15 research outputs found
Recent trends in the use of electrical neuromodulation in Parkinson's disease
Purpose of Review: This review aims to survey recent trends in electrical forms of neuromodulation, with a specific application to Parkinsonâs disease (PD). Emerging trends are identified, highlighting synergies in state-of-the-art neuromodulation strategies, with directions for future improvements in stimulation efficacy suggested.
Recent Findings: Deep brain stimulation remains the most common and effective form of electrical stimulation for the treatment of PD. Evidence suggests that transcranial direct current stimulation (tDCS) most likely impacts the motor symptoms of the disease, with the most prominent results relating to rehabilitation. However, utility is limited due to its weak effects and high variability, with medication state a key confound for efficacy level. Recent innovations in transcranial alternating current stimulation (tACS) offer new areas for investigation.
Summary: Our understanding of the mechanistic foundations of electrical current stimulation is advancing and as it does so, trends emerge which steer future clinical trials towards greater efficacy
Multizentrische Studie zur Tiefen Hirnstimulation bei essentiellem Tremor identifiziert optimalen Stimulationsort
Netzwerk-KonnektivitĂ€t fĂŒr die Verbesserung von Freezing of Gait nach tiefer Hirnstimulation des Nucleus subthalamicus
Subjectively perceived personality and mood changes associated with subthalamic stimulation in patients with Parkinson\u27s disease
Dyskinesia-inducing lead contacts optimize outcome of subthalamic stimulation in Parkinson's disease
Acute dyskinesias elicited by STN-DBS, here referred to as stimulation-induced dyskinesias, predict optimal clinical outcome in PD. However, it remains elusive whether stimulation-induced dyskinesias can guide DBS programming