Freedom of the Press 2014

Global press freedom fell to its lowest level in over a decade in 2013, as hopes raised by the Arab Spring were further dashed by major regression in Egypt, Libya, and Jordan, and marked setbacks also occurred in Turkey, Ukraine, and a number of countries in East Africa. In another key development, media freedom in the United States deteriorated due primarily to attempts by the government to inhibit reporting on national security issues.Meanwhile, as a result of declines in democratic settings over the past several years, the share of the world's population that enjoys a Free press remained at 14 percent, meaning only one in seven people live in countries where coverage of political news is robust, the safety of journalists is guaranteed, state intrusion in media affairs is minimal, and the press is not subject to onerous legal or economic pressures.These are the most significant findings of this report, the latest edition of an annual report published by Freedom House since 1980. While there were positive developments in a number of countries, most notably in sub-Saharan Africa, the dominant trends were reflected in setbacks in a range of settings.The year's declines were driven by the desire of governments -- particularly in authoritarian states or polarized political environments -- to control news content, whether through the physical harassment of journalists covering protest movements or other sensitive news stories; restrictions on foreign reporters; or tightened constraints on online news outlets and social media. In addition, press freedom in a number of countries was threatened by private owners -- especially those with close connections to governments or ruling parties -- who altered editorial lines or dismissed key staff after acquiring previously independent outlets.These factors were behind the majority of the status downgrades for 2013, including the shifts from Partly Free to Not Free in Libya, South Sudan, Turkey, Ukraine, and Zambia. Significant declines also occurred in the Central African Republic, Egypt, Greece, Jordan, Kenya, Montenegro, Mozambique, Tanzania, and Uganda.Separately, influential authoritarian powers such as China and Russia continued to maintain a tight grip on locally based print and broadcast media, while also attempting to control the more independent views provided either in the blogosphere or by foreign news sources. Both countries introduced additional legal measures to penalize online speech in 2013. And while China focused on suppressing dissent on popular microblogging services and obstructing the foreign press, the Russian government closed RIA Novosti, a long-established news service, replacing it with an organization more openly under direct Kremlin control. Conditions in Eurasia remain bleak, with 97 percent of the region's population living in Not Free media environments.Even more open media environments are not immune to pressure on press freedom. The year featured the most significant decline of the past decade in one of the world's largest democracies, the United States, due to government attempts to control official information flows, particularly concerning national security -- related issues; the legal harassment of journalists with regard to protection of sources; and revelations of surveillance that included both the bulk collection of communications data by the National Security Agency (NSA) and the targeted wiretapping of media outlets. Disclosures that surveillance was being conducted by a range of governments -- many of them democratic -- against ordinary citizens as well as key political figures intensified concerns on a global level about the ability of journalists and others who gather and disseminate news and information to protect sources and maintain their digital privacy

Muslim women in colonial North India circa 1920-1947 : politics, law and community identity

This dissertation explores the relationship between gender and Muslim community identity in late colonial India. It pursues two broad themes. The first of these is the way in which gender issues were used symbolically by Muslim religious and political leaders to give substance to a community identity based largely on religious and cultural ideals in the three decades prior to independence. The second is the activities of elite Muslim women in social reform organisations and their entry into politics. Most of the recent literature on the development of a distinct Muslim identity during this period focuses entirely on politics and thus on relatively short-term factors leading to Partition. However, gender makes us look again at the longer term, especially the way in which it gave substance to the imagining of an all- India Muslim identity. I examine the various constructions and stereotypes of the Muslim woman and the ways in which she was seen as being in need of special protection in the political sphere while being in an advantageous position with regard to Muslim personal law. Of particular importance here are the discourse on purdah, which had become communalised during this period even as purdah practices were changing, and the ways in which Islamic law became considered as a 'sacred site' for Muslims in the late colonial period. I argue that the focus on gender issues by certain political and religious leaders was a 'universalising' factor: while it was difficult to portray all Indian Muslims as constituting a definitive and united group, all Indian Muslim women could be depicted as being alike, with the same interests and problems. These tendencies were strengthened by the Indian Muslim awareness of a wider Muslim community. In terms of practice, I examine women's entry into the political sphere, as well as their relationship with national women's organisations. I show that women were not passive onlookers to the debates on gender, but contributed to them, although their interest was more on improving women's rights than on formulating community identities. The dissertation examines women's conflicting identities as women and as Muslims, particularly as the initial unity among women on social reform issues was eroded due to communal antagonism in the realm of politics. The focus of the dissertation will be on the public sphere, which is where one can best examine the interactions between men and women, Hindus and Muslims, and Indian and British representatives. Given the diversity of the Indian Muslim experience, I concentrate on and give examples primarily from the United Provinces, but owing to wider connections between women I also look at other north Indian examples

