Centre d’anthropologie sociale – CAS

Jean-Pierre Albert, directeur d’étudesAnne Bouchy, directrice d’études à l’EFEO La part du rite dans les attitudes religieuses contemporaines. Orthopraxie, réinterprétations, adaptations, sécularisation Avec Marlène Albert-Llorca, Alain Ballabriga, Anny Bloch-Raymond, Marine Carrin, Patrizia Ciambelli, Jean-Louis Ormières, Valérie Robin, Guillaume Rozenberg, Harald Tambs-Lyche, Sébastien Tank-Storper, Claudine Vassas. Pour sa première année, le séminaire a été consacré à une réflexion de fond..

Centre d’anthropologie sociale – CAS

Jean-Pierre Albert, directeur d’étudesAnne Bouchy, directrice d’études à l’EFEO La part du rite dans les attitudes religieuses contemporaines. Orthopraxie, réinterprétations, adaptations, sécularisation Avec Marlène Albert-Llorca, Alain Ballabriga, Anny Bloch-Raymond, Marine Carrin, Patrizia Ciambelli, Jean-Louis Ormières, Valérie Robin, Guillaume Rozenberg, Harald Tambs-Lyche, Sébastien Tank-Storper, Claudine Vassas. Pour sa seconde année, le séminaire a continué d’explorer quelques-uns des ..

Centre d’anthropologie sociale – CAS

Jean-Pierre Albert, directeur d’étudesAnne Bouchy, directrice d’études à l’EFEO La mort et les religions. Études comparatives Avec Marlène Albert-Llorca, Alain Ballabriga, Anny Bloch-Raymond, Marine Carrin, Patrizia Ciambelli, Jean-Louis Ormières, Valérle Robin, Guillaume Rozenberg, Harald Tambs-Lyche, Sébastien Tank-Storper, Claudine Vassas. Les séances ont été centrées sur le thème « Mort, religion et politique », avec deux orientations principales : Les enjeux des rites funéraires et de la..

О становлении трансплантологии в Украине: юридические аспекты

Рассмотрены основные аспекты развития трансплантологии, их положительное и отрицательное влияние на прогресс пересадки органов в странах с различным уровнем развития демократических принципов. Показано значение юридических проблем в развитии клинической и экспериментальной трансплантологии.Main aspects of transplantology development, their favorable and unfavorable influence on the process of organ transplantation in the countries with different level of democracy are featured. Significance of legal problems in clinical and experimental transplantology is shown

Centre d’anthropologie sociale – CAS

Jean-Pierre Albert, directeur d’étudesAnne Bouchy, directrice d’études à l’EFEO La mort et les religions. Études comparatives Avec Marlène Albert-Llorca, Alain Ballabriga, Anny Bloch-Raymond, Marine Carrin, Patrizia Ciambelli, Jean-Louis Ormières, Valérle Robin, Guillaume Rozenberg, Harald Tambs-Lyche, Sébastien Tank-Storper, Claudine Vassas. Les séances ont été centrées sur le thème « Mort, religion et politique », avec deux orientations principales : Les enjeux des rites funéraires et de la..

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.

We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 × 10-7); of these, 16 map outside known risk-associated loci. We make two important observations. First, only five of these signals are driven by low-frequency variants: even for these, effect sizes are modest (odds ratio ≤1.29). Second, when we used large-scale genome-wide association data to fine-map the associated variants in their regional context, accounting for the global enrichment of complex trait associations in coding sequence, compelling evidence for coding variant causality was obtained for only 16 signals. At 13 others, the associated coding variants clearly represent 'false leads' with potential to generate erroneous mechanistic inference. Coding variant associations offer a direct route to biological insight for complex diseases and identification of validated therapeutic targets; however, appropriate mechanistic inference requires careful specification of their causal contribution to disease predisposition

Meta-analysis of genome-wide association studies of HDL cholesterol response to statins

BACKGROUND: In addition to lowering low density lipoprotein cholesterol (LDL-C), statin therapy also raises high density lipoprotein cholesterol (HDL-C) levels. Inter-individual variation in HDL-C response to statins may be partially explained by genetic variation.METHODS AND RESULTS: We performed a meta-analysis of genome-wide association studies (GWAS) to identify variants with an effect on statin-induced high density lipoprotein cholesterol (HDL-C) changes. The 123 most promising signals with p&lt;1×10(-4) from the 16 769 statin-treated participants in the first analysis stage were followed up in an independent group of 10 951 statin-treated individuals, providing a total sample size of 27 720 individuals. The only associations of genome-wide significance (p&lt;5×10(-8)) were between minor alleles at the CETP locus and greater HDL-C response to statin treatment.CONCLUSIONS: Based on results from this study that included a relatively large sample size, we suggest that CETP may be the only detectable locus with common genetic variants that influence HDL-C response to statins substantially in individuals of European descent. Although CETP is known to be associated with HDL-C, we provide evidence that this pharmacogenetic effect is independent of its association with baseline HDL-C levels.</p