Evolution of the UV LF from z~15 to z~8 Using New JWST NIRCam Medium-Band Observations over the HUDF/XDF

Here we present the first constraints on the prevalence of z>10 galaxies in the Hubble Ultra Deep Field (HUDF) leveraging new NIRCam medium-band observations taken with JWST. These NIRCam observations probe redward of 1.6microns, beyond the wavelength limit of HST, allowing us to search for galaxies to z>10. These observations indicate that the highest redshift candidate identified over the HUDF with HST, UDFj-39546284, has a redshift of z=12.0+/-0.1, as had been suggested in multiple analyses of the HUDF12/XDF data. This source thus appears to be the most distant galaxy discovered by HST in its more than 30 years of operation. Additionally, we identify nine other z~8-13 candidate galaxies over the HUDF, two of which are entirely new discoveries and appear to lie at z~11 and z~12. We use these results to characterize the evolution of the UV luminosity function (LF) from z~15 to z~8.7. While our LF results at z~8.7 and z~10.5 are consistent with previous findings over the HUDF, our new LF estimates at z~12.6 are substantially higher than other results in the literature, potentially pointing to a milder evolution in the UV luminosity density from z~12.6. We emphasize that our LF results are uncertain given the small number of sources in our z~12.6 selection and limited volume probed. The new NIRCam data also indicate that the faint z~8-13 galaxies in the HUDF/XDF show very blue UV-continuum slopes beta~-2.7, high specific star formation rates ~24.5 Gyr$^{-1}$, and high EW (~1300A) [OIII]+Hbeta emission, with two z~8.5 sources showing [OIII]+Hbeta EWs of ~2300 Angstroms.Comment: 19 pages, 14 figures, 7 tables, submitted to MNRAS, with some minor typos correcte

Mapping dusty galaxy growth at z>5z>5 with FRESCO: Detection of Hα\alpha in submm galaxy HDF850.1 and the surrounding overdense structures

We report the detection of a 13$\sigma$ H$\alpha$ emission line from HDF850.1 at $z=5.188\pm0.001$ using the FRESCO NIRCam F444W grism observations. Detection of H$\alpha$ in HDF850.1 is noteworthy, given its high far-IR luminosity, substantial dust obscuration, and the historical challenges in deriving its redshift. HDF850.1 shows a clear detection in the F444W imaging data, distributed between a northern and southern component, mirroring that seen in [CII] from the Plateau de Bure Interferometer. Modeling the SED of each component separately, we find that the northern component has a higher mass, star formation rate (SFR), and dust extinction than the southern component. The observed H$\alpha$ emission appears to arise entirely from the less-obscured southern component and shows a similar $\Delta$v$\sim$+130 km/s velocity offset to that seen for [CII] relative to the source systemic redshift. Leveraging H$\alpha$-derived redshifts from FRESCO observations, we find that HDF850.1 is forming in one of the richest environments identified to date at $z>5$, with 100 $z=5.17-5.20$ galaxies distributed across 10 structures and a $\sim$(15 cMpc)$^3$ volume. Based on the evolution of analogous structures in cosmological simulations, the $z=5.17-5.20$ structures seem likely to collapse into a single $>$10$^{14}$ $M_{\odot}$ cluster by $z\sim0$. Comparing galaxy properties forming within this overdensity with those outside, we find the masses, SFRs, and $UV$ luminosities inside the overdensity to be clearly higher. The prominence of H$\alpha$ line emission from HDF850.1 and other known highly-obscured $z>5$ galaxies illustrates the potential of NIRCam-grism programs to map both the early build-up of IR-luminous galaxies and overdense structures.Comment: Submitted to MNRAS. 20 pages, 10 figures and 8 tables (including appendices

The JWST FRESCO Survey:Legacy NIRCam/Grism Spectroscopy and Imaging in the two GOODS Fields

