Job Sharing among Elementary School Teachers

The practice of job sharing, in which two teachers share the responsibilities of one teacher, is described. A comprehensive review of related literature is presented. Perceptions of those directly affected by the practice in one school district were gathered through 70 structured interviews with elementary principals, job sharing teachers, full-time teacher colleagues, students in job sharing classrooms, and parents. The study reveals predominantly positive reactions to the practice, and supports continuation of job sharing as an employment option for teachers

A comparison of physical activity, physical fitness levels, BMI, and blood pressure of adults with intellectual disability, who do and do not take part in Special Olympics Ireland programmes.

Background: It has been reported in the literature that people with an intellectual disability (ID) are less physically active, live more sedentary lives, have lower fitness levels and are more likely to be overweight or obese than the general population. Nine thousand people with ID are participating in Special Olympics Ireland (SOI). To date, no evidence exists on the impact of SOI participation on physical activity (PA) and physical fitness levels of adults with ID’s in Ireland. Methods: Adults with ID (16-64 years) were recruited from 4 ID services and SOI clubs throughout Ireland (n=146, male 85, female 61). Both SOI participants and non SOI participants were invited to participate. Physical measures included waist circumference, height, weight, blood pressure, heart rate and the Six Minute Walking Test. Self-report questionnaires were administered to study participants to gather data on PA levels. To get an objective measure of PA, participants were asked to wear an Actigraph (GT3X) accelerometer for seven consecutive days. Results: Self-report data suggests SOI participants accumulated significantly more mean minutes moderate to vigorous physical activity (MVPA) daily than non-SOI participants (p = .002). SOI participants also recorded more minutes of accelerometer measured MVPA on average daily than non-SOI participants, however differences were not statistically significant. Significantly greater distances were walked in the Six Minute Walk test by SOI participants compared to non-SOI participants (p = .000), and those in SOI had a significantly more positive health profile score than those not in SOI (p = .013). Conclusion: Participants in SOI accumulated significantly more minutes of MVPA per day, had higher fitness levels, and more positive health profile scores than non-SOI participants. SOI has the potential to make a positive difference to people’s physical health and subsequently their overall health and wellbeing

Nucleotide bias of DCL and AGO in plant anti-virus gene silencing

Plant Dicer-like (DCL) and Argonaute (AGO) are the key enzymes involved in anti-virus post-transcriptional gene silencing (AV-PTGS). Here we show that AV-PTGS exhibited nucleotide preference by calculating a relative AV-PTGS efficiency on processing viral RNA substrates. In comparison with genome sequences of dicot-infecting Turnip mosaic virus (TuMV) and monocot-infecting Cocksfoot streak virus (CSV), viral-derived small interfering RNAs (vsiRNAs) displayed positive correlations between AV-PTGS efficiency and G+C content (GC%). Further investigations on nucleotide contents revealed that the vsiRNA populations had G-biases. This finding was further supported by our analyses of previously reported vsiRNA populations in diverse plant-virus associations, and AGO associated Arabidopsis endogenous siRNA populations, indicating that plant AGOs operated with G-preference. We further propose a hypothesis that AV-PTGS imposes selection pressure(s) on the evolution of plant viruses. This hypothesis was supported when potyvirus genomes were analysed for evidence of GC elimination, suggesting that plant virus evolution to have low GC% genomes would have a unique function, which is to reduce the host AV-PTGS attack during infections

“Babies come when they are ready”: Women’s experiences of resisting the medicalisation of prolonged pregnancy

Being pregnant beyond one’s estimated due date is a relatively common experience and requires complex decisions about whether to induce labour or wait for spontaneous onset. We report a qualitative study undertaken in the UK in 2016. We interviewed fifteen women and eleven more took part in an online focus group. Using thematic analysis, resistance to the medicalisation of prolonged pregnancy was identified as a strong theme. Drawing on the work of Armstrong and Murphy (2011), we identify both conceptual and behavioural resistance in the accounts of women who accepted, delayed or declined induction of labour. Experiential knowledge played a key role in resistance, but women found this was devalued. Some healthcare staff used risk discourse to pressure women to comply with induction protocols but were unwilling to engage in discussion. The social context provided further pressure to produce a baby ‘on time’, with induction normalised as the way to manage prolonged pregnancy. Online spaces provided additional information and support for women to question the medicalisation of prolonged pregnancy. We end by considering the implications for policies of choice and agency in maternity care as well as the need for additional social support for women who are ‘overdue’

“Babies come when they are ready”: women’s experiences of resisting the medicalisation of prolonged pregnancy

Being pregnant beyond one’s estimated due date is a relatively common experience and requires complex decisions about whether to induce labour or wait for spontaneous onset. We report a qualitative study undertaken in the UK in 2016. We interviewed fifteen women and eleven more took part in an online focus group. Using thematic analysis, resistance to the medicalisation of prolonged pregnancy was identified as a strong theme. Drawing on the work of Armstrong and Murphy (2011), we identify both conceptual and behavioural resistance in the accounts of women who accepted, delayed or declined induction of labour. Experiential knowledge played a key role in resistance, but women found this was devalued. Some healthcare staff used risk discourse to pressure women to comply with induction protocols but were unwilling to engage in discussion. The social context provided further pressure to produce a baby ‘on time’, with induction normalised as the way to manage prolonged pregnancy. Online spaces provided additional information and support for women to question the medicalisation of prolonged pregnancy. We end by considering the implications for policies of choice and agency in maternity care as well as the need for additional social support for women who are ‘overdue’

