Risk of Malnutrition and Its Effects on the Quality of Life of Hospitalized Cancer Patients

Aim:Malnutrition is one of the most common clinical problems in cancer patients. Its frequency increases in hospitalized cancer patients. In this study, it was aimed to investigate the frequency of malnutrition and its effect on quality of life (QOL) in hospitalized cancer patients.Materials and Methods:In this cross-sectional study, Nutrition Risk Screening-2002 (NRS-2002) and European Organization for the Research and Treatment of Cancer (EORTC)-QLQ C30 scales were completed for patients with cancer diagnosed in the medical oncology service. The relationship between clinical and laboratory parameters, malnutrition risk and QOL was analyzed by statistical methods.Results:One-hundred thirteen patients were included in the study. According to the results of NRS-2002, 42.5% (n=48) patients were at risk of malnutrition. There was no difference between the groups in terms of gender and age. When the EORTC-QLQ C30 scale scores were compared, the risk of malnutrition had no effect on the overall health score (p=0.679). Physical function and role function scores were significantly lower in those at risk of malnutrition (worse QOL). There was no statistically significant difference between the groups in terms of other functional scales. When univariate logistic regression (LR) was applied to the factors affecting better general health score, only hemoglobin level was found to be a significant factor. Therefore, multivariate LR was not done.Conclusion:Malnutrition risk assessment should be performed routinely in every hospitalized cancer patient. Early nutritional support should be given to patients at risk. It was observed that patients with malnutrition risk had worse QOL compared to the EORTC-QLQ C30 scale

Astronomide yaygin öğrenim arayişlari ve meyvesi beyaz cüce

Executing Expansive Learning, which means learning without any schedule, place or intructor, has confused every astronomers' mind. For us, as the students of different universities and perspectives, it was confusing how to share our knowledge and experience. The astronomy students who met at the 4th National Astronomy Student Congress in 2006, started a solution based on share of knowledge and experience. This report tells us the story of Beyaz Cüce workgroup which created as a result of sharing the knowledge and ideas.peer-reviewe

Tabu #1 : bilimsel makale yazmak çok zordur(!)

Target Group: Undergraduate student who has never made a scientific research, especially Astronomy students. Objective: To show this group, making a scientific research and resulting it is not much difficult. Method: Making a research on practical, and writing an article. Result: Young scientists who trust themselves, can make a scientific research, made a few support to the Oceon of Science.peer-reviewe

Kuramsal Anlamda Yönetim ve Strateji

Türkiye’nin Karadeniz’de tarihinin en büyük doğal gaz keşfinin ardından net doğal gaz ihracatçısı olmasına yetecek doğal gazı keşfetmesi ihtimaline dair bir gelecek öngörüsü sunmak amacıyla hazırlanan çalışma dünya doğal gaz piyasasını talep temelli inceleyerek doğal gaz pazarının 2019 yılındaki durumunu özetlemeyi hedeflemektedir. Bununla beraber çalışmada, doğal gazın taşınması için kullanılan denizyolu LNG taşımacılığı ve boru hattı taşımacılığını ayırt edici hale getirilmeye çalışılmıştır. Araştırma neticesinde elde edilen verilerden hareketle de tartışma bölümünde Türkiye’nin doğal gaz ihracatı için hangi pazarlara hangi taşımacılık yöntemiyle ulaşabileceği ve muhtemel uluslararası işbirliği ihtimalleri derlenmeye çalışılmıştır

Radiosensitization of HER2-positive breast cancer cell lines with trastuzumab

49th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO) -- MAY 31-JUN 04, 2013 -- Chicago, ILWOS: 000335419603139Amer Soc Clin Onco

Antibacterial Activities and Composition of the Essential Oils of Salvia sericeo-tomentosa Varieties

The essential oil compositions and antimicrobial activities of two varieties of a new endemic Salvia species growing in Turkey were compared. The essential oils (EOs) were obtained from the aerial parts by hydrodistillation and were analysed by gas chromatography (GC), and gas chromatography-mass spectrometry (GC-MS). The major constituents of essential oils were sabinyl acetate (79.9 - 80.1 %) and alpha-pinene (3.2 - 3.8 %) in both varieties. Such high sabinyl acetate content of an essential oil of a Salvia species has not been reported hitherto. The essential oil of Salvia sericeo-tomentosa var. sericeo-tomentosa (ST) (having MIC/MBC values of 0.3/1.25 mg/mL) showed better activity than the essential oil of Salvia sericeo-tomentosa var. hatayica (SH) (having MIC/MBC values of 0.6/1.25 mg/mL) especially against Staphylococcus aureus and Bacillus subtilis. The ST and SH have exhibited significant antimicrobial activity against Escherichia coli and, methicillin-resistant S. aureus (MRSA). Whereas only modest antimicrobial activity has been observed against Pseudomonas aeruginosa, and any activity against Enterococcus faecalis, Proteus mirabilis and Klebsiella pneumoniae