We present the JWST cycle 1 53.8 h medium program FRESCO, short for 'First Reionization Epoch Spectroscopically Complete Observations'. FRESCO covers 62 arcmin2 in each of the two GOODS/CANDELS fields for a total area of 124 arcmin2 exploiting JWST's powerful new grism spectroscopic capabilities at near-infrared wavelengths. By obtaining ∼2 h deep NIRCam/grism observations with the F444W filter, FRESCO yields unprecedented spectra at R ∼1600 covering 3.8-5.0 μm for most galaxies in the NIRCam field of view. This setup enables emission line measurements over most of cosmic history, from strong PAH lines at z ∼0.2-0.5, to Pa α and Pa β at z ∼1-3, He i and [S iii] at z ∼2.5-4.5, H α and [N ii] at z ∼5-6.5, up to [O iii] and H β for z ∼7-9 galaxies. FRESCO's grism observations provide total line fluxes for accurately estimating galaxy stellar masses and calibrating slit-loss corrections of NIRSpec/MSA spectra in the same field. Additionally, FRESCO results in a mosaic of F182M, F210M, and F444W imaging in the same fields to a depth of ∼28.2 mag (5σ in 032 diameter apertures). Here, we describe the overall survey design and the key science goals that can be addressed with FRESCO. We also highlight several, early science results, including: spectroscopic redshifts of Lyman break galaxies that were identified almost 20 yr ago, the discovery of broad-line active galactic nuclei at z &gt; 4, and resolved Pa α maps of galaxies at z ∼1.4. These results demonstrate the enormous power for serendipitous discovery of NIRCam/grism observations.</p

The JWST FRESCO Survey: Legacy NIRCam/Grism Spectroscopy and Imaging in the two GOODS Fields

We present the JWST Cycle 1 53.8hr medium program FRESCO, short for "First Reionization Epoch Spectroscopically Complete Observations". FRESCO covers 62 arcmin$^2$ in each of the two GOODS/CANDELS fields for a total area of 124 arcmin$^2$ exploiting JWST's powerful new grism spectroscopic capabilities at near-infrared wavelengths. By obtaining ~2 hr deep NIRCam/grism observations with the F444W filter, FRESCO yields unprecedented spectra at R~1600 covering 3.8 to 5.0 $\mu$m for most galaxies in the NIRCam field-of-view. This setup enables emission line measurements over most of cosmic history, from strong PAH lines at z~0.2-0.5, to Pa$\alpha$ and Pa$\beta$ at z~1-3, HeI and [SIII] at z~2.5-4.5, H$\alpha$ and [NII] at z~5-6.5, up to [OIII] and H$\beta$ for z~7-9 galaxies, and possibly even [OII] at z~10-12. FRESCO's grism observations provide total line fluxes for accurately estimating galaxy stellar masses and calibrating slit-loss corrections of NIRSpec/MSA spectra in the same field. Additionally, FRESCO results in a mosaic of F182M, F210M, and F444W imaging in the same fields to a depth of ~28.2 mag (5 $\sigma$ in 0.32" diameter apertures). Together with this publication, the v1 imaging mosaics are released as high-level science products via MAST. Here, we describe the overall survey design and the key science goals that can be addressed with FRESCO. We also highlight several, early science results, including: spectroscopic redshifts of Lyman break galaxies that were identified almost 20 years ago, the discovery of broad-line active galactic nuclei at z>4, and resolved Pa$\alpha$ maps of galaxies at z~1.4. These results demonstrate the enormous power for serendipitous discovery of NIRCam/grism observations. Given the wealth of ancillary data available in these fields, the zero-proprietary time FRESCO data is poised to enable a large amount of legacy science by the community.Comment: 11 pages, 11 figures; submitted to MNRAS; for more information on the survey and data releases, see http://jwst-fresco.astro.unige.ch

The JWST FRESCO Survey: Legacy NIRCam/Grism Spectroscopy and Imaging in the two GOODS Fields

We present the JWST Cycle 1 53.8hr medium program FRESCO, short for “First Reionization Epoch Spectroscopically Complete Observations”. FRESCO covers 62 arcmin2 in each of the two GOODS/CANDELS fields for a total area of 124 arcmin2 exploiting JWST’s powerful new grism spectroscopic capabilities at near-infrared wavelengths. By obtaining ∼2hr deep NIRCam/grism observations with the F444W filter, FRESCO yields unprecedented spectra at R ∼ 1600 covering 3.8 to 5.0 μm for most galaxies in the NIRCam field-of-view. This setup enables emission line measurements over most of cosmic history, from strong PAH lines at z ∼ 0.2 − 0.5, to Paα and Paβ at z ∼ 1 − 3, HeI and [SIII] at z ∼ 2.5 − 4.5, Hα and [NII] at z ∼ 5 − 6.5, up to [OIII] and Hβ for z∼7-9 galaxies. FRESCO’s grism observations provide total line fluxes for accurately estimating galaxy stellar masses and calibrating slit-loss corrections of NIRSpec/MSA spectra in the same field. Additionally, FRESCO results in a mosaic of F182M, F210M, and F444W imaging in the same fields to a depth of ∼28.2 mag (5 σ in 0${_{.}^{\prime\prime}}$32 diameter apertures). Here, we describe the overall survey design and the key science goals that can be addressed with FRESCO. We also highlight several, early science results, including: spectroscopic redshifts of Lyman break galaxies that were identified almost 20 years ago, the discovery of broad-line active galactic nuclei at z &amp;gt; 4, and resolved Paα maps of galaxies at z ∼ 1.4. These results demonstrate the enormous power for serendipitous discovery of NIRCam/grism observations

