Has VZV epidemiology changed in Italy? Results of a seroprevalence study

The aim of the study was to evaluate if and how varicella prevalence has changed in Italy. In particular a seroprevalence study was performed, comparing it to similar surveys conducted in pre-immunization era. During 2013–2014, sera obtained from blood samples taken for diagnostic purposes or routine investigations were collected in collaboration with at least one laboratory/center for each region, following the approval of the Ethics Committee. Data were stratified by sex and age. All samples were processed in a national reference laboratory by an immunoassay with high sensitivity and specificity. Statutory notifications, national hospital discharge database and mortality data related to VZV infection were analyzed as well. A total of 3707 sera were collected and tested. In the studied period both incidence and hospitalization rates decreased and about 5 deaths per year have been registered. The seroprevalence decreased in the first year of life in subjects passively protected by their mother, followed by an increase in the following age classes. The overall antibody prevalence was 84%. The comparison with surveys conducted with the same methodology in 1996–1997 and 2003–2004 showed significant differences in age groups 1–19 y. The study confirms that in Italy VZV infection typically occurs in children. The impact of varicella on Italian population is changing. The comparison between studies performed in different periods shows a significant increase of seropositivity in age class 1–4 years, expression of vaccine interventions already adopted in some regions

Herschel-ATLAS/GAMA: What determines the far-infrared properties of radio galaxies?

We perform a stacking analysis of Herschel Astrophysical Terahertz Large Area Survey (H-ATLAS) data in order to obtain isothermal dust temperatures and rest-frame luminosities at 250 μm (L_250), for a well-defined sample of 1599 radio sources over the H-ATLAS Phase 1/Galaxy and Mass Assembly (GAMA) area. The radio sample is generated using a combination of NRAO VLA Sky Survey data and K-band United Kingdom Infrared Telescope Deep Sky Survey–Large Area Survey data, over the redshift range 0.01 < z < 0.8. The far-infrared (FIR) properties of the sample are investigated as a function of 1.4-GHz luminosity, redshift, projected radio-source size and radio spectral index. In order to search for stellar-mass-dependent relations, we split the parent sample into those sources which are below and above 1.5 L∗_(K). After correcting for stellar mass and redshift, we find no relation between the 250-μm luminosity and the 1.4-GHz radio luminosity of radio active galactic nuclei. This implies that a galaxy's nominal radio luminosity has little or no bearing on the star formation rate (SFR) and/or dust mass content of the host system, although this does not mean that other variables (e.g. radio source size) related to the jets do not have an effect. The L_250 of both the radio detected and non-radio-detected galaxies (defined as those sources not detected at 1.4 GHz but detected in the Sloan Digital Sky Survey with r′ 30 kpc) counterparts. The higher dust temperature suggests that this may be attributed to enhanced SFRs in compact radio galaxies, but whether this is directly or indirectly due to radio activity (e.g. jet-induced or merger-driven star formation) is as yet unknown. For matched samples in L_K and g′–r′, sub-1.5 L∗_K and super-1.5 L∗_K radio-detected galaxies have 0.89±0.18 and 0.49±0.12 times the 250 μm luminosity of their non-radio-detected counterparts. Thus, while no difference in L_250 is observed in sub-1.5 L∗_K radio-detected galaxies, a strong deficit is observed in super-1.5 L∗_K radio-detected galaxies. We explain these results in terms of the hotter, denser and richer halo environments massive radio galaxies maintain and are embedded in. These environments are expected to quench the cold gas and dust supply needed for further star formation and therefore dust production. Our results indicate that all massive radio galaxies (>1.5 L∗_K) may have systematically lower FIR luminosities (∼25 per cent) than their colour-matched non-radio-detected counterparts. Finally, no relation between radio spectral index and L_250 is found for the subset of 1.4-GHz radio sources with detections at 330 MHz

Herpes zoster in general medicine: experience of the Italian group Netaudit

Herpes zoster is caused by the reactivation of the varicella-zoster virus (VZV) and usually appears many years after primary infection (varicella), induced by immunosuppression due to underlying diseases. Few epidemiological data in Italy are available concerning Herpes zoster, mainly because disease notification is not mandatory. An observational perspective trial was conducted for 12 months by 41 Italian general practitioners belonging to the Netaudit network to determine herpes zoster incidence and its correlation to patients' characteristics (age, gender, educational qualification, co-morbidities), the delay from correct diagnosis to the start of treatment and different drug prescription. In all, the study involved 193 patients with herpes zoster: this population included mostly female (60.6%) and elderly subjects (59.6%) with a mean age of 60.4 years. 46.1% of patients presented underlying diseases (diabetes 13%, solid tumours 5.7%). Correct diagnosis was achieved after a mean delay of 49 hours while therapy was started within 48 hours in most cases (75.1%). Aciclovir (51%) and valaciclovir (24%) were the most commonly used drugs. A significant correlation between educational level and prompt treatment suggests the major role of education in primary health prevention campaigns

[Early myoclonic epileptic encephalopathy (EMEE) (author's transl)]

The authors describe the electroclinical and evolutive aspects of 4 cases (including 2 brothers) of myoclonic epileptic encephalopathy beginning between 2 days and 10 weeks of life. From the onset of myoclonic jerks, polymorphous fits (partial seizures, tonic seizures) and multifocal electrical abnormalities are associated. Repeated spasms and 'suppression-burst' patterns appear later. The neurological status deteriorates progressively, leading within a few months to decerebration posture with opisthotonus. In spite of thorough neuroradiological, biochemical, cytological to metabolic investigations, etiology remains unknown. However, the electroclinical and evolutive patterns are similar to that of metabolic diseases, especially non-ketotic hyperglycemia. The authors discuss the relations between their observations and those in the literature and the nosological problems of this particular epileptic encephalopathy of infancy