Scientific Bulb Snatching

The subject of plant morphology is frequently considered a boring topic by both teacher and pupil, and consequently given a somewhat inadequate treatment. Several reasons can be adduced for this unfortunate neglect of a field of knowledge which is, in fact, particularly suitable for intensive study in schools. An unnecessary restriction of teaching types (e.g., broad bean, crocus, sweet pea, etc.) may evoke bored familiarity, or the subject may be given such a superficial treatment that no morphological analysis is achieved and interest is not aroused. Often, a grossly teleological approach is adopted in teaching morphology and many unproven assumptions are made

Henry VIII

From a Dissertation to the Royal Medical Society by G. DevonaldThis short article could have been aptly subtitled Sex, Syphilis and Sores, because this accurately conveys the impression that most people have of Henry VIII.  Mention his name, and a lecherous look comes into a person’s eye and he immediately makes some remark about Henry’s six wives and his syphilis. So much good and so much evil has been written about him that he must be the most controversial king in British history. Dickens described him as “a blot of blood and grease”, yet others have thought him to be the paragon of all the virtues. Religious convictions obviously played their part in colouring the opinions of earlier writers, Henry being Bluff King Hal, the merry, innocent monarch to the Protestant, and a cruel, sadistic ogre to the Catholic. The truth is that both sides were partly right. When Henry came to the throne he was considered to be the most intelligent, most tolerant and most athletic of all European kings. He was kind, considerate and reasonable, even Erasmus thought that his crowning heralded a Golden Age in the English Renaissance. Yet during his early forties a change came over him and he became an irritable, selfish, suspicious tyrant. At that time Castilian, the French ambassador described him as “the most dangerous and cruel man in the world”

Aggregate and Firm level volatility: the role of acquisitions and disposals.

The purpose of this paper is to revisit an intriguing finding. Although over the last few decades leading up to the financial crisis there was a marked reduction in the volatility of aggregate output and inflation, there appears to have been a corresponding increase in the sales volatility of individual firms. Here we argue that a significant reason for this apparent increase in firm level volatility was an increase in churning of firm activity through the acquisition and disposal of businesses. This created an increase in observed negative covariances between firms, so even if the volatility of underlying organic growth has also fallen, observed volatility has rise

Remote effects of acute kidney injury in a porcine model

Background: Acute Kidney Injury (AKI) is a common and serious disease with no specific treatment. An episode of AKI may affect organs distant to the kidney, further increasing the morbidity associated with AKI. The mechanism of organ cross-talk after AKI is unclear. The renal and immune systems of pigs and humans are alike. Using a preclinical animal (porcine) model, we test the hypothesis that early effects of AKI on distant organs is by immune cell infiltration leading to inflammatory cytokine production, extravasation and edema. Study Design: In 29 pigs exposed to either sham-surgery or renal ischemia-reperfusion (control, n=12; AKI, n=17) we assessed remote organ (liver, lung, brain) effects in the short-(from 2 to 48h reperfusion) and longer-term (5 weeks later) using immunofluorescence (for leucocyte infiltration, apoptosis), a cytokine array, tissue elemental analysis (electrolytes), blood hematology and chemistry (e.g. liver enzymes) and PCR (for inflammatory markers). Results: AKI elicited significant, short-term (~24h) increments in enzymes indicative of acute liver damage (e.g. AST:ALT ratio; P=0.02) and influenced tissue biochemistry in some remote organs (e.g. lung tissue [Ca++] increased; P=0.04). These effects largely resolved after 48h and no further histopathology, edema, apoptosis or immune cell infiltration was noted in liver, lung or hippocampus in the short- and longer-term. Conclusions: AKI has subtle biochemical effects on remote organs in the short-term including a transient increment in markers of acute liver damage. These effects resolved by 48h and no further remote organ histopathology, apoptosis, edema or immune cell infiltration was noted

Definition of hourly urine output influences reported incidence and staging of acute kidney injury

© 2020 The Author(s). Background: Acute kidney injury (AKI) is commonly defined using the KDIGO system, which includes criteria based on reduced urine output (UO). There is no consensus on whether UO should be measured using consecutive hourly readings or mean output. This makes KDIGO UO definition and staging of AKI vulnerable to inconsistency which has implications both for research and clinical practice. The objective of this study was to investigate whether the way in which UO is defined affects incidence and staging of AKI. Methods: We conducted a retrospective analysis of two single centre observational studies investigating (i) patients undergoing cardiac surgery and (ii) patients admitted to general intensive care units (ICU). AKI was identified using KDIGO serum creatinine (SCr) criteria and two methods of UO (UOcons: UO meeting KDIGO criteria in each consecutive hour; UOmean: Mean hourly UO meeting KDIGO criteria). Results: Data from 151 CICU and 150 ICU admissions were analysed. Incidence of AKI using SCr alone was 23.8% in CICU and 32% in ICU. Incidence increased in both groups when UO was considered, with inclusion of UOmean more than doubling reported incidence of AKI (CICU: UOcons 39.7%, UOmean 72.8%; ICU: UOcons 51.3%, UOmean 69.3%). In both groups UOcons led to a larger increase in KDIGO stage 1 but UOmean increased the incidence of KDIGO stage 2. Conclusions: We demonstrate a serious lack of clarity in the internationally accepted AKI definition leading to significant variability in reporting of AKI incidence

Remote conditioning or erythropoietin before surgery primes kidneys to clear ischemia-reperfusion-damaged cells: a renoprotective mechanism?

Acute kidney injury is common, serious with no specific treatment. Ischemia-reperfusion is a common cause of acute kidney injury (AKI). Clinical trials suggest that preoperative erythropoietin (EPO) or remote ischemic preconditioning may have a renoprotective effect. Using a porcine model of warm ischemia-reperfusion-induced AKI (40-min bilateral cross-clamping of renal arteries, 48-h reperfusion), we examined the renoprotective efficacy of EPO (1,000 iu/kg iv.) or remote ischemic preconditioning (3 cycles, 5-min inflation/deflation to 200 mmHg of a hindlimb sphygmomanometer cuff). Ischemia-reperfusion induced significant kidney injury at 24 and 48 h (χ(2), 1 degree of freedom, >10 for 6/7 histopathological features). At 2 h, a panel of biomarkers including plasma creatinine, neutrophil gelatinase-associated lipocalin, and IL-1β, and urinary albumin:creatinine could be used to predict histopathological injury. Ischemia-reperfusion increased cell proliferation and apoptosis in the renal cortex but, for pretreated groups, the apoptotic cells were predominantly intratubular rather than interstitial. At 48-h reperfusion, plasma IL-1β and the number of subcapsular cells in G2-M arrest were reduced after preoperative EPO, but not after remote ischemic preconditioning. These data suggest an intrarenal mechanism acting within cortical cells that may underpin a renoprotective function for preoperative EPO and, to a limited extent, remote ischemic preconditioning. Despite equivocal longer-term outcomes in clinical studies investigating EPO as a renoprotective agent in AKI, optimal clinical dosing and administration have not been established. Our data suggest further clinical studies on the potential renoprotective effect of EPO and remote ischemic preconditioning are justified

Res Medica, Summer 1963, Volume III, Number 4

TABLE OF CONTENTSMETABOLIC MISTAKES: M. Higgins, B.Sc.EDUCATION IN MEDICAL SCIENCES: Prof. W.L.M. Perry, O.B.E., M.D., D.Sc.HENRY VIII: G. DevonaldRES MEDICAPATHOLOGY AND AETIOLOGY OF PRE-ECLAMPSIA AND ECLAMPSIA: R. Marshal