MyD88 in lung resident cells governs airway inflammatory and pulmonary function responses to organic dust treatment

Inhalation of organic dusts within agriculture environments contributes to the development and/or severity of airway diseases, including asthma and chronic bronchitis. MyD88 KO (knockout) mice are nearly completely protected against the inflammatory and bronchoconstriction effects induced by acute organic dust extract (ODE) treatments. However, the contribution of MyD88 in lung epithelial cell responses remains unclear. In the present study, we first addressed whether ODE-induced changes in epithelial cell responses were MyD88-dependent by quantitating ciliary beat frequency and cell migration following wounding by electric cell-substrate impedance sensing. We demonstrate that the normative ciliary beat slowing response to ODE is delayed in MyD88 KO tracheal epithelial cells as compared to wild type (WT) control. Similarly, the normative ODE-induced slowing of cell migration in response to wound repair was aberrant in MyD88 KO cells. Next, we created MyD88 bone marrow chimera mice to investigate the relative contribution of MyD88-dependent signaling in lung resident (predominately epithelial cells) versus hematopoietic cells. Importantly, we demonstrate that ODE-induced airway hyperresponsiveness is MyD88-dependent in lung resident cells, whereas MyD88 action in hematopoietic cells is mainly responsible for ODE-induced TNF-α release. MyD88 signaling in lung resident and hematopoietic cells are necessary for ODE-induced IL-6 and neutrophil chemoattractant (CXCL1 and CXCL2) release and neutrophil influx. Collectively, these findings underscore an important role for MyD88 in lung resident cells for regulating ciliary motility, wound repair and inflammatory responses to ODE, and moreover, show that airway hyperresponsiveness appears uncoupled from airway inflammatory consequences to organic dust challenge in terms of MyD88 involvement. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12931-015-0272-9) contains supplementary material, which is available to authorized users

The JWST FRESCO survey: legacy NIRCam/grism spectroscopy and imaging in the two GOODS fields

We present the JWST cycle 1 53.8 h medium program FRESCO, short for 'First Reionization Epoch Spectroscopically Complete Observations'. FRESCO covers 62 arcmin2 in each of the two GOODS/CANDELS fields for a total area of 124 arcmin2 exploiting JWST's powerful new grism spectroscopic capabilities at near-infrared wavelengths. By obtaining ∼2 h deep NIRCam/grism observations with the F444W filter, FRESCO yields unprecedented spectra at R ∼1600 covering 3.8-5.0 μm for most galaxies in the NIRCam field of view. This setup enables emission line measurements over most of cosmic history, from strong PAH lines at z ∼0.2-0.5, to Pa α and Pa β at z ∼1-3, He i and [S iii] at z ∼2.5-4.5, H α and [N ii] at z ∼5-6.5, up to [O iii] and H β for z ∼7-9 galaxies. FRESCO's grism observations provide total line fluxes for accurately estimating galaxy stellar masses and calibrating slit-loss corrections of NIRSpec/MSA spectra in the same field. Additionally, FRESCO results in a mosaic of F182M, F210M, and F444W imaging in the same fields to a depth of ∼28.2 mag (5σ in 032 diameter apertures). Here, we describe the overall survey design and the key science goals that can be addressed with FRESCO. We also highlight several, early science results, including: spectroscopic redshifts of Lyman break galaxies that were identified almost 20 yr ago, the discovery of broad-line active galactic nuclei at z > 4, and resolved Pa α maps of galaxies at z ∼1.4. These results demonstrate the enormous power for serendipitous discovery of NIRCam/grism observations

Rapid detection of point mutations in Pneumocystis jiroveci DHPS gene by a real-time PCR-based fluorescence assay

International audienc

Rapid detection of point mutations in Pneumocystis jiroveci DHPS gene by a real-time PCR-based fluorescence assay

International audienc