23 research outputs found

    Conversations with my washing machine: an in-the-wild study of demand-shifting with self-generated energy

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    Domestic microgeneration is the onsite generation of low- and zero-carbon heat and electricity by private households to meet their own needs. In this paper we explore how an everyday household routine – that of doing laundry – can be augmented by digital technologies to help households with photovoltaic solar energy generation to make better use of self-generated energy. This paper presents an 8-month in-the-wild study that involved 18 UK households in longitudinal energy data collection, prototype deployment and participatory data analysis. Through a series of technology interventions mixing energy feedback, proactive suggestions and direct control the study uncovered opportunities, potential rewards and barriers for families to shift energy consuming household activities and highlights how digital technology can act as mediator between household laundry routines and energy demand-shifting behaviors. Finally, the study provides insights into how a “smart” energy-aware washing machine shapes organization of domestic life and how people “communicate” with their washing machine

    An assessment of orofacial clefts in Tanzania

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    <p>Abstract</p> <p>Background</p> <p>Clefts of the lip (CL), the palate (CP), or both (CLP) are the most common orofacial congenital malformations found among live births, accounting for 65% of all head and neck anomalies. The frequency and pattern of orofacial clefts in different parts of the world and among different human groups varies widely. Generally, populations of Asian or Native American origin have the highest prevalence, while Caucasian populations show intermediate prevalence and African populations the lowest. To date, little is known regarding the epidemiology and pattern of orofacial clefts in Tanzania.</p> <p>Methods</p> <p>A retrospective descriptive study was conducted at Bugando Medical Centre to identify all children with orofacial clefts that attended or were treated during a period of five years. Cleft lip and/or palate records were obtained from patient files in the Hospital's Departments of Surgery, Paediatrics and medical records. Age at presentation, sex, region of origin, type and laterality of the cleft were recorded. In addition, presence of associated congenital anomalies or syndromes was recorded.</p> <p>Results</p> <p>A total of 240 orofacial cleft cases were seen during this period. Isolated cleft lip was the most common cleft type followed closely by cleft lip and palate (CLP). This is a departure from the pattern of clefting reported for Caucasian and Asian populations, where CLP or isolated cleft palate is the most common type. The distribution of clefts by side showed a statistically significant preponderance of the left side (43.7%) (χ<sup>2 </sup>= 92.4, p < 0.001), followed by the right (28.8%) and bilateral sides (18.3%). Patients with isolated cleft palate presented at very early age (mean age 1.00 years, SE 0.56). Associated congenital anomalies were observed in 2.8% of all patients with orofacial clefts, and included neural tube defects, Talipes and persistent ductus arteriosus.</p> <p>Conclusions</p> <p>Unilateral orofacial clefts were significantly more common than bilateral clefts; with the left side being the most common affected side. Most of the other findings did not show marked differences with orofacial cleft distributions in other African populations.</p

    Systematic analysis of copy number variants of a large cohort of orofacial cleft patients identifies candidate genes for orofacial clefts

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    De mentale representatie van gewoontegedrag : een reactietijden-analyse

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    Voortbouwend op het idee dat gewoontes mentaal gerepresenteerd zijn, wordt verondersteld dat, naarmate hetzelfde doe lgerichte gedrag vaker in dezelfde situatie wordt vertoond, er geautomatiseerde associaties tussen siruatie en gedrag in het geheugen ontstaan. De activatie van een gedragsdoel is echter een voorwaarde om deze associaties re achterhalen. Deze gedachte werd in een experiment onderzochr voor fietsgebruik onder studenren. Gevonden werd dat, wanneer voorafeen verplaatsingsdoel (bijv. college gaan volgen) geactiveerd wordt, bij sterke fietsgewoonte de fiers sneller geassocieerd wordt met reislocaties (buy. universiteit) dan bij zwakke gewoonte. Dit verschil werd niet gevonden wanneer geen verplaatsingsdoel werd geactiveerd

    The influence of phenobarbital and butylated hydroxytoluene on the ploidy rate in rat hepatocarcinogenesis

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    The effect of the 'promoters' phenobarbital (PB) and butylated hydroxytoluene (BHT) on the ploidy changes during hepatocarcinogenesis in rats was compared in a densitometric analysis of Feulgen-stained nuclei on paraffin-embedded tissue slices. The triphasic Gerlans protocol for liver-cancer induction was applied. Initiation with a single dose of diethylnitrosamine (DEN), and selection with 2-acetylamino-fluorene (2-AAF) combined with a proliferative stimulus (CCl4 administration), was followed by a treatment with PB or BHT for periods up to 22 weeks. Control animals received no treatment after the initiation and selection procedure. Despite intra- and inter-individual variations, an increase in the amount of 2N nuclei is found in the putative preneoplastic lesions of animals that received initiation and selection (I-S) and 3 weeks basal diet (BD). When the diet is supplemented with PB (after I-S), the increase of diploid nuclei starts earlier. At the time carcinoma arise (22 weeks PB treatment) a decrease in the frequency of 2N nuclei is found. BHT-treated animals which develop no carcinoma within the considered timespan, show a clear increased amount of 2N nuclei in the precancerous lesions only after 14 weeks treatment. It seems that there is a positive correlation between the outgrowth of putative preneoplastic foci and nodules in rat liver and an increase of diploid nuclei in these lesions. PB, as promoter used after initiation and selection, speeds up the development of carcinoma in rat liver, and therefore also the shift to diploidization in these rats starts earlier in comparison with I-S-treated rats. Although BHT does not promote liver carcinogenesis, an increase of diploid nuclei is also observed here during lesion formation. It may, therefore, be concluded that the phenomenon of diploidization is closely linked to and probably necessary for preneoplastic development, but that it is not an absolute indicator for neoplastic transformation

    De mentale representatie van gewoontegedrag : een reactietijden-analyse

    No full text
    Voortbouwend op het idee dat gewoontes mentaal gerepresenteerd zijn, wordt verondersteld dat, naarmate hetzelfde doe lgerichte gedrag vaker in dezelfde situatie wordt vertoond, er geautomatiseerde associaties tussen siruatie en gedrag in het geheugen ontstaan. De activatie van een gedragsdoel is echter een voorwaarde om deze associaties re achterhalen. Deze gedachte werd in een experiment onderzochr voor fietsgebruik onder studenren. Gevonden werd dat, wanneer voorafeen verplaatsingsdoel (bijv. college gaan volgen) geactiveerd wordt, bij sterke fietsgewoonte de fiers sneller geassocieerd wordt met reislocaties (buy. universiteit) dan bij zwakke gewoonte. Dit verschil werd niet gevonden wanneer geen verplaatsingsdoel werd geactiveerd
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