Complexes of Salicylidene-o-aminothiophenol with Pd(II), Hg(I & II) & Ag(I) & Its Use as a New Analytical Reagent for Their Amperometric Determination

365-36

A study of adverse drug reactions among elderly patients in a tertiary care hospital

Background: Adverse drug reactions are major setback in the advancement of current therapeutic modalities and safe treatment becomes a challenge in elderly patients. Multifarious health issues in elderly patients require assorted groups of drugs leading to prominent ADRs (Adeverse drug reactions). This study was designed to analyse the most affront drug group causing ADRs among elderly patients and the most frequent signs and symptoms of ADR in tertiary care hospital.Methods: All elderly inpatients aged 60 years and above were included in the study. Clinical pharmacist monitored and reported ADRs which were analysed by pharmacologist and physicians. The drugs causing ADRs were identified and different signs and symptoms of ADR were evaluated.Results: A total of 810 (7.26%) ADRs were reported from 11157 inpatients. Out of 810 ADRs reported 320 (39.5%) ADRs were among elderly patients. ADR analyses showed a sight male predominance among elderly patients. Antibacterial agents were the most offended drug group contributing for 18.76% of ADR’s. Gastointestinal tract was the most frequently affected system with maximum number of ADRs 102 (31.88%).Conclusions: ADRs are major threat to hospitalized elderly patients. The risk of ADRs can be reduced by dosing the drug according to the age of the patient and by close monitoring of patients

Evaluation of antiulcer and antioxidant potential of Ipomoea Reniformis leaf extract against experimentally induced ulcer in rats

Background: Ulcer is a major disease of gastrointestinal system which affects about 10% of the world’s population. As conventional drugs can produce undesirable side effects on long term use it can be replaced by herbal medicines more safely. The study was designed to evaluate the antiulcer activity of ethanolic leaf extract of Ipomoea reniformis against pyloric ligated ulcer and cold restraint stress induced ulcer models in rats.Methods: Male Wistar albino rats were used. 0.1% Carboxy Methyl Cellulose (CMC) was used as vehicle. Ethanolic leaf extract of Ipomoea reniformis was employed at two dose levels (200 and 400mg/kg). Omeprazole (10mg/kg) was used as reference control in both the models. The test drugs were administered by suspending in CMC, through oral route. In pyloric ligated ulcer model, gastric volume, ulcer index and percentage protection were measured. In cold restraint stress induced ulcer model, ulcer index and percentage protection was measured. The stomach homogenate was subjected to antioxidant profiles.Results: Ethanolic leaf extract of Ipomoea reniformis dose dependently decreased the gastric volume in pyloric ligated ulcer model and significantly reduced the ulcer index in both the models. Ipomoea reniformis in both the doses significantly protected the animals against stress-induced free radical damage due to decrease in LPO and reversal of changes induced by stress on SOD and CAT.Conclusions: From the result, it was concluded that the Ipomoea reniformis leaf extract exhibited antiulcer activity in both the tested models were due to its antisecretary and antioxidant property

Multiple Slot Fractal Structured Antenna for Wi-Fi and Radio Altimeter for uncertain Applications

A multiple slot fractal antenna design has been determined communication efficiency and its multi-function activities.  High-speed small communication devices have been required for future smart chip applications, so that researchers have been employed new and creative antenna design. Antennas are key part in communication systems, those are used to improve communication parameters like gain, efficiency, and bandwidth. Consistently, modern antennas design with high bandwidth and gain balancing is very difficult, therefore an adaptive antenna array chip design is required. In this research work a coaxial fed antenna with fractal geometry design has been implemented for Wi-Fi and Radio altimeter application. The fractal geometry has been taken with multiple numbers of slots in the radiating structure for uncertain applications. The coaxial feeding location has been selected based on the good impedance matching condition (50 Ohms). The overall dimension mentioned for antenna are approximately 50X50X1.6 mm on FR4 substrate and performance characteristic analysis is performed with change in substrate material presented in this work. Dual-band resonant frequency is being emitted by the antenna with resonance at 3.1 and 4.3 GHz for FR4 substrate material and change in the resonant bands is obtained with change in substrate. The proposed Antenna is prototyped on Anritsu VNA tool and presented the comparative analysis like VSWR 12%, reflection coefficient 9.4%,3D-Gain 6.2% and surface current 9.3% had been improved

PATTERNS OF ACUTE POISONING AMONG PATIENTS TREATED IN THE EMERGENCY WARDS OF A TERTIARY CARE HOSPITAL: A CROSS-SECTIONAL STUDY