Autosomal dominant gyrate atrophy-like choroidal dystrophy revisited: 45 years follow-up and association with a novel C1QTNF5 missense variant

We present a long-term follow-up in autosomal dominant gyrate atrophy-like choroidal dystrophy (adGALCD) and propose a possible genotype/phenotype correlation. Ophthalmic examination of six patients from two families revealed confluent areas of choroidal atrophy resembling gyrate atrophy, starting in the second decade of life. Progression continued centrally, reaching the fovea at about 60 years of age. Subretinal deposits, retinal pigmentation or choroidal neovascularization as seen in late-onset retinal degeneration (LORD) were not observed. Whole genome sequencing revealed a novel missense variant in the C1QTNF5 gene (p.(Q180E)) which was found in heterozygous state in all affected subjects. Haplotype analysis showed that this variant found in both families is identical by descent. Three-dimensional modeling of the possible supramolecular assemblies of C1QTNF5 revealed that the p.(Q180E) variant led to the destabilization of protein tertiary and quaternary structures, affecting both the stability of the single protomer and the entire globular head, thus exerting detrimental effects on the formation of C1QTNF5 trimeric globular domains and their interaction. In conclusion, we propose that the p.(Q180E) variant causes a specific phenotype, adGALCD, that differs in multiple clinical aspects from LORD. Disruption of optimal cell-adhesion mechanisms is expected when analyzing the effects of the point mutation at the protein level

Ion stopping in dense plasma target for high energy density physics

The basic physics of nonrelativistic and electromagnetic ion stopping in hot and ionized plasma targets is thoroughly updated. Corresponding projectile-target interactions involve enhanced projectile ionization and coupling with target free electrons leading to significantly larger energy losses in hot targets when contrasted to their cold homologues. Standard stoppping formalism is framed around the most economical extrapolation of high velocity stopping in cold matter. Further elaborations pay attention to target electron coupling and nonlinearities due to enhanced projectile charge state, as well. Scaling rules are then used to optimize the enhanced stopping of MeV/amu ions in plasmas with electron linear densities nel ~ 10 18 -10 20 cm -2 . The synchronous firing of dense and strongly ionized plasmas with the time structure of bunched and energetic multicharged ion beam then allow to probe, for the first time, the long searched enhanced plasma stopping and projectile charge at target exit. Laser ablated plasmas (SPQR1) and dense linear plasma columns (SPQR2) show up as targets of choice in providing accurate and on line measurements of plasma parameters. Corresponding stopping results are of a central significance in asserting the validity of intense ion beam scenarios for driving thermonuclear pellets. Other applications of note feature thorium induced fission, novel ion sources and specific material processing through low energy ion beams. Last but not least, the given ion beam-plasma target interaction physics is likely to pave a way to the production and diagnostics of warm dense matter (WDM)

Low spinophilin expression enhances aggressive biological behavior of breast cancer

