166 research outputs found

    Malignant lymphomas of the eye

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    Results from 730 kg days of the CRESST-II Dark Matter Search

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    The CRESST-II cryogenic Dark Matter search, aiming at detection of WIMPs via elastic scattering off nuclei in CaWO4_4 crystals, completed 730 kg days of data taking in 2011. We present the data collected with eight detector modules, each with a two-channel readout; one for a phonon signal and the other for coincidently produced scintillation light. The former provides a precise measure of the energy deposited by an interaction, and the ratio of scintillation light to deposited energy can be used to discriminate different types of interacting particles and thus to distinguish possible signal events from the dominant backgrounds. Sixty-seven events are found in the acceptance region where a WIMP signal in the form of low energy nuclear recoils would be expected. We estimate background contributions to this observation from four sources: 1) "leakage" from the e/\gamma-band 2) "leakage" from the \alpha-particle band 3) neutrons and 4) Pb-206 recoils from Po-210 decay. Using a maximum likelihood analysis, we find, at a high statistical significance, that these sources alone are not sufficient to explain the data. The addition of a signal due to scattering of relatively light WIMPs could account for this discrepancy, and we determine the associated WIMP parameters.Comment: 17 pages, 13 figure

    The CRESST II Dark Matter Search

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    Direct Dark Matter detection with cryodetectors is briefly discussed, with particular mention of the possibility of the identification of the recoil nucleus. Preliminary results from the CREEST II Dark Matter search, with 730 kg-days of data, are presented. Major backgrounds and methods of identifying and dealing with them are indicated.Comment: Talk at DSU workshop, ITP Beijing, Oct. 2011. 9 figures, 2 table

    Status of the CRESST Dark Matter Search

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    The CRESST experiment aims for a detection of dark matter in the form of WIMPs. These particles are expected to scatter elastically off the nuclei of a target material, thereby depositing energy on the recoiling nucleus. CRESST uses scintillating CaWO4 crystals as such a target. The energy deposited by an interacting particle is primarily converted to phonons which are detected by transition edge sensors. In addition, a small fraction of the interaction energy is emitted from the crystals in the form of scintillation light which is measured in coincidence with the phonon signal by a separate cryogenic light detector for each target crystal. The ratio of light to phonon energy permits the discrimination between the nuclear recoils expected from WIMPs and events from radioactive backgrounds which primarily lead to electron recoils. CRESST has shown the success of this method in a commissioning run in 2007 and, since then, further investigated possibilities for an even better suppression of backgrounds. Here, we report on a new class of background events observed in the course of this work. The consequences of this observation are discussed and we present the current status of the experiment.Comment: Proceedings of the 13th International Workshop on Low Temperature Detectors, 4 pages, 3 figure

    Composite CaWO4 Detectors for the CRESST-II Experiment

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    CRESST-II, standing for Cryogenic Rare Events Search with Superconducting Thermometers phase II, is an experiment searching for Dark Matter. In the LNGS facility in Gran Sasso, Italy, a cryogenic detector setup is operated in order to detect WIMPs by elastic scattering off nuclei, generating phononic lattice excitations and scintillation light. The thermometers used in the experiment consist of a tungsten thin-film structure evaporated onto the CaWO4 absorber crystal. The process of evaporation causes a decrease in the scintillation light output. This, together with the need of a big-scale detector production for the upcoming EURECA experiment lead to investigations for producing thermometers on smaller crystals which are glued onto the absorber crystal. In our Run 31 we tested composite detectors for the first time in the Gran Sasso setup. They seem to produce higher light yields as hoped and could provide an additional time based discrimination mechanism for low light yield clamp events.Comment: Proceedings of the Thirteenth International Workshop on Low Temperature Detectors 4 pages, 9 figure

    Mycophenolic acid in the treatment of birdshot chorioretinopathy: long-term follow-up