Objective: Poisoning is a growing health-care burden in developing countries like India. Predicting the nature of the intention behind poisoning and type of poisoning agent involved will help in facilitating appropriate treatment measures, hence, improving the patient's quality of life.Methods: The prospective, observational study was conducted in a tertiary care multispecialty hospital for 6 months from November 2016 to April 2017 and involved a total of 133 patients. Treatment and outcomes of the patients were collected, documented in a data collection form. Chi-square test and logistic regression analysis were applied.Results: The mean age of the study participants was 27.76±15.5 with predominance seen in age groups of <30 years (59.3%), females (52.6%), and married (49.6%). Intentional poisoning (69.1%) through oral ingestion (81.2%) of medications (51.6%) in solid forms (60.2%) was predominant. Patients presenting with systemic manifestations (70.4%) arrived in a time duration >1 h (66.2%), received first aid (62.4%), and supportive care (52.7%). Higher ingestion of physical forms was significantly observed in both single (OR: 4.5) and married (OR: 3). The outcomes were correlated with poison severity score and patients with mild symptoms recovered (60.9%).Conclusion: The use of medicines for intentional poisoning continues to be rampant in younger age groups and married individuals. Educational programs with more accentuation on the data regarding toxic substances along with preventive measures are to be implemented to make mindfulness among the overall population

SOCIODEMOGRAPHIC PROFILE OF PATIENTS WITH ACUTE POISONING IN THE EMERGENCY WARDS OF A TERTIARY CARE HOSPITAL

Objective: To assess the socio-demographic profile and outcomes in the patients with poisoning admitted to the emergency wards of a tertiary care hospital.Methods: The prospective observational study was conducted for a period of six months in the emergency wards of a tertiary care hospital. The demographic data, hospital admission variables and outcomes were collected from various sources and documented. Cluster analysis was used to find the interaction between the socio-demographic and hospital admission variables in association with outcomes of poisoning.Results: A total of 133 patients were admitted with acute poisoning. The mean age was 27.76±15.5%. Females (51.1%) were dominant over males (48.8%). Incidents of poisoning were predominant in married (49.6%), literates (41.35%), abiding in urban region (86.4%) and belonging to upper lower class (37.6%). The poisonings were intentional (69.17%) occurring through oral route (81.2%) at home (82%). Reason for poisoning was the most significant (1.00*) predictor followed by route of poisoning. Patients with mild symptoms were 85.71% 10.5% moderate and severe symptoms 3.75%. Majority of the victims recovered (82.71%) whilst 4.51% died.Conclusion: Poisoning patterns vary with socio-demographic and socio-economic status, which is a prevalent social and economic issue in developing countries. Depression acts as a slow poison and is common among younger age groups leading to increased cases of intentional poisoning, thereby indicating a necessity for appropriate psychiatric counselling, medical and peer management strategies to identify the individuals in need that can reduce the risk of next attempt

Thyroid dysfunction in human immuno-deficiency virus infected patients: a non-randomized, cross-sectional, single-center study

Background: Increasing prevalence of thyroid dysfunction has been reported in human immuno-deficiency virus (HIV)-infected patients. However, there is insufficient evidence to recommend routine thyroid screening of asymptomatic individuals. Hence, this study was undertaken in an attempt to resolve these issues. Objectives of this non-randomized, cross-sectional, single-center study was to study thyroid function in HIV positive patients at various stages of disease. Methods: This single-center study was carried out at Al-Ameen Medical College Hospital and Government District Hospital Bijapur, Karnataka, India from December 2020 to December 2022. The final selected study population included newly diagnosed adult and adolescent (17-60 years) HIV+ patients was composed of 100 participants of either gender. Patients were interviewed and enrolled in the study after examining in detail according to the proforma and then by taking their written consent and explaining the purpose of the study. The thyroid hormone assays (S. TSH, FT3 and FT4) were done by chemiluminescence immuno assay (CLIA) using ADVIA Centaur-equipment. Results: Overall mean age was 36 years (range in years: 17–66 years) and 66 patients (66%) were males. Male: female ratio of 1.94:1 was recorded. In the 50 patients having acquired immuno-deficiency virus (AIDS), FT3 levels ranged from 0.230 to 4.0 picogram/ml with a mean of 2.131+0.9826 picogram/ml. In 50 patients having AIDS, the FT4 levels ranged from 0.30 to 1.90 nanogram/dI with a mean 1.179±0.4484 nanogram/dl. Conclusions: All forms of thyroid dysfunction were observed