Spinophilin, a putative tumor suppressor gene, has been shown to be involved in the pathogenesis of certain types of cancer, but its role has never been systematically explored in breast cancer. In this study, we determined for the first time the expression pattern of spinophilin in human breast cancer molecular subtypes (n = 489) and correlated it with survival (n = 921). We stably reduced spinophilin expression in breast cancer cells and measured effects on cellular growth, apoptosis, anchorage-independent growth, migration, invasion and self-renewal capacity in vitro and metastases formation in vivo. Microarray profiling was used to determine the most abundantly expressed genes in spinophilin-silenced breast cancer cells. Spinophilin expression was significantly lower in basal-like breast cancer (p<0.001) and an independent poor prognostic factor in breast cancer patients (hazard ratio = 1.93, 95% confidence interval: 1.24-3.03; p = 0.004) A reduction of spinophilin levels increased cellular growth in breast cancer cells (p<0.05), without influencing activation of apoptosis. Anchorage-independent growth, migration and self-renewal capacity in vitro and metastatic potential in vivo were also significantly increased in spinophilin-silenced cells (p<0.05). Finally, we identified several differentially expressed genes in spinophilin-silenced cells. According to our data, low levels of spinophilin are associated with aggressive behavior of breast cancer

Patterns of nitrogen fixation along 10°N in the tropical Atlantic

Nitrogen fixation supports new production in the oligotrophic oceans and removes dinitrogen and carbon dioxide from mixed layer waters. N‐fixation rates have been estimated in various ways but measurements are still too rare and factors limiting N‐fixation are not yet fully understood. Here we present data from a transect along 10°N through the tropical Atlantic on the Meteor Cruise 55 where N‐fixation rates between 3.7 and 255 μmol N*m−2*d−1 were recorded. The highest rates occurred off Africa in the eastern tropical North Atlantic (ETNA), and in the Amazon River plume in the West and contributed to 1–12.2% of the N‐demand of primary production. N‐fixation rates correlated with dissolved Fe concentrations, which were 20–280 times greater than the estimated demand. High atmospheric Fe inputs combined with the shallow nutricline make the ETNA a favourable environment for N‐fixers

Different Neutralization Profiles After Primary SARS-CoV-2 Omicron BA.1 and BA.2 Infections

Background and MethodsThe SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) Omicron (B.1.1.529) variant is the antigenically most distinct variant to date. As the heavily mutated spike protein enables neutralization escape, we studied serum-neutralizing activities of naïve and vaccinated individuals after Omicron BA.1 or BA.2 sub-lineage infections in live virus neutralization tests with Omicron BA.1, Omicron BA.2, wildtype (WT, B1.1), and Delta (B.1.617.2) strains. Serum samples obtained after WT infections and three-dose mRNA vaccinations with and without prior infection were included as controls.ResultsPrimary BA.1 infections yielded reduced neutralizing antibody levels against WT, Delta, and Omicron BA.2, while samples from BA.2-infected individuals showed almost no cross-neutralization against the other variants. Serum neutralization of Omicron BA.1 and BA.2 variants was detectable after three-dose mRNA vaccinations, but with reduced titers. Vaccination-breakthrough infections with either Omicron BA.1 or BA.2, however, generated equal cross-neutralizing antibody levels against all SARS-CoV-2 variants tested.ConclusionsOur study demonstrates that although Omicron variants are able to enhance cross-neutralizing antibody levels in pre-immune individuals, primary infections with BA.1 or BA.2 induced mostly variant-specific neutralizing antibodies, emphasizing the differently shaped humoral immunity induced by the two Omicron variants. These data thus contribute substantially to the understanding of antibody responses induced by primary Omicron infections or multiple exposures to different SARS-CoV-2 variants and are of particular importance for developing vaccination strategies in the light of future emerging variants

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death.

Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation

The first case of Brucella canis in Sweden: background, case report and recommendations from a northern European perspective

Infection with Brucella canis has been diagnosed in Sweden for the first time. It was diagnosed in a three-year-old breeding bitch with reproductive disturbances. Fifteen in-contact dogs were tested repeatedly and all of them were negative for B. canis. The source of infection could not be defined. The present article describes the case and the measures undertaken and gives a short review over B. canis. Recommendations on how to avoid the infection in non-endemic countries are given