The relationship between eGFR and capecitabine efficacy/toxicity in metastatic breast cancer

The objective of this study was to evaluate the efficacy and toxicity of capecitabine in metastatic breast cancer (mBC) according to the estimated glomerular filtration rate (eGFR). A total of 135 patients included in the final analysis were stratified into 3 categories according to baseline eGFR, i.e., eGFR 90 mL/min/1.73 m(2) (Group 3). If a patient developed a level of toxicity that would lead to capecitabine dose reduction, this was recognized as dose-limiting toxicity (DLT). The dose was reduced due to toxicity in 95 cycles. A total of 95 DLTs were seen in 76 (56.2%) of the 135 patients. When 76 patients with DLT were evaluated according to eGFR, DLT was observed in 93.3% of those in Group 1, 72.5% of those in Group 2 and 41.3% of those in Group 3 (p < 0.001). The median time to progression (TTP) of all patients was 7.4 months. No significant difference in TTP was observed in patients stratified into 3 groups according to eGFR. When the patients were divided into two groups as DLT and without DLT, the median TTP was 8.68 months (95% CI, 7.53-9.81 months) in those with toxicity and 6.23 months (95% CI, 4.04-8.43 months) in those without toxicity (log-rank p = 0.004). We found a significant relationship between low eGFR and increased risk of DLT. Having a DLT was associated with a longer TTP. It indicates the need for more data/larger study investigating these discrepancies

Antimycobacterial and Antifungal Activities of Selected Four Salvia Species

The content of essential oils of endemic Salvia cilicica was analyzed by GC-FID and GC-MS techniques. Spathulenol (23.8 %), caryophyllene oxide (14.9 %) and hexadecanoic acid (10.3 %) were identified as the major components in the oil of Salvia cilicica. Additionally, in this study ethanol extracts of the aerial parts and essential oils of four Salvia species ( S. cilicica, S. officinalis, S. fruticosa, S. tomentosa ) , as well as the roots of S. cilicica were investigated their antimycobacterial and antifungal activities including infectious diseases. The antimycobacterial activity was analyzed against three Mycobacterium tuberculosis (sensitive-, resistant-standard strains and multidrug resistance clinical isolate) strains and the antifungal activity was compared with two dermotophytes (Microsporum gypseum and Trichophyton mentagrophytes var. erinacei) and three Candida species by the broth microdilution method. The essentials oils of the four tested Salvia species showed high antimycobacterial and antifungal activity (MIC between 0.2-12.5 mcg/mL) in comparison to the aerial parts and root extracts . The antifungal and antimycobacterial potential of the ethanol extracts and essential oils were introduced to determine whether, Salvia species can be used in phytotherapy against the yeasts, dermatophytes and M. tuberculosis. To the best of our knowledge this is the first study of S. cilicica about their antimycobacterial and antifungal activities and chemical composition of its essential oils

Real-life comparison of afatinib and erlotinib in non-small cell lung cancer with rare EGFR exon 18 and exon 20 mutations: a Turkish Oncology Group (TOG) study

Objectives To compare the survival of first- and second-generation tyrosine kinase inhibitors (TKIs) in patients with rare EGFR exon 18 and exon 20 mutation-positive non-small cell lung cancer (NSCLC). Materials and methods We retrospectively evaluated survival characteristics of 125 patients with EGFR exon 18 and exon 20 mutated NSCLC who received erlotinib or afatinib as first line treatment between 2012 and 2021 from 34 oncology centres. Since exon 20 insertion is associated with TKI resistance, these 18 patients were excluded from the study. Results EGFR exon 18 mutations were seen in 60%, exon 20 mutations in 16%, and complex mutations in 24% of the patients with NSCLC who were evaluated for the study. There were 75 patients in erlotinib treated arm and 50 patients in afatinib arm. Patients treated with erlotinib had progression-free survival time (PFS) of 8.0 months and PFS was 7.0 months in the afatinib arm (p = 0.869), while overall survival time (OS) was 20.0 vs 24.8 months, respectively (p = 0.190). PFS of exon 18 mutated arm was 7.0 months, exon 20 mutated arm was 4.3 months, and complex mutation positive group was 17.3 months, and this was statistically significant (p = 0.036). The longest OS was 32.5 months, seen in the complex mutations group, which was not statistically different than exon 18 and in exon 20 mutated groups (21.0 and 21.2 months, respectively) (p = 0.323). Conclusion In this patient group, especially patients with complex mutations are as sensitive to EGFR TKI treatment similar to classical mutations, and in patients with rare exon 18 and exon 20 EGFR mutation both first- and second-generation EGFR-TKIs should be considered, especially as first- and second-line options