Quantum arrival time measurement and backflow effect

The current density for a freely evolving state without negative momentum components can temporarily be negative. The operational arrival time distribution, defined by the absorption rate of an ideal detector, is calculated for a model detector and compared with recently proposed distributions. Counterintuitive features of the backflow regime are discussed.Comment: LATEX, 9 pages, 2 postscript figure

Time-of-Arrival States

Although one can show formally that a time-of-arrival operator cannot exist, one can modify the low momentum behaviour of the operator slightly so that it is self-adjoint. We show that such a modification results in the difficulty that the eigenstates are drastically altered. In an eigenstate of the modified time-of-arrival operator, the particle, at the predicted time-of-arrival, is found far away from the point of arrival with probability 1/2.Comment: 15 pages, 2 figure

Spin dependent observable effect for free particles using the arrival time distribution

The mean arrival time of free particles is computed using the quantum probability current. This is uniquely determined in the non-relativistic limit of Dirac equation, although the Schroedinger probability current has an inherent non-uniqueness. Since the Dirac probability current involves a spin-dependent term, an arrival time distribution based on the probability current shows an observable spin-dependent effect, even for free particles. This arises essentially from relativistic quantum dynamics, but persists even in the non-relativistic regime.Comment: 5 Latex pages, 2.eps figures; discussions sharpened and references added; accepted for publication in Physical Review

The effect of mirabegron on patient-related outcomes in patients with overactive bladder: the results of post hoc correlation and responder analyses using pooled data from three randomized Phase III trials

Purpose To understand how improvements in the symptoms of overactive bladder (OAB) seen with the b3-adrenoceptor agonist mirabegron 50 mg, correlate with patient experience as measured by validated and standard patient-reported outcomes (PROs), and to identify whether there is overall directional consistency in the responsiveness of PROs to treatment effect. Methods In a post hoc analysis of pooled data from three randomized, double-blind, placebo-controlled, 12-week Phase III trials of mirabegron 50 mg once daily, responder rates for incontinence frequency (C50 % reduction in incontinence episodes/24 h from baseline to final visit), micturition frequency (B8 micturitions/24 h at final visit), and PROs [minimally important differences in patient perception of bladder condition (PPBC) and subsets of the overactive bladder questionnaire (OAB-q) measuring total health-related quality of life (HRQoL), and symptom bother] were evaluated individually and in combination. Results Mirabegron 50 mg demonstrated greater improvement from baseline to final visit than placebo for each of the responder analyses, whether for individual objective and subjective outcomes or combinations thereof. These improvements versus placebo were statistically significant for all double and triple responder analyses and for all single responder analyses except PPBC. PRO measurements showed directional consistency and significant correlations, and there were also significant correlations between objective and subjective measures of efficacy. Conclusions The improvements in objective measures seen with mirabegron 50 mg translate into a meaningful clinical benefit as evident by the directional consistency seen in HRQoL measures of benefit

Single waveguide silicon-organic hybrid modulator

We present a novel silicon-organic hybrid modulator based on an integrated dual-mode interferometer. The modulator offers a compact, simplified design and enhanced robustness to on-chip fluctuations of temperature compared to conventional Mach-Zehnder based systems. A prototype modulator showing a voltage dependent transmission spectrum is obtained by cladding a dual-mode waveguide in a 250 nm silicon-on-insulator technology with a customized organic electro-optic layer. Estimated phase shifts and corresponding figures of merit are discussed in this contribution. The used organic layer is based on the guest-host approach with customized donor-acceptor chromophore embedded and poled in a poly(methylmethacrylate) matrix. The presented prototype is to the best of the authors'' knowledge the first integrated single waveguide silicon-organic hybrid modulator

Higgs as a pseudo-Goldstone boson, the mu problem and gauge-mediated supersymmetry breaking

We study the interplay between the spontaneous breaking of a global symmetry of the Higgs sector and gauge-mediated supersymmetry breaking, in the framework of a supersymmetric model with global SU(3) symmetry. In addition to solving the supersymmetric flavour problem and alleviating the little hierarchy problem, this scenario automatically triggers the breaking of the global symmetry and provides an elegant solution to the mu/Bmu problem of gauge mediation. We study in detail the processes of global symmetry and electroweak symmetry breaking, including the contributions of the top/stop and gauge-Higgs sectors to the one-loop effective potential of the pseudo-Goldstone Higgs boson. While the joint effect of supersymmetry and of the global symmetry allows in principle the electroweak symmetry to be broken with little fine-tuning, the simplest version of the model fails to bring the Higgs mass above the LEP bound due to a suppressed tree-level quartic coupling. To cure this problem, we consider the possibility of additional SU(3)-breaking contributions to the Higgs potential, which results in a moderate fine-tuning. The model predicts a rather low messenger scale, a small tan beta value, a light Higgs boson with Standard Model-like properties, and heavy higgsinos.Comment: 19 pages, 6 figures. New section 3.3 on the mu/Bmu problem, more detailed analytic computation in section 4.1, error in Fig. 5 corrected, significant redactional changes (including abstract, introduction and conclusion) in order to better emphasize the main results of the paper. Title changed in journal. Final version to appear in Eur. Phys. J.

