273 research outputs found
SzemĂ©lyre szabott kezelĂ©s szinkrĂłn, nyirokcsomĂł-pozitĂv petefĂ©szek- Ă©s vastagbĂ©ldaganatban
Absztrakt
A 71 éves nőbetegnél jobb alhasi fájdalom és láz miatt sürgősségi laparotomiára
került sor. Makroszkóposan duplex coecum és colon transversum, továbbá
szigma/bal petefészek daganatának gyanúja merült fel. A szövettani vizsgálat
szinkrón bal petefészek- (papillaris adenocarcinoma) és colon transversum
(tubularis adenocarcinoma) daganatot mutatott. Mind a két primer daganat a
regionális nyirokcsomóikba adott áttétet, továbbá a petefészek-daganat
infiltrálta a szigmabelet és távoli áttétet képzett a coecum területére.
ImmunhisztokĂ©miával a nyirokcsomóáttĂ©tek egyĂ©rtelműen elkĂĽlönĂthetĹ‘k voltak:
petefĂ©szek-eredetű CK7-pozitĂv, coloneredetű CK20- Ă©s CEA-pozitĂv. A szikrĂłn
primer daganatokat kombinált kemoterápiával kezeltük (FOLFOX-4 és heti
paclitaxel). A kombinált kezelést a beteg jól tolerálta. A ritka eset
hangsúlyozza annak jelentőségét, hogy a többszörös primer daganatok egyénre
szabott kemoterápiás sémával kezelhetők jó hatásfokkal és enyhe
mellékhatásokkal. Orv. Hetil., 2015, 156(23), 939–943
Versatile synthesis of novel tetrahydroquinolines as potentialy active semicarbazide-sensitive amine oxidase (SSAO) inhibitors via tert-amino effect
Hemophagocytic lymphohistiocytosis secondary to infections:a tertiary care experience
Background: Hemophagocytic lymphohistiocytosis is an uncommon complication of various conditions. It is characterized by immune dysregulation and massive cytokine release causing multiorgan dysfunction. It is classified as primary and secondary to various etiologies like infections, malignancies and autoimmune disease. As it has high mortality, clinician awareness is important for early diagnosis and improved outcome. Aim of the study was to study the etiologies, clinical manifestations, complications and laboratory features in patients diagnosed with infection associated hemophagocytic syndrome (IAHS).Methods: We have done retrospective analysis of all cases diagnosed to have Infection Associated Hemophagocytic Syndrome (IAHS) between March 2012 to November 2015 in a 1000 bedded tertiary care hospital in south India.Results: Total five cases detected. Most of the cases are related to tropical infections (80%). All of them presented with fever, cytopenias and organomegaly. Ferritin and Triglycerides were elevated in all patients. Bone marrow hemophagocytosis was observed in 80% of cases. Diagnostic protocol of HLH 2004 was followed. Only 20% survival observed.Conclusions: IAHS is a rare fulminant complication associated with diagnostic and therapeutic challenges because of overlapping clinical features with sepsis. Increased physician awareness, early diagnosis and therapeutic interventions may improve survival
Dynamiques d'exploitation et de valorisation des ressources halieutiques dans la Réserve de Biosphère du Delta du Saloum (RBDS) = Dynamics operation and resource development of fish in the Biosphere Reserve of the Saloum Delta (RBDS)
Caractérisation des sables et morphologie du fond du lac du barrage hydroélectrique de Taabo (Côte d\'Ivoire)
Une analyse sédimentologique et minéralogique réalisée sur un cycle hydrologique entre octobre 2004 et août 2005 a permis d\'évaluer les charges solides en suspension et de caractériser les sédiments du lac du barrage de Taabo.
La concentration moyenne en matières en suspension (12 mg.L-1) et la turbidité moyenne (20 NTU) montrent que les eaux du lac sont relativement peu chargées. Ces charges en suspension sont composées d\'une fraction inorganique et d\'une fraction organique.