Anti-Cancer Activity and Mutagenic Potential of Novel Copper (II) Quinolinone Schiff Base Complexes in Hepatocarinoma Cells

This study determined the cytotoxic, cyto-selective and mutagenic potential of novel quinolinone Schiff base ligands and their corresponding copper(II) complexes in human-derived hepatic carcinoma cells (Hep-G2) and non-malignant human-derived hepatic cells (Chang). Results indicated that complexation of quinolinone Schiff bases with copper served to significantly enhance cytotoxicity. Here, the complex of (7E)-7-(3-ethoxy-2-hydroxybenzylideamino)-4-methylquinolin-2(1H)-one (TV117-FM) exhibited the lowest IC50 value (17.9 μM) following 96 h continuous exposure, which was comparable to cisplatin (15.0 μM). However, results revealed that TV117-FM lacked cytoselectivity over non-malignant cells. Additionally, the complex was minimally effluxed from cells via Pglycoprotein (P-gp) and was shown to be non-mutagenic in the Standard Ames test. Furthermore, BrdU incorporation assays showed that it was capable of inhibiting DNA synthesis in a concentrationand time-dependent manner. However, inhibition was not as a consequence of DNA intercalation, as illustrated in electrophoretic mobility shift assays. Interestingly, it was shown that the ligand was capable of inhibiting the action of topoisomerase II, but this was lost following complexation. This indicated that the mechanism of action of the novel copper(II) complex was different from that of the parent ligand and suggests that TV117-FM may have a therapeutic role to play in the treatment of hepatocellular carcinoma. Studies are currently underway to elucidate the exact in vitro mechanism of action of this novel, metal-based anti-cancer agent

Increasing the Civic and Political Participation of Women (2017)

In 2016, USAID's Center of Excellence on Democracy, Human Rights, and Governance launched its Learning Agenda—a set of research questions designed to address the issues that confront staff in USAID field offices working on the intersection of development and democracy, human rights, and governance. This literature review—produced by a team of UVA professors and graduate students representing the academic disciplines of anthropology, history, political science, religious studies, and sociology—synthesizes scholarship from diverse research traditions on the following Learning Agenda question:What are the most effective ways to encourage women's civic (e.g., volunteer, advocacy, etc.) and political (e.g., voting, running for office) participation? What are the risks to women of these strategies in contexts where resistance to changing gender norms is strong?Building on an ODI report, "Women's Voice and Leadership in Decision-Making: Assessing the Evidence" (2015) that identified seven strategies to support women's civic and political representation, the UVA team focused on the second half of the research question, using a flexible systematic review process that included defining and operationalizing strong resistance. Overall, the team found that 1) research on resistance that aims to limit or end challenges to the status quo is under-theorized and in need of concept-building before researchers can make the analytical distinctions necessary to assess resistance fully and 2) where the literature does exist, it has an almost exclusive focus on female politicians.With these limitations in mind, key findings include:Resistance—which may include physical and sexual violence; social and familial censure; ostracization by the religious community; and various overt or subtle forms of restriction, deprivation, and exclusion—varies according to multiple factors, including by not limited to gender norms, the broader cultural context, regime type, local power structures, economic opportunities, and the form of participation sought.All women do not experience the same levels of risk, and are not vulnerable to the same types of resistance. For example, even within a single socio-cultural context, women who are marginalized (economically, racially, linguistically, religiously, or otherwise) are likely to bear greater burdens of risk.Strong resistance in response to the seven strategies identified in the ODI report is not pervasive but does occur, and that it can discourage women's participation.Low to moderate resistance is ubiquitous, but generally has less deleterious effects.Sites where strong resistance occurs vary within countries and even among local areas within a single country, suggesting that a country-level analysis of gender norms is inadequate and ineffective for assessing and understanding women's risk of strong resistance.The implications of these findings are that practitioner risk assessments should be:Routine and done prior to engaging in any intervention, and require information extending far beyond local gender norms.Focused on low to moderate forms of resistance in situations of backlash, and attentive to the possibility of strong resistance in situations of entrenched resistance.Designed for the specific site where the intervention occurs, while remaining attentive to national- and individual-level factors that shape resistance

“Babies come when they are ready”: women’s experiences of resisting the medicalisation of prolonged pregnancy

Being pregnant beyond one’s estimated due date is a relatively common experience and requires complex decisions about whether to induce labour or wait for spontaneous onset. We report a qualitative study undertaken in the UK in 2016. We interviewed fifteen women and eleven more took part in an online focus group. Using thematic analysis, resistance to the medicalisation of prolonged pregnancy was identified as a strong theme. Drawing on the work of Armstrong and Murphy (2011), we identify both conceptual and behavioural resistance in the accounts of women who accepted, delayed or declined induction of labour. Experiential knowledge played a key role in resistance, but women found this was devalued. Some healthcare staff used risk discourse to pressure women to comply with induction protocols but were unwilling to engage in discussion. The social context provided further pressure to produce a baby ‘on time’, with induction normalised as the way to manage prolonged pregnancy. Online spaces provided additional information and support for women to question the medicalisation of prolonged pregnancy. We end by considering the implications for policies of choice and agency in maternity care as well as the need for additional social support for women who are ‘overdue’