A Study to Optimize Heterogeneous Resources for Open IoT

Recently, IoT technologies have been progressed, and many sensors and actuators are connected to networks. Previously, IoT services were developed by vertical integration style. But now Open IoT concept has attracted attentions which achieves various IoT services by integrating horizontal separated devices and services. For Open IoT era, we have proposed the Tacit Computing technology to discover the devices with necessary data for users on demand and use them dynamically. We also implemented elemental technologies of Tacit Computing. In this paper, we propose three layers optimizations to reduce operation cost and improve performance of Tacit computing service, in order to make as a continuous service of discovered devices by Tacit Computing. In optimization process, appropriate function allocation or offloading specific functions are calculated on device, network and cloud layer before full-scale operation.Comment: 3 pages, 1 figure, 2017 Fifth International Symposium on Computing and Networking (CANDAR2017), Nov. 201

新規ホスホジエステラーゼ4阻害剤TAS-203の薬理学的作用に関する研究

首都大学東

Helical Foldamers and Stapled Peptides as New Modalities in Drug Discovery: Modulators of Protein-Protein Interactions

A "foldamer" is an artificial oligomeric molecule with a regular secondary or tertiary structure consisting of various building blocks. A "stapled peptide" is a peptide with stabilized secondary structures, in particular, helical structures by intramolecular covalent side-chain cross-linking. Helical foldamers and stapled peptides are potential drug candidates that can target protein-protein interactions because they enable multipoint molecular recognition, which is difficult to achieve with low-molecular-weight compounds. This mini-review describes a variety of peptide-based foldamers and stapled peptides with a view to their applications in drug discovery, including our recent progress

Control of STING Agonistic/Antagonistic Activity Using Amine-Skeleton-Based c-di-GMP Analogues

Stimulator of Interferon Genes (STING) is a type of endoplasmic reticulum (ER)-membrane receptor. STING is activated by a ligand binding, which leads to an enhancement of the immune-system response. Therefore, a STING ligand can be used to regulate the immune system in therapeutic strategies. However, the natural (or native) STING ligand, cyclic-di-nucleotide (CDN), is unsuitable for pharmaceutical use because of its susceptibility to degradation by enzymes and its low cell-membrane permeability. In this study, we designed and synthesized CDN derivatives by replacing the sugar-phosphodiester moiety, which is responsible for various problems of natural CDNs, with an amine skeleton. As a result, we identified novel STING ligands that activate or inhibit STING. The cyclic ligand 7, with a cyclic amine structure containing two guanines, was found to have agonistic activity, whereas the linear ligand 12 showed antagonistic activity. In addition, these synthetic ligands were more chemically stable than the natural ligands

Medical Application of Nonwoven Fabrics - Intra-abdominal Spacers for Particle Therapy

The authors aimed to introduce a medical application for nonwoven fabric as spacers in particle therapy. Particle therapy, exhibiting more focused effects on target tissues, has emerged as a promising treatment modality. However, close proximity of tumor tissue and adjacent organs makes delivery of curative doses to the tumor difficult because severe radiation morbidities might occur. A method using surgically placed GORE-TEX sheets as a spacer has been reported. Although this method provides for separation of adjacent organs, the material is not resorbed. To overcome these anatomical and therapeutic difficulties, and to deliver effective radiation doses to treat upper abdominal tumors, we have developed a nonwoven fabric spacer composed of bioabsorbable suture material. The absorbable polyglycolic acid (PGA) spacer had water-equivalent, biocompatible, and thickness-retaining properties. Although further evaluation is warranted in a clinical setting, the PGA spacer may be effective to block particle beams and to separate normal tissues from the radiation field. These findings suggest that the nonwoven-fabric PGA spacer might become a useful device in particle therapy

国産二輪車の誕生から100年、最強の二輪車国となって50年 : 先駆者・島津楢蔵と戦後二輪車のイノベーション

Few people knows the fact that the first home-manufactured motorcycle with gasoline engine was produced by Narazo Shimazu in 1909. On the first part of this paper, I explain how N. Shimazu developed his gasoline engine from the technical point of view. The procedure of producing motorcycles, cyclecars, airplanes is discussed, introducing several episodes how he sometimes failed as a pioneer. I discuss N. Shimazu as a pioneer and as an owner of an automobile school and factory of motorcycles. After he became an engineer in a company, he began the study of combustion chamber. The first home-manufactured motorcycle was produced a century ago. Then a lot of small companies began to produce motorcycles. They were too small scale companies to call them industry. On the second part of this paper, motorcycle industry after the world war II is discussed. The innovation of motorcycle technology occurred from 1950\u27s to 1960\u27s. Then the motorcycle industry in Japan became the strongest in the world. I discussed case studies of Honda motor and Ymaha motor in Japan

アメリカ市場拡大に向けた大型二輪車の商品化 : ホンダとカワサキにおける大型二輪車の漸進的イノベーション

Japanese manufacturers started exporting the motorcycles to American market in the early 1960\u27s and won the market from small motorcycles of Europe in the middle of 1960\u27s. Then Japanese manufacturers developed the large-scale motorcycles and dominated the market in the beginning of the 1970\u27s. Motorcycle production became the strongest industry of which Japan boasted. In this paper the processes of technological development of the large-scale motorcycles produced by Honda and Kawasaki are discussed. Technical domination of Japan at the motorcycle market had been steady for twenty years, but Harley, the USA manufacturer regained lost market in the after 1990\u27s, and has been dominating the large-scale market motorcycle not only in the United States but also in Japan. The success of Harley depends on the lifestyle marketing. They sell motorcycles matched well with lifestyle and culture. However, Japanese manufacturers such as HONDA hold a dominant position in the world for their high-quality mass production system and high technology