Fodder Scenario and Hortipastoral Opportunities to Enhance Fodder Production in India

Food grain production and livestock production are closely related in India as crop-residue forms the major source of fodder for livestock. It’s thus assumed that increase in food grain production has positive effect on availability of dry matter to the livestock. Using land use classification, crop production (2015 to 2020) and livestock census (2019) data, dry matter (DM) availability for livestock for 28 states of India was estimated. Hortipastoral opportunities by estimating area available under orchards in southern India were done to assess the possibility of introducing fodder crops in orchards. Some of the fodder crops were introduced in orchards of livestock farmers to know how fodder crops address the issue of fodder availability at household level. The lowest DM available state was Assam (52.80 % availability) and highest available state was Haryana (110.80 %). Eight states have surplus DM (+110.80% to +2.3%). Twelve states experience DM deficiency (-2.96 to -47.20%). Inter spaces in orchards, a niche to cultivate fodder crops to reduce such fodder shortage, estimated to produce 67.13 MT of green fodder sufficing yearly requirement of 13.57 million Adult Cattle Units. Adult Cattle Unit is a reference unit which facilitates the aggregation of livestock from various species and age using specific coefficients derived based on the nutritional and feed requirement of each type of animal. Perennial fodder crops were introduced to 450 Mango and Coconut farmers (from 2016-2021) that reduced fodder shortage (50.6±4.39 to 9±1.64%)

Physics Potential of the ICAL detector at the India-based Neutrino Observatory (INO)

The upcoming 50 kt magnetized iron calorimeter (ICAL) detector at the India-based Neutrino Observatory (INO) is designed to study the atmospheric neutrinos and antineutrinos separately over a wide range of energies and path lengths. The primary focus of this experiment is to explore the Earth matter effects by observing the energy and zenith angle dependence of the atmospheric neutrinos in the multi-GeV range. This study will be crucial to address some of the outstanding issues in neutrino oscillation physics, including the fundamental issue of neutrino mass hierarchy. In this document, we present the physics potential of the detector as obtained from realistic detector simulations. We describe the simulation framework, the neutrino interactions in the detector, and the expected response of the detector to particles traversing it. The ICAL detector can determine the energy and direction of the muons to a high precision, and in addition, its sensitivity to multi-GeV hadrons increases its physics reach substantially. Its charge identification capability, and hence its ability to distinguish neutrinos from antineutrinos, makes it an efficient detector for determining the neutrino mass hierarchy. In this report, we outline the analyses carried out for the determination of neutrino mass hierarchy and precision measurements of atmospheric neutrino mixing parameters at ICAL, and give the expected physics reach of the detector with 10 years of runtime. We also explore the potential of ICAL for probing new physics scenarios like CPT violation and the presence of magnetic monopoles.Comment: 139 pages, Physics White Paper of the ICAL (INO) Collaboration, Contents identical with the version published in Pramana - J. Physic

Receptor Heteromerization Expands the Repertoire of Cannabinoid Signaling in Rodent Neurons

A fundamental question in G protein coupled receptor biology is how a single ligand acting at a specific receptor is able to induce a range of signaling that results in a variety of physiological responses. We focused on Type 1 cannabinoid receptor (CB1R) as a model GPCR involved in a variety of processes spanning from analgesia and euphoria to neuronal development, survival and differentiation. We examined receptor dimerization as a possible mechanism underlying expanded signaling responses by a single ligand and focused on interactions between CB1R and delta opioid receptor (DOR). Using co-immunoprecipitation assays as well as analysis of changes in receptor subcellular localization upon co-expression, we show that CB1R and DOR form receptor heteromers. We find that heteromerization affects receptor signaling since the potency of the CB1R ligand to stimulate G-protein activity is increased in the absence of DOR, suggesting that the decrease in CB1R activity in the presence of DOR could, at least in part, be due to heteromerization. We also find that the decrease in activity is associated with enhanced PLC-dependent recruitment of arrestin3 to the CB1R-DOR complex, suggesting that interaction with DOR enhances arrestin-mediated CB1R desensitization. Additionally, presence of DOR facilitates signaling via a new CB1R-mediated anti-apoptotic pathway leading to enhanced neuronal survival. Taken together, these results support a role for CB1R-DOR heteromerization in diversification of endocannabinoid signaling and highlight the importance of heteromer-directed signal trafficking in enhancing the repertoire of GPCR signaling