A comparative study about antioxidant activity and phenolic composition of cumin (Cuminum cyminum L.) and coriander (Coriandrum sativum L.)

383-393Apiaceae (Umbelliferae) is a large family which involves approximately 455 genus and 3600 species. Coriander (C. sativum L.) and cumin (C. cyminum L.) are two members of Apiaceae family which commonly used for medicinal purpose due to their antioxidant activity. Since the antioxidants are compounds that prevent the oxidation by neutralizing free radicals, researches about their potential utilizations are of great interest for food science and technology. Due to the consumer preference and the worries about synthetic antioxidant compounds, the food industry shows tendency to use natural antioxidant compounds obtained from plant materials. FDA has recognized more than 150 plants as GRAS, without no limitations intake. Coriander, cumin, anise, fennel, thyme and oregano are some plants found in this list. The focus of this research is to contrast the composition of phenolic profile and antioxidant activity of ethanolic and methanolic extracts of these two medicinal herbs belonging to the Apiaceae family. For this purpose, coriander and cumin were analyzed for phenolic compounds and antioxidant assay. Antioxidant assay analyses were performed by applying cupric reducing antioxidant capacity (CUPRAC), 2,2'-azino-bis3-ethylbenzothiazoline-6-sulphonic acid (ABTS), ferric reducing antioxidant power (FRAP), 1,1-diphenyl-2-picrylhydrazyl methods (DPPH)

Aortocaval Fistula in a Behcet's Disease Patient

Behcet's disease (BD) is a chronic, recurrent, systemic disease that is characterized by oral and genital ulcers and oculocutaneous inflammatory lesions. Cardiovascular involvement especially large artery involvement is a serious and vital complication of BD. Pseudoaneurysms in the major arteries may be the cause of sudden death in BD. In our case a pulsatile abdominal mass was determined to be an aortic pseudoaneurysm associated with BD and an aortocaval fistula. Here we report this case and a short review of literature because this is the first reported aortocaval fistula in a BD patient in English literature

An Important Document for the History of Turkish Radiation Oncology: “The Principles of Radium Treatment” / Türk Radyasyon Onkolojisi Tarihi Adına Önemli Bir Belge: “Radyumla Tedavi Esasları”

Abstract The aim of this study was to evaluate the information in the book about the usage of radium for treatment purposes in the light of current scientific knowledge by abbreviating and translating it into modern-day Turkish. With this study, Turkish Medical History will acquire a new source document. First, the book that was the subject of this work, was reviewed by the researchers. After the first evaluation, it was re-read by an academician, who is an expert in Turkish Language and Literature, and it was abbreviated in order to make it more articulate. Finally, after this process, the obtained information was interpreted in the light of current scientific knowledge. The book, which was written by a Turkish physician, covers utilization areas of radium, mechanism of effect and comparison with x-ray treatment. Written in the Young Turkish Republic about “modern medicine” practices, the book is considerably detailed and shows parallels with other practices of that period in the world. In addition to the brief theoretical information about the atom and radium, the application methods of radium treatment are covered by the book. Summarized information about the benefits and the risks of the treatment and warnings related to the practice can also be found in the book. The common feature of the medical books about x-ray and radium written almost a century ago is that they cover the theoretical information or the story of the discovery of x-ray and radium. On the other hand, “Radyumla Tedavi Esasları (The Principles of Radium Treatment)” was a unique pioneering work of its time covering the utilization methods of radium and x-ray, the advantages and disadvantages of these methods and the comparison of the two methods. It also discusses the administration methods of x-ray and radium, the pros and cons of these methods and the comparison of the two methods made it exclusive.   Öz Bu çalışmayla, Radyumla tedavi esasları adlı eserde yer alan radyumun tedavi amaçlı kullanımına ilişkin verilen bilgilerin günümüz Türkçesine çevrilip sadeleştirilerek güncel bilimsel bilgiler ışığında değerlendirilmesi amaçlanmıştır. Ayrıca bu çalışma ile Türk Tıp Tarihi yeni bir kaynak belge daha kazanmış olacaktır. Araştırmaya konu olan eser, öncelikle araştırmacılar tarafından gözden geçirilmiştir, yapılan ilk değerlendirmeden sonra Türk Dili ve Edebiyatı alanında uzman olan bir akademisyen ile tekrar okunarak kolay anlaşılmasını sağlamak için sadeleştirme işlemi yapılmıştır. Bu işlemin ardından elde edilen veriler güncel bilimsel bilgiler ışığında yorumlanmıştır. Bir Türk hekimi tarafından yazılan bu kitapta; radyumun kullanım alanları, etki mekanizması ve x ray tedavisi ile karşılaştırması yapılmaktadır. Genç Türkiye Cumhuriyetinde “modern tıp” uygulamaları hakkında yazılmış bu kitap oldukça ayrıntılıdır ve zamanındaki dünyadaki diğer uygulamalara paralellik göstermektedir. Kitapta atom ve radyum hakkında kısa teorik bilgilerin yanı sıra daha çok radyum tedavisinin uygulama yöntemlerinden söz edilmektedir. Ayrıca tedavinin yarar ve riskleri ile pratiğe yönelik olarak dikkat çekici uyarıları da içeren maddeler halinde verilmiş özet bilgiler yer almaktadır. Yaklaşık bir asır önce kaleme alınan röntgen ve radyum hakkında yazılan tıp kitaplarının ortak özelliği kuramsal bilgiden veya röntgen ve radyumun keşfinin hikâyesinden söz etmeleridir. Bu çalışmaya konu olan “Radyumla tedavi esasları” adlı kitap ise; radyum ve röntgenin uygulama yöntemleri, bu yöntemlerin olumlu/olumsuz yanları ve iki yöntemin birbirleri ile karşılaştırılması adına döneminde öncülük yapmış ayrıcalıklı bir eserdir

