baroque et déchristianisation en Provence au XVIIIe siècle. Les attitudes devant la mort d'après les clauses des testaments. Coll. Civilisations et mentalités, Paris, Pion, 1973. In: Le Monde alpin et rhodanien. Revue régionale d'ethnologie, n°1/1974. pp. 131-132