Time of arrival through interacting environments: Tunneling processes

We discuss the propagation of wave packets through interacting environments. Such environments generally modify the dispersion relation or shape of the wave function. To study such effects in detail, we define the distribution function P_{X}(T), which describes the arrival time T of a packet at a detector located at point X. We calculate P_{X}(T) for wave packets traveling through a tunneling barrier and find that our results actually explain recent experiments. We compare our results with Nelson's stochastic interpretation of quantum mechanics and resolve a paradox previously apparent in Nelson's viewpoint about the tunneling time.Comment: Latex 19 pages, 11 eps figures, title modified, comments and references added, final versio

Time-of-arrival distributions from position-momentum and energy-time joint measurements

The position-momentum quasi-distribution obtained from an Arthurs and Kelly joint measurement model is used to obtain indirectly an ``operational'' time-of-arrival (TOA) distribution following a quantization procedure proposed by Kocha\'nski and W\'odkiewicz [Phys. Rev. A 60, 2689 (1999)]. This TOA distribution is not time covariant. The procedure is generalized by using other phase-space quasi-distributions, and sufficient conditions are provided for time covariance that limit the possible phase-space quasi-distributions essentially to the Wigner function, which, however, provides a non-positive TOA quasi-distribution. These problems are remedied with a different quantization procedure which, on the other hand, does not guarantee normalization. Finally an Arthurs and Kelly measurement model for TOA and energy (valid also for arbitrary conjugate variables when one of the variables is bounded from below) is worked out. The marginal TOA distribution so obtained, a distorted version of Kijowski's distribution, is time covariant, positive, and normalized

Charged lepton electric dipole moments with the localized leptons and the new Higgs doublet in the two Higgs doublet model

We study the lepton electric dipole moments in the split fermion scenario, in the two Higgs doublet model, where the new Higgs scalars are localized around the origin in the extra dimension, with the help of the localizer field. We observe that the numerical value of the electron (muon, tau) electric dipole moment is at the order of the magnitude of 10^{-31} (10^{-24}, 10^{-22}) (e-cm) and this quantity is sensitive the new Higgs localization in the extra dimension.Comment: 20 pages, 7 figure

Pegasus IV: Discovery and Spectroscopic Confirmation of an Ultra-faint Dwarf Galaxy in the Constellation Pegasus

We report the discovery of Pegasus IV, an ultra-faint dwarf galaxy found in archival data from the Dark Energy Camera processed by the DECam Local Volume Exploration Survey. Pegasus IV is a compact, ultra-faint stellar system (r1 2 = 41-+68 pc; MV = −4.25 ± 0.2 mag) located at a heliocentric distance of 90-+64 kpc. Based on spectra of seven nonvariable member stars observed with Magellan/IMACS, we confidently resolve Pegasus IV’s velocity dispersion, measuring sv = 3.3-+1.11.7 km s−1 (after excluding three velocity outliers); this implies a mass-to-light ratio of M1 2 LV,1 2 = 167-+99224M☉ L☉ for the system. From the five stars with the highest signal-to-noise spectra, we also measure a systemic metallicity of [Fe/H] =-2.63-+0.300.26 dex, making Pegasus IV one of the most metal-poor ultra-faint dwarfs. We tentatively resolve a nonzero metallicity dispersion for the system. These measurements provide strong evidence that Pegasus IV is a dark-matter-dominated dwarf galaxy, rather than a star cluster. We measure Pegasus IV’s proper motion using data from Gaia Early Data Release 3, finding (μα*, μδ) = (0.33 ± 0.07, −0.21 ± 0.08) mas yr−1. When combined with our measured systemic velocity, this proper motion suggests that Pegasus IV is on an elliptical, retrograde orbit, and is currently near its orbital apocenter. Lastly, we identify three potential RR Lyrae variable stars within Pegasus IV, including one candidate member located more than 10 half-light radii away from the system’s centroid. The discovery of yet another ultra-faint dwarf galaxy strongly suggests that the census of Milky Way satellites is still incomplete, even within 100 kpc