Arboretumlar, özellikleri ve Karaca Arboretumu

Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih Bölümü, 2018.This work is a student project of the Department of History, Faculty of Economics, Administrative and Social Sciences, İhsan Doğramacı Bilkent University.The History of Turkey course (HIST200) is a requirement for all Bilkent undergraduates. It is designed to encourage students to work in groups on projects concerning any topic of their choice that relates to the history of Turkey. It is designed as an interactive course with an emphasis on research and the objective of investigating events, chronologically short historical periods, as well as historic representations. Students from all departments prepare and present final projects for examination by a committee, with 10 projects chosen to receive awards.Includes bibliographical references (pages 26-29).by Kudret Emiroğlu

Comprehensive multi-technique approach reveals the high diversity of microcystins in field collections and an associated isolate of Microcystis aeruginosa from a Turkish lake

Microcystins (MCs) are hepatotoxic and potentially carcinogenic cyanotoxins. They exhibit high structural variability, with nearly 250 variants described to date. This variability can result in incomplete detection of MC variants during lake surveys due to the frequent use of targeted analytical methods and a lack of standards available for identification and quantitation. In this study, Lake Uluabat in Turkey was sampled during the summer of 2015. Phylogenetic analysis of the environmental mcyA sequences suggested Microcystis spp. were the major MC contributors. A combination of liquid chromatography-tandem mass spectrometry (LC-MS/MS), liquid chromatography with UV detection and mass spectrometry (LC-UV-MS), and a novel liquid chromatography-high resolution mass spectrometry (LC-HRMS) method, together with thiol and periodate reactivity, revealed more than 36 MC variants in the lake samples and a strain of M. aeruginosa (AQUAMEB-24) isolated from Lake Uluabat. Only MCs containing arginine at position-4 were detected in the culture, while MC-LA, -LY, -LW and -LF were also detected in the lake samples, suggesting the presence of other MC producers in the lake. The previously unreported MCs MC-(H2)YR (dihydrotyrosine at position-2) (17), [epoxyAdda(5)]MC-LR, [DMAdda(5)]MC-RR (1) and [Mser(7)]MC-RR (8) were detected in the culture and/or field samples. This study is a good example of how commonly used targeted LC-MS methods can underestimate the diversity of MCs in freshwater lakes and cyanobacteria cultures and how untargeted LC-MS methods can be used to comprehensively assess MC diversity present in a new system

The Impact of Whole Body Vibration Therapy on Spasticity and Disability of the Patients with Poststroke Hemiplegia

Objective. To determine if whole body vibration therapy (WBV) effectively improves functional outcome in patients with poststroke hemiplegia. Materials and Methods. In this single-blind RCT, WBV group (n=10) had 40 hz frequency/4 mm amplitude vibration during 5 minutes/session, 3 days a week, for a duration of 4 weeks. The control group (n=11) had no vibration therapy for the same duration while standing on the same platform. Patients in both of the groups did 15 minutes of stretching and active range of motion exercises before the intervention. Outcome measures were Modified Ashworth Scale (MAS), Functional Independence Measurement (FIM), and Timed 10-Meter Walk Test (10 mWT). Results. Only 10 mWT improved at the 1st week (p=0.002), 1st month (p<0.001), and 3rd month (p<0.001) in favor of the intervention group. There was positive correlation also between 10 mWT and ankle spasticity (p<0.001, r=0.931). Conclusion. This study suggests that WBV therapy may be a complementary therapy in gait rehabilitation and functional outcome of the patients with calf muscle spasticity