154 research outputs found
Resolvent Estimates in L^p for the Stokes Operator in Lipschitz Domains
We establish the resolvent estimates for the Stokes operator in
Lipschitz domains in , for . The result, in particular, implies that the Stokes operator in a
three-dimensional Lipschitz domain generates a bounded analytic semigroup in
for (3/2)-\varep < p< 3+\epsilon. This gives an affirmative answer to a
conjecture of M. Taylor.Comment: 28 page. Minor revision was made regarding the definition of the
Stokes operator in Lipschitz domain
Some genus 3 curves with many points
Using an explicit family of plane quartic curves, we prove the existence of a
genus 3 curve over any finite field of characteristic 3 whose number of
rational points stays within a fixed distance from the Hasse-Weil-Serre upper
bound. We also provide an intrinsic characterization of so-called Legendre
elliptic curves
Computing Hilbert Class Polynomials
We present and analyze two algorithms for computing the Hilbert class
polynomial . The first is a p-adic lifting algorithm for inert primes p
in the order of discriminant D < 0. The second is an improved Chinese remainder
algorithm which uses the class group action on CM-curves over finite fields.
Our run time analysis gives tighter bounds for the complexity of all known
algorithms for computing , and we show that all methods have comparable
run times
Equidistribution of Heegner Points and Ternary Quadratic Forms
We prove new equidistribution results for Galois orbits of Heegner points
with respect to reduction maps at inert primes. The arguments are based on two
different techniques: primitive representations of integers by quadratic forms
and distribution relations for Heegner points. Our results generalize one of
the equidistribution theorems established by Cornut and Vatsal in the sense
that we allow both the fundamental discriminant and the conductor to grow.
Moreover, for fixed fundamental discriminant and variable conductor, we deduce
an effective surjectivity theorem for the reduction map from Heegner points to
supersingular points at a fixed inert prime. Our results are applicable to the
setting considered by Kolyvagin in the construction of the Heegner points Euler
system
On multiplicities in length spectra of arithmetic hyperbolic three-orbifolds
Asymptotic laws for mean multiplicities of lengths of closed geodesics in
arithmetic hyperbolic three-orbifolds are derived. The sharpest results are
obtained for non-compact orbifolds associated with the Bianchi groups SL(2,o)
and some congruence subgroups. Similar results hold for cocompact arithmetic
quaternion groups, if a conjecture on the number of gaps in their length
spectra is true. The results related to the groups above give asymptotic lower
bounds for the mean multiplicities in length spectra of arbitrary arithmetic
hyperbolic three-orbifolds. The investigation of these multiplicities is
motivated by their sensitive effect on the eigenvalue spectrum of the
Laplace-Beltrami operator on a hyperbolic orbifold, which may be interpreted as
the Hamiltonian of a three-dimensional quantum system being strongly chaotic in
the classical limit.Comment: 29 pages, uuencoded ps. Revised version, to appear in NONLINEARIT
What is the potential benefit of pre-hospital extracorporeal cardiopulmonary resuscitation for patients with an out-of-hospital cardiac arrest?:A predictive modelling study
AIM: In this predictive modelling study we aimed to investigate how many patients with an out-of-hospital cardiac arrest (OHCA) would benefit from pre-hospital as opposed to in-hospital initiation of extracorporeal cardiopulmonary resuscitation (ECPR).METHODS: A temporal spatial analysis of Utstein data was performed for all adult patients with a non-traumatic OHCA attended by three emergency medical services (EMS) covering the north of the Netherlands during a one-year period. Patients were considered potentially eligible for ECPR if they had a witnessed arrest with immediate bystander CPR, an initial shockable rhythm (or signs of life during resuscitation) and could be presented in an ECPR-centre within 45 minutes of the arrest. Endpoint of interest was defined as the hypothetical number of ECPR eligible patients after 10, 15 and 20 minutes of conventional CPR and upon (hypothetical) arrival in an ECPR-centre as a fraction of the