What Type of Training Predicts Adherence to CBT-I Among Professionals Specializing in the Treatment of Insomnia?

This study explored the relationship between certain educational and professional variables that influence the adherence to empirically supported practices in cognitive-behavioral therapy for insomnia (CBT-I). The variables of interest included the practitioner’s level of training as measured by the number of hours of advanced training in CBT-I, the total number of hours practicing CBT-I out of the total annual clinical practice hours, and the total number of years practicing CBT-I. The final variable of interest was treatment preference and practice knowledge. The study used a one-time, cross-sectional, web-based survey. The participants consisted of 165 mental health and medical professionals of various disciplines who were trained in CBT-I. The results suggested that individuals with more training were significantly more likely to apply CBT-I. Practitioners with more training had a higher percentage of CBT-I on their caseloads than those with less training. The total number of training hours did not significantly predict adherence, with all practitioners scoring similarly

Sequence History Update Tool

The Sequence History Update Tool performs Web-based sequence statistics archiving for Mars Reconnaissance Orbiter (MRO). Using a single UNIX command, the software takes advantage of sequencing conventions to automatically extract the needed statistics from multiple files. This information is then used to populate a PHP database, which is then seamlessly formatted into a dynamic Web page. This tool replaces a previous tedious and error-prone process of manually editing HTML code to construct a Web-based table. Because the tool manages all of the statistics gathering and file delivery to and from multiple data sources spread across multiple servers, there is also a considerable time and effort savings. With the use of The Sequence History Update Tool what previously took minutes is now done in less than 30 seconds, and now provides a more accurate archival record of the sequence commanding for MRO

Exogenous activation of tumor necrosis factor receptor 2 promotes recovery from sensory and motor disease in a model of multiple sclerosis

Tumor necrosis factor receptor 2 (TNFR2) is a transmembrane receptor that promotes immune modulation and tissue regeneration and is recognized as a potential therapeutic target for multiple sclerosis (MS). However, TNFR2 also contributes to T effector cell function and macrophage-TNFR2 recently was shown to promote disease development in the experimental autoimmune encephalomyelitis (EAE) model of MS. We here demonstrate that systemic administration of a TNFR2 agonist alleviates peripheral and central inflammation, and reduces demyelination and neurodegeneration, indicating that protective signals induced by TNFR2 exceed potential pathogenic TNFR2-dependent responses. Our behavioral data show that systemic treatment of female EAE mice with a TNFR2 agonist is therapeutic on motor symptoms and promotes long-term recovery from neuropathic pain. Mechanistically, our data indicate that TNFR2 agonist treatment follows a dual mode of action and promotes both suppression of CNS autoimmunity and remyelination. Strategies based on the concept of exogenous activation of TNFR2 therefore hold great promise as a new therapeutic approach to treat motor and sensory disease in MS as well as other inflammatory diseases or neuropathic pain conditions