Les sables qui composent les sĂ©diments de ce lac sont majoritairement moyens Ă grossiers et mĂ©diocrement classĂ©s avec une moyenne granulomĂ©trique de 451,48 μm et un indice de classement moyen de 1,13. Les vases et les sables fins occupent les zones profondes du lac et les zones envahies par les vĂ©gĂ©taux aquatiques. Les sables moyens sont localisĂ©s aux voisinages des berges tandis que les sables grossiers sont situĂ©s aux voisinages des Ă®les et de la digue. Le cortège minĂ©ralogique des sĂ©diments est caractĂ©risĂ© de minĂ©raux lourds (l\'amphibole, la tourmaline, le diopside et l\'Ă©pidote) et de minĂ©raux lĂ©gers (le quartz et les feldspaths). Par ailleurs, cette Ă©tude a permis de rĂ©aliser la première carte bathymĂ©trique du lac de Taabo 26 ans après sa mise en eau.A sedimentological and mineralogical study carried out on a hydrological cycle from October 2004 to August 2005 has permitted to assess the solid suspended matters and to characterize the sediments of the Taabo dam lake. The average of suspended matters concentration (12 mg.L -1) and the average of turbidity (20 NTU) reveal that the lake is relatively little loaded with suspended matters. These suspended matters are compound of an inorganic fraction and an organic fraction. Sands size in the sediments of this lake are from middle to coarse and badly classified. The grain size average is 451,48 μm; the standard deviation average is 1,13. Muds and fine sands are found in the deeper zones of the lake and also in
the zones invaded by the aquatic plants. Middle sands are located near banks while coarse sands are located aside the islands and the dam. The minerals found in the sediments are characterized by heavy minerals (the amphibole, tourmaline, diopside and epidote) and light minerals (quartz and feldspars). Elsewhere, this study has permitted to carry out the first bathymetric Map of this lake 26 years after its setting in water. Keywords: keywordBarrage, lac, granulométrie, minéralogie, bathymétrie, Taabo./Dam, lake, grain size, mineralogy, bathymetry, Taabo.Sciences & Nature Vol. 4 (1) 2007: pp. 93-10
A signal sequence suppressor mutant that stabilizes an assembled state of the twin arginine translocase
A signal sequence suppressor mutant that stabilizes an assembled state of the twin arginine translocase
The twin-arginine protein translocation (Tat) system mediates transport of folded proteins across the cytoplasmic membrane of bacteria and the thylakoid membrane of chloroplasts. The Tat system of Escherichia coli is made up of TatA, TatB and TatC components. TatBC comprise the substrate receptor complex, and active Tat translocases are formed by the substrate-induced association of TatA oligomers with this receptor. Proteins are targeted to TatBC by signal peptides containing an essential pair of arginine residues. We isolated substitutions, locating to the transmembrane helix of TatB that restored transport activity to Tat signal peptides with inactivating twin arginine substitutions. A subset of these variants also suppressed inactivating substitutions in the signal peptide binding site on TatC. The suppressors did not function by restoring detectable signal peptide binding to the TatBC complex. Instead, site specific crosslinking experiments indicate that the suppressor substitutions induce conformational change in the complex and movement of the TatB subunit. The TatB F13Y substitution was associated with the strongest suppressing activity, even allowing transport of a Tat substrate lacking a signal peptide. In vivo analysis using a TatA-YFP fusion showed that the TatB F13Y substitution resulted in signal peptide independent assembly of the Tat translocase. We conclude that Tat signal peptides play roles in substrate targeting and in triggering assembly of the active translocase
Interactions between Australian cancer physicians and the pharmaceutical industry: a qualitative study
Structural insights into the mechanism of protein transport by the Type 9 Secretion System translocon
Secretion systems are protein export machines that enable bacteria to exploit their environment through the release of protein effectors. The Type 9 Secretion System (T9SS) is responsible for protein export across the outer membrane (OM) of bacteria of the phylum Bacteroidota. Here we trap the T9SS of Flavobacterium johnsoniae in the process of substrate transport by disrupting the T9SS motor complex. Cryo-EM analysis of purified substrate-bound T9SS translocons reveals an extended translocon structure in which the previously described translocon core is augmented by a periplasmic structure incorporating the proteins SprE, PorD and a homologue of the canonical periplasmic chaperone Skp. Substrate proteins bind to the extracellular loops of a carrier protein within the translocon pore. As transport intermediates accumulate on the translocon when energetic input is removed, we deduce that release of the substrate–carrier protein complex from the translocon is the energy-requiring step in T9SS transport
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