The application of experimental data to blade wake interaction noise prediction

Blade wake interaction noise (BWI) has been defined as the broadband noise generated by the ingestion of turbulent trailing tip vortices by helicopter rotors. This has been shown to be the dominant contributor to the subjectively important part of the acoustic spectrum for the approach stage of a helicopter flyover. A prediction method for BWI noise based on the calculated trailing vortex trajectories has been developed and estimates of the vortex turbulence have been made. These measurements were made on a trailing vortex from a split wing arrangement and did not give the spectrum of the velocity fluctuations. A recent experiment carried out to measure the turbulence associated with a trailing vortex and the application of the results to BWI noise prediction is described

Flow structure generated by perpendicular blade vortex interaction and implications for helicopter noise predictions

Activities carried out in support of research on flow structure generated by perpendicular blade vortex interaction and implications for helicopter noise prediction are summarized. Progress in the following areas is described: (1) construction of 8 inch-chord NACA 0012 full-span blade; (2) Acquisition of two full-span blades; (3) preparation for hot wire measurements; (4) related work on a modified Betz's theory; and (5) work related to helicopter noise prediction. In addition, a list of publications based on the results of prior experimentation is presented

Perpendicular blade vortex interaction and its implications for helicopter noise prediction: Wave-number frequency spectra in a trailing vortex for BWI noise prediction

Perpendicular blade vortex interactions are a common occurrence in helicopter rotor flows. Under certain conditions they produce a substantial proportion of the acoustic noise. However, the mechanism of noise generation is not well understood. Specifically, turbulence associated with the trailing vortices shed from the blade tips appears insufficient to account for the noise generated. The hypothesis that the first perpendicular interaction experienced by a trailing vortex alters its turbulence structure in such a way as to increase the acoustic noise generated by subsequent interactions is examined. To investigate this hypothesis a two-part investigation was carried out. In the first part, experiments were performed to examine the behavior of a streamwise vortex as it passed over and downstream of a spanwise blade in incompressible flow. Blade vortex separations between +/- one eighth chord were studied for at a chord Reynolds number of 200,000. Three-component velocity and turbulence measurements were made in the flow from 4 chord lengths upstream to 15 chordlengths downstream of the blade using miniature 4-sensor hot wire probes. These measurements show that the interaction of the vortex with the blade and its wake causes the vortex core to loose circulation and diffuse much more rapidly than it otherwise would. Core radius increases and peak tangential velocity decreases with distance downstream of the blade. True turbulence levels within the core are much larger downstream than upstream of the blade. The net result is a much larger and more intense region of turbulent flow than that presented by the original vortex and thus, by implication, a greater potential for generating acoustic noise. In the second part, the turbulence measurements described above were used to derive the necessary inputs to a Blade Wake Interaction (BWI) noise prediction scheme. This resulted in significantly improved agreement between measurements and calculations of the BWI noise spectrum especially for the spectral peak at low frequencies, which previously was poorly predicted

Civil society participation in the Scottish marine planning process and the role of Environmental Non-Governmental Organisations

Sustainable development principles are based on the fundamental recognition of humans as an integral part of the ecosystem. Participation of civil society should therefore be central to marine planning processes and enabling ecosystem-based management, and development of mechanisms for effective participation is critical. To date, little attention has been given to the role of Environmental Non-Governmental Organisations (ENGOs) in public participation. In this paper, the results of two workshops, which involved various stakeholders and addressed public participation in marine planning, are reported and discussed in the context of the Scottish marine planning process. ENGOs’ role in communicating complex policies, representing members’ interests and contributing towards participatory governance in marine planning is highlighted. Innovative outreach methods are still required by decision-makers to translate technical information, integrate local knowledge, improve public representation and conserve resources. This could include collaboration with ENGOs to help promote public participation in decision-making processes

Three-dimensional instability during vortex merging

4 p.The interaction of two parallel vortices of equal circulation is observed experimentally. For low Reynolds numbers ($Re$), the vortices remain two-dimensional and merge into a single one, when their time-dependent core size exceeds approximately 30\% of the vortex separation distance. At higher $Re$, a three-dimensional instability is discovered, showing the characteristics of an elliptic instability of the vortex cores. The instability rapidly generates small-scale turbulent motion, which initiates merging for smaller core sizes and produces a bigger final vortex than for laminar 2D flow

Comprehensive review of genetic factors contributing to head and neck squamous cell carcinoma development in low‐risk, nontraditional patients