total number of OHCA patients attended by EMS.RESULTS: During the study period 622 OHCA patients were attended, of which 200 (32%) met ECPR eligibility criteria upon EMS arrival. The optimal transition point between conventional CPR and ECPR was found to be after 15 minutes. Hypothetical intra-arrest transport of all patients in whom no return of spontaneous circulation (ROSC) was obtained after that point (n = 84) would have yielded 16/622 (2.5%) patients being potentially ECPR eligible upon hospital arrival (average low-flow time 52 minutes), whereas on-scene initiation of ECPR would have resulted in 84/622 (13.5%) potential candidates (average estimated low-flow time 24 minutes before cannulation).CONCLUSION: Even in healthcare systems with relatively short transport distances to hospital, consideration should be given to pre-hospital initiation of ECPR for OHCA as it shortens low-flow time and increases the number of potentially eligible patients.</p
Suppression of airway inflammation by Illicium verum and trans-anethole
_Background_
SH2 domain containing inositol-5-phosphatase (SHIP1) is an important modulator of innate
and adaptive immunity. In mice, loss of SHIP1 provokes severe ileitis resembling Crohn's
disease (CD), as a result of deregulated immune responses, altered cytokine production
and intestinal fibrosis. Recently, SHIP1 activity was shown to be correlated to the presence
of a CD-associated single nucleotide polymorphism in ATG16L1. Here, we studied SHIP1
activity and expression in an adult cohort of CD patients.
_Methods_
SHIP1 activity, protein and mRNA expression in peripheral blood mononuclear cells from
CD patients in clinical remission were determined by Malachite green assay, Western blotting
an
A Novel Pzg-NURF Complex Regulates Notch Target Gene Activity
The Putzig (Pzg) protein is associated with the NURF nucleosome remodeling complex, thereby promoting Notch target gene expression. Our findings suggest a novel Pzg-NURF complex that is responsible for the epigenetic regulation of Notch target genes
The Nucleosome-Remodeling ATPase ISWI Is Regulated by Poly-ADP-Ribosylation
ATP-dependent nucleosome-remodeling enzymes and covalent modifiers of chromatin set the functional state of chromatin. However, how these enzymatic activities are coordinated in the nucleus is largely unknown. We found that the evolutionary conserved nucleosome-remodeling ATPase ISWI and the poly-ADP-ribose polymerase PARP genetically interact. We present evidence showing that ISWI is target of poly-ADP-ribosylation. Poly-ADP-ribosylation counteracts ISWI function in vitro and in vivo. Our work suggests that ISWI is a physiological target of PARP and that poly-ADP-ribosylation can be a new, important post-translational modification regulating the activity of ATP-dependent nucleosome remodelers
Stress-Induced PARP Activation Mediates Recruitment of Drosophila Mi-2 to Promote Heat Shock Gene Expression
Eukaryotic cells respond to genomic and environmental stresses, such as DNA damage and heat shock (HS), with the synthesis of poly-[ADP-ribose] (PAR) at specific chromatin regions, such as DNA breaks or HS genes, by PAR polymerases (PARP). Little is known about the role of this modification during cellular stress responses. We show here that the nucleosome remodeler dMi-2 is recruited to active HS genes in a PARP–dependent manner. dMi-2 binds PAR suggesting that this physical interaction is important for recruitment. Indeed, a dMi-2 mutant unable to bind PAR does not localise to active HS loci in vivo. We have identified several dMi-2 regions which bind PAR independently in vitro, including the chromodomains and regions near the N-terminus containing motifs rich in K and R residues. Moreover, upon HS gene activation, dMi-2 associates with nascent HS gene transcripts, and its catalytic activity is required for efficient transcription and co-transcriptional RNA processing. RNA and PAR compete for dMi-2 binding in vitro, suggesting a two step process for dMi-2 association with active HS genes: initial recruitment to the locus via PAR interaction, followed by binding to nascent RNA transcripts. We suggest that stress-induced chromatin PARylation serves to rapidly attract factors that are required for an efficient and timely transcriptional response
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