326 research outputs found
Quantum arrival time measurement and backflow effect
The current density for a freely evolving state without negative momentum
components can temporarily be negative. The operational arrival time
distribution, defined by the absorption rate of an ideal detector, is
calculated for a model detector and compared with recently proposed
distributions. Counterintuitive features of the backflow regime are discussed.Comment: LATEX, 9 pages, 2 postscript figure
Time-of-Arrival States
Although one can show formally that a time-of-arrival operator cannot exist,
one can modify the low momentum behaviour of the operator slightly so that it
is self-adjoint. We show that such a modification results in the difficulty
that the eigenstates are drastically altered. In an eigenstate of the modified
time-of-arrival operator, the particle, at the predicted time-of-arrival, is
found far away from the point of arrival with probability 1/2.Comment: 15 pages, 2 figure
Spin dependent observable effect for free particles using the arrival time distribution
The mean arrival time of free particles is computed using the quantum
probability current. This is uniquely determined in the non-relativistic limit
of Dirac equation, although the Schroedinger probability current has an
inherent non-uniqueness. Since the Dirac probability current involves a
spin-dependent term, an arrival time distribution based on the probability
current shows an observable spin-dependent effect, even for free particles.
This arises essentially from relativistic quantum dynamics, but persists even
in the non-relativistic regime.Comment: 5 Latex pages, 2.eps figures; discussions sharpened and references
added; accepted for publication in Physical Review
The effect of mirabegron on patient-related outcomes in patients with overactive bladder: the results of post hoc correlation and responder analyses using pooled data from three randomized Phase III trials
Purpose To understand how improvements in the symptoms
of overactive bladder (OAB) seen with the b3-adrenoceptor
agonist mirabegron 50 mg, correlate with patient experience
as measured by validated and standard patient-reported
outcomes (PROs), and to identify whether there is overall
directional consistency in the responsiveness of PROs to
treatment effect.
Methods In a post hoc analysis of pooled data from three
randomized, double-blind, placebo-controlled, 12-week
Phase III trials of mirabegron 50 mg once daily, responder
rates for incontinence frequency (C50 % reduction in
incontinence episodes/24 h from baseline to final visit),
micturition frequency (B8 micturitions/24 h at final visit),
and PROs [minimally important differences in patient
perception of bladder condition (PPBC) and subsets of the
overactive bladder questionnaire (OAB-q) measuring total
health-related quality of life (HRQoL), and symptom
bother] were evaluated individually and in combination.
Results Mirabegron 50 mg demonstrated greater
improvement from baseline to final visit than placebo for
each of the responder analyses, whether for individual
objective and subjective outcomes or combinations thereof.
These improvements versus placebo were statistically significant
for all double and triple responder analyses and for
all single responder analyses except PPBC. PRO measurements
showed directional consistency and significant
correlations, and there were also significant correlations
between objective and subjective measures of efficacy.
Conclusions The improvements in objective measures
seen with mirabegron 50 mg translate into a meaningful
clinical benefit as evident by the directional consistency
seen in HRQoL measures of benefit
Single waveguide silicon-organic hybrid modulator
We present a novel silicon-organic hybrid modulator based on an integrated dual-mode interferometer. The modulator offers a compact, simplified design and enhanced robustness to on-chip fluctuations of temperature compared to conventional Mach-Zehnder based systems. A prototype modulator showing a voltage dependent transmission spectrum is obtained by cladding a dual-mode waveguide in a 250 nm silicon-on-insulator technology with a customized organic electro-optic layer. Estimated phase shifts and corresponding figures of merit are discussed in this contribution. The used organic layer is based on the guest-host approach with customized donor-acceptor chromophore embedded and poled in a poly(methylmethacrylate) matrix. The presented prototype is to the best of the authors'' knowledge the first integrated single waveguide silicon-organic hybrid modulator
Higgs as a pseudo-Goldstone boson, the mu problem and gauge-mediated supersymmetry breaking
We study the interplay between the spontaneous breaking of a global symmetry
of the Higgs sector and gauge-mediated supersymmetry breaking, in the framework
of a supersymmetric model with global SU(3) symmetry. In addition to solving
the supersymmetric flavour problem and alleviating the little hierarchy
problem, this scenario automatically triggers the breaking of the global
symmetry and provides an elegant solution to the mu/Bmu problem of gauge
mediation. We study in detail the processes of global symmetry and electroweak
symmetry breaking, including the contributions of the top/stop and gauge-Higgs
sectors to the one-loop effective potential of the pseudo-Goldstone Higgs
boson. While the joint effect of supersymmetry and of the global symmetry
allows in principle the electroweak symmetry to be broken with little
fine-tuning, the simplest version of the model fails to bring the Higgs mass
above the LEP bound due to a suppressed tree-level quartic coupling. To cure
this problem, we consider the possibility of additional SU(3)-breaking
contributions to the Higgs potential, which results in a moderate fine-tuning.