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    Aim: To assess the long-term efficacy and tolerability of both derivatives of mycophenolic acid, mycophenolate mofetil (MMF) and mycophenolate sodium (MPS), in the therapy of patients with birdshot chorioretinopathy (BSCR). Methods: Retrospective analysis of 24 patients (48 eyes) with BSCR, treated with MMF or MPS with a follow-up of at least 1 year. The main outcome measures included control of inflammation, steroid-sparing potential and side effects. Secondary outcome measure was the development of retinal function during the therapy measured by best-corrected visual acuity (BCVA), visual field and/or electroretinography (ERG). Results: Twelve patients (50%) were treated with MMF and 12 patients (50%) with MPS. Control of intraocular inflammation, defined as complete lack of clinical and angiographic signs of inflammatory activity, was achieved in 16 of 24 patients (67%). The angiographic signs of activity were significantly reduced during the follow-up (p0.05). In 20 out of 21 patients (95%) who received systemic corticosteroids, the corticosteroids could be tapered to a daily dose of ≤10 mg (rate 0.26/patient-year). Drug-related side effects occurred in 12 patients (50%, rate 0.16/patient-year). In four patients (17%), a therapy switch from MMF to MPS was undertaken due to gastrointestinal discomfort. Conclusions: Derivatives of mycophenolic acid are effective and safe drugs for the treatment of BSCR. In cases with gastrointestinal side effects, a therapy switch from MMF to MPS should be considered

    GROND - a 7-channel imager

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    We describe the construction of GROND, a 7-channel imager, primarily designed for rapid observations of gamma-ray burst afterglows. It allows simultaneous imaging in the Sloan g'r'i'z' and near-infrared JHKJHK bands. GROND was commissioned at the MPI/ESO 2.2m telescope at La Silla (Chile) in April 2007, and first results of its performance and calibration are presented.Comment: 25 pages, 21 figs, PASP (subm); version with full-resolution figures at http://www.mpe.mpg.de/~jcg/GROND/grond_pasp.pd

    Intraocular pressure and ocular pulse amplitude using dynamic contour tonometry and contact lens tonometry

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    BACKGROUND: The new Ocular Dynamic Contour Tonometer (DCT), investigational device supplied by SMT (Swiss Microtechnology AG, Switzerland) allows simultaneous recording of intraocular pressure (IOP) and ocular pulse amplitude (OPA). It was the aim of this study to compare the IOP results of this new device with Goldmann tonometry. Furthermore, IOP and OPA measured with the new slitlamp-mounted DCT were compared to the IOP and OPA measured with the hand-held SmartLens(®), a gonioscopic contact lens tonometer (ODC Ophthalmic Development Company AG, Switzerland). METHODS: Nineteen healthy subjects were included in this study. IOP was determined by three consecutive measurements with each of the DCT, SmartLens(®), and Goldmann tonometer. Furthermore, OPA was measured three times consecutively by DCT and SmartLens(®). RESULTS: No difference (P = 0.09) was found between the IOP values by means of DCT (mean: 16.6 mm Hg, median: 15.33 mm Hg, SD: +/- 4.04 mm Hg) and Goldmann tonometry (mean: 16.17 mm Hg, median: 15.33 mm Hg, SD: +/- 4.03 mm Hg). The IOP values of SmartLens(® )(mean: 20.25 mm Hg, median: 19.00 mm Hg, SD: +/- 4.96 mm Hg) were significantly higher (P = 0.0008) both from Goldmann tonometry and DCT. The OPA values of the DCT (mean: 3.08 mm Hg, SD: +/- 0.92 mm Hg) were significantly lower (P = 0.0003) than those obtained by SmartLens(® )(mean: 3.92 mm Hg, SD: +/- 0.83 mm Hg). CONCLUSIONS: DCT was equivalent to Goldmann applanation tonometry in measurement of IOP in a small group of normal subjects. In contrast, SmartLens(® )(contact lens tonometry) gave IOP readings that were significantly higher compared with Goldmann applanation tonometer readings. Both devices, DCT and SmartLens(® )provide the measurement of OPA which could be helpful e.g. for the management of glaucoma

    Discrimination of Recoil Backgrounds in Scintillating Calorimeters

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    The alpha decay of \n{{}^{210}Po} is a dangerous background to rare event searches. Here, we describe observations related to this alpha decay in the Cryogenic Rare Event Search with Superconducting Thermometers (CRESST). We find that lead nuclei show a scintillation light yield in our \n{CaWO_4} crystals of 0.0142±0.00130.0142\pm0.0013 relative to electrons of the same energy. We describe a way to discriminate this source of nuclear recoil background by means of a scintillating foil, and demonstrate its effectiveness. This leads to an observable difference in the pulse shape of the light detector, which can be used to tag these events. Differences in pulse shape of the phonon detector between lead and electron recoils are also extracted, opening the window to future additional background suppression techniques based on pulse shape discrimination in such experiments.Comment: 5 pages, 9 figure
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