Integrated Project Support Study Group : findings

The challenges of the LHC project have lead CERN to produce a comprehensive set of project management tools covering engineering data management, project scheduling and costing, event management and document management. Each of these tools represents a significant and world-recognised advance in their respective domains. Reviewing the offering on the eve of LHC commissioning one can identify three major challenges: 1. How to integrate the tools to provide a uniform and integrated full-product lifecycle solution 2. How to evolve the functionality in certain areas to address weaknesses identified with our experience in constructing the LHC and integrate emerging industry best practices 3. How to coherently package the offering not just for future projects in CERN, but moreover in the context of providing a centre of excellence for worldwide collaboration in future HEP projects

Europa. 1:10335906

Coordenadas : E12 -O52 /N72 -N35 . Meridiano de ParísInserta tabla de línea divisoria de las aguasAdemás escala gráfica en leguas españolas, alemanas, geográficas...Relieve : líneas perpendiculares normale

Career-computer simulation increases perceived importance of learning about rare diseases

Background: Rare diseases may be defined as occurring in less than 1 in 2000 patients. Such conditions are, however, so numerous that up to 5.9% of the population is afflicted by a rare disease. The gambling industry attests that few people have native skill evaluating probabilities. We believe that both students and academics, under-estimate the likelihood of encountering rare diseases. This combines with pressure on curriculum time, to reduce both student interest in studying rare diseases, and academic content preparing students for clinical practice. Underestimation of rare diseases, may also contribute to unhelpful blindness to considering such conditions in the clinic. Methods: We first developed a computer simulation, modelling the number of cases of increasingly rare conditions encountered by a cohort of clinicians. The simulation captured results for each year of practice, and for each clinician throughout the entirety of their careers. Four hundred sixty-two theoretical conditions were considered, with prevalence ranging from 1 per million people through to 64.1% of the population. We then delivered a class with two in-class on-line surveys evaluating student perception of the importance of learning about rare diseases, one before and the other after an in-class real-time computer simulation. Key simulation variables were drawn from the student group, to help students project themselves into the simulation. Results: The in-class computer simulation revealed that all graduating clinicians from that class would frequently encounter rare conditions. Comparison of results of the in-class survey conducted before and after the computer simulation, revealed a significant increase in the perceived importance of learning about rare diseases (p < 0.005). Conclusions: The computer career simulation appeared to affect student perception. Because the computer simulation demonstrated clinicians frequently encounter patients with rare diseases, we further suggest this should be considered by academics during curriculum review and design

Effect of varying material anisotropy on critical current anistropy in vicinal YBa2_2Cu3_3O7−δ_{7-\delta} thin films

The high $T_{c}$ cuprate superconductors are noted for their anisotropic layered structure, certain of these materials indeed tend toward the limit of a Lawrence-Doniach superconductor. However, YBa$_2$Cu$_3$O$_{7-\delta}$ has a smaller anisotropy than would be expected from its interlayer spacing. This is due to the cuprate chains in the structure. To investigate the influence of the chain oxygen on transport properties critical current versus applied field angle measurements were performed on fully oxygenated and de-oxygenated YBa$_2$Cu$_3$O$_{7-\delta}$ thin films and optimally oxygenated Y$_{0.75}$Ca$_{0.2}$Ba$_2$Cu$_3$O$_{7-\delta}$ thin films. The films were grown on 10$^{\circ}$ mis-cut SrTiO$_3$ substrates to enable the intrinsic vortex channelling effect to be observed. The form of the vortex channelling minimum observed in field angle dependent critical current studies on the films was seen to depend on film oxygenation. The vortex channelling effect is dependent on a angular dependent cross-over to a string-pancake flux line lattice. The results obtained appear to be consistent with the prediction of Blatter et al. [Rev. Mod. Phys., 66 (4): 1125 (1994)] that increased superconducting anisotropy leads to the kinked string-pancake lattice existing over a smaller angular range.Comment: To be submitted to AP

Growth of Epitaxial Tungsten Nanorods

A simple vapour deposition technique was used to prepare WO3 one-dimensional nanostructures.WO3 is sublimated at a relatively low temperature (550 1C) in air at atmospheric pressure.The sublimated species are condensed on mica substrate at 500 1C.Single crystalline nanorods are grown in epitaxy on the mica surface with a growth axis along [0 1 0] directions and (0 0 1) plane parallel to the substrate.A growth process is proposed in which the formation of a onedimensional tetragonal tungsten bronze as precursor is the determining factor