The model predicts a rather low messenger scale, a small tan beta value, a
light Higgs boson with Standard Model-like properties, and heavy higgsinos.Comment: 19 pages, 6 figures. New section 3.3 on the mu/Bmu problem, more
detailed analytic computation in section 4.1, error in Fig. 5 corrected,
significant redactional changes (including abstract, introduction and
conclusion) in order to better emphasize the main results of the paper. Title
changed in journal. Final version to appear in Eur. Phys. J.
Time of arrival through interacting environments: Tunneling processes
We discuss the propagation of wave packets through interacting environments.
Such environments generally modify the dispersion relation or shape of the wave
function. To study such effects in detail, we define the distribution function
P_{X}(T), which describes the arrival time T of a packet at a detector located
at point X. We calculate P_{X}(T) for wave packets traveling through a
tunneling barrier and find that our results actually explain recent
experiments. We compare our results with Nelson's stochastic interpretation of
quantum mechanics and resolve a paradox previously apparent in Nelson's
viewpoint about the tunneling time.Comment: Latex 19 pages, 11 eps figures, title modified, comments and
references added, final versio
Time-of-arrival distributions from position-momentum and energy-time joint measurements
The position-momentum quasi-distribution obtained from an Arthurs and Kelly
joint measurement model is used to obtain indirectly an ``operational''
time-of-arrival (TOA) distribution following a quantization procedure proposed
by Kocha\'nski and W\'odkiewicz [Phys. Rev. A 60, 2689 (1999)]. This TOA
distribution is not time covariant. The procedure is generalized by using other
phase-space quasi-distributions, and sufficient conditions are provided for
time covariance that limit the possible phase-space quasi-distributions
essentially to the Wigner function, which, however, provides a non-positive TOA
quasi-distribution. These problems are remedied with a different quantization
procedure which, on the other hand, does not guarantee normalization. Finally
an Arthurs and Kelly measurement model for TOA and energy (valid also for
arbitrary conjugate variables when one of the variables is bounded from below)
is worked out. The marginal TOA distribution so obtained, a distorted version
of Kijowski's distribution, is time covariant, positive, and normalized
Charged lepton electric dipole moments with the localized leptons and the new Higgs doublet in the two Higgs doublet model
We study the lepton electric dipole moments in the split fermion scenario, in
the two Higgs doublet model, where the new Higgs scalars are localized around
the origin in the extra dimension, with the help of the localizer field. We
observe that the numerical value of the electron (muon, tau) electric dipole
moment is at the order of the magnitude of 10^{-31} (10^{-24}, 10^{-22}) (e-cm)
and this quantity is sensitive the new Higgs localization in the extra
dimension.Comment: 20 pages, 7 figure
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Pegasus IV: Discovery and Spectroscopic Confirmation of an Ultra-faint Dwarf Galaxy in the Constellation Pegasus
We report the discovery of Pegasus IV, an ultra-faint dwarf galaxy found in archival data from the Dark Energy Camera processed by the DECam Local Volume Exploration Survey. Pegasus IV is a compact, ultra-faint stellar system (r1 2 = 41-+68 pc; MV = −4.25 ± 0.2 mag) located at a heliocentric distance of 90-+64 kpc. Based on spectra of seven nonvariable member stars observed with Magellan/IMACS, we confidently resolve Pegasus IV’s velocity dispersion, measuring sv = 3.3-+1.11.7 km s−1 (after excluding three velocity outliers); this implies a mass-to-light ratio of M1 2 LV,1 2 = 167-+99224M☉ L☉ for the system. From the five stars with the highest signal-to-noise spectra, we also measure a systemic metallicity of [Fe/H] =-2.63-+0.300.26 dex, making Pegasus IV one of the most metal-poor ultra-faint dwarfs. We tentatively resolve a nonzero metallicity dispersion for the system. These measurements provide strong evidence that Pegasus IV is a dark-matter-dominated dwarf galaxy, rather than a star cluster. We measure Pegasus IV’s proper motion using data from Gaia Early Data Release 3, finding (μα*, μδ) = (0.33 ± 0.07, −0.21 ± 0.08) mas yr−1. When combined with our measured systemic velocity, this proper motion suggests that Pegasus IV is on an elliptical, retrograde orbit, and is currently near its orbital apocenter. Lastly, we identify three potential RR Lyrae variable stars within Pegasus IV, including one candidate member located more than 10 half-light radii away from the system’s centroid. The discovery of yet another ultra-faint dwarf galaxy strongly suggests that the census of Milky Way satellites is still incomplete, even within 100 kpc
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