The increasing importance of economic conditions on fertility

This paper investigates whether there has been a fundamental change in the importance of economic conditions on fertility. Through the 1980s econometric studies had found at best a mixed, neutral or negative effect of economic conditions on fertility. Notably, Butz and Ward (1979) concluded that fertility was counter-cyclical, with fertility falling in good times, as the opportunity costs of childbearing rose. More recently, there have been signs that fluctuations in fertility have been pro-cyclical, with good economic times being associated with higher birth rates, and the recent recession with lower birth rates. In this paper, we use panel methods to study short term changes in aggregate fertility and economic measures in OECD countries from 1976-2008. We find indeed that fertility became positively associated with good economic conditions. Furthermore, the increasing importance of economic conditions was detected for both tempo and quantum.economic conditions, total fertility rate

A case of tinea incognito mimicking subcorneal pustular dermatosis

An 89-year-old woman presented with plaque-like lesions, accompanied with pustules and desquamation on the back and front of the trunk for approximately one year. Long term use of potent topical corticosteroids was ineffective. Because of the chronicity of her condition, the diagnoses of subcorneal dermatosis or subcorneal pustular dermatosis type of IgA pemphigus were considered. However, fungal hyphae were observed in the potassium hydroxide examination. Therefore, we present this case since this clinical appearance of tinea incognito can also mimic various pustular dermatoses

Survival, Quality of Life and Effects of Enzyme Replacement Therapy in Adults with Pompe Disease

Pompe disease, or glycogen storage disorder type II, is a rare inherited metabolic disorder caused by deficiency of the lysosomal enzyme acid α-glucosidase. This results in accumulation of glycogen in cells throughout the body, particularly muscle cells. The disease presents with (progressive) muscle weakness and can hence be categorized as a lysosomal storage disorder, a glycogen storage disorder and also a neuromuscular disorder. Pompe disease was the first neuromuscular disorder for which treatment became available, and the development of enzyme replacement therapy for Pompe disease has played a fundamental role in the development of therapies for other rare diseases including neuromuscular and lysosomal storage disorders. This introductory chapter reviews the history, pathophysiology and clinical characteristics of Pompe disease and provides an overview on the effects of enzyme replacement therapy

Relationships between land use and nitrogen and phosphorus in New Zealand lakes

Developing policies to address lake eutrophication requires an understanding of the relative contribution of different nutrient sources and of how lake and catchment characteristics interact to mediate the source–receptor pathway. We analysed total nitrogen (TN) and total phosphorus (TP) data for 101 New Zealand lakes and related these to land use and edaphic sources of phosphorus (P). We then analysed a sub-sample of lakes in agricultural catchments to investigate how lake and catchment variables influence the relationship between land use and in-lake nutrients. Following correction for the effect of co-variation amongst predictor variables, high producing grassland (intensive pasture) was the best predictor of TN and TP, accounting for 38.6% and 41.0% of variation, respectively. Exotic forestry and urban area accounted for a further 18.8% and 3.6% of variation in TP and TN, respectively. Soil P (representing naturally-occurring edaphic P) was negatively correlated with TP, owing to the confounding effect of pastoral land use. Lake and catchment morphology (zmax and lake : catchment area) and catchment connectivity (lake order) mediated the relationship between intensive pasture and in-lake nutrients. Mitigating eutrophication in New Zealand lakes requires action to reduce nutrient export from intensive pasture and quantifying P export from plantation forestry requires further consideration

Velocity Correlations in Dense Gravity Driven Granular Chute Flow

We report numerical results for velocity correlations in dense, gravity-driven granular flow down an inclined plane. For the grains on the surface layer, our results are consistent with experimental measurements reported by Pouliquen. We show that the correlation structure within planes parallel to the surface persists in the bulk. The two-point velocity correlation function exhibits exponential decay for small to intermediate values of the separation between spheres. The correlation lengths identified by exponential fits to the data show nontrivial dependence on the averaging time \dt used to determine grain velocities. We discuss the correlation length dependence on averaging time, incline angle, pile height, depth of the layer, system size and grain stiffness, and relate the results to other length scales associated with the rheology of the system. We find that correlation lengths are typically quite small, of the order of a particle diameter, and increase approximately logarithmically with a minimum pile height for which flow is possible, \hstop, contrary to the theoretical expectation of a proportional relationship between the two length scales.Comment: 21 pages, 16 figure

Quantum Simulator Based on the Paraxial Wave Equation

We propose a paraxial quantum simulator that requires only widely available optical fibers or metamaterials. Such a simulator would facilitate cost-effective quantum simulation without specialized techniques. We show theoretically that the method accurately simulates quantum dynamics and quantum effects for an example system, which invites extension of the method to many-body systems using nonlinear optical elements and implementation of the paraxial quantum simulator to extend access to quantum computation and prototype quantum parity-time reversal ($\mathcal{PT}$) symmetric technologies

Model Continuity in Discrete Event Simulation: A Framework for Model-Driven Development of Simulation Models.

Most of the well known modeling and simulation methodologies state the importance of conceptual modeling in simulation studies and they suggest the use of conceptual models during the simulation model development process. However, only a limited number of methodologies refers to howto move from a conceptual model to an executable simulation model. Besides, existing modeling and simulation methodologies do not typically provide a formal method for model transformations between the models in different stages of the development process. Hence, in the current M&S practice, model continuity is usually not fulfilled. In this article, a model driven development framework for modeling and simulation is in order to bridge the gap between different stages of a simulation study and to obtain model continuity. The applicability of the framework is illustrated with a prototype modeling environment and a case study in the discrete event simulation domain

Statistics of Largest Loops in a Random Walk

We report further findings on the size distribution of the largest neutral segments in a sequence of N randomly charged monomers [D. Ertas and Y. Kantor, Phys. Rev. E53, 846 (1996); cond-mat/9507005]. Upon mapping to one--dimensional random walks (RWs), this corresponds to finding the probability distribution for the size L of the largest segment that returns to its starting position in an N--step RW. We primarily focus on the large N, \ell = L/N << 1 limit, which exhibits an essential singularity. We establish analytical upper and lower bounds on the probability distribution, and numerically probe the distribution down to \ell \approx 0.04 (corresponding to probabilities as low as 10^{-15}) using a recursive Monte Carlo algorithm. We also investigate the possibility of singularities at \ell=1/k for integer k.Comment: 5 pages and 4 eps figures, requires RevTeX, epsf and multicol. Postscript file also available at http://cmtw.harvard.edu/~deniz/publications.htm