BackgroundThe past 2 decades have seen an increased incidence of head and neck squamous cell carcinoma (HNSCC) in a nontraditional, low‐risk patient population (ie, ≤45 years of age, no substance use history), owing to a combination of human papillomavirus (HPV) infection and individual genetic variation.MethodsArticles positing genetic variants as contributing factors in HNSCC incidence in low‐risk, nontraditional patients were identified using a PubMed search, reviewed in detail, and concisely summarized herein.ResultsRecent data suggest that common polymorphisms in DNA repair enzymes, cell‐cycle control proteins, apoptotic pathway members, and Fanconi anemia‐associated genes likely modulate susceptibility to HNSCC development in low‐risk, nontraditional patients.ConclusionAt present, there is a lack of robust, comprehensive data on genetic drivers of oncogenesis in low‐risk patients and a clear need for further research on genetic alterations underlying the rising incidence of HNSCC in low‐risk, nontraditional patients.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/143606/1/hed25057_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/143606/2/hed25057.pd

An off-the-shelf CD2 universal CAR-T therapy for T-cell malignancies

T-cell malignancies are associated with frequent relapse and high morbidity, which is partly due to the lack of effective or targeted treatment options. To broaden the use of CAR-T cells in pan T-cell malignancies, we developed an allogeneic universal CD2-targeting CAR-T cell (UCART2), in which the CD2 antigen is deleted to prevent fratricide, and the T-cell receptor is removed to prevent GvHD. UCART2 demonstrated efficacy against T-ALL and CTCL and prolonged the survival of tumor-engrafted NSG mice in vivo. To evaluate the impact of CD2 on CAR-T function, we generated CD19 CAR-T cells (UCART19) with or without CD2 deletion, single-cell secretome analysis revealed that CD2 deletion in UCART19 reduced frequencies of the effector cytokines (Granzyme-B and IFN-γ). We also observed that UCART19ΔCD2 had reduced anti-tumor efficacy compared to UCART19 in a CD19+NALM6 xenograft model. Of note is that the reduced efficacy resulting from CD2 deletion was reversed when combined with rhIL-7-hyFc, a long-acting recombinant human interleukin-7. Treatment with rhIL-7-hyFc prolonged UCART2 persistence and increased survival in both the tumor re-challenge model and primary patient T-ALL model in vivo. Together, these data suggest that allogeneic fratricide-resistant UCART2, in combination with rhIL-7-hyFc, could be a suitable approach for treating T-cell malignancies

Excitation of airborne acoustic surface modes driven by a turbulent flow

This is the author accepted manuscript. The final version is available from AIAA via the DOI in this recordThis experiment demonstrated the generation of trapped acoustic surface waves excited by a turbulent flow source through the coupling of pressure fluctuations at the interface between an acoustic metamaterial and a flow environment. The turbulent flow, which behaves as a stochastic pressure source, was produced using a fully developed turbulent wall jet. The plate in the wall jet was perforated with a single cavity. On the flow-side it was capped by a Kevlar weave to ensure the cavity did not significantly disturb the flow, whilst on the adjacent side the cavity was open to the quiescent (static) environment. The through-cavity opening, on the quiescent side, was flush with an acoustic metasurface waveguide, which, through evanescent diffractive coupling of the pressure field, produced an acoustic surface mode. This acoustic mode was trapped at the plate surface, with its mode dispersion determined by the surface geometry. The results of two different metasurface geometries are discussed; (1) a slotted cavity array, and (2) a meander connected cavity array, each demonstrating a different trapped surface wave dispersion behavior. Fourier transform and correlation analyses of spatially-resolved temporal acoustic signals, measured close to the metamaterial surface, were used to construct the frequency and wave vector-dependent acoustic mode dispersion. Results demonstrated the flow can indeed be used to excite these acoustic modes and that their mode dispersion can be tailored towards realizing novel control of turbulent flow through acoustic-flow interactionsDefence Science and Technology Laboratory (DSTL

Instantaneous and time-averaged flow fields of multiple vortices in the tip region of a ducted propulsor

The instantaneous and time-averaged flow fields in the tip region of a ducted marine propulsor are examined. In this flow, a primary tip-leakage vortex interacts with a secondary, co-rotating trailing edge vortex and other co- and counter-rotating vorticity found in the blade wake. Planar particle imaging velocimetry (PIV) is used to examine the flow in a plane approximately perpendicular to the mean axis of the primary vortex. An identification procedure is used to characterize multiple regions of compact vorticity in the flow fields as series of Gaussian vortices. Significant differences are found between the vortex properties from the time-averaged flow fields and the average vortex properties identified in the instantaneous flow fields. Variability in the vortical flow field results from spatial wandering of the vortices, correlated fluctuations of the vortex strength and core size, and both correlated and uncorrelated fluctuations in the relative positions of the vortices. This variability leads to pseudo-turbulent velocity fluctuations. Corrections for some of this variability are performed on the instantaneous flow fields. The resulting processed flow fields reveal a significant increase in flow variability in a region relatively far downstream of the blade trailing edge, a phenomenon that is masked through the process of simple averaging. This increased flow variability is also accompanied by the inception of discrete vortex cavitation bubbles, which is an unexpected result, since the mean flow pressures in the region of inception are much higher than the vapor pressure of the liquid. This suggests that unresolved fine-scale vortex interactions and stretching may be occurring in the region of increased flow variability.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47076/1/348_2005_Article_938.pd