Experimental and Numerical Studies on Setback Buildings Considering the SSI Effect under Seismic Response

From the previous studies it is observed that due to the effect of the earthquake, several irregular buildings failed vulnerably. Further the effect of sub soil conditions where these buildings have been founded also play an important role on the seismic response of these buildings. In the past, experimental studies on the seismic response of different setback building configurations have not been carried out. Therefore, in the present study the seismic behaviour of setback buildings considering Soil Structure Interaction (SSI) has been evaluated by conducting experimental and numerical investigations. Buildings with various setback configurations were considered and are designed as pile foundation supported structures. The irregularity index of these building configurations have been determined as per the existing codal provisions. These piles supported buildings representing the prototype structure have been scaled down according to geometric, kinematic and dynamic scaling laws. The scaled building models are subjected to vibrations beyond resonant frequencies using shake table facility. A comparison of the results has been made between experimental and numerical investigations. Based on the study it has been observed that storey displacements of building with regular configurations are higher in comparison with the setback buildings. It is also found that asymmetrical and symmetrical setback buildings having different irregularity indices as per IS:1893-2016 indicate nearly the same displacements at resonant frequencies. Doi: 10.28991/cej-2021-03091664 Full Text: PD

The New Economic Policy and Perspective for Marine Fisheries Research and Development in India

The New Economic Policy and Perspective for Marine Fisheries Research and Development in Indi

Some observations on the possibilities of culture of the Indian sand whiting Sillago sihama (Forskal) in brackish waters

Indian sand whiting, Sillago sihama (Forskal) forms a dominant species in the estuarine fish catches during the south-west monsoon when they are in great demand and fetch a high price as sea fishing remains suspended due to rough weather conditions. The paper deals with preliminary observations on certain aspects of the biology of the fish related to its culture. The ability of the species to withstand very wide raoges of salinity makes it suitable for culture io both brackish and fresh waters

Studies on the activities of antioxidant enzymes under induced drought stress in in vivo and in vitro plants of Macrotyloma uniflorum (Lam.) Verdc.

Activities of glutathione reductase, guaiacol peroxidase, catalase and contents of ascorbic acid, Hydrogen peroxide were analysed in in vitro and in vivo plants of Macrotyloma uniflorum under Polyethylene glycol (PEG) induced drought condition. Water stress was induced in in vitro plants by supplementing the regeneration medium with PEG (Mol. Wt. 6000) at the concentrations ranging from 5 to 25% while in in vivo plants by watering PEG solution with the same concentrations. The activities of glutathione reductase and guaiacol peroxidase were increased under induced drought stress condition in both treated samples. On contrary, catalase activities were decreased. The contents of ascorbic acid and hydrogen peroxide were enhanced correspondingly as the concentration of the PEG increased from 5 to 25%. The role of antioxidant enzymes under water stress condition is discussed. Further, the feasibility of mining the novel genes of drought resistance from the in vitro plants of Macrotyloma uniflorum is highlighted

ASSOCIATION OF SERUM URIC ACID AND LIPID PROFILE IN TYPE 2 DIABETIC PATIENTS WITH AND WITHOUT DIABETIC RETINOPATHY

Objectives: Diabetic retinopathy (DR) is one of the microvascular complications in type 2 diabetes (T2D).  Elevated serum uric acid (SUA) has been shown to play a significant role in diabetic neuropathy and nephropathy but there is little information on retinopathy. Therefore, the present study was aimed to investigate the SUA and lipid profile in T2D patients with and without DR and the association between SUA and severity of DR.Methods: The study was conducted in the ophthalmology OPD at Sri Lakshmi Narayana Institute of Medical Sciences. The presence of T2D was confirmed by investigating fasting blood glucose level (normal limit < 110 mg/dl) in all the individuals. DR was examined by detailed dilated fundoscopic examination. Based on the fundus examination, patients were divided in to diabetes with signs of DR and those without signs of DR. Age and sex matched healthy were taken as controls. Fasting blood sugar, SUA and lipid profile were investigated for these groups. Results: The study found elevated SUA and abnormal lipid profile in DR group when compared to non-DR and control groups. We also found the significant association between SUA and severity of DR particularly in males.Conclusion: We found a significant association between SUA and severity of DR in T2D patients. Further studies with large sample size are needed to establish the role of elevated SUA and the mechanism involved in the pathogenesis of retinopathy in diabetic patients. Regular measurements of SUA level could be advised to the diabetic patients for the early management

Statin Therapy in Metabolic Syndrome and Hypertension Post-JUPITER: What is the Value of CRP?

Much evidence supports a pivotal role for inflammation in atherosclerosis. C-reactive protein (CRP), the prototypic marker of inflammation in humans, is a cardiovascular risk marker and may also promote atherogenesis. CRP levels are increased in metabolic syndrome and hypertension and confer increased risk of cardiovascular events in patients in these subgroups. Statins have been shown to lower low-density lipoproteins and CRP independently, and reduce cardiovascular events in subjects with and without metabolic syndrome and hypertension. In this review, we focus on the results from the primary prevention statin trial, Justification for the Use of statins in Primary prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER), which showed reductions in LDL, CRP, and cardiovascular events. Post-JUPITER, the new guidelines will now need to consider recommending high-sensitivity CRP testing to intermediate-risk metabolic syndrome patients and those with hypertension and intermediate risk so that we can better identify candidates at greater risk and reduce cardiovascular burden in these subjects with statin therapy

Three-dimensional anatomical accuracy of cranial models created by rapid prototyping techniques validated using a neuronavigation station

In neurosurgery and ear, nose and throat surgery the application of computerised navigation systems for guiding operations has been expanding rapidly. However, suitable models to train surgeons in using navigation systems are not yet available. We have developed a technique using an industrial, rapid prototyping process from which accurate spatial models of the cranium, its contents and pathology can be reproduced for teaching. We were able to register, validate and navigate using these models with common available navigation systems such as the Medtronic StealthStation S7 (R). (C) 2011 Elsevier Ltd. All rights reserved. This record was migrated from the OpenDepot repository service in June, 2017 before shutting down

Ethnicity, popular democratic movements and labour in Malaysia

This article uses framing theory to examine how activists and trade unions have framed labour’s political agenda in Malaysia. A polity grounded in ethnicity continues to hinder the formation of cross-ethnic collective worker identities and labour politics. However, inclusive popular democratising movements have strengthened in recent years, providing a favourable context for greater emphasis on non-ethnic political action by trade unions. The latter have shifted in this direction, adopting elements of the popular movement’s ‘human rights’ internationalism. Thus, the democratic movement’s frame has influenced that of the trade unions, with implications for framing theory

Tetrazine-Triggered Release of Carboxylic-Acid-Containing Molecules for Activation of an Anti-inflammatory Drug.

In addition to its use for the study of biomolecules in living systems, bioorthogonal chemistry has emerged as a promising strategy to enable protein or drug activation in a spatially and temporally controlled manner. This study demonstrates the application of a bioorthogonal inverse electron-demand Diels-Alder (iEDDA) reaction to cleave trans-cyclooctene (TCO) and vinyl protecting groups from carboxylic acid-containing molecules. The tetrazine-mediated decaging reaction proceeded under biocompatible conditions with fast reaction kinetics (<2 min). The anti-inflammatory activity of ketoprofen was successfully reinstated after decaging of the nontoxic TCOprodrug in live macrophages. Overall, this work expands the scope of functional groups and the application of decaging reactions to a new class of drugs