Detection of antibacterial activity of essential oil components by TLC-bioautography using luminescent bacteria

The aim of the present study was the chemical characterization of some medically relevant essential oils (tea tree, clove, cinnamon bark, thyme and eucalyptus) and the investigation of antibacterial effect of the components of these oils by use of a direct bioautographic method. Thin layer chromatography (TLC) was combined with biological detection in this process. The chemical composition of the oils was determined by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). Eucalyptol (84.2%) was the main component of the essential oil of eucalyptus, eugenol (83.7%) of clove oil, and trans-cinnamic aldehyde (73.2%), thymol (49.9%) and terpinen-4-ol (45.8%) of cinnamon bark, thyme and tea tree oils, respectively. Antibacterial activity of the separated components of these oils, as well as their pure main components (eucalyptol, eugenol, trans-cinnamic aldehyde and thymol) was observed against the Gram-negative luminescence tagged plant pathogenic bacterium Pseudomonas syringae pv. maculicola (Psmlux) and the Gram-negative, naturally luminescent marine bacterium Vibrio fischeri. On the whole, the antibacterial activity of the essential oils could be related to their main components, but the minor constituents may be involved in this process. Trans-cinnamic aldehyde and eugenol were the most active compounds in TLC-bioautography. The sensitivity of TLC-bioautographic method can be improved with using luminescent test bacteria. This method is more cost-effective and provides more reliable results in comparison with conventional microbiological methods, e.g. disc-diffusion technique

SLAC's polarized electron source laser system for the E-158 parity violation experiment

SLAC E158 is an experiment to make the first measurement of parity violation in Moller scattering. The left-right cross-section asymmetry in the elastic scattering of a 45-GeV polarized electron beam off unpolarized electrons in a liquid hydrogen target will be measured to an accuracy of better than 10-8, with the expected Standard Model asymmetry being approximately 10-7. An intense circularly polarized laser beam for the polarized electron source is required with the ability to quickly switch between left and right polarization states with minimal left-right asymmetries in the parameters of the electron beam. This laser beam is produced by a unique SLAC-designed, flash-lamp pumped, Ti:Sapphire laser. We present this laser system design and initial results from recent commissioning runs

SLAC's polarized electron source laser system for the E-158 parity violation experiment

SLAC E158 is an experiment to make the first measurement of parity violation in Moller scattering. The left-right cross-section asymmetry in the elastic scattering of a 45-GeV polarized electron beam off unpolarized electrons in a liquid hydrogen target will be measured to an accuracy of better than 10-8, with the expected Standard Model asymmetry being approximately 10-7. An intense circularly polarized laser beam for the polarized electron source is required with the ability to quickly switch between left and right polarization states with minimal left-right asymmetries in the parameters of the electron beam. This laser beam is produced by a unique SLAC-designed, flash-lamp pumped, Ti:Sapphire laser. We present this laser system design and initial results from recent commissioning runs

Antiretroviral-naive and -treated HIV-1 patients can harbour more resistant viruses in CSF than in plasma

Objectives The neurological disorders in HIV-1-infected patients remain prevalent. The HIV-1 resistance in plasma and CSF was compared in patients with neurological disorders in a multicentre study. Methods Blood and CSF samples were collected at time of neurological disorders for 244 patients. The viral loads were >50 copies/mL in both compartments and bulk genotypic tests were realized. Results On 244 patients, 89 and 155 were antiretroviral (ARV) naive and ARV treated, respectively. In ARV-naive patients, detection of mutations in CSF and not in plasma were reported for the reverse transcriptase (RT) gene in 2/89 patients (2.2%) and for the protease gene in 1/89 patients (1.1%). In ARV-treated patients, 19/152 (12.5%) patients had HIV-1 mutations only in the CSF for the RT gene and 30/151 (19.8%) for the protease gene. Two mutations appeared statistically more prevalent in the CSF than in plasma: M41L (P = 0.0455) and T215Y (P = 0.0455). Conclusions In most cases, resistance mutations were present and similar in both studied compartments. However, in 3.4% of ARV-naive and 8.8% of ARV-treated patients, the virus was more resistant in CSF than in plasma. These results support the need for genotypic resistance testing when lumbar puncture is performe